Doxorubicin bypasses the cytoprotective effects of eIF2α phosphorylation and promotes PKR-mediated cell death

Cell Death and Differentiation

Volumn 18, Issue 1, 2011, Pages 145-154

  Peidis, P ^a   Papadakis, A I ^a,b   Muaddi, H ^a,b   Richard, S ^a,c   Koromilas, A E ^a,c  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

apoptosis; doxorubicin; eIF2 ; JNK; PKR; protein phosphorylation

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; DOXORUBICIN; INITIATION FACTOR 2ALPHA; MESSENGER RNA; PROTEIN KINASE R; STRESS ACTIVATED PROTEIN KINASE;

ARTICLE; CELL DEATH; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; DNA DAMAGE; DRUG INHIBITION; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RNA TRANSLATION; SIGNAL TRANSDUCTION;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; CELL LINE; CYTOPROTECTION; DNA DAMAGE; DNA REPAIR; DOXORUBICIN; EIF-2 KINASE; EUKARYOTIC INITIATION FACTOR-2; HUMANS; MICE; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION;

EUKARYOTA;

EID: 78650176190     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2010.76     Document Type: Article

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