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Volumn , Issue , 2014, Pages 349-395

Efflux-mediated antimicrobial resistance

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EID: 84929574738     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4614-1400-1_10     Document Type: Chapter
Times cited : (25)

References (394)
  • 1
    • 46249113031 scopus 로고    scopus 로고
    • RamR mutations involved in efflux-mediated multidrug resistance in Salmonella enterica serovar Typhimurium
    • Abouzeed YM, Baucheron S, Cloeckaert A (2008) ramR mutations involved in efflux-mediated multidrug resistance in Salmonella enterica serovar Typhimurium. Antimicrob Agents Chemother 52:2428-2434
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 2428-2434
    • Abouzeed, Y.M.1    Baucheron, S.2    Cloeckaert, A.3
  • 2
    • 11144222920 scopus 로고    scopus 로고
    • Crystal structure of the drug-discharge outer membrane protein, OprM, of Pseudomonas aeruginosa: Dual modes of membrane anchoring and occluded cavity end
    • Akama H, Kanemaki M, Yoshimura M et al (2004) Crystal structure of the drug-discharge outer membrane protein, OprM, of Pseudomonas aeruginosa: dual modes of membrane anchoring and occluded cavity end. J Biol Chem 17:52816-52819
    • (2004) J Biol Chem , vol.17 , pp. 52816-52819
    • Akama, H.1    Kanemaki, M.2    Yoshimura, M.3
  • 3
    • 2942731519 scopus 로고    scopus 로고
    • Crystal structure of the membrane fusion protein, MexA, of the multidrug transporter in Pseudomonas aeruginosa
    • Akama H, Matsuura T, Kashiwagi S et al (2004) Crystal structure of the membrane fusion protein, MexA, of the multidrug transporter in Pseudomonas aeruginosa. J Biol Chem 279: 25939-25942
    • (2004) J Biol Chem , vol.279 , pp. 25939-25942
    • Akama, H.1    Matsuura, T.2    Kashiwagi, S.3
  • 4
    • 30344434342 scopus 로고    scopus 로고
    • Interaction of CmeABC and CmeDEF in conferring antimicrobial resistance and maintaining cell viability in Campylobacter jejuni
    • Akiba M, Lin J, Barton YW et al (2006) Interaction of CmeABC and CmeDEF in conferring antimicrobial resistance and maintaining cell viability in Campylobacter jejuni. J Antimicrob Chemother 57:52-60
    • (2006) J Antimicrob Chemother , vol.57 , pp. 52-60
    • Akiba, M.1    Lin, J.2    Barton, Y.W.3
  • 5
    • 0032844440 scopus 로고    scopus 로고
    • The mar regulon: Multiple resistance to antbiotics and other toxic chemicals
    • Alekshun MN, Levy SB (1999) The mar regulon: multiple resistance to antbiotics and other toxic chemicals. Trends Microbiol 7:410-413
    • (1999) Trends Microbiol , vol.7 , pp. 410-413
    • Alekshun, M.N.1    Levy, S.B.2
  • 6
    • 0033734699 scopus 로고    scopus 로고
    • Cloning and characterization of SmeDEF, a novel multidrug efflux pump from Stenotrophomonas maltophilia
    • Alonso A, Martinez JL (2000) Cloning and characterization of SmeDEF, a novel multidrug efflux pump from Stenotrophomonas maltophilia. Antimicrob Agents Chemother 44:3079-3086
    • (2000) Antimicrob Agents Chemother , vol.44 , pp. 3079-3086
    • Alonso, A.1    Martinez, J.L.2
  • 7
    • 0032860807 scopus 로고    scopus 로고
    • Emergence of multidrug-resistant mutants is increased under antibiotic selective pressure in Pseudomonas aeruginosa
    • Alonso A, Campanario E, Martinez JL (1999) Emergence of multidrug-resistant mutants is increased under antibiotic selective pressure in Pseudomonas aeruginosa. Microbiology 145: 2857-2862
    • (1999) Microbiology , vol.145 , pp. 2857-2862
    • Alonso, A.1    Campanario, E.2    Martinez, J.L.3
  • 8
    • 0036015627 scopus 로고    scopus 로고
    • An aspartate ring at the TolC tunnel entrance determines ion selectivity and presents a target for blocking by large cations
    • Andersen C, Koronakis E, Hughes C et al (2002) An aspartate ring at the TolC tunnel entrance determines ion selectivity and presents a target for blocking by large cations. Mol Microbiol 44:1131-1139
    • (2002) Mol Microbiol , vol.44 , pp. 1131-1139
    • Andersen, C.1    Koronakis, E.2    Hughes, C.3
  • 9
    • 14644422292 scopus 로고    scopus 로고
    • A multiwell assay to isolate compounds inhibiting the assembly of the prokaryotic RNA polymerase
    • Andre E, Bastide L, Villain-Guillot P et al (2004) A multiwell assay to isolate compounds inhibiting the assembly of the prokaryotic RNA polymerase. Assay Drug Dev Technol 2: 629-635
    • (2004) Assay Drug Dev Technol , vol.2 , pp. 629-635
    • Andre, E.1    Bastide, L.2    Villain-Guillot, P.3
  • 10
    • 34247134023 scopus 로고    scopus 로고
    • Dissemination of sul3 -containing elements linked to class 1 integrons with an unusual 3 conserved sequence region among Salmonella isolates
    • Antunes P, Machado J, Peixe L (2007) Dissemination of sul3 -containing elements linked to class 1 integrons with an unusual 3 conserved sequence region among Salmonella isolates. Antimicrob Agents Chemother 51:1545-1548
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 1545-1548
    • Antunes, P.1    Machado, J.2    Peixe, L.3
  • 11
    • 54049102056 scopus 로고    scopus 로고
    • RamA confers multidrug-resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine
    • Bailey AM, Paulsen IT, Piddock LJ (2008) RamA confers multidrug-resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine. Antimicrob Agents Chemother 52:3604-3611
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 3604-3611
    • Bailey, A.M.1    Paulsen, I.T.2    Piddock, L.J.3
  • 12
    • 33845688870 scopus 로고    scopus 로고
    • Conjugating berberine to a multidrug efflux pump inhibitor creates an effective antimicrobial
    • Ball AR, Casadei G, Samosorn S et al (2006) Conjugating berberine to a multidrug efflux pump inhibitor creates an effective antimicrobial. ACS Chem Biol 1:594-600
    • (2006) ACS Chem Biol , vol.1 , pp. 594-600
    • Ball, A.R.1    Casadei, G.2    Samosorn, S.3
  • 13
    • 12244312498 scopus 로고    scopus 로고
    • The AcrB multidrug transporter plays a major role in high-level fluoroquinolone resistance in Salmonella enterica serovar typhimurium phage type DT204
    • Baucheron S, Imberechts H, Chaslus-Dancla E et al (2002) The AcrB multidrug transporter plays a major role in high-level fluoroquinolone resistance in Salmonella enterica serovar typhimurium phage type DT204. Microb Drug Resist 8:281-289
    • (2002) Microb Drug Resist , vol.8 , pp. 281-289
    • Baucheron, S.1    Imberechts, H.2    Chaslus-Dancla, E.3
  • 14
    • 4644351584 scopus 로고    scopus 로고
    • AcrAB-TolC directs efflux-mediated multidrug resistance in Salmonella enterica serovar typhimurium DT104
    • Baucheron S, Tyler S, Boyd D et al (2004) AcrAB-TolC directs efflux-mediated multidrug resistance in Salmonella enterica serovar typhimurium DT104. Antimicrob Agents Chemother 48:3729-3735
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 3729-3735
    • Baucheron, S.1    Tyler, S.2    Boyd, D.3
  • 15
    • 39749097282 scopus 로고    scopus 로고
    • The role of the Serratia marcescens SdeAB multidrug efflux pump and TolC homologue in fluoroquinolone resistance studied via gene-knockout mutagenesis
    • Begic S, Worobec EA (2008) The role of the Serratia marcescens SdeAB multidrug efflux pump and TolC homologue in fluoroquinolone resistance studied via gene-knockout mutagenesis. Microbiology 154:454-461
    • (2008) Microbiology , vol.154 , pp. 454-461
    • Begic, S.1    Worobec, E.A.2
  • 16
    • 43949103042 scopus 로고    scopus 로고
    • Characterization of the Serratia marcescens SdeCDE multidrug efflux pump studied via gene knockout mutagenesis
    • Begic S, Worobec EA (2008) Characterization of the Serratia marcescens SdeCDE multidrug efflux pump studied via gene knockout mutagenesis. Can J Microbiol 54:411-416
    • (2008) Can J Microbiol , vol.54 , pp. 411-416
    • Begic, S.1    Worobec, E.A.2
  • 17
    • 28044441589 scopus 로고    scopus 로고
    • Gene cloning and characterization of four MATE family multidrug efflux pumps from Vibrio cholerae non-O1
    • Begum A, Rahman MM, Ogawa W et al (2005) Gene cloning and characterization of four MATE family multidrug efflux pumps from Vibrio cholerae non-O1. Microbiol Immunol 49:949-957
    • (2005) Microbiol Immunol , vol.49 , pp. 949-957
    • Begum, A.1    Rahman, M.M.2    Ogawa, W.3
  • 18
    • 33747679384 scopus 로고    scopus 로고
    • Characterization of the Vibrio cholerae vexAB and vexCD efflux systems
    • Bina JE, Provenzano D, Wang C et al (2006) Characterization of the Vibrio cholerae vexAB and vexCD efflux systems. Arch Microbiol 186:171-181
    • (2006) Arch Microbiol , vol.186 , pp. 171-181
    • Bina, J.E.1    Provenzano, D.2    Wang, C.3
  • 19
    • 38349144550 scopus 로고    scopus 로고
    • The AcrAB RND efflux system from the live vaccine strain of Francisella tularensis is a multiple drug efflux system that is required for virulence in mice
    • Bina XR, Lavine CL, Miller MA et al (2008) The AcrAB RND efflux system from the live vaccine strain of Francisella tularensis is a multiple drug efflux system that is required for virulence in mice. FEMS Microbiol Lett 279:226-233
    • (2008) FEMS Microbiol Lett , vol.279 , pp. 226-233
    • Bina, X.R.1    Lavine, C.L.2    Miller, M.A.3
  • 20
    • 48849102268 scopus 로고    scopus 로고
    • Vibrio cholerae RND-family efflux systems are required for antimicrobial resistance, optimal virulence factor production and colonization of the infant mouse small intestine
    • Bina XR, Provenzano D, Nguyen N et al (2008) Vibrio cholerae RND-family efflux systems are required for antimicrobial resistance, optimal virulence factor production and colonization of the infant mouse small intestine. Infect Immun 76:3595-3605
    • (2008) Infect Immun , vol.76 , pp. 3595-3605
    • Bina, X.R.1    Provenzano, D.2    Nguyen, N.3
  • 21
    • 31944441499 scopus 로고    scopus 로고
    • Distribution of tetracycline resistance genes in Actinobacillus pleuropneumoniae isolates from Spain
    • Blanco M, Gutierrez-Martin CB, Rodriguez-Ferri EF et al (2006) Distribution of tetracycline resistance genes in Actinobacillus pleuropneumoniae isolates from Spain. Antimicrob Agents Chemother 50:702-708
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 702-708
    • Blanco, M.1    Gutierrez-Martin, C.B.2    Rodriguez-Ferri, E.F.3
  • 22
    • 33644657837 scopus 로고    scopus 로고
    • Effect of efflux on telithromycin and macrolide susceptibility in Haemophilus influenzae
    • Bogdanovich T, Bozdogan B, Appelbaum PC (2006) Effect of efflux on telithromycin and macrolide susceptibility in Haemophilus influenzae. Antimicrob Agents Chemother 50: 893-898
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 893-898
    • Bogdanovich, T.1    Bozdogan, B.2    Appelbaum, P.C.3
  • 23
    • 12944316448 scopus 로고    scopus 로고
    • Selected arylpiperazines are capable of reversing multidrug resistance in Escherichia coli overexpressing RND efflux pumps
    • Bohnert JA, Kern WV (2005) Selected arylpiperazines are capable of reversing multidrug resistance in Escherichia coli overexpressing RND efflux pumps. Antimicrob Agents Chemother 49:849-852
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 849-852
    • Bohnert, J.A.1    Kern, W.V.2
  • 24
    • 34447534306 scopus 로고    scopus 로고
    • Altered spectrum of multidrug resistance associated with a single point mutation in the Escherichia coli RND-type MDR efflux pump YhiV (MdtF)
    • Bohnert JA, Schuster S, Fahnrich E et al (2007) Altered spectrum of multidrug resistance associated with a single point mutation in the Escherichia coli RND-type MDR efflux pump YhiV (MdtF). J Antimicrob Chemother 59:1216-1222
    • (2007) J Antimicrob Chemother , vol.59 , pp. 1216-1222
    • Bohnert, J.A.1    Schuster, S.2    Fahnrich, E.3
  • 25
    • 0347123168 scopus 로고    scopus 로고
    • Detection of an is 21 insertion sequence in the mexR gene of Pseudomonas aeruginosa increasing b -lactam resistance
    • Boutoille D, Corvec S, Caroff N et al (2004) Detection of an IS 21 insertion sequence in the mexR gene of Pseudomonas aeruginosa increasing b -lactam resistance. FEMS Microbiol Lett 230:143-146
    • (2004) FEMS Microbiol Lett , vol.230 , pp. 143-146
    • Boutoille, D.1    Corvec, S.2    Caroff, N.3
  • 26
    • 0345832055 scopus 로고    scopus 로고
    • Adaptive resistance to biocides in Salmonella enterica and Escherichia coli O157 and cross-resistance to antimicrobial agents
    • Braoudaki M, Hilton AC (2004) Adaptive resistance to biocides in Salmonella enterica and Escherichia coli O157 and cross-resistance to antimicrobial agents. J Clin Microbiol 42:73-78
    • (2004) J Clin Microbiol , vol.42 , pp. 73-78
    • Braoudaki, M.1    Hilton, A.C.2
  • 27
    • 2942583970 scopus 로고    scopus 로고
    • Low level of cross-resistance between triclosan and antibiotics in Escherichia coli K-12 and E. coli O55 compared to E. coli O157
    • Braoudaki M, Hilton AC (2004) Low level of cross-resistance between triclosan and antibiotics in Escherichia coli K-12 and E. coli O55 compared to E. coli O157. FEMS Microbiol Lett 235:305-309
    • (2004) FEMS Microbiol Lett , vol.235 , pp. 305-309
    • Braoudaki, M.1    Hilton, A.C.2
  • 28
    • 50949092103 scopus 로고    scopus 로고
    • Correlation of antimicrobial resistance with b -lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City
    • Bratu S, Landman D, Martin DA et al (2008) Correlation of antimicrobial resistance with b -lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City. Antimicrob Agents Chemother 52:2999-3005
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 2999-3005
    • Bratu, S.1    Landman, D.2    Martin, D.A.3
  • 29
    • 34248143835 scopus 로고    scopus 로고
    • Two host-induced Ralstonia solanacearum genes, acrA and dinF, encode multidrug efflux pumps and contribute to bacterial wilt virulence
    • Brown DG, Swanson JK, Allen C (2007) Two host-induced Ralstonia solanacearum genes, acrA and dinF, encode multidrug efflux pumps and contribute to bacterial wilt virulence. Appl Environ Microbiol 73:2777-2786
    • (2007) Appl Environ Microbiol , vol.73 , pp. 2777-2786
    • Brown, D.G.1    Swanson, J.K.2    Allen, C.3
  • 30
    • 33645548647 scopus 로고    scopus 로고
    • The AcrAB-TolC efflux system of Salmonella enterica serovar Typhimurium plays a role in pathogenesis
    • Buckley AM, Webber MA, Cooles S et al (2006) The AcrAB-TolC efflux system of Salmonella enterica serovar Typhimurium plays a role in pathogenesis. Cell Microbiol 8:847-856
    • (2006) Cell Microbiol , vol.8 , pp. 847-856
    • Buckley, A.M.1    Webber, M.A.2    Cooles, S.3
  • 31
    • 40349106166 scopus 로고    scopus 로고
    • An RND-type efflux system in Borrelia burgdorferi is involved in virulence and resistance to antimicrobial compounds
    • Bunikis I, Denker K, Ostberg Y et al (2008) An RND-type efflux system in Borrelia burgdorferi is involved in virulence and resistance to antimicrobial compounds. PLoS Pathog 4:e1000009
    • (2008) PLoS Pathog , vol.4 , pp. e1000009
    • Bunikis, I.1    Denker, K.2    Ostberg, Y.3
  • 32
    • 33745610459 scopus 로고    scopus 로고
    • Synthesis and antibacterial activity of novel C12 ethyl ketolides
    • Burger MT, Hiebert C, Seid M et al (2006) Synthesis and antibacterial activity of novel C12 ethyl ketolides. Bioorg Med Chem 14:5592-5604
