Astragalus saponins modulate mTOR and ERK signaling to promote apoptosis through the extrinsic pathway in HT-29 colon cancer cells

International Journal of Molecular Medicine

Volumn 26, Issue 3, 2010, Pages 341-349

  Auyeung, Kathy Ka Wai ^a   Mok, Nga Lai ^a   Wong, Ching Man ^b   Cho, Chi Hin ^b   Ko, Joshua Ka Shun ^a  

^a HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

^b and Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics   (Hong Kong)

Author keywords

Astragalus saponins; Extracellular signal regulated protein kinase; HT 29 cells; Mammalian target of rapamycin; Nuclear factor B; Tumor necrosis factor

Indexed keywords

CASPASE 8; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MAPK1 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MTOR PROTEIN, HUMAN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN PRECURSOR; PROTEIN SERINE THREONINE KINASE; SAPONIN; SIGNAL PEPTIDE; TARGET OF RAPAMYCIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

ANTAGONISTS AND INHIBITORS; APOPTOSIS; ASTRAGALUS PLANT; CHEMISTRY; DRUG EFFECTS; ENZYME ACTIVATION; HT 29 CELL LINE; HUMAN; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

APOPTOSIS; ASTRAGALUS PLANT; CASPASE 8; ENZYME ACTIVATION; HT29 CELLS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NF-KAPPA B; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN PRECURSORS; PROTEIN-SERINE-THREONINE KINASES; SAPONINS; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77956712197     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm_00000471     Document Type: Article

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