Chrysin sensitizes tumor necrosis factor-α-induced apoptosis in human tumor cells via suppression of nuclear factor-kappaB

Cancer Letters

Volumn 293, Issue 1, 2010, Pages 109-116

  Li, Xin ^a   Huang, Qing ^b   Ong, Choon Nam ^b   Yang, Xing Fen ^a   Shen, Han Ming ^b,c  

^a GUANGZHOU CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Apoptosis; Cancer; Chrysin; NF B; TNF

Indexed keywords

CASPASE 8; CHRYSIN; FLICE INHIBITORY PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; SYNAPTOTAGMIN I; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL COUNT; CELL STRAIN HCT116; CELL STRAIN HEPG2; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY TEST; DOWN REGULATION; DRUG EFFICACY; GENE ACTIVATION; GENE ACTIVITY; GENE TARGETING; HUMAN; HUMAN CELL; NASOPHARYNX CANCER; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN DEGRADATION; REGULATORY MECHANISM; TUMOR CELL;

APOPTOSIS; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; COLORECTAL NEOPLASMS; DOWN-REGULATION; DRUG SYNERGISM; FLAVONOIDS; HCT116 CELLS; HEP G2 CELLS; HUMANS; IMMUNOBLOTTING; LIVER NEOPLASMS; NASOPHARYNGEAL NEOPLASMS; NEOPLASMS; NF-KAPPA B; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77952428515     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2010.01.002     Document Type: Article

References (43)