    • (2006) Bioorg Med Chem , vol.14 , pp. 5592-5604
    • Burger, M.T.1    Hiebert, C.2    Seid, M.3
  • 33
    • 0041833332 scopus 로고    scopus 로고
    • Mobile genes coding for efflux-mediated antimicrobial resistance in gram-positive and gram-negative bacteria
    • Butaye P, Cloeckaert A, Schwarz S (2003) Mobile genes coding for efflux-mediated antimicrobial resistance in gram-positive and gram-negative bacteria. Int J Antimicrob Agents 22:205-210
    • (2003) Int J Antimicrob Agents , vol.22 , pp. 205-210
    • Butaye, P.1    Cloeckaert, A.2    Schwarz, S.3
  • 34
    • 27744597006 scopus 로고    scopus 로고
    • Involvement of the CmeABC efflux pump in the macrolide resistance of Campylobacter coli
    • Cagliero C, Mouline C, Payot S et al (2005) Involvement of the CmeABC efflux pump in the macrolide resistance of Campylobacter coli. J Antimicrob Chemother 56:948-950
    • (2005) J Antimicrob Chemother , vol.56 , pp. 948-950
    • Cagliero, C.1    Mouline, C.2    Payot, S.3
  • 35
    • 33750577739 scopus 로고    scopus 로고
    • Synergy between the efflux pump CmeABC and modifications in ribosomal proteins L4 and L22 in conferring macrolide resistance in Campylobacter jejuni and C. coli
    • Cagliero C, Mouline C, Cloeckaert A et al (2006) Synergy between the efflux pump CmeABC and modifications in ribosomal proteins L4 and L22 in conferring macrolide resistance in Campylobacter jejuni and C. coli. Antimicrob Agents Chemother 50:3893-3896
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 3893-3896
    • Cagliero, C.1    Mouline, C.2    Cloeckaert, A.3
  • 36
    • 33846098720 scopus 로고    scopus 로고
    • Regulation of the expression of the CmeABC efflux pump in Campylobacter jejuni: Identification of a point mutation abolishing the binding of the CmeR repressor in an in vitro-selected multidrug-resistant mutant
    • Cagliero C, Maurel MC, Cloeckaert A et al (2007) Regulation of the expression of the CmeABC efflux pump in Campylobacter jejuni: identification of a point mutation abolishing the binding of the CmeR repressor in an in vitro-selected multidrug-resistant mutant. FEMS Microbiol Lett 267:89-94
    • (2007) FEMS Microbiol Lett , vol.267 , pp. 89-94
    • Cagliero, C.1    Maurel, M.C.2    Cloeckaert, A.3
  • 37
    • 53149149100 scopus 로고    scopus 로고
    • European emergence of ciprofloxacin-resistant Escherichia coli clonal groups O25:H4-ST 131 and O15:K52:H1 causing communityacquired uncomplicated cystitis
    • Cagnacci S, Gualco L, Debbia E et al (2008) European emergence of ciprofloxacin-resistant Escherichia coli clonal groups O25:H4-ST 131 and O15:K52:H1 causing communityacquired uncomplicated cystitis. J Clin Microbiol 46:2605-2612
    • (2008) J Clin Microbiol , vol.46 , pp. 2605-2612
    • Cagnacci, S.1    Gualco, L.2    Debbia, E.3
  • 38
    • 34548079271 scopus 로고    scopus 로고
    • Three new macrolide efflux ( mef ) gene variants in Streptococcus agalactiae
    • Cai Y, Kong F, Gilbert GL (2007) Three new macrolide efflux ( mef ) gene variants in Streptococcus agalactiae. J Clin Microbiol 45:2754-2755
    • (2007) J Clin Microbiol , vol.45 , pp. 2754-2755
    • Cai, Y.1    Kong, F.2    Gilbert, G.L.3
  • 39
    • 4444317855 scopus 로고    scopus 로고
    • MexAB-OprM hyperexpression in NalC type multidrug resistant Pseudomonas aeruginosa: Identification and characterization of the nalC gene encoding a repressor of PA3720-PA3719
    • Cao L, Srikumar R, Poole K (2004) MexAB-OprM hyperexpression in NalC type multidrug resistant Pseudomonas aeruginosa: identification and characterization of the nalC gene encoding a repressor of PA3720-PA3719. Mol Microbiol 53:1423-1436
    • (2004) Mol Microbiol , vol.53 , pp. 1423-1436
    • Cao, L.1    Srikumar, R.2    Poole, K.3
  • 40
    • 3042685848 scopus 로고    scopus 로고
    • Characterization of the molecular mechanisms of quinolone resistance in Yersinia enterocolitica O: 3 clinical isolates
    • Capilla S, Ruiz J, Goni P et al (2004) Characterization of the molecular mechanisms of quinolone resistance in Yersinia enterocolitica O: 3 clinical isolates. J Antimicrob Chemother 53:1068-1071
    • (2004) J Antimicrob Chemother , vol.53 , pp. 1068-1071
    • Capilla, S.1    Ruiz, J.2    Goni, P.3
  • 41
    • 54049103638 scopus 로고    scopus 로고
    • Plasmid-Mediated Quinolone Resistance QepA2 from Escherichia coli in France
    • Cattoir V, Poirel L, Nordmann P (2008) Plasmid-Mediated Quinolone Resistance QepA2 from Escherichia coli in France. Antimicrob Agents Chemother 52:3801-3804
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 3801-3804
    • Cattoir, V.1    Poirel, L.2    Nordmann, P.3
  • 42
    • 50149114373 scopus 로고    scopus 로고
    • Prevalence of quinolone resistance mechanisms and associations to minimum inhibitory concentrations in quinolone-resistant Escherichia coli isolated from humans and swine in Denmark
    • Cavaco LM, Frimodt-Moller N, Hasman H et al (2008) Prevalence of quinolone resistance mechanisms and associations to minimum inhibitory concentrations in quinolone-resistant Escherichia coli isolated from humans and swine in Denmark. Microb Drug Resist 14:163-169
    • (2008) Microb Drug Resist , vol.14 , pp. 163-169
    • Cavaco, L.M.1    Frimodt-Moller, N.2    Hasman, H.3
  • 43
    • 12244310147 scopus 로고    scopus 로고
    • Mechanisms of b -lactam resistance in Pseudomonas aeruginosa: Prevalence of OprM-overproducing strains in a French multicentre study (1997)
    • Cavallo JD, Plesiat P, Couetdic G et al (2002) Mechanisms of b -lactam resistance in Pseudomonas aeruginosa: prevalence of OprM-overproducing strains in a French multicentre study (1997). J Antimicrob Chemother 50:1039-1043
    • (2002) J Antimicrob Chemother , vol.50 , pp. 1039-1043
    • Cavallo, J.D.1    Plesiat, P.2    Couetdic, G.3
  • 44
    • 33745622170 scopus 로고    scopus 로고
    • New cluster of plasmid-located class 1 integrons in Vibrio cholerae O1 and a dfrA15 cassette-containing integron in Vibrio parahaemolyticus isolated in Angola
    • Ceccarelli D, Salvia AM, Sami J et al (2006) New cluster of plasmid-located class 1 integrons in Vibrio cholerae O1 and a dfrA15 cassette-containing integron in Vibrio parahaemolyticus isolated in Angola. Antimicrob Agents Chemother 50:2493-2499
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 2493-2499
    • Ceccarelli, D.1    Salvia, A.M.2    Sami, J.3
  • 45
    • 1642543200 scopus 로고    scopus 로고
    • BpeAB-OprB, a multidrug efflux pump in Burkholderia pseudomallei
    • Chan YY, Tan TM, Ong YM et al (2004) BpeAB-OprB, a multidrug efflux pump in Burkholderia pseudomallei. Antimicrob Agents Chemother 48:1128-1135
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 1128-1135
    • Chan, Y.Y.1    Tan, T.M.2    Ong, Y.M.3
  • 46
    • 33846572768 scopus 로고    scopus 로고
    • Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei
    • Chan YY, Ong YM, Chua KL (2007) Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. Antimicrob Agents Chemother 51:623-630
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 623-630
    • Chan, Y.Y.1    Ong, Y.M.2    Chua, K.L.3
  • 47
    • 1642322821 scopus 로고    scopus 로고
    • Contribution of integrons, and SmeABC and SmeDEF efflux pumps to multidrug resistance in clinical isolates of Stenotrophomonas maltophilia
    • Chang LL, Chen HF, Chang CY et al (2004) Contribution of integrons, and SmeABC and SmeDEF efflux pumps to multidrug resistance in clinical isolates of Stenotrophomonas maltophilia. J Antimicrob Chemother 53:518-521
    • (2004) J Antimicrob Chemother , vol.53 , pp. 518-521
    • Chang, L.L.1    Chen, H.F.2    Chang, C.Y.3
  • 48
    • 36549052154 scopus 로고    scopus 로고
    • Characterization of fluoroquinolone resistance mechanisms and their correlation with the degree of resistance to clinically used fluoroquinolones among Escherichia coli isolates
    • Chang TM, Lu PL, Li HH et al (2007) Characterization of fluoroquinolone resistance mechanisms and their correlation with the degree of resistance to clinically used fluoroquinolones among Escherichia coli isolates. J Chemother 19:488-494
    • (2007) J Chemother , vol.19 , pp. 488-494
    • Chang, T.M.1    Lu, P.L.2    Li, H.H.3
  • 49
    • 4644327512 scopus 로고    scopus 로고
    • Novel resistance-nodulation-cell division efflux system AdeDE in Acinetobacter genomic DNA group 3
    • Chau SL, Chu YW, Houang ET (2004) Novel resistance-nodulation-cell division efflux system AdeDE in Acinetobacter genomic DNA group 3. Antimicrob Agents Chemother 48: 4054-4055
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 4054-4055
    • Chau, S.L.1    Chu, Y.W.2    Houang, E.T.3
  • 50
    • 0043029931 scopus 로고    scopus 로고
    • An RND-type multidrug efflux pump SdeXY from Serratia marcescens
    • Chen J, Kuroda T, Huda MN et al (2003) An RND-type multidrug efflux pump SdeXY from Serratia marcescens. J Antimicrob Chemother 52:176-179
    • (2003) J Antimicrob Chemother , vol.52 , pp. 176-179
    • Chen, J.1    Kuroda, T.2    Huda, M.N.3
  • 51
    • 33846645342 scopus 로고    scopus 로고
    • Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials
    • Chen S, Cui S, McDermott PF et al (2007) Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. Antimicrob Agents Chemother 51:535-542
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 535-542
    • Chen, S.1    Cui, S.2    McDermott, P.F.3
  • 52
    • 33845370997 scopus 로고    scopus 로고
    • Analysis of the mechanisms of fluoroquinolone resistance in urinary tract pathogens
    • Chenia HY, Pillay B, Pillay D (2006) Analysis of the mechanisms of fluoroquinolone resistance in urinary tract pathogens. J Antimicrob Chemother 58:1274-1278
    • (2006) J Antimicrob Chemother , vol.58 , pp. 1274-1278
    • Chenia, H.Y.1    Pillay, B.2    Pillay, D.3
  • 53
    • 0035829416 scopus 로고    scopus 로고
    • New pyridoquinoline derivatives as potential inhibitors of the fluoroquinolone efflux pump in resistant Enterobacter aerogenes strains
    • Chevalier J, AtifiS, Eyraud A et al (2001) New pyridoquinoline derivatives as potential inhibitors of the fluoroquinolone efflux pump in resistant Enterobacter aerogenes strains. J Med Chem 44:4023-4026
    • (2001) J Med Chem , vol.44 , pp. 4023-4026
    • Chevalier, J.1    Atifi, S.2    Eyraud, A.3
  • 54
    • 1442300064 scopus 로고    scopus 로고
    • Inhibitors of antibiotic efflux in resistant Enterobacter aerogenes and Klebsiella pneumoniae strains
    • Chevalier J, Bredin J, Mahamoud A et al (2004) Inhibitors of antibiotic efflux in resistant Enterobacter aerogenes and Klebsiella pneumoniae strains. Antimicrob Agents Chemother 48:1043-1046
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 1043-1046
    • Chevalier, J.1    Bredin, J.2    Mahamoud, A.3
  • 55
    • 52449126124 scopus 로고    scopus 로고
    • Identification and evolution of drug efflux pump in clinical Enterobacter aerogenes strains isolated in 1995 and 2003
    • Chevalier J, Mulfinger C, Garnotel E et al (2008) Identification and evolution of drug efflux pump in clinical Enterobacter aerogenes strains isolated in 1995 and 2003. PLoS One 3:e3203
    • (2008) PLoS One , vol.3 , pp. e3203
    • Chevalier, J.1    Mulfinger, C.2    Garnotel, E.3
  • 56
    • 4344612328 scopus 로고    scopus 로고
    • The AcrAB-TolC pump is involved in macrolide resistance but not in telithromycin efflux in Enterobacter aerogenes and Escherichia coli
    • Chollet R, Chevalier J, Bryskier A et al (2004) The AcrAB-TolC pump is involved in macrolide resistance but not in telithromycin efflux in Enterobacter aerogenes and Escherichia coli. Antimicrob Agents Chemother 48:3621-3624
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 3621-3624
    • Chollet, R.1    Chevalier, J.2    Bryskier, A.3
  • 57
    • 0034973583 scopus 로고    scopus 로고
    • Tetracycline antibiotics: Mode of action, applications, molecular biology, and epidemiology of bacterial resistance
    • Chopra I, Roberts M (2001) Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance. Microbiol Mol Biol Rev 65:232-260
    • (2001) Microbiol Mol Biol Rev , vol.65 , pp. 232-260
    • Chopra, I.1    Roberts, M.2
  • 58
    • 0036796243 scopus 로고    scopus 로고
    • Overexpression and functional characterization of an ABC (ATP-binding cassette) transporter encoded by the genes drrA and drrB of Mycobacterium tuberculosis
    • Choudhuri BS, Bhakta S, Barik R et al (2002) Overexpression and functional characterization of an ABC (ATP-binding cassette) transporter encoded by the genes drrA and drrB of Mycobacterium tuberculosis. Biochem J 367:279-285
    • (2002) Biochem J , vol.367 , pp. 279-285
    • Choudhuri, B.S.1    Bhakta, S.2    Barik, R.3
  • 59
    • 26444470906 scopus 로고    scopus 로고
    • Resistance to fluoroquinolones linked to gyrA and par C mutations and overexpression of AcrAB efflux pump in Salmonella enterica serotype Choleraesuis
    • Chu C, Su LH, Chu CH et al (2005) Resistance to fluoroquinolones linked to gyrA and par C mutations and overexpression of AcrAB efflux pump in Salmonella enterica serotype Choleraesuis. Microb Drug Resist 11:248-253
    • (2005) Microb Drug Resist , vol.11 , pp. 248-253
    • Chu, C.1    Su, L.H.2    Chu, C.H.3
  • 60
    • 33645471682 scopus 로고    scopus 로고
    • Presence of active efflux systems AdeABC, AdeDE and AdeXYZ in different Acinetobacter genomic DNA groups
    • Chu YW, Chau SL, Houang ET (2006) Presence of active efflux systems AdeABC, AdeDE and AdeXYZ in different Acinetobacter genomic DNA groups. J Med Microbiol 55:477-478
    • (2006) J Med Microbiol , vol.55 , pp. 477-478
    • Chu, Y.W.1    Chau, S.L.2    Houang, E.T.3
  • 61
    • 0035139556 scopus 로고    scopus 로고
    • Cross-resistance between triclosan and antibiotics in Pseudomonas aeruginosa is mediated by multidrug efflux pumps: Exposure of a susceptible mutant strain to triclosan selects nfxB mutants overexpressing MexCD-OprJ
    • Chuanchuen R, Beinlich K, Hoang TT et al (2001) Cross-resistance between triclosan and antibiotics in Pseudomonas aeruginosa is mediated by multidrug efflux pumps: exposure of a susceptible mutant strain to triclosan selects nfxB mutants overexpressing MexCD-OprJ. Antimicrob Agents Chemother 45:428-432
    • (2001) Antimicrob Agents Chemother , vol.45 , pp. 428-432
    • Chuanchuen, R.1    Beinlich, K.2    Hoang, T.T.3
  • 62
    • 0037389825 scopus 로고    scopus 로고
    • High-level triclosan resistance in Pseudomonas aeruginosa is solely a result of efflux
    • Chuanchuen R, Karkhoff-Schweizer RR, Schweizer HP (2003) High-level triclosan resistance in Pseudomonas aeruginosa is solely a result of efflux. Am J Infect Control 31:124-127
    • (2003) Am J Infect Control , vol.31 , pp. 124-127
    • Chuanchuen, R.1    Karkhoff-Schweizer, R.R.2    Schweizer, H.P.3
  • 63
    • 54749154805 scopus 로고    scopus 로고
    • Role of the MexXY multidrug efflux pump in moderate aminoglycoside resistance in Pseudomonas aeruginosa isolates from Pseudomonas mastitis
    • Chuanchuen R, Wannaprasat W, Ajariyakhajorn K et al (2008) Role of the MexXY multidrug efflux pump in moderate aminoglycoside resistance in Pseudomonas aeruginosa isolates from Pseudomonas mastitis. Microbiol Immunol 52:392-398
    • (2008) Microbiol Immunol , vol.52 , pp. 392-398
    • Chuanchuen, R.1    Wannaprasat, W.2    Ajariyakhajorn, K.3
  • 64
