Control of oncogenesis by eIF2α phosphorylation: Implications in PTEN and PI3K-Akt signaling and tumor treatment

Future Oncology

Volumn 9, Issue 7, 2013, Pages 1005-1015

  Koromilas, Antonis E ^a,b   Mounir, Zineb ^a,c  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

Akt; cell death; cell proliferation; chemotherapeutic drug; mRNA translation; mTOR; protein phosphorylation; translation initiation factor eIF2; tuberous sclerosis; tumorigenesis

Indexed keywords

1 (1 CYANO 1 METHYLETHYL) 3 METHYL 8 (3 QUINOLINYL)IMIDAZO[4,5 C]QUINOLIN 2(1H,3H) ONE; 4 [2 (4 AMINO 1,2,5 OXADIAZOL 3 YL) 1 ETHYL 7 (3 PIPERIDINYLMETHOXY) 1H IMIDAZO[4,5 C]PYRIDIN 4 YL] 2 METHYL 3 BUTYN 2 OL; 8 [4 (1 AMINOCYCLOBUTYL)PHENYL] 9 PHENYL 1,2,4 TRIAZOLO[3,4 F][1,6]NAPHTHYRIDIN 3(2H) ONE; [1 (4 OXO 8 PHENYL 4H 1 BENZOPYRAN 2 YL)MORPHOLINIO]METHOXYSUCCINYLARGINYLGLYCYLASPARTYLSERINE ACETATE; BCR ABL PROTEIN; CAPPED RNA; EVEROLIMUS; INITIATION FACTOR 2ALPHA; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; MESSENGER RNA; PERIFOSINE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN P100; PROTEIN P53; TEMSIROLIMUS; TRANSCRIPTION FACTOR FOXO;

5' UNTRANSLATED REGION; CARCINOGENESIS; CELL CYCLE ARREST; CELL DEATH; CELL FATE; CELL PROLIFERATION; CELL PROTECTION; CELL SURVIVAL; COMPLEX FORMATION; DNA DAMAGE; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ENVIRONMENTAL STRESS; EUKARYOTIC CELL; GLOBIN SYNTHESIS; HUMAN; INTERNAL RIBOSOME ENTRY SITE; MISSENSE MUTATION; NONHUMAN; OPEN READING FRAME; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITION; REVIEW; RNA TRANSLATION; SIGNAL TRANSDUCTION; SOLID TUMOR; UNFOLDED PROTEIN RESPONSE;

ANIMALS; APOPTOSIS; CARCINOGENESIS; CELL SURVIVAL; EUKARYOTIC INITIATION FACTOR-2; HUMANS; MICE; MOLECULAR TARGETED THERAPY; NEOPLASMS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; SIGNAL TRANSDUCTION;

EID: 84880223571     PISSN: 14796694     EISSN: 17448301     Source Type: Journal    
DOI: 10.2217/fon.13.49     Document Type: Review

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