eIF2α phosphorylation bypasses premature senescence caused by oxidative stress and pro-oxidant antitumor therapies

Aging

Volumn 5, Issue 12, 2013, Pages 884-901

  Rajesh, Kamindla ^a   Papadakis, Andreas I ^a   Kazimierczak, Urszula ^a,b   Peidis, Philippos ^a   Wang, Shuo ^a   Ferbeyre, Gerardo ^c   Kaufman, Randal J ^d   Koromilas, Antonis E ^a,e  

^a MCGILL UNIVERSITY   (Canada)

^b POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

^c UNIVERSITÉ DE MONTRÉAL   (Canada)

^d BURNHAM INSTITUTE   (United States)

^e MCGILL UNIVERSITY   (Canada)

Author keywords

Cellular senescence; DNA damage; Doxorubicin; eIF2; mRNA translation; Protein phosphorylation; Reactive oxygen species

Indexed keywords

ANTINEOPLASTIC AGENT; DOXORUBICIN; EIF2AK3 PROTEIN, HUMAN; INITIATION FACTOR 2; PERK KINASE; PROTEIN KINASE R; REACTIVE OXYGEN METABOLITE;

ANIMAL; ARTICLE; CELL LINE; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; MOUSE; NUDE MOUSE; OXIDATIVE STRESS; PHOSPHORYLATION; PHYSIOLOGY; PREMATURE AGING;

AGING, PREMATURE; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE; DOXORUBICIN; EIF-2 KINASE; EUKARYOTIC INITIATION FACTOR-2; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; MICE; MICE, NUDE; OXIDATIVE STRESS; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES;

EID: 84891544677     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.100620     Document Type: Article

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