    • 19544386997 scopus 로고    scopus 로고
    • Occurrence of hypermutable Pseudomonas aeruginosa in cystic fibrosis patients is associated with the oxidative stress caused by chronic lung inflammation
    • Ciofu O, Riis B, Pressler T et al (2005) Occurrence of hypermutable Pseudomonas aeruginosa in cystic fibrosis patients is associated with the oxidative stress caused by chronic lung inflammation. Antimicrob Agents Chemother 49:2276-2282
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 2276-2282
    • Ciofu, O.1    Riis, B.2    Pressler, T.3
  • 65
    • 28844454923 scopus 로고    scopus 로고
    • Molecular characterization of pneumococci with efflux-mediated erythromycin resistance and identification of a novel mef gene subclass, mef (I)
    • Cochetti I, Vecchi M, Mingoia M et al (2005) Molecular characterization of pneumococci with efflux-mediated erythromycin resistance and identification of a novel mef gene subclass, mef (I). Antimicrob Agents Chemother 49:4999-5006
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 4999-5006
    • Cochetti, I.1    Vecchi, M.2    Mingoia, M.3
  • 66
    • 20144387448 scopus 로고    scopus 로고
    • The Mycobacterium tuberculosis iniA gene is essential for activity of an efflux pump that confers drug tolerance to both isoniazid and ethambutol
    • Colangeli R, Helb D, Sridharan S et al (2005) The Mycobacterium tuberculosis iniA gene is essential for activity of an efflux pump that confers drug tolerance to both isoniazid and ethambutol. Mol Microbiol 55:1829-1840
    • (2005) Mol Microbiol , vol.55 , pp. 1829-1840
    • Colangeli, R.1    Helb, D.2    Sridharan, S.3
  • 67
    • 0141539263 scopus 로고    scopus 로고
    • Investigation of antibiotic and antibacterial agent cross-resistance in target bacteria from homes of antibacterial product users and nonusers
    • Cole EC, Addison RM, Rubino JR et al (2003) Investigation of antibiotic and antibacterial agent cross-resistance in target bacteria from homes of antibacterial product users and nonusers. J Appl Microbiol 95:664-676
    • (2003) J Appl Microbiol , vol.95 , pp. 664-676
    • Cole, E.C.1    Addison, R.M.2    Rubino, J.R.3
  • 68
    • 12244277396 scopus 로고    scopus 로고
    • Acquired macrolide resistance genes and the 1 bp deletion in the mtrR promoter in Neisseria gonorrhoeae
    • Cousin JS Jr, Whittington WL, Roberts MC (2003) Acquired macrolide resistance genes and the 1 bp deletion in the mtrR promoter in Neisseria gonorrhoeae. J Antimicrob Chemother 51:131-133
    • (2003) J Antimicrob Chemother , vol.51 , pp. 131-133
    • Cousin, J.S.1    Whittington, W.L.2    Roberts, M.C.3
  • 69
    • 0345306159 scopus 로고    scopus 로고
    • Acquired macrolide resistance genes in pathogenic Neisseria spp. isolated between 1940 and 1987
    • Cousin S Jr, Whittington WL, Roberts MC (2003) Acquired macrolide resistance genes in pathogenic Neisseria spp. isolated between 1940 and 1987. Antimicrob Agents Chemother 47:3877-3880
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 3877-3880
    • Cousin, S.1    Whittington, W.L.2    Roberts, M.C.3
  • 70
    • 33845881184 scopus 로고    scopus 로고
    • TdeA, a TolC-like protein required for toxin and drug export in Aggregatibacter ( Actinobacillus ) actinomycetemcomitans
    • Crosby JA, Kachlany SC (2007) TdeA, a TolC-like protein required for toxin and drug export in Aggregatibacter ( Actinobacillus ) actinomycetemcomitans. Gene 388:83-92
    • (2007) Gene , vol.388 , pp. 83-92
    • Crosby, J.A.1    Kachlany, S.C.2
  • 71
    • 46249094919 scopus 로고    scopus 로고
    • The complete genome, comparative and functional analysis of Stenotrophomonas maltophilia reveals an organism heavily shielded by drug resistance determinants
    • Crossman LC, Gould VC, Dow JM et al (2008) The complete genome, comparative and functional analysis of Stenotrophomonas maltophilia reveals an organism heavily shielded by drug resistance determinants. Genome Biol 9:R74
    • (2008) Genome Biol , vol.9 , pp. R74
    • Crossman, L.C.1    Gould, V.C.2    Dow, J.M.3
  • 72
  • 73
    • 40749088858 scopus 로고    scopus 로고
    • Evolution of macrolide resistance in Streptococcus pneumoniae clinical isolates in the prevaccine era
    • Daikos GL, Koutsolioutsou A, Tsiodras S et al (2008) Evolution of macrolide resistance in Streptococcus pneumoniae clinical isolates in the prevaccine era. Diagn Microbiol Infect Dis 60:393-398
    • (2008) Diagn Microbiol Infect Dis , vol.60 , pp. 393-398
    • Daikos, G.L.1    Koutsolioutsou, A.2    Tsiodras, S.3
  • 75
    • 38649116649 scopus 로고    scopus 로고
    • AdeIJK, a resistance-nodulation-cell division pump effluxing multiple antibiotics in Acinetobacter baumannii
    • Damier-Piolle L, Magnet S, Bremont S et al (2008) AdeIJK, a resistance-nodulation-cell division pump effluxing multiple antibiotics in Acinetobacter baumannii. Antimicrob Agents Chemother 52:557-562
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 557-562
    • Damier-Piolle, L.1    Magnet, S.2    Bremont, S.3
  • 76
    • 50949127310 scopus 로고    scopus 로고
    • Identification of a novel multidrug efflux pump of Mycobacterium tuberculosis
    • Danilchanka O, Mailaender C, Niederweis M (2008) Identification of a novel multidrug efflux pump of Mycobacterium tuberculosis. Antimicrob Agents Chemother 52:3127-3134
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 3127-3134
    • Danilchanka, O.1    Mailaender, C.2    Niederweis, M.3
  • 77
    • 0031950082 scopus 로고    scopus 로고
    • Molecular cloning and functional analysis of a novel tetracycline resistance determinant, tet (V), from Mycobacterium smegmatis
    • De Rossi E, Blokpoel MC, Cantoni R et al (1998) Molecular cloning and functional analysis of a novel tetracycline resistance determinant, tet (V), from Mycobacterium smegmatis. Antimicrob Agents Chemother 42:1931-1937
    • (1998) Antimicrob Agents Chemother , vol.42 , pp. 1931-1937
    • De Rossi, E.1    Blokpoel, M.C.2    Cantoni, R.3
  • 78
    • 33644900505 scopus 로고    scopus 로고
    • Role of mycobacterial efflux transporters in drug resistance: An unresolved question
    • De Rossi E, Ainsa JA, Riccardi G (2006) Role of mycobacterial efflux transporters in drug resistance: an unresolved question. FEMS Microbiol Rev 30:36-52
    • (2006) FEMS Microbiol Rev , vol.30 , pp. 36-52
    • De Rossi, E.1    Ainsa, J.A.2    Riccardi, G.3
  • 79
    • 0037417013 scopus 로고    scopus 로고
    • Efflux-mediated resistance to tigecycline (GAR- 936) in Pseudomonas aeruginosa PAO1
    • Dean CR, Visalli MA, Projan SJ et al (2003) Efflux-mediated resistance to tigecycline (GAR- 936) in Pseudomonas aeruginosa PAO1. Antimicrob Agents Chemother 47:972-978
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 972-978
    • Dean, C.R.1    Visalli, M.A.2    Projan, S.J.3
  • 80
    • 23044442679 scopus 로고    scopus 로고
    • Role of the AcrAB-TolC efflux pump in determining susceptibility of Haemophilus influenzae to the novel peptide deformylase inhibitor LBM415
    • Dean CR, Narayan S, Daigle DM et al (2005) Role of the AcrAB-TolC efflux pump in determining susceptibility of Haemophilus influenzae to the novel peptide deformylase inhibitor LBM415. Antimicrob Agents Chemother 49:3129-3135
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 3129-3135
    • Dean, C.R.1    Narayan, S.2    Daigle, D.M.3
  • 81
    • 14944344361 scopus 로고    scopus 로고
    • Molecular characterization of an epidemic clone of panantibiotic-resistant Pseudomonas aeruginosa
    • Deplano A, Denis O, Poirel L et al (2005) Molecular characterization of an epidemic clone of panantibiotic-resistant Pseudomonas aeruginosa. J Clin Microbiol 43:1198-1204
    • (2005) J Clin Microbiol , vol.43 , pp. 1198-1204
    • Deplano, A.1    Denis, O.2    Poirel, L.3
  • 82
    • 33750977812 scopus 로고    scopus 로고
    • Macrolide and ketolide resistance with Streptococcus pneumoniae
    • Doern GV (2006) Macrolide and ketolide resistance with Streptococcus pneumoniae. Med Clin North Am 90:1109-1124
    • (2006) Med Clin North Am , vol.90 , pp. 1109-1124
    • Doern, G.V.1
  • 83
    • 0942279627 scopus 로고    scopus 로고
    • Plasmid-mediated 16 S rRNA methylase in Serratia marcescens conferring high-level resistance to aminoglycosides
    • Doi Y, Yokoyama K, Yamane K et al (2004) Plasmid-mediated 16 S rRNA methylase in Serratia marcescens conferring high-level resistance to aminoglycosides. Antimicrob Agents Chemother 48:491-496
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 491-496
    • Doi, Y.1    Yokoyama, K.2    Yamane, K.3
  • 84
    • 43149096467 scopus 로고    scopus 로고
    • Antibiotic susceptibility and mechanisms of b -lactam resistance among clinical strains of Pseudomonas aeruginosa: First report in Algeria
    • Drissi M, Ahmed ZB, Dehecq B et al (2008) Antibiotic susceptibility and mechanisms of b -lactam resistance among clinical strains of Pseudomonas aeruginosa: first report in Algeria. Med Mal Infect 38:187-191
    • (2008) Med Mal Infect , vol.38 , pp. 187-191
    • Drissi, M.1    Ahmed, Z.B.2    Dehecq, B.3
  • 85
    • 17444369811 scopus 로고    scopus 로고
    • Bacteriostatic and bactericidal activities of eight fluoroquinolones against MexAB-OprM-overproducing clinical strains of Pseudomonas aeruginosa
    • Dupont P, Hocquet D, Jeannot K et al (2005) Bacteriostatic and bactericidal activities of eight fluoroquinolones against MexAB-OprM-overproducing clinical strains of Pseudomonas aeruginosa. J Antimicrob Chemother 55:518-522
    • (2005) J Antimicrob Chemother , vol.55 , pp. 518-522
    • Dupont, P.1    Hocquet, D.2    Jeannot, K.3
  • 86
    • 34249720498 scopus 로고    scopus 로고
    • The mode of action of 2-(thiazol-2-ylthio)- 1 b -methylcarbapenems against Pseudomonas aeruginosa: The impact of outer membrane permeability and the contribution of MexAB-OprM efflux system
    • Eguchi K, Ueda Y, Kanazawa K et al (2007) The mode of action of 2-(thiazol-2-ylthio)- 1 b -methylcarbapenems against Pseudomonas aeruginosa: the impact of outer membrane permeability and the contribution of MexAB-OprM efflux system. J Antibiot (Tokyo) 60:129-135
    • (2007) J Antibiot (Tokyo) , vol.60 , pp. 129-135
    • Eguchi, K.1    Ueda, Y.2    Kanazawa, K.3
  • 87
    • 17144384736 scopus 로고    scopus 로고
    • Carbapenem resistance mechanisms in Pseudomonas aeruginosa: Alterations of porin OprD and efflux proteins do not fully explain resistance patterns observed in clinical isolates
    • El Amin N, Giske CG, Jalal S et al (2005) Carbapenem resistance mechanisms in Pseudomonas aeruginosa: alterations of porin OprD and efflux proteins do not fully explain resistance patterns observed in clinical isolates. APMIS 113:187-196
    • (2005) APMIS , vol.113 , pp. 187-196
    • El Amin, N.1    Giske, C.G.2    Jalal, S.3
  • 88
    • 0042838181 scopus 로고    scopus 로고
    • Chimeric analysis of AcrA function reveals the importance of its C-terminal domain in its interaction with the AcrB multidrug efflux pump
    • Elkins CA, Nikaido H (2003) Chimeric analysis of AcrA function reveals the importance of its C-terminal domain in its interaction with the AcrB multidrug efflux pump. J Bacteriol 185:5349-5356
    • (2003) J Bacteriol , vol.185 , pp. 5349-5356
    • Elkins, C.A.1    Nikaido, H.2
  • 89
    • 33646584802 scopus 로고    scopus 로고
    • Structural features of new quinolones and relationship to antibacterial activity against Gram-positive bacteria
    • Emami S, Shafiee A, Foroumadi A (2006) Structural features of new quinolones and relationship to antibacterial activity against Gram-positive bacteria. Mini Rev Med Chem 6: 375-386
    • (2006) Mini Rev Med Chem , vol.6 , pp. 375-386
    • Emami, S.1    Shafiee, A.2    Foroumadi, A.3
  • 90
    • 38349094212 scopus 로고    scopus 로고
    • Fluoroquinolone resistance in Neisseria meningitidis in Spain
    • Enriquez R, Abad R, Salcedo C et al (2008) Fluoroquinolone resistance in Neisseria meningitidis in Spain. J Antimicrob Chemother 61:286-290
    • (2008) J Antimicrob Chemother , vol.61 , pp. 286-290
    • Enriquez, R.1    Abad, R.2    Salcedo, C.3
  • 91
    • 36048965153 scopus 로고    scopus 로고
    • Importance of the efflux pump systems in the resistance of Mycobacterium tuberculosis to fluoroquinolones and linezolid
    • Basel
    • Escribano I, Rodriguez JC, Llorca B et al (2007) Importance of the efflux pump systems in the resistance of Mycobacterium tuberculosis to fluoroquinolones and linezolid. Chemotherapy 53:397-401 (Basel)
    • (2007) Chemotherapy , vol.53 , pp. 397-401
    • Escribano, I.1    Rodriguez, J.C.2    Llorca, B.3
  • 92
    • 17644389620 scopus 로고    scopus 로고
    • Colistin: The revival of polymyxins for the management of multidrug-resistant gram-negative bacterial infections
    • Falagas ME, Kasiakou SK (2005) Colistin: the revival of polymyxins for the management of multidrug-resistant gram-negative bacterial infections. Clin Infect Dis 40:1333-1341
    • (2005) Clin Infect Dis , vol.40 , pp. 1333-1341
    • Falagas, M.E.1    Kasiakou, S.K.2
  • 93
    • 34447125719 scopus 로고    scopus 로고
    • Regional trends in beta-lactam, macrolide, fluoroquinolone and telithromycin resistance among Streptococcus pneumoniae isolates 2001-2004
    • Felmingham D, Canton R, Jenkins SG (2007) Regional trends in beta-lactam, macrolide, fluoroquinolone and telithromycin resistance among Streptococcus pneumoniae isolates 2001-2004. J Infect 55:111-118
    • (2007) J Infect , vol.55 , pp. 111-118
    • Felmingham, D.1    Canton, R.2    Jenkins, S.G.3
  • 94
    • 57049127817 scopus 로고    scopus 로고
    • The MexCD-OprJ multidrug efflux system of Pseudomonas aeruginosa: Involvement in chlorhexidine resistance and induction by membrane damaging agents dependent upon the AlgU stress-response sigma factor
    • Fraud S, Campigotto AJ, Chen Z, Poole K (2008) The MexCD-OprJ multidrug efflux system of Pseudomonas aeruginosa: involvement in chlorhexidine resistance and induction by membrane damaging agents dependent upon the AlgU stress-response sigma factor. Antimicrob Agents Chemother 52:4478-4482
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 4478-4482
    • Fraud, S.1    Campigotto, A.J.2    Chen, Z.3    Poole, K.4
  • 95
    • 53849112279 scopus 로고    scopus 로고
    • Insights into the environmental resistance gene pool from the genome sequence of the multidrug-resistant environmental isolate E. coli SMS-3-5
    • Fricke WF, Wright MS, Lindell AH et al (2008) Insights into the environmental resistance gene pool from the genome sequence of the multidrug-resistant environmental isolate E. coli SMS-3-5. J Bacteriol 190:6779-6794
    • (2008) J Bacteriol , vol.190 , pp. 6779-6794
    • Fricke, W.F.1    Wright, M.S.2    Lindell, A.H.3
  • 96
    • 0028929129 scopus 로고
    • NfxC -type quinolone resistance in a clinical isolate of Pseudomonas aeruginosa
    • Fukuda H, Hosaka M, Iyobe S et al (1995) nfxC -type quinolone resistance in a clinical isolate of Pseudomonas aeruginosa. Antimicrob Agents Chemother 39:790-792
    • (1995) Antimicrob Agents Chemother , vol.39 , pp. 790-792
    • Fukuda, H.1    Hosaka, M.2    Iyobe, S.3
  • 97
    • 35449002547 scopus 로고    scopus 로고
    • Characterization of Pseudomonas aeruginosa isolated from clinical and environmental samples in Minia, Egypt: Prevalence, antibiogram and resistance mechanisms
