eIF2α kinase PKR modulates the hypoxic response by stat3-dependent transcriptional suppression of HIF-1α

Cancer Research

Volumn 70, Issue 20, 2010, Pages 7820-7829

  Papadakis, Andreas I ^a,b   Paraskeva, Efrosyni ^e   Peidis, Philippos ^a   Muaddi, Hala ^a,b   Li, Suiyang ^c   Raptis, Leda ^g   Pantopoulos, Kostas ^a,b   Simos, George ^e,f   Koromilas, Antonis E ^a,b,d  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c MCGILL UNIVERSITY   (Canada)

^d MCGILL UNIVERSITY   (Canada)

^e School of Medicine   (Greece)

^f UNIVERSITY OF THESSALY   (Greece)

^g QUEEN S UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; PROTEIN KINASE R; STAT3 PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; EMBRYO; GENE INDUCTION; HYPOXIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TRANSCRIPTION REGULATION;

ACTINS; ANIMALS; CELL HYPOXIA; EIF-2 KINASE; GENES, REPORTER; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICE; MICE, KNOCKOUT; PROTEIN-SERINE-THREONINE KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; STAT3 TRANSCRIPTION FACTOR; SUPPRESSION, GENETIC; TRANSCRIPTION, GENETIC; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 78049314880     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-10-0215     Document Type: Article

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