The unfolded protein response as a target for cancer therapy

Biochimica et Biophysica Acta - Reviews on Cancer

Volumn 1846, Issue 2, 2014, Pages 277-284

  Nagelkerke, Anika ^a,b   Bussink, Johan ^a   Sweep, Fred C G J ^a   Span, Paul N ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

Author keywords

Autophagy; Cancer; Endoplasmic reticulum stress; Therapy; Unfolded protein response

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; ANTINEOPLASTIC AGENT; CARBOPLATIN; CISPLATIN; GLUCOSE REGULATED PROTEIN 78; PROTEIN IRE1; PROTEIN PERK; UNCLASSIFIED DRUG; ACTIVATING TRANSCRIPTION FACTOR 4; BORTEZOMIB; EEYARESTATIN 1; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2ALPHA; INOSITOL REQUIRING ENZYME 1 ALPHA; INOSITOL REQUIRING ENZYME 1 BETA; MEMBRANE PROTEIN; PROTEIN KINASE R LIKE ENDOPLASMIC RETICULUM KINASE; TAMOXIFEN; TUNICAMYCIN; EIF2AK3 PROTEIN, HUMAN; ERN1 PROTEIN, HUMAN; HEAT SHOCK PROTEIN; MOLECULAR CHAPERONE GRP78; PROTEIN KINASE R; PROTEIN SERINE THREONINE KINASE; RIBONUCLEASE;

AUTOPHAGY; CANCER CELL LINE; CANCER THERAPY; CELL DEATH; CELL SURVIVAL; DRUG MECHANISM; ENDOPLASMIC RETICULUM STRESS; HUMAN; NEOPLASM; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; THERAPY RESISTANCE; TUMOR MICROENVIRONMENT; UNFOLDED PROTEIN RESPONSE; ANTINEOPLASTIC ACTIVITY; CANCER CHEMOTHERAPY; CANCER HORMONE THERAPY; CANCER RADIOTHERAPY; CANCER RESISTANCE; CELL CYCLE ARREST; CELL NUCLEUS; CELL PROTECTION; CYTOPLASM; ENZYME ACTIVATION; ENZYME ACTIVITY; GOLGI COMPLEX; HOMEOSTASIS; PROTEIN OVEREXPRESSION; PROTEIN TARGETING; PROTEIN TRANSPORT; TRANSLATION REGULATION; TRANSLATIONAL ARREST; TUMOR CELL; ANIMAL; DRUG EFFECTS; NEOPLASMS; PHYSIOLOGY;

ANIMALS; AUTOPHAGY; EIF-2 KINASE; ENDOPLASMIC RETICULUM STRESS; ENDORIBONUCLEASES; HEAT-SHOCK PROTEINS; HUMANS; NEOPLASMS; PROTEIN-SERINE-THREONINE KINASES; UNFOLDED PROTEIN RESPONSE;

EID: 84906273649     PISSN: 0304419X     EISSN: 18792561     Source Type: Journal    
DOI: 10.1016/j.bbcan.2014.07.006     Document Type: Review

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