    • Gad GF, El Domany RA, Zaki S et al (2007) Characterization of Pseudomonas aeruginosa isolated from clinical and environmental samples in Minia, Egypt: prevalence, antibiogram and resistance mechanisms. J Antimicrob Chemother 60:1010-1017
    • (2007) J Antimicrob Chemother , vol.60 , pp. 1010-1017
    • Gad, G.F.1    El Domany, R.A.2    Zaki, S.3
  • 98
    • 34447256788 scopus 로고    scopus 로고
    • Ampicillin-resistant non- b -lactamase-producing Haemophilus influenzae in Spain: Recent emergence of clonal isolates with increased resistance to cefotaxime and cefixime
    • Garcia-Cobos S, Campos J, Lazaro E et al (2007) Ampicillin-resistant non- b -lactamase-producing Haemophilus influenzae in Spain: recent emergence of clonal isolates with increased resistance to cefotaxime and cefixime. Antimicrob Agents Chemother 51:2564-2573
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 2564-2573
    • Garcia-Cobos, S.1    Campos, J.2    Lazaro, E.3
  • 99
    • 42949152261 scopus 로고    scopus 로고
    • The efflux pump inhibitor reserpine selects multidrug-resistant Streptococcus pneumoniae strains that overexpress the ABC transporters PatA and PatB
    • Garvey MI, Piddock LJ (2008) The efflux pump inhibitor reserpine selects multidrug-resistant Streptococcus pneumoniae strains that overexpress the ABC transporters PatA and PatB. Antimicrob Agents Chemother 52:1677-1685
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 1677-1685
    • Garvey, M.I.1    Piddock, L.J.2
  • 100
    • 23044512221 scopus 로고    scopus 로고
    • Role of efflux pumps and topoisomerase mutations in fluoroquinolone resistance in Campylobacter jejuni and Campylobacter coli
    • Ge B, McDermott PF, White DG et al (2005) Role of efflux pumps and topoisomerase mutations in fluoroquinolone resistance in Campylobacter jejuni and Campylobacter coli. Antimicrob Agents Chemother 49:3347-3354
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 3347-3354
    • Ge, B.1    McDermott, P.F.2    White, D.G.3
  • 101
    • 54149101312 scopus 로고    scopus 로고
    • Synthesis and evaluation of fluoroquinolone derivatives as substrate-based inhibitors of bacterial efflux pumps
    • German N, Wei P, Kaatz GW et al (2008) Synthesis and evaluation of fluoroquinolone derivatives as substrate-based inhibitors of bacterial efflux pumps. Eur J Med Chem 43: 2453-2463
    • (2008) Eur J Med Chem , vol.43 , pp. 2453-2463
    • German, N.1    Wei, P.2    Kaatz, G.W.3
  • 102
    • 33646882584 scopus 로고    scopus 로고
    • Chloroquinolines block antibiotic efflux pumps in antibiotic-resistant Enterobacter aerogenes isolates
    • Ghisalberti D, Mahamoud A, Chevalier J et al (2006) Chloroquinolines block antibiotic efflux pumps in antibiotic-resistant Enterobacter aerogenes isolates. Int J Antimicrob Agents 27:565-569
    • (2006) Int J Antimicrob Agents , vol.27 , pp. 565-569
    • Ghisalberti, D.1    Mahamoud, A.2    Chevalier, J.3
  • 103
    • 35948957361 scopus 로고    scopus 로고
    • Contribution of the CmeABC efflux pump to macrolide and tetracycline resistance in Campylobacter jejuni
    • Gibreel A, Wetsch NM, Taylor DE (2007) Contribution of the CmeABC efflux pump to macrolide and tetracycline resistance in Campylobacter jejuni. Antimicrob Agents Chemother 51:3212-3216
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 3212-3216
    • Gibreel, A.1    Wetsch, N.M.2    Taylor, D.E.3
  • 104
    • 33748068465 scopus 로고    scopus 로고
    • Deletion of TolC orthologs in Francisella tularensis identifies roles in multidrug resistance and virulence
    • Gil H, Platz GJ, Forestal CA et al (2006) Deletion of TolC orthologs in Francisella tularensis identifies roles in multidrug resistance and virulence. Proc Natl Acad Sci USA 103: 12897-12902
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 12897-12902
    • Gil, H.1    Platz, G.J.2    Forestal, C.A.3
  • 105
    • 41149095072 scopus 로고    scopus 로고
    • Alterations of porin, pumps, and penicillinbinding proteins in carbapenem resistant clinical isolates of Pseudomonas aeruginosa
    • Giske CG, Buaro L, Sundsfjord A et al (2008) Alterations of porin, pumps, and penicillinbinding proteins in carbapenem resistant clinical isolates of Pseudomonas aeruginosa. Microb Drug Resist 14:23-30
    • (2008) Microb Drug Resist , vol.14 , pp. 23-30
    • Giske, C.G.1    Buaro, L.2    Sundsfjord, A.3
  • 107
    • 0029966719 scopus 로고    scopus 로고
    • Multiple antibiotic resistance ( mar ) locus protects Escherichia coli from rapid cell killing by fluoroquinolones
    • Goldman JD, White DG, Levy SB (1996) Multiple antibiotic resistance ( mar ) locus protects Escherichia coli from rapid cell killing by fluoroquinolones. Antimicrob Agents Chemother 40:1266-1269
    • (1996) Antimicrob Agents Chemother , vol.40 , pp. 1266-1269
    • Goldman, J.D.1    White, D.G.2    Levy, S.B.3
  • 108
    • 33846422394 scopus 로고    scopus 로고
    • Genes that enhance the ecological fitness of Shewanella oneidensis MR-1 in sediments reveal the value of antibiotic resistance
    • Groh JL, Luo Q, Ballard JD et al (2007) Genes that enhance the ecological fitness of Shewanella oneidensis MR-1 in sediments reveal the value of antibiotic resistance. Appl Environ Microbiol 73:492-498
    • (2007) Appl Environ Microbiol , vol.73 , pp. 492-498
    • Groh, J.L.1    Luo, Q.2    Ballard, J.D.3
  • 109
    • 33747410819 scopus 로고    scopus 로고
    • Efflux pump genes of the resistancenodulation- division family in Burkholderia cenocepacia genome
    • Guglierame P, Pasca MR, De Rossi E et al (2006) Efflux pump genes of the resistancenodulation- division family in Burkholderia cenocepacia genome. BMC Microbiol 6:66
    • (2006) BMC Microbiol , vol.6 , pp. 66
    • Guglierame, P.1    Pasca, M.R.2    De Rossi, E.3
  • 110
    • 33846142868 scopus 로고    scopus 로고
    • Isoniazid's bactericidal activity ceases because of the emergence of resistance, not depletion of Mycobacterium tuberculosis in the log phase of growth
    • Gumbo T, Louie A, Liu W et al (2007) Isoniazid's bactericidal activity ceases because of the emergence of resistance, not depletion of Mycobacterium tuberculosis in the log phase of growth. J Infect Dis 195:194-201
    • (2007) J Infect Dis , vol.195 , pp. 194-201
    • Gumbo, T.1    Louie, A.2    Liu, W.3
  • 111
    • 36749062400 scopus 로고    scopus 로고
    • Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa isolates from Spanish hospitals
    • Gutierrez O, Juan C, Cercenado E et al (2007) Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa isolates from Spanish hospitals. Antimicrob Agents Chemother 51:4329-4335
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 4329-4335
    • Gutierrez, O.1    Juan, C.2    Cercenado, E.3
  • 112
    • 33750217091 scopus 로고    scopus 로고
    • Intrinsic and selected resistance to antibiotics binding the ribosome: Analyses of Brucella 23 S rrn, L4, L22, EF-Tu1, EF-Tu2, efflux and phylogenetic implications
    • Halling SM, Jensen AE (2006) Intrinsic and selected resistance to antibiotics binding the ribosome: analyses of Brucella 23 S rrn, L4, L22, EF-Tu1, EF-Tu2, efflux and phylogenetic implications. BMC Microbiol 6:84
    • (2006) BMC Microbiol , vol.6 , pp. 84
    • Halling, S.M.1    Jensen, A.E.2
  • 113
    • 0028828456 scopus 로고
    • OprK and OprM define two genetically distinct multidrug efflux systems in Pseudomonas aeruginosa
    • Hamzehpour MM, Pechere J-C, Plesiat P et al (1995) OprK and OprM define two genetically distinct multidrug efflux systems in Pseudomonas aeruginosa. Antimicrob Agents Chemother 39:2392-2396
    • (1995) Antimicrob Agents Chemother , vol.39 , pp. 2392-2396
    • Hamzehpour, M.M.1    Pechere, J.-C.2    Plesiat, P.3
  • 114
    • 36448940487 scopus 로고    scopus 로고
    • Spontaneous mutation frequency and emergence of ciprofloxacin resistance in Campylobacter jejuni and Campylobacter coli
    • Hanninen ML, Hannula M (2007) Spontaneous mutation frequency and emergence of ciprofloxacin resistance in Campylobacter jejuni and Campylobacter coli. J Antimicrob Chemother 60:1251-1257
    • (2007) J Antimicrob Chemother , vol.60 , pp. 1251-1257
    • Hanninen, M.L.1    Hannula, M.2
  • 115
    • 48949101441 scopus 로고    scopus 로고
    • Effect of putative efflux pump inhibitors and inducers on the antimicrobial susceptibility of Campylobacter jejuni and Campylobacter coli
    • Hannula M, Hanninen ML (2008) Effect of putative efflux pump inhibitors and inducers on the antimicrobial susceptibility of Campylobacter jejuni and Campylobacter coli. J Med Microbiol 57:851-855
    • (2008) J Med Microbiol , vol.57 , pp. 851-855
    • Hannula, M.1    Hanninen, M.L.2
  • 116
    • 4344614478 scopus 로고    scopus 로고
    • Plasmid-encoded multidrug efflux pump conferring resistance to olaquindox in Escherichia coli
    • Hansen LH, Johannesen E, Burmolle M et al (2004) Plasmid-encoded multidrug efflux pump conferring resistance to olaquindox in Escherichia coli. Antimicrob Agents Chemother 48:3332-3337
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 3332-3337
    • Hansen, L.H.1    Johannesen, E.2    Burmolle, M.3
  • 117
    • 34447547677 scopus 로고    scopus 로고
    • Substrate specificity of the OqxAB multidrug resistance pump in Escherichia coli and selected enteric bacteria
    • Hansen LH, Jensen LB, Sorensen HI et al (2007) Substrate specificity of the OqxAB multidrug resistance pump in Escherichia coli and selected enteric bacteria. J Antimicrob Chemother 60:145-147
    • (2007) J Antimicrob Chemother , vol.60 , pp. 145-147
    • Hansen, L.H.1    Jensen, L.B.2    Sorensen, H.I.3
  • 118
    • 2942615162 scopus 로고    scopus 로고
    • Detection and prevalence of active drug efflux mechanism in various multidrug-resistant Klebsiella pneumoniae strains from Turkey
    • Hasdemir UO, Chevalier J, Nordmann P et al (2004) Detection and prevalence of active drug efflux mechanism in various multidrug-resistant Klebsiella pneumoniae strains from Turkey. J Clin Microbiol 42:2701-2706
    • (2004) J Clin Microbiol , vol.42 , pp. 2701-2706
    • Hasdemir, U.O.1    Chevalier, J.2    Nordmann, P.3
  • 119
    • 35848954104 scopus 로고    scopus 로고
    • Resistance mechanisms of multiresistant Pseudomonas aeruginosa strains from Germany and correlation with hypermutation
    • Henrichfreise B, Wiegand I, Pfister W et al (2007) Resistance mechanisms of multiresistant Pseudomonas aeruginosa strains from Germany and correlation with hypermutation. Antimicrob Agents Chemother 51:4062-4070
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 4062-4070
    • Henrichfreise, B.1    Wiegand, I.2    Pfister, W.3
  • 120
    • 42049096731 scopus 로고    scopus 로고
    • Role of the AheABC efflux pump in Aeromonas hydrophila intrinsic multidrug resistance
    • Hernould M, Gagne S, Fournier M et al (2008) Role of the AheABC efflux pump in Aeromonas hydrophila intrinsic multidrug resistance. Antimicrob Agents Chemother 52:1559-1563
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 1559-1563
    • Hernould, M.1    Gagne, S.2    Fournier, M.3
  • 121
    • 0037405379 scopus 로고    scopus 로고
    • Mutations in GyrA, ParC, MexR and NfxB in clinical isolates of Pseudomonas aeruginosa
    • Higgins PG, Fluit AC, Milatovic D et al (2003) Mutations in GyrA, ParC, MexR and NfxB in clinical isolates of Pseudomonas aeruginosa. Int J Antimicrob Agents 21:409-413
    • (2003) Int J Antimicrob Agents , vol.21 , pp. 409-413
    • Higgins, P.G.1    Fluit, A.C.2    Milatovic, D.3
  • 123
    • 3042838743 scopus 로고    scopus 로고
    • Structure of the periplasmic component of a bacterial drug efflux pump
    • Higgins MK, Bokma E, Koronakis E et al (2004) Structure of the periplasmic component of a bacterial drug efflux pump. Proc Natl Acad Sci USA 101:9994-9999
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 9994-9999
    • Higgins, M.K.1    Bokma, E.2    Koronakis, E.3
  • 124
    • 6344222032 scopus 로고    scopus 로고
    • Selection of topoisomerase mutations and overexpression of adeB mRNA transcripts during an outbreak of Acinetobacter baumannii
    • Higgins PG, Wisplinghoff H, Stefanik D et al (2004) Selection of topoisomerase mutations and overexpression of adeB mRNA transcripts during an outbreak of Acinetobacter baumannii. J Antimicrob Chemother 54:821-823
    • (2004) J Antimicrob Chemother , vol.54 , pp. 821-823
    • Higgins, P.G.1    Wisplinghoff, H.2    Stefanik, D.3
  • 125
    • 2542444502 scopus 로고    scopus 로고
    • Effects of efflux transporter genes on susceptibility of Escherichia coli to tigecycline (GAR-936)
    • Hirata T, Saito A, Nishino K et al (2004) Effects of efflux transporter genes on susceptibility of Escherichia coli to tigecycline (GAR-936). Antimicrob Agents Chemother 48:2179-2184
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 2179-2184
    • Hirata, T.1    Saito, A.2    Nishino, K.3
  • 126
    • 0037378945 scopus 로고    scopus 로고
    • MexXY-OprM efflux pump is necessary for adaptive resistance of Pseudomonas aeruginosa to aminoglycosides
    • Hocquet D, Vogne C, El Garch F et al (2003) MexXY-OprM efflux pump is necessary for adaptive resistance of Pseudomonas aeruginosa to aminoglycosides. Antimicrob Agents Chemother 47:1371-1375
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 1371-1375
    • Hocquet, D.1    Vogne, C.2    El Garch, F.3
  • 127
    • 33645757771 scopus 로고    scopus 로고
    • Involvement of the MexXY-OprM efflux system in emergence of cefepime resistance in clinical strains of Pseudomonas aeruginosa
    • Hocquet D, Nordmann P, El Garch F et al (2006) Involvement of the MexXY-OprM efflux system in emergence of cefepime resistance in clinical strains of Pseudomonas aeruginosa. Antimicrob Agents Chemother 50:1347-1351
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 1347-1351
    • Hocquet, D.1    Nordmann, P.2    El Garch, F.3
  • 128
    • 35848940235 scopus 로고    scopus 로고
    • An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii
    • Hu WS, Yao SM, Fung CP et al (2007) An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. Antimicrob Agents Chemother 51:3844-3852
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 3844-3852
    • Hu, W.S.1    Yao, S.M.2    Fung, C.P.3
  • 129
    • 53949106973 scopus 로고    scopus 로고
    • Differential susceptibility to carbapenems due to the AdeABC efflux pump among nosocomial outbreak isolates of Acinetobacter baumannii in a Chinese hospital
    • Huang L, Sun L, Xu G et al (2008) Differential susceptibility to carbapenems due to the AdeABC efflux pump among nosocomial outbreak isolates of Acinetobacter baumannii in a Chinese hospital. Diagn Microbiol Infect Dis 62(3):326-332
    • (2008) Diagn Microbiol Infect Dis , vol.62 , Issue.3 , pp. 326-332
    • Huang, L.1    Sun, L.2    Xu, G.3
  • 130
    • 0041767580 scopus 로고    scopus 로고
    • Molecular cloning and characterization of an ABC multidrug efflux pump, VcaM, in Non-O1 Vibrio cholerae
    • Huda N, Lee EW, Chen J et al (2003) Molecular cloning and characterization of an ABC multidrug efflux pump, VcaM, in Non-O1 Vibrio cholerae. Antimicrob Agents Chemother 47:2413-2417
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 2413-2417
    • Huda, N.1    Lee, E.W.2    Chen, J.3
  • 131
    • 0036841303 scopus 로고    scopus 로고
