The murine double-stranded RNA-dependent protein kinase PKR is required for resistance to vesicular stomatitis virus

Journal of Virology

Volumn 74, Issue 20, 2000, Pages 9580-9585

  Stojdl, D F ^a   Abraham, N ^a   Knowles, S ^a   Marius, R ^a   Brasey, A ^a   Lichty, B D ^a   Brown, E G ^a   Sonenberg, N ^a   Bell, J C ^a  

^a OTTAWA REGIONAL CANCER CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; DOUBLE STRANDED DNA; PROTEIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; FIBROBLAST; IMMUNOREGULATION; INFECTION RESISTANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; VESICULAR STOMATITIS VIRUS; VIRUS RESISTANCE;

ANIMAL; EIF-2 KINASE; FEMALE; INTERFERONS; LUNG; MICE; MICE, INBRED BALB C; RHABDOVIRIDAE INFECTIONS; SUPPORT, NON-U.S. GOV'T; VESICULAR STOMATITIS-INDIANA VIRUS;

EID: 0033809383     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.74.20.9580-9585.2000     Document Type: Article

References (39)

1. Characterization of transgenic mice with targeted disruption of the catalytic domain of the double-stranded RNA-dependent protein kinase, PKR
2. Minor-groove recognition of double-stranded RNA by the double-stranded RNA-binding domain from the RNA-activated protein kinase PKR
3. Inhibition of vesicular stomatitis virus infection by nitric oxide
4. Defective interfering virus particles modulate virulence
5. The E3L gene of vaccinia virus encodes an inhibitor of the interferon-induced, double-stranded RNA-dependent protein kinase
6. The vaccinia virus K3L gene product potentiates translation by inhibiting double-stranded-RNA-activated protein kinase and phosphorylation of the alpha subunit of eukaryotic initiation factor 2
7. A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis
8. Inducible expression of the 2-5A synthetase/RNase L system results in inhibition of vaccinia virus replication
9. Murine infection by vesicular stomatitis virus: Initial characterization of the H-2(d) system
10. Autophosphorylation of the protein kinase dependent on double stranded RNA
11. Mx proteins: Mediators of innate resistance to RNA viruses
12. Gamma interferon-induced, nitric oxide-mediated inhibition of vaccinia virus replication
13. Identification of the murine Mx2 gene: Interferon-induced expression of the Mx2 protein from the feral mouse gene confers resistance to vesicular stomatitis virus
14. Characterization and expression of the Mx1 gene in wild mouse species
15. Inhibition of viral replication by interferon-gamma-induced nitric oxide synthase
16. pppA2'p5'A2'p5'A: An inhibitor of protein synthesis synthesized with an enzyme fraction from interferon-treated cells
17. Double-stranded RNA is a trigger for apoptosis in vaccinia virus-infected cells
18. Inhibition of protein synthesis by nitric oxide correlates with cytostatic activity: Nitric oxide induces phosphorylation of initiation factor eIF-2 alpha
19. Interferon-induced human MxA GTPase blocks nuclear import of Thogoto virus nucleocapsids
20. Isolation of the interferon-inducible RNA-dependent protein kinase Pkr promoter and identification of a novel DNA element within the 5'-flanking region of human and mouse Pkr genes
21. Regulated expression of the interferon-induced protein kinase p68 (PKR) by vaccinia virus recombinants inhibits the replication of vesicular stomatitis virus but not that of poliovirus
22. The interferon-induced double-stranded RNA-activated human p68 protein kinase inhibits the replication of vaccinia virus
23. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
24. Selective infections of olfactory and respiratory epithelium by vesicular stomatitis and Sendai viruses
25. Mice lacking inducible nitric-oxide synthase are more susceptible to herpes simplex virus infection despite enhanced Th1 cell responses
26. Inhibition of vaccinia virus DNA replication by inducible expression of nitric oxide synthase
27. Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon
28. Constitutive expression of human double-stranded RNA-activated p68 kinase in murine cells mediates phosphorylation of eukaryotic initiation factor 2 and partial resistance to encephalomyocarditis virus growth
29. An antiviral effect of nitric oxide: Inhibition of reovirus replication
30. The earliest events in vesicular stomatitis virus infection of the murine olfactory neuroepithelium and entry of the central nervous system
31. Vaccination with a recombinant vesicular stomatitis virus expressing an influenza virus hemagglutinin provides complete protection from influenza virus challenge
32. Regulation of IFN-alpha/beta, MxA, 2',5'-oligoadenylate synthetase, and HLA gene expression in influenza A-infected human lung epithelial cells
33. An antiviral mechanism of nitric oxide: Inhibition of a viral protease
34. Trypanosoma brucei: Analysis of cytoplasmic Ca2+ during differentiation of bloodstream stages in vitro
35. Possible involvement of double-stranded RNA-activated protein kinase in cell death by influenza virus infection
36. Deficient signalling in mice devoid of double-stranded RNA-dependent protein kinase
37. An essential role for the interferon-inducible, double-stranded RNA-activated protein kinase PKR in the tumor necrosis factor-induced apoptosis in U937 cells
38. Interferon action and apoptosis are defective in mice devoid of 2',5'-oligoadenylate-dependent RNase L
39. Interferon action in triply deficient mice reveals the existence of alternative antiviral pathways