The effect of Amaryllidaceae alkaloids haemanthamine and haemanthidine on cell cycle progression and apoptosis in p53-negative human leukemic Jurkat cells

Phytomedicine

Volumn 21, Issue 4, 2014, Pages 479-490

  Havelek, Radim ^a   Seifrtova, Martina ^c   Kralovec, Karel ^a   Bruckova, Lenka ^a   Cahlikova, Lucie ^b   Dalecka, Marketa ^a   Vavrova, Jirina ^d   Rezacova, Martina ^c   Opletal, Lubomir ^b   Bilkova, Zuzana ^a  

^a UNIVERSITY OF PARDUBICE   (Czech Republic)

^b Charles University in Prague Faculty of Pharmacy   (Czech Republic)

^c CHARLES UNIVERSITY   (Czech Republic)

^d UNIVERSITY OF DEFENCE   (Czech Republic)

Author keywords

Apoptosis; Caspases; Cell cycle; Haemanthamine; Haemanthidine; Jurkat

Indexed keywords

AMARYLLIDACEAE ALKALOID; CASPASE 3; CASPASE 7; CASPASE 8; CASPASE 9; CHECKPOINT KINASE 1; CYCLIN DEPENDENT KINASE INHIBITOR 2A; HAEMANTHAMINE; HAEMANTHIDINE; LIPOCORTIN 5; PROTEIN P53; ANTINEOPLASTIC AGENT; CASPASE; PHENANTHRIDINE DERIVATIVE; PLANT EXTRACT; PROTEIN KINASE;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BRIGHT FIELD MICROSCOPY; CASY CELL COUNTER; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE M PHASE; CELL CYCLE PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXICITY; DNA DAMAGE; DNA DAMAGE CHECKPOINT; ENZYME ACTIVATION; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GAMMA RADIATION; HUMAN; HUMAN CELL; IONIZING RADIATION; LEUKEMIA CELL LINE; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RADIOSENSITIVITY; T CELL LEUKEMIA; CELL CYCLE CHECKPOINT; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; JURKAT CELL LINE; LEUKEMIA; LILIACEAE; METABOLISM; PHYTOTHERAPY; TUMOR SUPPRESSOR GENE;

AMARYLLIDACEAE;

AMARYLLIDACEAE ALKALOIDS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CASPASES; CELL CYCLE CHECKPOINTS; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DRUG SCREENING ASSAYS, ANTITUMOR; GENES, P53; HUMANS; JURKAT CELLS; LEUKEMIA; LILIACEAE; MEMBRANE POTENTIAL, MITOCHONDRIAL; PHENANTHRIDINES; PHYTOTHERAPY; PLANT EXTRACTS; PROTEIN KINASES;

EID: 84897398012     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2013.09.005     Document Type: Article

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