    • Dual targeting of DNA gyrase and topoisomerase IV: Target interactions of garenoxacin (BMS-284756, T-3811ME), a new desfluoroquinolone
    • Ince D, Zhang X, Silver LC et al (2002) Dual targeting of DNA gyrase and topoisomerase IV: target interactions of garenoxacin (BMS-284756, T-3811ME), a new desfluoroquinolone. Antimicrob Agents Chemother 46:3370-3380
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 3370-3380
    • Ince, D.1    Zhang, X.2    Silver, L.C.3
  • 132
    • 6444222946 scopus 로고    scopus 로고
    • Expression of the MexXY efflux pump in amikacinresistant isolates of Pseudomonas aeruginosa
    • Islam S, Jalal S, Wretlind B (2004) Expression of the MexXY efflux pump in amikacinresistant isolates of Pseudomonas aeruginosa. Clin Microbiol Infect 10:877-883
    • (2004) Clin Microbiol Infect , vol.10 , pp. 877-883
    • Islam, S.1    Jalal, S.2    Wretlind, B.3
  • 133
    • 4344630939 scopus 로고    scopus 로고
    • In vitro activity of the new quinolone WCK 771 against staphylococci
    • Jacobs MR, Bajaksouzian S, Windau A et al (2004) In vitro activity of the new quinolone WCK 771 against staphylococci. Antimicrob Agents Chemother 48:3338-3342
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 3338-3342
    • Jacobs, M.R.1    Bajaksouzian, S.2    Windau, A.3
  • 134
    • 0026490125 scopus 로고
    • Occurrence of the nfxB type mutation in clinical isolates of Pseudomonas aeruginosa
    • Jakics EB, Iyobe S, Hirai K et al (1992) Occurrence of the nfxB type mutation in clinical isolates of Pseudomonas aeruginosa. Antimicrob Agents Chemother 36:2562-2565
    • (1992) Antimicrob Agents Chemother , vol.36 , pp. 2562-2565
    • Jakics, E.B.1    Iyobe, S.2    Hirai, K.3
  • 135
    • 0032414382 scopus 로고    scopus 로고
    • Mechanisms of quinolone resistance in clinical strains of Pseudomonas aeruginosa
    • Jalal S, Wretlind B (1998) Mechanisms of quinolone resistance in clinical strains of Pseudomonas aeruginosa. Microb Drug Resist 4:257-261
    • (1998) Microb Drug Resist , vol.4 , pp. 257-261
    • Jalal, S.1    Wretlind, B.2
  • 136
    • 0033384416 scopus 로고    scopus 로고
    • Rapid identification of mutations in a multidrug efflux pump in Pseudomonas aeruginosa
    • Jalal S, Wretlind G, Gotoh N et al (1999) Rapid identification of mutations in a multidrug efflux pump in Pseudomonas aeruginosa. APMIS 107:1109-1116
    • (1999) APMIS , vol.107 , pp. 1109-1116
    • Jalal, S.1    Wretlind, G.2    Gotoh, N.3
  • 137
    • 0033999155 scopus 로고    scopus 로고
    • Molecular mechanisms of fluoroquinolone resistance in Pseudomonas aeruginosa isolates from cystic fibrosos
    • Jalal S, Ciofu O, Hoiby N et al (2000) Molecular mechanisms of fluoroquinolone resistance in Pseudomonas aeruginosa isolates from cystic fibrosos. Antimicrob Agents Chemother 44:710-712
    • (2000) Antimicrob Agents Chemother , vol.44 , pp. 710-712
    • Jalal, S.1    Ciofu, O.2    Hoiby, N.3
  • 138
    • 22544461608 scopus 로고    scopus 로고
    • Induction of the MexXY efflux pump in Pseudomonas aeruginosa is dependent on drug-ribosome interaction
    • Jeannot K, Sobel ML, El Garch F et al (2005) Induction of the MexXY efflux pump in Pseudomonas aeruginosa is dependent on drug-ribosome interaction. J Bacteriol 187: 5341-5346
    • (2005) J Bacteriol , vol.187 , pp. 5341-5346
    • Jeannot, K.1    Sobel, M.L.2    El Garch, F.3
  • 139
    • 46249116233 scopus 로고    scopus 로고
    • Resistance and virulence of Pseudomonas aeruginosa clinical strains overproducing the MexCD-OprJ efflux pump
    • Jeannot K, Elsen S, Kohler T et al (2008) Resistance and virulence of Pseudomonas aeruginosa clinical strains overproducing the MexCD-OprJ efflux pump. Antimicrob Agents Chemother 52:2455-2462
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 2455-2462
    • Jeannot, K.1    Elsen, S.2    Kohler, T.3
  • 140
    • 0035028431 scopus 로고    scopus 로고
    • Enhanced expression of the multidrug efflux pumps AcrAB and AcrEF associated with insertion element transposition in Escherichia coli mutants selected with a fluoroquinolone
    • Jellen-Ritter AS, Kern WV (2001) Enhanced expression of the multidrug efflux pumps AcrAB and AcrEF associated with insertion element transposition in Escherichia coli mutants selected with a fluoroquinolone. Antimicrob Agents Chemother 45:1467-1472
    • (2001) Antimicrob Agents Chemother , vol.45 , pp. 1467-1472
    • Jellen-Ritter, A.S.1    Kern, W.V.2
  • 141
    • 0141446140 scopus 로고    scopus 로고
    • A gonococcal efflux pump system enhances bacterial survival in a female mouse model of genital tract infection
    • Jerse AE, Sharma ND, Simms AN et al (2003) A gonococcal efflux pump system enhances bacterial survival in a female mouse model of genital tract infection. Infect Immun 71: 5576-5582
    • (2003) Infect Immun , vol.71 , pp. 5576-5582
    • Jerse, A.E.1    Sharma, N.D.2    Simms, A.N.3
  • 142
    • 41149120586 scopus 로고    scopus 로고
    • Assessment of efflux pump gene expression in a clinical isolate Mycobacterium tuberculosis by real-time reverse transcription PCR
    • Jiang X, Zhang W, Zhang Y et al (2008) Assessment of efflux pump gene expression in a clinical isolate Mycobacterium tuberculosis by real-time reverse transcription PCR. Microb Drug Resist 14:7-11
    • (2008) Microb Drug Resist , vol.14 , pp. 7-11
    • Jiang, X.1    Zhang, W.2    Zhang, Y.3
  • 143
    • 0035143255 scopus 로고    scopus 로고
    • Differential selection of multidrug efflux mutants by trovafloxacin and ciprofloxacin in an experimental model of Pseudomonas aeruginosa acute pneumonia in rats
    • Join-Lambert OF, Michea-Hamzehpour M, Kohler T et al (2001) Differential selection of multidrug efflux mutants by trovafloxacin and ciprofloxacin in an experimental model of Pseudomonas aeruginosa acute pneumonia in rats. Antimicrob Agents Chemother 45:571-576
    • (2001) Antimicrob Agents Chemother , vol.45 , pp. 571-576
    • Join-Lambert, O.F.1    Michea-Hamzehpour, M.2    Kohler, T.3
  • 144
    • 0036919938 scopus 로고    scopus 로고
    • Identification and characterization of a novel effluxrelated multidrug resistance phenotype in Staphylococcus aureus
    • Kaatz GW, Moudgal VV, Seo SM (2002) Identification and characterization of a novel effluxrelated multidrug resistance phenotype in Staphylococcus aureus. J Antimicrob Chemother 50:833-838
    • (2002) J Antimicrob Chemother , vol.50 , pp. 833-838
    • Kaatz, G.W.1    Moudgal, V.V.2    Seo, S.M.3
  • 145
    • 0042835371 scopus 로고    scopus 로고
    • Phenylpiperidine selective serotonin reuptake inhibitors interfere with multidrug efflux pump activity in Staphylococcus aureus
    • Kaatz GW, Moudgal VV, Seo SM et al (2003) Phenylpiperidine selective serotonin reuptake inhibitors interfere with multidrug efflux pump activity in Staphylococcus aureus. Int J Antimicrob Agents 22:254-261
    • (2003) Int J Antimicrob Agents , vol.22 , pp. 254-261
    • Kaatz, G.W.1    Moudgal, V.V.2    Seo, S.M.3
  • 146
    • 18244388696 scopus 로고    scopus 로고
    • Multidrug resistance in Staphylococcus aureus due to overexpression of a novel multidrug and toxin extrusion (MATE) transport protein
    • Kaatz GW, McAleese F, Seo SM (2005) Multidrug resistance in Staphylococcus aureus due to overexpression of a novel multidrug and toxin extrusion (MATE) transport protein. Antimicrob Agents Chemother 49:1857-1864
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 1857-1864
    • Kaatz, G.W.1    McAleese, F.2    Seo, S.M.3
  • 147
    • 2142827105 scopus 로고    scopus 로고
    • Genetic and molecular characterization of b -lactamase-negative ampicillin-resistant Haemophilus influenzae with unusually high resistance to ampicillin
    • Kaczmarek FS, Gootz TD, Dib-Hajj F et al (2004) Genetic and molecular characterization of b -lactamase-negative ampicillin-resistant Haemophilus influenzae with unusually high resistance to ampicillin. Antimicrob Agents Chemother 48:1630-1639
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 1630-1639
    • Kaczmarek, F.S.1    Gootz, T.D.2    Dib-Hajj, F.3
  • 148
    • 54549118261 scopus 로고    scopus 로고
    • Cefuroxime non-susceptibility in multidrugresistant Klebsiella pneumoniae overexpressing ramA and acrA and expressing ompK35 at reduced levels
    • Kallman O, MotakefiA, Wretlind B et al (2008) Cefuroxime non-susceptibility in multidrugresistant Klebsiella pneumoniae overexpressing ramA and acrA and expressing ompK35 at reduced levels. J Antimicrob Chemother 62:986-990
    • (2008) J Antimicrob Chemother , vol.62 , pp. 986-990
    • Kallman, O.1    Motakefi, A.2    Wretlind, B.3
  • 149
    • 35448989850 scopus 로고    scopus 로고
    • Prolonged treatment of Salmonella enterica serovar Typhimurium with commercial disinfectants selects for multiple antibiotic resistance, increased efflux and reduced invasiveness
    • Karatzas KA, Webber MA, Jorgensen F et al (2007) Prolonged treatment of Salmonella enterica serovar Typhimurium with commercial disinfectants selects for multiple antibiotic resistance, increased efflux and reduced invasiveness. J Antimicrob Chemother 60:947-955
    • (2007) J Antimicrob Chemother , vol.60 , pp. 947-955
    • Karatzas, K.A.1    Webber, M.A.2    Jorgensen, F.3
  • 150
    • 40549124293 scopus 로고    scopus 로고
    • Phenotypic and proteomic characterization of multiply antibiotic-resistant variants of Salmonella enterica serovar Typhimurium selected following exposure to disinfectants
    • Karatzas KA, Randall LP, Webber M et al (2008) Phenotypic and proteomic characterization of multiply antibiotic-resistant variants of Salmonella enterica serovar Typhimurium selected following exposure to disinfectants. Appl Environ Microbiol 74:1508-1516
    • (2008) Appl Environ Microbiol , vol.74 , pp. 1508-1516
    • Karatzas, K.A.1    Randall, L.P.2    Webber, M.3
  • 151
    • 34249708519 scopus 로고    scopus 로고
    • RamA, a transcriptional regulator, and AcrAB, an RND-type efflux pump, are associated with decreased susceptibility to tigecycline in Enterobacter cloacae
    • Keeney D, Ruzin A, Bradford PA (2007) RamA, a transcriptional regulator, and AcrAB, an RND-type efflux pump, are associated with decreased susceptibility to tigecycline in Enterobacter cloacae. Microb Drug Resist 13:1-6
    • (2007) Microb Drug Resist , vol.13 , pp. 1-6
    • Keeney, D.1    Ruzin, A.2    Bradford, P.A.3
  • 152
    • 37549027624 scopus 로고    scopus 로고
    • MarA-mediated overexpression of the AcrAB efflux pump results in decreased susceptibility to tigecycline in Escherichia coli
    • Keeney D, Ruzin A, McAleese F et al (2008) MarA-mediated overexpression of the AcrAB efflux pump results in decreased susceptibility to tigecycline in Escherichia coli. J Antimicrob Chemother 61:46-53
    • (2008) J Antimicrob Chemother , vol.61 , pp. 46-53
    • Keeney, D.1    Ruzin, A.2    McAleese, F.3
  • 153
    • 23844432753 scopus 로고    scopus 로고
    • Tet (L)-mediated tetracycline resistance in bovine Mannheimia and Pasteurella isolates
    • Kehrenberg C, Catry B, Haesebrouck F et al (2005) tet (L)-mediated tetracycline resistance in bovine Mannheimia and Pasteurella isolates. J Antimicrob Chemother 56:403-406
    • (2005) J Antimicrob Chemother , vol.56 , pp. 403-406
    • Kehrenberg, C.1    Catry, B.2    Haesebrouck, F.3
  • 154
    • 34447572658 scopus 로고    scopus 로고
    • Molecular mechanisms of decreased susceptibility to fluoroquinolones in avian Salmonella serovars and their mutants selected during the determination of mutant prevention concentrations
    • Kehrenberg C, de Jong A, Friederichs S et al (2007) Molecular mechanisms of decreased susceptibility to fluoroquinolones in avian Salmonella serovars and their mutants selected during the determination of mutant prevention concentrations. J Antimicrob Chemother 59:886-892
    • (2007) J Antimicrob Chemother , vol.59 , pp. 886-892
    • Kehrenberg, C.1    De Jong, A.2    Friederichs, S.3
  • 155
    • 31544441414 scopus 로고    scopus 로고
    • Effect of 1-(1-naphthylmethyl)-piperazine, a novel putative efflux pump inhibitor, on antimicrobial drug susceptibility in clinical isolates of Escherichia coli
    • Kern WV, Steinke P, Schumacher A et al (2006) Effect of 1-(1-naphthylmethyl)-piperazine, a novel putative efflux pump inhibitor, on antimicrobial drug susceptibility in clinical isolates of Escherichia coli. J Antimicrob Chemother 57:339-343
    • (2006) J Antimicrob Chemother , vol.57 , pp. 339-343
    • Kern, W.V.1    Steinke, P.2    Schumacher, A.3
  • 156
    • 42449128654 scopus 로고    scopus 로고
    • Identification of novel metronidazole-inducible genes in Mycobacterium smegmatis using a customized amplification library
    • Kim SY, Shin SJ, Song CH et al (2008) Identification of novel metronidazole-inducible genes in Mycobacterium smegmatis using a customized amplification library. FEMS Microbiol Lett 282:282-289
    • (2008) FEMS Microbiol Lett , vol.282 , pp. 282-289
    • Kim, S.Y.1    Shin, S.J.2    Song, C.H.3
  • 157
    • 0034806355 scopus 로고    scopus 로고
    • Novel macrolide-specific ABC-type efflux transporter in Escherichia coli
    • Kobayashi N, Nishino K, Yamaguchi A (2001) Novel macrolide-specific ABC-type efflux transporter in Escherichia coli. J Bacteriol 183:5639-5644
    • (2001) J Bacteriol , vol.183 , pp. 5639-5644
    • Kobayashi, N.1    Nishino, K.2    Yamaguchi, A.3
  • 158
    • 48749127049 scopus 로고    scopus 로고
    • Potent in vitro activity of tomopenem (CS-023) against methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa
    • Koga T, Masuda N, Kakuta M et al (2008) Potent in vitro activity of tomopenem (CS-023) against methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa. Antimicrob Agents Chemother 52:849-854
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 849-854
    • Koga, T.1    Masuda, N.2    Kakuta, M.3
  • 159
    • 0344131941 scopus 로고    scopus 로고
    • Characterization of MexT, the Regulator of the MexE-MexF-OprN Multidrug Efflux System of Pseudomonas aeruginosa
    • Köhler T, Epp SF, Curty LK et al (1999) Characterization of MexT, the Regulator of the MexE-MexF-OprN Multidrug Efflux System of Pseudomonas aeruginosa. J Bacteriol 181:6300-6305
    • (1999) J Bacteriol , vol.181 , pp. 6300-6305
    • Köhler, T.1    Epp, S.F.2    Curty, L.K.3
  • 160
    • 0034702177 scopus 로고    scopus 로고
    • Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export
    • Koronakis V, Sharff A, Koronakis E et al (2000) Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export. Nature 405:914-919
    • (2000) Nature , vol.405 , pp. 914-919
    • Koronakis, V.1    Sharff, A.2    Koronakis, E.3
  • 161
    • 12944249381 scopus 로고    scopus 로고
    • Use of an efflux pump inhibitor to determine the prevalence of efflux pump-mediated fluoroquinolone resistance and multidrug resistance in Pseudomonas aeruginosa
    • Kriengkauykiat J, Porter E, Lomovskaya O et al (2005) Use of an efflux pump inhibitor to determine the prevalence of efflux pump-mediated fluoroquinolone resistance and multidrug resistance in Pseudomonas aeruginosa. Antimicrob Agents Chemother 49:565-570
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 565-570
    • Kriengkauykiat, J.1    Porter, E.2    Lomovskaya, O.3
  • 162
    • 38749137423 scopus 로고    scopus 로고
    • Fitting periplasmic membrane fusion proteins to inner membrane transporters: Mutations that enable Escherichia coli AcrA to function with Pseudomonas aeruginosa MexB
