Uncoupling proteostasis and development in vitro with a small molecule inhibitor of the pancreatic endoplasmic reticulum kinase, PERK

Journal of Biological Chemistry

Volumn 287, Issue 53, 2012, Pages 44338-44344

  Harding, Heather P ^a   Zyryanova, Alisa F ^a   Ron, David ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CELL; ENDOPLASMIC RETICULUM; GLUCOSE CONCENTRATION; IN-VITRO; ISLETS OF LANGERHANS; PHYSIOLOGICAL LEVELS; PROTEIN SYNTHESIS; SMALL MOLECULE INHIBITOR; UNFOLDED PROTEIN RESPONSE; UNFOLDED PROTEINS;

CELL MEMBRANES; INSULIN;

PROTEINS;

GLUCOSE; GSK 2606414; INITIATION FACTOR 2ALPHA; PANCREATIC ENDOPLASMIC RETICULUM KINASE; PROINSULIN; PROTEIN KINASE INHIBITOR; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CELL MATURATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; IMMUNOBLOTTING; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROCESS DEVELOPMENT; PROTEIN DETERMINATION; PROTEIN FOLDING; PROTEIN HOMEOSTASIS; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS REGULATION; PROTEIN TRANSPORT; RAT;

ANIMALS; CELLS, CULTURED; EIF-2 KINASE; ENDOPLASMIC RETICULUM; EUKARYOTIC INITIATION FACTOR-2; GLUCOSE; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MICE; MICE, KNOCKOUT; PROTEIN BIOSYNTHESIS; PROTEIN FOLDING; PROTEIN KINASE INHIBITORS; RATS; UNFOLDED PROTEIN RESPONSE;

EID: 84871759394     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.428987     Document Type: Article

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