1. Balkwill F. Tumour necrosis factor and cancer. Nat. Rev. Cancer 2009, 9:361-371.
2. Chen G., Goeddel D.V. TNF-R1 signaling: a beautiful pathway. Science 2002, 296:1634-1635.
3. Valmiki M.G., Ramos J.W. Death effector domain-containing proteins. Cell. Mol. Life Sci. 2009, 66:814-830.
4. Karin M., Lin A. NF-kappaB at the crossroads of life and death. Nat. Immunol. 2002, 3:221-227.
5. Vallabhapurapu S., Karin M. Regulation and function of NF-kappaB transcription factors in the immune system. Ann. Rev. Immunol. 2009, 27:693-733.
6. Micheau O., Lens S., Gaide O., Alevizopoulos K., Tschopp J. NF-kappaB signals induce the expression of c-FLIP. Mol. Cell Biol. 2001, 21:5299-5305.
7. Karin M., Yamamoto Y., Wang Q.M. The IKK NF-kappa B system: a treasure trove for drug development. Nat. Rev. Drug Disc. 2004, 3:17-26.
8. Arts I.C. A review of the epidemiological evidence on tea, flavonoids, and lung cancer. J. Nutr. 2008, 138:1561S-1566S.
9. Le Marchand L. Cancer preventive effects of flavonoids - a review. Biomed. Pharmacother. 2002, 56:296-301.
10. Birt D.F., Hendrich S., Wang W. Dietary agents in cancer prevention: flavonoids and isoflavonoids. Pharmacol. Ther. 2001, 90:157-177.
11. Manthey J.A., Guthrie N. Antiproliferative activities of citrus flavonoids against six human cancer cell lines. J. Agric. Food Chem. 2002, 50:5837-5843.
12. Chung F.L., Schwartz J., Herzog C.R., Yang Y.M. Tea and cancer prevention: studies in animals and humans. J. Nutr. 2003, 133:3268S-3274S.
13. Williams C.A., Harborne J.B., Newman M., Greenham J., Eagles J. Chrysin and other leaf exudate flavonoids in the genus Pelargonium. Phytochemistry 1997, 46:1349-1353.
14. Rapta P., Misik V., Stasko A., Vrabel I. Redox intermediates of flavonoids and caffeic acid esters from propolis: an EPR spectroscopy and cyclic voltammetry study. Free Radic. Biol. Med. 1995, 18:901-908.
15. Habtemariam S. Flavonoids as inhibitors or enhancers of the cytotoxicity of tumor necrosis factor-alpha in L-929 tumor cells. J. Nat. Prod. 1997, 60:775-778.
16. Koganov M.M., Dueva O.V., Tsorin B.L. Activities of plant-derived phenols in a fibroblast cell culture model. J. Nat. Prod. 1999, 62:481-483.
17. Lapidot T., Walker M.D., Kanner J. Antioxidant and prooxidant effects of phenolics on pancreatic beta-cells in vitro. J. Agric. Food Chem. 2002, 50:7220-7225.
18. Cho H., Yun C.W., Park W.K., Kong J.Y., Kim K.S., Park Y., Lee S., Kim B.K. Modulation of the activity of pro-inflammatory enzymes, COX-2 and iNOS, by chrysin derivatives. Pharmacol. Res. 2004, 49:37-43.
19. Zhang T., Chen X., Qu L., Wu J., Cui R., Zhao Y. Chrysin and its phosphate ester inhibit cell proliferation and induce apoptosis in Hela cells. Bioorg. Med. Chem. 2004, 12:6097-6105.
20. Monasterio A., Urdaci M.C., Pinchuk I.V., Lopez-Moratalla N., Martinez-Irujo J.J. Flavonoids induce apoptosis in human leukemia U937 cells through caspase- and caspase-calpain-dependent pathways. Nutr. Cancer 2004, 50:90-100.
21. Woo K.J., Jeong Y.J., Park J.W., Kwon T.K. Chrysin-induced apoptosis is mediated through caspase activation and Akt inactivation in U937 leukemia cells. Biochem. Biophys. Res. Commun. 2004, 325:1215-1222.
22. Cipak L., Rauko P., Miadokova E., Cipakova I., Novotny L. Effects of flavonoids on cisplatin-induced apoptosis of HL-60 and L1210 leukemia cells. Leuk. Res. 2003, 27:65-72.
23. Fu B., Xue J., Li Z., Shi X., Jiang B.H., Fang J. Chrysin inhibits expression of hypoxia-inducible factor-1alpha through reducing hypoxia-inducible factor-1alpha stability and inhibiting its protein synthesis. Mol. Cancer Ther. 2007, 6:220-226.
24. Shen H., Yang C., Liu J., Ong C. Dual role of glutathione in selenite-induced oxidative stress and apoptosis in human hepatoma cells. Free Radic. Biol. Med. 2000, 28:1115-1124.
25. Denecker G., Vercammen D., Steemans M., Vanden Berghe T., Brouckaert G., Van Loo G., Zhivotovsky B., Fiers W., Grooten J., Declercq W., Vandenabeele P. Death receptor-induced apoptotic and necrotic cell death: differential role of caspases and mitochondria. Cell Death Differ. 2001, 8:829-840.
26. Darzynkiewicz Z., Bedner E., Traganos F., Murakami T. Critical aspects in the analysis of apoptosis and necrosis. Hum. Cell 1998, 11:3-12.
27. Strasser A., Newton K. FADD/MORT1, a signal transducer that can promote cell death or cell growth. Int. J. Biochem. Cell Biol. 1999, 31:533-537.
28. Yamamoto Y., Gaynor R.B. Therapeutic potential of inhibition of the NF-kappaB pathway in the treatment of inflammation and cancer. J. Clin. Invest. 2001, 107:135-142.
29. Chen C.C., Chow M.P., Huang W.C., Lin Y.C., Chang Y.J. Flavonoids inhibit tumor necrosis factor-alpha-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells through activator protein-1 and nuclear factor-kappaB: structure-activity relationships. Mol. Pharmacol. 2004, 66:683-693.
30. Irmler M., Thome M., Hahne M., Schneider P., Hofmann K., Steiner V., Bodmer J.L., Schroter M., Burns K., Mattmann C., Rimoldi D., French L.E., Tschopp J. Inhibition of death receptor signals by cellular FLIP. Nature 1997, 388:190-195.
31. Muzio M., Salvesen G.S., Dixit V.M. FLICE induced apoptosis in a cell-free system. Cleavage of caspase zymogens. J. Biol. Chem. 1997, 272:2952-2956.
32. Wu Y.X., Fang X. Apigenin, chrysin, and luteolin selectively inhibit chymotrypsin-like and trypsin-like proteasome catalytic activities in tumor cells. Planta Med 2009.
33. Zhang Q., Zhao X.H., Wang Z.J. Flavones and flavonols exert cytotoxic effects on a human oesophageal adenocarcinoma cell line (OE33) by causing G2/M arrest and inducing apoptosis. Food Chem. Toxicol. 2008, 46:2042-2053.
34. Zhang Q., Zhao X.H., Wang Z.J. Cytotoxicity of flavones and flavonols to a human esophageal squamous cell carcinoma cell line (KYSE-510) by induction of G2/M arrest and apoptosis. Toxicol. In Vitro 2009, 23:797-807.
35. Shi R.X., Ong C.N., Shen H.M. Luteolin sensitizes tumor necrosis factor-alpha-induced apoptosis in human tumor cells. Oncogene 2004, 23:7712-7721.
36. Surh Y.J., Chun K.S., Cha H.H., Han S.S., Keum Y.S., Park K.K., Lee S.S. Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation. Mutat. Res. 2001, 480-481:243-268.
37. Shin E.K., Kwon H.S., Kim Y.H., Shin H.K., Kim J.K. Chrysin, a natural flavone, improves murine inflammatory bowel diseases. Biochem. Biophys. Res. Commun. 2009, 381:502-507.
38. Romier B., Van De Walle J., During A., Larondelle Y., Schneider Y.J. Modulation of signalling nuclear factor-kappaB activation pathway by polyphenols in human intestinal Caco-2 cells. Brit. J. Nutr. 2008, 100:542-551.
39. Woo K.J., Jeong Y.J., Inoue H., Park J.W., Kwon T.K. Chrysin suppresses lipopolysaccharide-induced cyclooxygenase-2 expression through the inhibition of nuclear factor for IL-6 (NF-IL6) DNA-binding activity. FEBS Lett. 2005, 579:705-711.
40. Hecker M., Preiss C., Klemm P., Busse R. Inhibition by antioxidants of nitric oxide synthase expression in murine macrophages: role of nuclear factor kappa B and interferon regulatory factor 1. Brit. J. Pharmacol. 1996, 118:2178-2184.
41. Lin Y., Shi R., Wang X., Shen H.M. Luteolin, a flavonoid with potential for cancer prevention and therapy. Curr. Cancer Drug Target 2008, 8:634-646.
42. Krueger A., Schmitz I., Baumann S., Krammer P.H., Kirchhoff S. Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex. J. Biol. Chem. 2001, 276:20633-20640.
43. Nakajima A., Kojima Y., Nakayama M., Yagita H., Okumura K., Nakano H. Downregulation of c-FLIP promotes caspase-dependent JNK activation and reactive oxygen species accumulation in tumor cells. Oncogene 2008, 27:76-84.