    • Krishnamoorthy G, Tikhonova EB, Zgurskaya HI (2008) Fitting periplasmic membrane fusion proteins to inner membrane transporters: mutations that enable Escherichia coli AcrA to function with Pseudomonas aeruginosa MexB. J Bacteriol 190:691-698
    • (2008) J Bacteriol , vol.190 , pp. 691-698
    • Krishnamoorthy, G.1    Tikhonova, E.B.2    Zgurskaya, H.I.3
  • 163
    • 16244421361 scopus 로고    scopus 로고
    • Cloning, sequencing, and characterization of the SdeAB multidrug efflux pump of Serratia marcescens
    • Kumar A, Worobec EA (2005) Cloning, sequencing, and characterization of the SdeAB multidrug efflux pump of Serratia marcescens. Antimicrob Agents Chemother 49:1495-1501
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 1495-1501
    • Kumar, A.1    Worobec, E.A.2
  • 164
    • 33749511442 scopus 로고    scopus 로고
    • Method for regulated expression of single-copy efflux pump genes in a surrogate Pseudomonas aeruginosa strain: Identification of the BpeEF-OprC chloramphenicol and trimethoprim efflux pump of Burkholderia pseudomallei 1026b
    • Kumar A, Chua KL, Schweizer HP (2006) Method for regulated expression of single-copy efflux pump genes in a surrogate Pseudomonas aeruginosa strain: identification of the BpeEF-OprC chloramphenicol and trimethoprim efflux pump of Burkholderia pseudomallei 1026b. Antimicrob Agents Chemother 50:3460-3463
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 3460-3463
    • Kumar, A.1    Chua, K.L.2    Schweizer, H.P.3
  • 165
    • 35748966708 scopus 로고    scopus 로고
    • Mechanisms of erythromycin resistance of Campylobacter spp. isolated from food, animals and humans
    • Kurincic M, Botteldoorn N, Herman L et al (2007) Mechanisms of erythromycin resistance of Campylobacter spp. isolated from food, animals and humans. Int J Food Microbiol 120:186-190
    • (2007) Int J Food Microbiol , vol.120 , pp. 186-190
    • Kurincic, M.1    Botteldoorn, N.2    Herman, L.3
  • 167
    • 0842287245 scopus 로고    scopus 로고
    • Cross-resistance to antibiotics of Escherichia coli adapted to benzalkonium chloride or exposed to stress-inducers
    • Langsrud S, Sundheim G, Holck AL (2004) Cross-resistance to antibiotics of Escherichia coli adapted to benzalkonium chloride or exposed to stress-inducers. J Appl Microbiol 96:201-208
    • (2004) J Appl Microbiol , vol.96 , pp. 201-208
    • Langsrud, S.1    Sundheim, G.2    Holck, A.L.3
  • 168
    • 4444293722 scopus 로고    scopus 로고
    • The cme gene of Clostridium difficile confers multidrug resistance in Enterococcus faecalis
    • Lebel S, Bouttier S, Lambert T (2004) The cme gene of Clostridium difficile confers multidrug resistance in Enterococcus faecalis. FEMS Microbiol Lett 238:93-100
    • (2004) FEMS Microbiol Lett , vol.238 , pp. 93-100
    • Lebel, S.1    Bouttier, S.2    Lambert, T.3
  • 169
    • 47249085716 scopus 로고    scopus 로고
    • Plant phenolic compounds as ethidium bromide efflux inhibitors in Mycobacterium smegmatis
    • Lechner D, Gibbons S, Bucar F (2008) Plant phenolic compounds as ethidium bromide efflux inhibitors in Mycobacterium smegmatis. J Antimicrob Chemother 62:345-348
    • (2008) J Antimicrob Chemother , vol.62 , pp. 345-348
    • Lechner, D.1    Gibbons, S.2    Bucar, F.3
  • 170
    • 0036094201 scopus 로고    scopus 로고
    • Active efflux, a common mechanism for biocide and antibiotic resistance
    • Levy SB (2002) Active efflux, a common mechanism for biocide and antibiotic resistance. J Appl Microbiol 92(Suppl):65S-71S
    • (2002) J Appl Microbiol , vol.92 , pp. 65S-71S
    • Levy, S.B.1
  • 171
    • 33645981245 scopus 로고    scopus 로고
    • Inactivation of the putative tetracycline resistance gene HP1165 in Helicobacter pylori led to loss of inducible tetracycline resistance
    • Li Y, Dannelly HK (2006) Inactivation of the putative tetracycline resistance gene HP1165 in Helicobacter pylori led to loss of inducible tetracycline resistance. Arch Microbiol 185:255-262
    • (2006) Arch Microbiol , vol.185 , pp. 255-262
    • Li, Y.1    Dannelly, H.K.2
  • 172
    • 0036148599 scopus 로고    scopus 로고
    • SmeC, an outer membrane multidrug efflux protein of Stenotrophomonas maltophilia
    • Li X-Z, Zhang L, Poole K (2002) SmeC, an outer membrane multidrug efflux protein of Stenotrophomonas maltophilia. Antimicrob Agents Chemother 46:333-343
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 333-343
    • Li, X.-Z.1    Zhang, L.2    Poole, K.3
  • 173
    • 12244293832 scopus 로고    scopus 로고
    • Contributions of MexAB-OprM and an EmrE homologue to intrinsic resistance of Pseudomonas aeruginosa to aminoglycosides and dyes
    • Li X-Z, Poole K, Nikaido H (2003) Contributions of MexAB-OprM and an EmrE homologue to intrinsic resistance of Pseudomonas aeruginosa to aminoglycosides and dyes. Antimicrob Agents Chemother 47:27-33
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 27-33
    • Li, X.-Z.1    Poole, K.2    Nikaido, H.3
  • 174
    • 0141963102 scopus 로고    scopus 로고
    • A new member of the tripartite multidrug efflux pumps, MexVW-OprM, in Pseudomonas aeruginosa
    • Li Y, Mima T, Komori Y et al (2003) A new member of the tripartite multidrug efflux pumps, MexVW-OprM, in Pseudomonas aeruginosa. J Antimicrob Chemother 52:572-575
    • (2003) J Antimicrob Chemother , vol.52 , pp. 572-575
    • Li, Y.1    Mima, T.2    Komori, Y.3
  • 175
    • 5444276383 scopus 로고    scopus 로고
    • Multicopy suppressors for novel antibacterial compounds reveal targets and drug efflux susceptibility
    • Li X, Zolli-Juran M, Cechetto JD et al (2004) Multicopy suppressors for novel antibacterial compounds reveal targets and drug efflux susceptibility. Chem Biol 11:1423-1430
    • (2004) Chem Biol , vol.11 , pp. 1423-1430
    • Li, X.1    Zolli-Juran, M.2    Cechetto, J.D.3
  • 176
    • 3042585064 scopus 로고    scopus 로고
    • Efflux pump-mediated intrinsic drug resistance in Mycobacterium smegmatis
    • Li XZ, Zhang L, Nikaido H (2004) Efflux pump-mediated intrinsic drug resistance in Mycobacterium smegmatis. Antimicrob Agents Chemother 48:2415-2423
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 2415-2423
    • Li, X.Z.1    Zhang, L.2    Nikaido, H.3
  • 177
    • 41849149702 scopus 로고    scopus 로고
    • Properties and expression of a multidrug efflux pump AcrAB-KocC from Klebsiella pneumoniae
    • Li DW, Onishi M, Kishino T et al (2008) Properties and expression of a multidrug efflux pump AcrAB-KocC from Klebsiella pneumoniae. Biol Pharm Bull 31:577-582
    • (2008) Biol Pharm Bull , vol.31 , pp. 577-582
    • Li, D.W.1    Onishi, M.2    Kishino, T.3
  • 178
    • 39049189736 scopus 로고    scopus 로고
    • Effect of efflux pump inhibitors on bile resistance and in vivo colonization of Campylobacter jejuni
    • Lin J, Martinez A (2006) Effect of efflux pump inhibitors on bile resistance and in vivo colonization of Campylobacter jejuni. J Antimicrob Chemother 58:966-972
    • (2006) J Antimicrob Chemother , vol.58 , pp. 966-972
    • Lin, J.1    Martinez, A.2
  • 179
    • 0036635124 scopus 로고    scopus 로고
    • CmeABC functions as a multidrug efflux system in Campylobacter jejuni
    • Lin J, Michel LO, Zhang Q (2002) CmeABC functions as a multidrug efflux system in Campylobacter jejuni. Antimicrob Agents Chemother 46:2124-2131
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 2124-2131
    • Lin, J.1    Michel, L.O.2    Zhang, Q.3
  • 180
    • 0042265519 scopus 로고    scopus 로고
    • Critical role of multidrug efflux pump CmeABC in bile resistance and in vivo colonization of Campylobacter jejuni
    • Lin J, Sahin O, Michel LO et al (2003) Critical role of multidrug efflux pump CmeABC in bile resistance and in vivo colonization of Campylobacter jejuni. Infect Immun 71: 4250-4259
    • (2003) Infect Immun , vol.71 , pp. 4250-4259
    • Lin, J.1    Sahin, O.2    Michel, L.O.3
  • 181
    • 27144500167 scopus 로고    scopus 로고
    • Bile salts modulate expression of the CmeABC multidrug efflux pump in Campylobacter jejuni
    • Lin J, Cagliero C, Guo B et al (2005) Bile salts modulate expression of the CmeABC multidrug efflux pump in Campylobacter jejuni. J Bacteriol 187:7417-7424
    • (2005) J Bacteriol , vol.187 , pp. 7417-7424
    • Lin, J.1    Cagliero, C.2    Guo, B.3
  • 182
    • 34248345414 scopus 로고    scopus 로고
    • Effect of macrolide usage on emergence of erythromycinresistant Campylobacter isolates in chickens
    • Lin J, Yan M, Sahin O et al (2007) Effect of macrolide usage on emergence of erythromycinresistant Campylobacter isolates in chickens. Antimicrob Agents Chemother 51:1678-1686
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 1678-1686
    • Lin, J.1    Yan, M.2    Sahin, O.3
  • 183
    • 0027120761 scopus 로고
    • Substrate specificity and energetics of antiseptic and disinfectant resistance in Staphylococcus aureus
    • Littlejohn TG, Paulsen IT, Gillespie MT et al (1992) Substrate specificity and energetics of antiseptic and disinfectant resistance in Staphylococcus aureus. FEMS Microbiol Lett 74:259-265
    • (1992) FEMS Microbiol Lett , vol.74 , pp. 259-265
    • Littlejohn, T.G.1    Paulsen, I.T.2    Gillespie, M.T.3
  • 184
    • 48749120335 scopus 로고    scopus 로고
    • Co-prevalence of plasmid-mediated quinolone resistance determinants QepA, Qnr and AAC(6)-Ib-cr among 16 S rRNA methylase RmtBproducing Escherichia coli isolates from pigs
    • Liu JH, Deng YT, Zeng ZL et al (2008) Co-prevalence of plasmid-mediated quinolone resistance determinants QepA, Qnr and AAC(6)-Ib-cr among 16 S rRNA methylase RmtBproducing Escherichia coli isolates from pigs. Antimicrob Agents Chemother 52(8): 2992-2993
    • (2008) Antimicrob Agents Chemother , vol.52 , Issue.8 , pp. 2992-2993
    • Liu, J.H.1    Deng, Y.T.2    Zeng, Z.L.3
  • 185
    • 0035093095 scopus 로고    scopus 로고
    • Of Pseudomonas, porins, pumps and carbapenems
    • Livermore DM (2001) Of Pseudomonas, porins, pumps and carbapenems. J Antimicrob Chemother 47:247-250
    • (2001) J Antimicrob Chemother , vol.47 , pp. 247-250
    • Livermore, D.M.1
  • 186
    • 15844377845 scopus 로고    scopus 로고
    • Selectivity of ertapenem for Pseudomonas aeruginosa mutants cross-resistant to other carbapenems
    • Livermore DM, Mushtaq S, Warner M (2005) Selectivity of ertapenem for Pseudomonas aeruginosa mutants cross-resistant to other carbapenems. J Antimicrob Chemother 55:306-311
    • (2005) J Antimicrob Chemother , vol.55 , pp. 306-311
    • Livermore, D.M.1    Mushtaq, S.2    Warner, M.3
  • 187
    • 2142824217 scopus 로고    scopus 로고
    • Clinical strains of Pseudomonas aeruginosa overproducing MexAB-OprM and MexXY efflux pumps simultaneously
    • Llanes C, Hocquet D, Vogne C et al (2004) Clinical strains of Pseudomonas aeruginosa overproducing MexAB-OprM and MexXY efflux pumps simultaneously. Antimicrob Agents Chemother 48:1797-1802
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 1797-1802
    • Llanes, C.1    Hocquet, D.2    Vogne, C.3
  • 188
    • 34248359106 scopus 로고    scopus 로고
    • A periplasmic coiled-coil interface underlying TolC recruitment and the assembly of bacterial drug efflux pumps
    • Lobedanz S, Bokma E, Symmons MF et al (2007) A periplasmic coiled-coil interface underlying TolC recruitment and the assembly of bacterial drug efflux pumps. Proc Natl Acad Sci USA 104:4612-4617
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 4612-4617
    • Lobedanz, S.1    Bokma, E.2    Symmons, M.F.3
  • 189
    • 33644499476 scopus 로고    scopus 로고
    • Practical applications and feasibility of efflux pump inhibitors in the clinic-A vision for applied use
    • Lomovskaya O, Bostian KA (2006) Practical applications and feasibility of efflux pump inhibitors in the clinic-a vision for applied use. Biochem Pharmacol 71:910-918
    • (2006) Biochem Pharmacol , vol.71 , pp. 910-918
    • Lomovskaya, O.1    Bostian, K.A.2
  • 190
    • 0035079739 scopus 로고    scopus 로고
    • Inhibition of efflux pumps as a novel approach to combat drug resistance in bacteria
    • Lomovskaya O, Watkins W (2001) Inhibition of efflux pumps as a novel approach to combat drug resistance in bacteria. J Mol Microbiol Biotechnol 3:225-236
    • (2001) J Mol Microbiol Biotechnol , vol.3 , pp. 225-236
    • Lomovskaya, O.1    Watkins, W.2
  • 191
    • 0033031244 scopus 로고    scopus 로고
    • Use of a genetic approach to evaluate the consequences of inhibition of efflux pumps in Pseudomonas aeruginosa
    • Lomovskaya O, Lee A, Hoshino K et al (1999) Use of a genetic approach to evaluate the consequences of inhibition of efflux pumps in Pseudomonas aeruginosa. Antimicrob Agents Chemother 43:1340-1346
    • (1999) Antimicrob Agents Chemother , vol.43 , pp. 1340-1346
    • Lomovskaya, O.1    Lee, A.2    Hoshino, K.3
  • 192
    • 0035162640 scopus 로고    scopus 로고
    • Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: Novel agents for combination therapy
    • Lomovskaya O, Warren MS, Lee A et al (2001) Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: novel agents for combination therapy. Antimicrob Agents Chemother 45:105-116
    • (2001) Antimicrob Agents Chemother , vol.45 , pp. 105-116
    • Lomovskaya, O.1    Warren, M.S.2    Lee, A.3
  • 193
    • 50949102768 scopus 로고    scopus 로고
    • Functional cloning and characterization of the multidrug efflux pumps NorM from Neisseria gonorrhoeae and YdhE from Escherichia coli
    • Long F, Rouquette-Loughlin C, Shafer WM et al (2008) Functional cloning and characterization of the multidrug efflux pumps NorM from Neisseria gonorrhoeae and YdhE from Escherichia coli. Antimicrob Agents Chemother 52:3052-3060
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 3052-3060
    • Long, F.1    Rouquette-Loughlin, C.2    Shafer, W.M.3
  • 194
    • 34548724460 scopus 로고    scopus 로고
    • Distribution and physiology of ABC-type transporters contributing to multidrug resistance in bacteria
    • Lubelski J, Konings WN, Driessen AJ (2007) Distribution and physiology of ABC-type transporters contributing to multidrug resistance in bacteria. Microbiol Mol Biol Rev 71:463-476
    • (2007) Microbiol Mol Biol Rev , vol.71 , pp. 463-476
    • Lubelski, J.1    Konings, W.N.2    Driessen, A.J.3
  • 195
    • 0033845018 scopus 로고    scopus 로고
    • Identification of the conjugative mef gene in clinical Acinetobacter junii and Neisseria gonorrhoeae isolates
    • Luna VA, Cousin S Jr, Whittington WL et al (2000) Identification of the conjugative mef gene in clinical Acinetobacter junii and Neisseria gonorrhoeae isolates. Antimicrob Agents Chemother 44:2503-2506
    • (2000) Antimicrob Agents Chemother , vol.44 , pp. 2503-2506
    • Luna, V.A.1    Cousin, S.2    Whittington, W.L.3
  • 196
    • 34147202392 scopus 로고    scopus 로고
    • Molecular basis of resistance to macrolides and lincosamides among staphylococci and streptococci from various animal sources collected in the resistance monitoring program BfT-GermVet
    • Luthje P, Schwarz S (2007) Molecular basis of resistance to macrolides and lincosamides among staphylococci and streptococci from various animal sources collected in the resistance monitoring program BfT-GermVet. Int J Antimicrob Agents 29:528-535
    • (2007) Int J Antimicrob Agents , vol.29 , pp. 528-535
    • Luthje, P.1    Schwarz, S.2
