Roles of the translation initiation factor eIF2α serine 51 phosphorylation in cancer formation and treatment

Biochimica et Biophysica Acta - Gene Regulatory Mechanisms

Volumn 1849, Issue 7, 2015, Pages 871-880

  Koromilas, Antonis E ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Cell proliferation; Chemotherapeutic drug; MRNA translation; Protein phosphorylation; Translation initiation factor eIF2; Tumorigenesis

Indexed keywords

ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; CYCLIN D1; EUKARYOTIC INITIATION FACTOR 2ALPHA SERINE 51; GSK 2656157; INITIATION FACTOR 2ALPHA; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; PROTEIN; PROTEIN GCN2; PROTEIN P53; PROTEIN PERK; PROTEIN PKR; PROTEIN TYROSINE PHOSPHATASE 1B; STAT1 PROTEIN; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; INITIATION FACTOR 2; PROTEIN SERINE THREONINE KINASE; RNA; TUMOR PROTEIN;

ANTINEOPLASTIC ACTIVITY; CANCER THERAPY; CARCINOGENESIS; CELL FATE; CELL PROLIFERATION; CELL STRESS; CELL SURVIVAL; CONFORMATIONAL TRANSITION; DRUG EFFICACY; ENDOPLASMIC RETICULUM STRESS; ENZYME PHOSPHORYLATION; EPITHELIAL MESENCHYMAL TRANSITION; GENE EXPRESSION; HUMAN; IMMUNE RESPONSE; METABOLIC STRESS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN SYNTHESIS; RADIATION RESPONSE; REVIEW; RNA TRANSLATION; SIGNAL TRANSDUCTION; TUMOR GROWTH; ANIMAL; GENETICS; METABOLISM; MOUSE; NEOPLASM; PATHOLOGY; PHOSPHORYLATION;

ANIMALS; EUKARYOTIC INITIATION FACTOR-2; HUMANS; MICE; NEOPLASM PROTEINS; NEOPLASMS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RNA, MESSENGER; RNA, NEOPLASM;

EID: 84930823512     PISSN: 18749399     EISSN: 18764320     Source Type: Journal    
DOI: 10.1016/j.bbagrm.2014.12.007     Document Type: Review

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