Interaction of Nck1 and PERK phosphorylated at Y561 negatively modulates PERK activity and PERK regulation of pancreatic β-cell proinsulin content

Molecular Biology of the Cell

Volumn 25, Issue 5, 2014, Pages 702-711

  Yamani, Lama ^a   Latreille, Mathieu ^a,b   Larose, Louise ^a  

^a RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^b ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTATHIONE TRANSFERASE; INITIATION FACTOR 2ALPHA; INSULIN; NCK1 PROTEIN; PEPTIDES AND PROTEINS; PHOSPHOAMINO ACID; PKR LIKE ENDOPLASMIC RETICULUM KINASE; POLYCLONAL ANTISERUM; PROINSULIN; PROTEIN SERINE THREONINE KINASE; PROTEIN SH2; SHORT HAIRPIN RNA; THAPSIGARGIN; UNCLASSIFIED DRUG; NCK PROTEIN; ONCOPROTEIN; PERK KINASE; PROTEIN KINASE R; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING ASSAY; BINDING SITE; CONTROLLED STUDY; DELETION MUTANT; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; IN VITRO STUDY; INSULIN SYNTHESIS; INSULINOMA; KNOCKOUT MOUSE; MOUSE; MUTATION; NONHUMAN; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN HOMEOSTASIS; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RNA TRANSLATION; SRC HOMOLOGY DOMAIN; ANIMAL; BIOSYNTHESIS; CELL LINE; CHLOROCEBUS AETHIOPS; COS 1 CELL LINE; GENETICS; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CELL LINE; CERCOPITHECUS AETHIOPS; COS CELLS; EIF-2 KINASE; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MICE; MICE, KNOCKOUT; ONCOGENE PROTEINS; PHOSPHORYLATION; PROINSULIN;

EID: 84896846085     PISSN: 10591524     EISSN: 19394586     Source Type: Journal    
DOI: 10.1091/mbc.E13-09-0511     Document Type: Article

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