  • 197
    • 33644552115 scopus 로고    scopus 로고
    • Efflux systems in bacterial pathogens: An opportunity for therapeutic intervention? An industry view
    • Lynch AS (2006) Efflux systems in bacterial pathogens: an opportunity for therapeutic intervention? An industry view. Biochem Pharmacol 71:949-956
    • (2006) Biochem Pharmacol , vol.71 , pp. 949-956
    • Lynch, A.S.1
  • 198
    • 0344011974 scopus 로고    scopus 로고
    • A genetic basis for Pseudomonas aeruginosa biofilm antibiotic resistance
    • Mah TF, Pitts B, Pellock B et al (2003) A genetic basis for Pseudomonas aeruginosa biofilm antibiotic resistance. Nature 426:306-310
    • (2003) Nature , vol.426 , pp. 306-310
    • Mah, T.F.1    Pitts, B.2    Pellock, B.3
  • 199
    • 33745737489 scopus 로고    scopus 로고
    • Quinoline derivatives as promising inhibitors of antibiotic efflux pump in multidrug resistant Enterobacter aerogenes isolates
    • Mahamoud A, Chevalier J, Davin-Regli A et al (2006) Quinoline derivatives as promising inhibitors of antibiotic efflux pump in multidrug resistant Enterobacter aerogenes isolates. Curr Drug Targets 7:843-847
    • (2006) Curr Drug Targets , vol.7 , pp. 843-847
    • Mahamoud, A.1    Chevalier, J.2    Davin-Regli, A.3
  • 200
    • 34447562686 scopus 로고    scopus 로고
    • Antibiotic efflux pumps in Gramnegative bacteria: The inhibitor response strategy
    • Mahamoud A, Chevalier J, Alibert-Franco S et al (2007) Antibiotic efflux pumps in Gramnegative bacteria: the inhibitor response strategy. J Antimicrob Chemother 59:1223-1229
    • (2007) J Antimicrob Chemother , vol.59 , pp. 1223-1229
    • Mahamoud, A.1    Chevalier, J.2    Alibert-Franco, S.3
  • 201
    • 0347986616 scopus 로고    scopus 로고
    • Alkylaminoquinolines inhibit the bacterial antibiotic efflux pump in multidrug-resistant clinical isolates
    • Mallea M, Mahamoud A, Chevalier J et al (2003) Alkylaminoquinolines inhibit the bacterial antibiotic efflux pump in multidrug-resistant clinical isolates. Biochem J 376:801-805
    • (2003) Biochem J , vol.376 , pp. 801-805
    • Mallea, M.1    Mahamoud, A.2    Chevalier, J.3
  • 202
    • 0041833328 scopus 로고    scopus 로고
    • A phenylalanine-arginine b -naphthylamide sensitive multidrug efflux pump involved in intrinsic and acquired resistance of Campylobacter to macrolides
    • Mamelli L, Amoros JP, Pages JM et al (2003) A phenylalanine-arginine b -naphthylamide sensitive multidrug efflux pump involved in intrinsic and acquired resistance of Campylobacter to macrolides. Int J Antimicrob Agents 22:237-241
    • (2003) Int J Antimicrob Agents , vol.22 , pp. 237-241
    • Mamelli, L.1    Amoros, J.P.2    Pages, J.M.3
  • 203
    • 33947499074 scopus 로고    scopus 로고
    • Prevalence of efflux activity in lowlevel macrolide-resistant Campylobacter species
    • Mamelli L, Demoulin E, Prouzet-Mauleon V et al (2007) Prevalence of efflux activity in lowlevel macrolide-resistant Campylobacter species. J Antimicrob Chemother 59:327-328
    • (2007) J Antimicrob Chemother , vol.59 , pp. 327-328
    • Mamelli, L.1    Demoulin, E.2    Prouzet-Mauleon, V.3
  • 204
    • 34447568290 scopus 로고    scopus 로고
    • A highly carbapenem-resistant Pseudomonas aeruginosa isolate with a novel bla VIM-4/bla P1b integron overexpresses two efflux pumps and lacks OprD
    • Maniati M, Ikonomidis A, Mantzana P et al (2007) A highly carbapenem-resistant Pseudomonas aeruginosa isolate with a novel bla VIM-4/bla P1b integron overexpresses two efflux pumps and lacks OprD. J Antimicrob Chemother 60:132-135
    • (2007) J Antimicrob Chemother , vol.60 , pp. 132-135
    • Maniati, M.1    Ikonomidis, A.2    Mantzana, P.3
  • 205
    • 4344572020 scopus 로고    scopus 로고
    • Expression of the RND-type efflux pump AdeABC in Acinetobacter baumannii is regulated by the AdeRS two-component system
    • Marchand I, Damier-Piolle L, Courvalin P et al (2004) Expression of the RND-type efflux pump AdeABC in Acinetobacter baumannii is regulated by the AdeRS two-component system. Antimicrob Agents Chemother 48:3298-3304
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 3298-3304
    • Marchand, I.1    Damier-Piolle, L.2    Courvalin, P.3
  • 206
    • 31944438999 scopus 로고    scopus 로고
    • Involvement of the putative ATP-dependent efflux proteins PatA and PatB in fluoroquinolone resistance of a multidrug-resistant mutant of Streptococcus pneumoniae
    • Marrer E, Schad K, Satoh AT et al (2006) Involvement of the putative ATP-dependent efflux proteins PatA and PatB in fluoroquinolone resistance of a multidrug-resistant mutant of Streptococcus pneumoniae. Antimicrob Agents Chemother 50:685-693
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 685-693
    • Marrer, E.1    Schad, K.2    Satoh, A.T.3
  • 207
    • 33846195801 scopus 로고    scopus 로고
    • Effect of an efflux pump inhibitor on the function of the multidrug efflux pump CmeABC and antimicrobial resistance in Campylobacter
    • Martinez A, Lin J (2006) Effect of an efflux pump inhibitor on the function of the multidrug efflux pump CmeABC and antimicrobial resistance in Campylobacter. Foodborne Pathog Dis 3:393-402
    • (2006) Foodborne Pathog Dis , vol.3 , pp. 393-402
    • Martinez, A.1    Lin, J.2
  • 208
    • 0344863188 scopus 로고    scopus 로고
    • Energy-dependent accumulation of fluoroquinolones in quinolone-resistant Klebsiella pneumoniae strains
    • Martínez-Martínez L, García I, Ballesta S et al (1998) Energy-dependent accumulation of fluoroquinolones in quinolone-resistant Klebsiella pneumoniae strains. Antimicrob Agents Chemother 42:1850-1852
    • (1998) Antimicrob Agents Chemother , vol.42 , pp. 1850-1852
    • Martínez-Martínez, L.1    García, I.2    Ballesta, S.3
  • 209
    • 33750578428 scopus 로고    scopus 로고
    • An instrument-free method for the demonstration of efflux pump activity of bacteria
    • Martins M, Santos B, Martins A et al (2006) An instrument-free method for the demonstration of efflux pump activity of bacteria. In Vivo 20:657-664
    • (2006) In Vivo , vol.20 , pp. 657-664
    • Martins, M.1    Santos, B.2    Martins, A.3
  • 210
    • 33749178428 scopus 로고    scopus 로고
    • Production of the cryptic EefABC efflux pump in Enterobacter aerogenes chloramphenicol-resistant mutants
    • Masi M, Pages JM, Pradel E (2006) Production of the cryptic EefABC efflux pump in Enterobacter aerogenes chloramphenicol-resistant mutants. J Antimicrob Chemother 57:1223-1226
    • (2006) J Antimicrob Chemother , vol.57 , pp. 1223-1226
    • Masi, M.1    Pages, J.M.2    Pradel, E.3
  • 211
    • 0033060792 scopus 로고    scopus 로고
    • Interplay between chromosomal b -lactamase and the MexAB-OprM efflux system in intrinsic resistance to b -lactams in Pseudomonas aeruginosa
    • Masuda N, Gotoh N, Ishii C et al (1999) Interplay between chromosomal b -lactamase and the MexAB-OprM efflux system in intrinsic resistance to b -lactams in Pseudomonas aeruginosa. Antimicrob Agents Chemother 43:400-402
    • (1999) Antimicrob Agents Chemother , vol.43 , pp. 400-402
    • Masuda, N.1    Gotoh, N.2    Ishii, C.3
  • 212
    • 0034426126 scopus 로고    scopus 로고
    • Substrate specificities of MexAB-OprM, MexCD-OprJ, and MexXY-OprM efflux pumps in Pseudomonas aeruginosa
    • Masuda N, Sakagawa E, Ohya S et al (2000) Substrate specificities of MexAB-OprM, MexCD-OprJ, and MexXY-OprM efflux pumps in Pseudomonas aeruginosa. Antimicrob Agents Chemother 44:3322-3327
    • (2000) Antimicrob Agents Chemother , vol.44 , pp. 3322-3327
    • Masuda, N.1    Sakagawa, E.2    Ohya, S.3
  • 213
    • 0033840162 scopus 로고    scopus 로고
    • Contribution of the MexX-MexY-OprM efflux system to intrinsic resistance in Pseudomonas aeruginosa
    • Masuda N, Sakagawa E, Ohya S et al (2000) Contribution of the MexX-MexY-OprM efflux system to intrinsic resistance in Pseudomonas aeruginosa. Antimicrob Agents Chemother 44:2242-2246
    • (2000) Antimicrob Agents Chemother , vol.44 , pp. 2242-2246
    • Masuda, N.1    Sakagawa, E.2    Ohya, S.3
  • 214
    • 37449013355 scopus 로고    scopus 로고
    • VmeAB, an RND-type multidrug efflux transporter in Vibrio parahaemolyticus
    • Matsuo T, Hayashi K, Morita Y et al (2007) VmeAB, an RND-type multidrug efflux transporter in Vibrio parahaemolyticus. Microbiology 153:4129-4137
    • (2007) Microbiology , vol.153 , pp. 4129-4137
    • Matsuo, T.1    Hayashi, K.2    Morita, Y.3
  • 215
    • 38749151369 scopus 로고    scopus 로고
    • SmdAB, a heterodimeric ABC-Type multidrug efflux pump, in Serratia marcescens
    • Matsuo T, Chen J, Minato Y et al (2008) SmdAB, a heterodimeric ABC-Type multidrug efflux pump, in Serratia marcescens. J Bacteriol 190:648-654
    • (2008) J Bacteriol , vol.190 , pp. 648-654
    • Matsuo, T.1    Chen, J.2    Minato, Y.3
  • 216
    • 0036895630 scopus 로고    scopus 로고
    • AcrAB efflux system: Expression and contribution to fluoroquinolone resistance in Klebsiella spp
    • Mazzariol A, Zuliani J, Cornaglia G et al (2002) AcrAB efflux system: expression and contribution to fluoroquinolone resistance in Klebsiella spp. Antimicrob Agents Chemother 46:3984-3986
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 3984-3986
    • Mazzariol, A.1    Zuliani, J.2    Cornaglia, G.3
  • 217
    • 18244403495 scopus 로고    scopus 로고
    • A novel MATE family efflux pump contributes to the reduced susceptibility of laboratory-derived Staphylococcus aureus mutants to tigecycline
    • McAleese F, Petersen P, Ruzin A et al (2005) A novel MATE family efflux pump contributes to the reduced susceptibility of laboratory-derived Staphylococcus aureus mutants to tigecycline. Antimicrob Agents Chemother 49:1865-1871
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 1865-1871
    • McAleese, F.1    Petersen, P.2    Ruzin, A.3
  • 218
    • 0036955396 scopus 로고    scopus 로고
    • Possible implications of biocide accumulation in the environment on the prevalence of bacterial antibiotic resistance
    • McBain AJ, Rickard AH, Gilbert P (2002) Possible implications of biocide accumulation in the environment on the prevalence of bacterial antibiotic resistance. J Ind Microbiol Biotechnol 29:326-330
    • (2002) J Ind Microbiol Biotechnol , vol.29 , pp. 326-330
    • McBain, A.J.1    Rickard, A.H.2    Gilbert, P.3
  • 219
    • 0032529948 scopus 로고    scopus 로고
    • Overexpression of marA, soxS, or acrAB produces resistance to triclosan in laboratory and clinical strains of Escherichia coli
    • McMurry LM, Oethinger M, Levy SB (1998) Overexpression of marA, soxS, or acrAB produces resistance to triclosan in laboratory and clinical strains of Escherichia coli. FEMS Microbiol Lett 166:305-309
    • (1998) FEMS Microbiol Lett , vol.166 , pp. 305-309
    • McMurry, L.M.1    Oethinger, M.2    Levy, S.B.3
  • 220
    • 34248197053 scopus 로고    scopus 로고
    • A combined phenotypic and genotypic method for the detection of Mex efflux pumps in Pseudomonas aeruginosa
    • Mesaros N, Glupczynski Y, Avrain L et al (2007) A combined phenotypic and genotypic method for the detection of Mex efflux pumps in Pseudomonas aeruginosa. J Antimicrob Chemother 59:378-386
    • (2007) J Antimicrob Chemother , vol.59 , pp. 378-386
    • Mesaros, N.1    Glupczynski, Y.2    Avrain, L.3
  • 221
    • 38749095520 scopus 로고    scopus 로고
    • Aerosolized colistin as adjunctive treatment of ventilator-associated pneumonia due to multidrug-resistant Gram-negative bacteria: A prospective study
    • Michalopoulos A, Fotakis D, Virtzili S et al (2008) Aerosolized colistin as adjunctive treatment of ventilator-associated pneumonia due to multidrug-resistant Gram-negative bacteria: a prospective study. Respir Med 102:407-412
    • (2008) Respir Med , vol.102 , pp. 407-412
    • Michalopoulos, A.1    Fotakis, D.2    Virtzili, S.3
  • 222
    • 48749117988 scopus 로고    scopus 로고
    • Discovery and characterization of QPT-1, the progenitor of a new class of bacterial topoisomerase inhibitors
    • Miller AA, Bundy GL, Mott JE et al (2008) Discovery and characterization of QPT-1, the progenitor of a new class of bacterial topoisomerase inhibitors. Antimicrob Agents Chemother 52:2806-2812
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 2806-2812
    • Miller, A.A.1    Bundy, G.L.2    Mott, J.E.3
  • 223
    • 28044451986 scopus 로고    scopus 로고
    • Gene cloning and properties of the RND-type multidrug efflux pumps MexPQ-OpmE and MexMN-OprM from Pseudomonas aeruginosa
    • Mima T, Sekiya H, Mizushima T et al (2005) Gene cloning and properties of the RND-type multidrug efflux pumps MexPQ-OpmE and MexMN-OprM from Pseudomonas aeruginosa. Microbiol Immunol 49:999-1002
    • (2005) Microbiol Immunol , vol.49 , pp. 999-1002
    • Mima, T.1    Sekiya, H.2    Mizushima, T.3
  • 224
    • 41149121534 scopus 로고    scopus 로고
    • Functional gene cloning and characterization of the SsmE multidrug efflux pump from Serratia marcescens
    • Minato Y, Shahcheraghi F, Ogawa W et al (2008) Functional gene cloning and characterization of the SsmE multidrug efflux pump from Serratia marcescens. Biol Pharm Bull 31: 516-519
    • (2008) Biol Pharm Bull , vol.31 , pp. 516-519
    • Minato, Y.1    Shahcheraghi, F.2    Ogawa, W.3
  • 225
    • 0030809884 scopus 로고    scopus 로고
    • Selection of multiple-antibiotic-resistant (mar) mutants of Escherichia coli by using the disinfectant pine oil: Roles of the mar and acrAB loci
    • Moken MC, McMurry LM, Levy SB (1997) Selection of multiple-antibiotic-resistant (mar) mutants of Escherichia coli by using the disinfectant pine oil: roles of the mar and acrAB loci. Antimicrob Agents Chemother 41:2770-2772
    • (1997) Antimicrob Agents Chemother , vol.41 , pp. 2770-2772
    • Moken, M.C.1    McMurry, L.M.2    Levy, S.B.3
  • 226
    • 59749085790 scopus 로고    scopus 로고
    • Mechanisms accounting for fluoroquinolone resistance in Escherichia coli clinical isolates
    • Morgan-Linnell SK, Becnel BL, Steffen D et al (2008) Mechanisms accounting for fluoroquinolone resistance in Escherichia coli clinical isolates. Antimicrob Agents Chemother 53(1):235-241
    • (2008) Antimicrob Agents Chemother , vol.53 , Issue.1 , pp. 235-241
    • Morgan-Linnell, S.K.1    Becnel, B.L.2    Steffen, D.3
  • 227
    • 0034459552 scopus 로고    scopus 로고
    • NorM of Vibrio parahaemolyticus is an Na + - Driven multidrug efflux pump
    • Morita Y, Kataoka A, Shiota S et al (2000) NorM of Vibrio parahaemolyticus is an Na + - driven multidrug efflux pump. J Bacteriol 182:6694-6697
    • (2000) J Bacteriol , vol.182 , pp. 6694-6697
    • Morita, Y.1    Kataoka, A.2    Shiota, S.3
  • 228
    • 0242432499 scopus 로고    scopus 로고
    • Induction of mexCD-oprJ operon for a multidrug efflux pump by disinfectants in wild-type Pseudomonas aeruginosa PAO1
    • Morita Y, Murata T, Mima T et al (2003) Induction of mexCD-oprJ operon for a multidrug efflux pump by disinfectants in wild-type Pseudomonas aeruginosa PAO1. J Antimicrob Chemother 5:991-994
    • (2003) J Antimicrob Chemother , vol.5 , pp. 991-994
    • Morita, Y.1    Murata, T.2    Mima, T.3
  • 229
    • 33644746633 scopus 로고    scopus 로고
    • Antibiotic inducibility of the MexXY multidrug efflux system of Pseudomonas aeruginosa: Involvement of the antibiotic-inducible PA5471 gene product
    • Morita Y, Sobel ML, Poole K (2006) Antibiotic inducibility of the MexXY multidrug efflux system of Pseudomonas aeruginosa: involvement of the antibiotic-inducible PA5471 gene product. J Bacteriol 188:1847-1855
    • (2006) J Bacteriol , vol.188 , pp. 1847-1855
    • Morita, Y.1    Sobel, M.L.2    Poole, K.3
  • 230
    • 49549088341 scopus 로고    scopus 로고
    • Multidrug efflux transporter, AcrB-The pumping mechanism
    • Murakami S (2008) Multidrug efflux transporter, AcrB-the pumping mechanism. Curr Opin Struct Biol 18:459-465
    • (2008) Curr Opin Struct Biol , vol.18 , pp. 459-465
    • Murakami, S.1
  • 231
    • 33748670458 scopus 로고    scopus 로고
    • Crystal structures of a multidrug transporter reveal a functionally rotating mechanism
    • Murakami S, Nakashima R, Yamashita E et al (2006) Crystal structures of a multidrug transporter reveal a functionally rotating mechanism. Nature 443:173-179
    • (2006) Nature , vol.443 , pp. 173-179
    • Murakami, S.1    Nakashima, R.2    Yamashita, E.3
  • 232
    • 3342905057 scopus 로고    scopus 로고
    • Doripenem versus Pseudomonas aeruginosa in vitro: Activity against characterized isolates, mutants, and transconjugants and resistance selection potential
    • Mushtaq S, Ge Y, Livermore DM (2004) Doripenem versus Pseudomonas aeruginosa in vitro: activity against characterized isolates, mutants, and transconjugants and resistance selection potential. Antimicrob Agents Chemother 48:3086-3092
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 3086-3092
    • Mushtaq, S.1    Ge, Y.2    Livermore, D.M.3
  • 233
    • 0242569169 scopus 로고    scopus 로고
    • MexAB-OprM-specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 1: Discovery and early strategies for lead optimization
    • Nakayama K, Ishida Y, Ohtsuka M et al (2003) MexAB-OprM-specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 1: discovery and early strategies for lead optimization. Bioorg Med Chem Lett 13:4201-4204
    • (2003) Bioorg Med Chem Lett , vol.13 , pp. 4201-4204
    • Nakayama, K.1    Ishida, Y.2    Ohtsuka, M.3
  • 234
    • 10744222660 scopus 로고    scopus 로고
    • MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 2: Achieving activity in vivo through the use of alternative scaffolds
    • Nakayama K, Ishida Y, Ohtsuka M et al (2003) MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 2: achieving activity in vivo through the use of alternative scaffolds. Bioorg Med Chem Lett 13:4205-4208
    • (2003) Bioorg Med Chem Lett , vol.13 , pp. 4205-4208
    • Nakayama, K.1    Ishida, Y.2    Ohtsuka, M.3
  • 235
    • 0347360262 scopus 로고    scopus 로고
    • MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 3: Optimization of potency in the pyridopyrimidine series through the application of a pharmacophore model
    • Nakayama K, Kawato H, Watanabe J et al (2004) MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 3: Optimization of potency in the pyridopyrimidine series through the application of a pharmacophore model. Bioorg Med Chem Lett 14:475-479
    • (2004) Bioorg Med Chem Lett , vol.14 , pp. 475-479
    • Nakayama, K.1    Kawato, H.2    Watanabe, J.3
  • 236
    • 11144355174 scopus 로고    scopus 로고
    • MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 4: Addressing the problem of poor stability due to photoisomerization of an acrylic acid moiety
    • Nakayama K, Kuru N, Ohtsuka M et al (2004) MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 4: addressing the problem of poor stability due to photoisomerization of an acrylic acid moiety. Bioorg Med Chem Lett 14:2493-2497
    • (2004) Bioorg Med Chem Lett , vol.14 , pp. 2493-2497
    • Nakayama, K.1    Kuru, N.2    Ohtsuka, M.3
  • 237
    • 25844457479 scopus 로고    scopus 로고
    • Interaction of the MexA and MexB components of the MexABOprM multidrug efflux system of Pseudomonas aeruginosa: Identification of MexA extragenic suppressors of a T578I mutation in MexB
    • Nehme D, Poole K (2005) Interaction of the MexA and MexB components of the MexABOprM multidrug efflux system of Pseudomonas aeruginosa: identification of MexA extragenic suppressors of a T578I mutation in MexB. Antimicrob Agents Chemother 49:4375-4378
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 4375-4378
    • Nehme, D.1    Poole, K.2
  • 238
    • 34548491825 scopus 로고    scopus 로고
    • Assembly of the MexAB-OprM multidrug pump of Pseudomonas aeruginosa: Component interactions defined by the study of pump mutant suppressors
    • Nehme D, Poole K (2007) Assembly of the MexAB-OprM multidrug pump of Pseudomonas aeruginosa: component interactions defined by the study of pump mutant suppressors. J Bacteriol 189:6118-6127
    • (2007) J Bacteriol , vol.189 , pp. 6118-6127
    • Nehme, D.1    Poole, K.2
  • 239
    • 2342664171 scopus 로고    scopus 로고
    • Assembly of the MexAB-OprM multidrug efflux system of Pseudomonas aeruginosa: Identification and characterization of mutations in mexA compromising MexA multimerization and interaction with MexB
    • Nehme D, Li XZ, Elliot R et al (2004) Assembly of the MexAB-OprM multidrug efflux system of Pseudomonas aeruginosa: identification and characterization of mutations in mexA compromising MexA multimerization and interaction with MexB. J Bacteriol 186: 2973-2983
    • (2004) J Bacteriol , vol.186 , pp. 2973-2983
    • Nehme, D.1    Li, X.Z.2    Elliot, R.3
  • 240
    • 53049101909 scopus 로고    scopus 로고
    • AcrAB multidrug efflux pump regulation in Salmonella enterica serovar Typhimurium by RamA in response to environmental signals
    • Nikaido E, Yamaguchi A, Nishino K (2008) AcrAB multidrug efflux pump regulation in Salmonella enterica serovar Typhimurium by RamA in response to environmental signals. J Biol Chem 283:24245-24253
    • (2008) J Biol Chem , vol.283 , pp. 24245-24253
    • Nikaido, E.1    Yamaguchi, A.2    Nishino, K.3
  • 241
    • 0034817367 scopus 로고    scopus 로고
    • Analysis of a complete library of putative drug transporter genes in Escherichia coli
    • Nishino K, Yamaguchi A (2001) Analysis of a complete library of putative drug transporter genes in Escherichia coli. J Bacteriol 183:5803-5812
    • (2001) J Bacteriol , vol.183 , pp. 5803-5812
    • Nishino, K.1    Yamaguchi, A.2
  • 242
    • 33645062695 scopus 로고    scopus 로고
    • Virulence and drug resistance roles of multidrug efflux systems of Salmonella enterica serovar Typhimurium
    • Nishino K, LatifiT, Groisman EA (2006) Virulence and drug resistance roles of multidrug efflux systems of Salmonella enterica serovar Typhimurium. Mol Microbiol 59:126-141
    • (2006) Mol Microbiol , vol.59 , pp. 126-141
    • Nishino, K.1    Latifi, T.2    Groisman, E.A.3
  • 243
    • 44649178249 scopus 로고    scopus 로고
    • Nucleotide sequence of pOLA52: A conjugative IncX1 plasmid from Escherichia coli which enables biofilm formation and multidrug efflux
    • Norman A, Hansen LH, She Q et al (2008) Nucleotide sequence of pOLA52: a conjugative IncX1 plasmid from Escherichia coli which enables biofilm formation and multidrug efflux. Plasmid 60:59-74
    • (2008) Plasmid , vol.60 , pp. 59-74
    • Norman, A.1    Hansen, L.H.2    She, Q.3
  • 244
    • 0032959773 scopus 로고    scopus 로고
    • Negative regulation of the Pseudomonas aeruginosa outer membrane porin OprD selective for imipenem and basic amino acids
    • Ochs MM, McCusker MP, Bains M et al (1999) Negative regulation of the Pseudomonas aeruginosa outer membrane porin OprD selective for imipenem and basic amino acids. Antimicrob Agents Chemother 43:1085-1090
    • (1999) Antimicrob Agents Chemother , vol.43 , pp. 1085-1090
    • Ochs, M.M.1    McCusker, M.P.2    Bains, M.3
  • 245
    • 0033989647 scopus 로고    scopus 로고
    • Ineffectiveness of topoisomerase mutations in mediating clinically significant fluoroquinolone resistance in Escherichia coli in the absence of the AcrAB efflux pump
    • Oethinger M, Kern WV, Jellen-Ritter AS et al (2000) Ineffectiveness of topoisomerase mutations in mediating clinically significant fluoroquinolone resistance in Escherichia coli in the absence of the AcrAB efflux pump. Antimicrob Agents Chemother 44:10-13
    • (2000) Antimicrob Agents Chemother , vol.44 , pp. 10-13
    • Oethinger, M.1    Kern, W.V.2    Jellen-Ritter, A.S.3
  • 246
    • 4344706235 scopus 로고    scopus 로고
    • The mef(A) gene predominates among seven macrolide resistance genes identified in gram-negative strains representing 13 genera, isolated from healthy Portuguese children
    • Ojo KK, Ulep C, Van Kirk N et al (2004) The mef(A) gene predominates among seven macrolide resistance genes identified in gram-negative strains representing 13 genera, isolated from healthy Portuguese children. Antimicrob Agents Chemother 48:3451-3456
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 3451-3456
    • Ojo, K.K.1    Ulep, C.2    Van Kirk, N.3
  • 247
    • 33644655365 scopus 로고    scopus 로고
    • Staphylococcus efflux msr(A) gene characterized in Streptococcus, Enterococcus, Corynebacterium, and Pseudomonas isolates
    • Ojo KK, Striplin MJ, Ulep CC et al (2006) Staphylococcus efflux msr(A) gene characterized in Streptococcus, Enterococcus, Corynebacterium, and Pseudomonas isolates. Antimicrob Agents Chemother 50:1089-1091
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 1089-1091
    • Ojo, K.K.1    Striplin, M.J.2    Ulep, C.C.3
  • 248
    • 4444292914 scopus 로고    scopus 로고
    • Role of an acrR mutation in multidrug resistance of in vitro-selected fluoroquinolone-resistant mutants of Salmonella enterica serovar Typhimurium
    • Olliver A, Valle M, Chaslus-Dancla E et al (2004) Role of an acrR mutation in multidrug resistance of in vitro-selected fluoroquinolone-resistant mutants of Salmonella enterica serovar Typhimurium. FEMS Microbiol Lett 238:267-272
    • (2004) FEMS Microbiol Lett , vol.238 , pp. 267-272
    • Olliver, A.1    Valle, M.2    Chaslus-Dancla, E.3
  • 249
    • 23144431968 scopus 로고    scopus 로고
    • Inhibitors of efflux pumps in Gram-negative bacteria
    • Pages JM, Masi M, Barbe J (2005) Inhibitors of efflux pumps in Gram-negative bacteria. Trends Mol Med 11:382-389
    • (2005) Trends Mol Med , vol.11 , pp. 382-389
    • Pages, J.M.1    Masi, M.2    Barbe, J.3
  • 250
    • 40549126258 scopus 로고    scopus 로고
    • Tolerance to the antimicrobial peptide colistin in Pseudomonas aeruginosa biofilms is linked to metabolically active cells, and depends on the pmr and mexAB-oprM genes
    • Pamp SJ, Gjermansen M, Johansen HK et al (2008) Tolerance to the antimicrobial peptide colistin in Pseudomonas aeruginosa biofilms is linked to metabolically active cells, and depends on the pmr and mexAB-oprM genes. Mol Microbiol 68:223-240
    • (2008) Mol Microbiol , vol.68 , pp. 223-240
    • Pamp, S.J.1    Gjermansen, M.2    Johansen, H.K.3
  • 251
    • 0028336672 scopus 로고
    • Tetracycline resistance determinants in Mycobacterium and Streptomyces species
    • Pang Y, Brown BA, Steingrube VA et al (1994) Tetracycline resistance determinants in Mycobacterium and Streptomyces species. Antimicrob Agents Chemother 38:1408-1412
    • (1994) Antimicrob Agents Chemother , vol.38 , pp. 1408-1412
    • Pang, Y.1    Brown, B.A.2    Steingrube, V.A.3
  • 253
    • 28644441427 scopus 로고    scopus 로고
    • Activity of five quinolones, three macrolides and telithromycin against 12 Haemophilus influenzae strains with different resistance phenotypes
    • Pankuch GA, Lin G, Appelbaum PC (2005) Activity of five quinolones, three macrolides and telithromycin against 12 Haemophilus influenzae strains with different resistance phenotypes. Clin Microbiol Infect 11:1040-1044
    • (2005) Clin Microbiol Infect , vol.11 , pp. 1040-1044
    • Pankuch, G.A.1    Lin, G.2    Appelbaum, P.C.3
  • 254
    • 33645828405 scopus 로고    scopus 로고
    • Multidrug efflux inhibition in Acinetobacter baumannii: Comparison between 1-(1-naphthylmethyl)-piperazine and phenyl-arginine- b - Naphthylamide
    • Pannek S, Higgins PG, Steinke P et al (2006) Multidrug efflux inhibition in Acinetobacter baumannii: comparison between 1-(1-naphthylmethyl)-piperazine and phenyl-arginine- b - naphthylamide. J Antimicrob Chemother 57:970-974
    • (2006) J Antimicrob Chemother , vol.57 , pp. 970-974
    • Pannek, S.1    Higgins, P.G.2    Steinke, P.3
  • 255
    • 27644475760 scopus 로고    scopus 로고
    • MmpL7 gene of Mycobacterium tuberculosis is responsible for isoniazid efflux in Mycobacterium smegmatis
    • Pasca MR, Guglierame P, De Rossi E et al (2005) mmpL7 gene of Mycobacterium tuberculosis is responsible for isoniazid efflux in Mycobacterium smegmatis. Antimicrob Agents Chemother 49:4775-4777
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 4775-4777
    • Pasca, M.R.1    Guglierame, P.2    De Rossi, E.3
  • 257
    • 2342652248 scopus 로고    scopus 로고
    • Relative contribution of target gene mutation and efflux to fluoroquinolone and erythromycin resistance, in French poultry and pig isolates of Campylobacter coli
    • Payot S, Avrain L, Magras C et al (2004) Relative contribution of target gene mutation and efflux to fluoroquinolone and erythromycin resistance, in French poultry and pig isolates of Campylobacter coli. Int J Antimicrob Agents 23:468-472
    • (2004) Int J Antimicrob Agents , vol.23 , pp. 468-472
    • Payot, S.1    Avrain, L.2    Magras, C.3
  • 258
    • 33746631314 scopus 로고    scopus 로고
    • Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp
    • Payot S, Bolla JM, Corcoran D et al (2006) Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp. Microbes Infect 8:1967-1971
    • (2006) Microbes Infect , vol.8 , pp. 1967-1971
    • Payot, S.1    Bolla, J.M.2    Corcoran, D.3
  • 259
    • 48949092646 scopus 로고    scopus 로고
    • Molecular characterization of multidrugresistant Shigella species isolated from epidemic and endemic cases of shigellosis in India
    • Pazhani GP, Niyogi SK, Singh AK et al (2008) Molecular characterization of multidrugresistant Shigella species isolated from epidemic and endemic cases of shigellosis in India. J Med Microbiol 57:856-863
    • (2008) J Med Microbiol , vol.57 , pp. 856-863
    • Pazhani, G.P.1    Niyogi, S.K.2    Singh, A.K.3
  • 260
    • 33845892102 scopus 로고    scopus 로고
    • Acinetobacter baumannii bloodstream infection while receiving tigecycline: A cautionary report
    • Peleg AY, Potoski BA, Rea R et al (2006) Acinetobacter baumannii bloodstream infection while receiving tigecycline: a cautionary report. J Antimicrob Chemother 59:128-131
    • (2006) J Antimicrob Chemother , vol.59 , pp. 128-131
    • Peleg, A.Y.1    Potoski, B.A.2    Rea, R.3
  • 261
    • 34250171728 scopus 로고    scopus 로고
    • Tigecycline efflux as a mechanism for nonsusceptibility in Acinetobacter baumannii
    • Peleg AY, Adams J, Paterson DL (2007) Tigecycline efflux as a mechanism for nonsusceptibility in Acinetobacter baumannii. Antimicrob Agents Chemother 51:2065-2069
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 2065-2069
    • Peleg, A.Y.1    Adams, J.2    Paterson, D.L.3
  • 262
    • 35948945306 scopus 로고    scopus 로고
    • Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate
    • Perez A, Canle D, Latasa C et al (2007) Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. Antimicrob Agents Chemother 51:3247-3253
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 3247-3253
    • Perez, A.1    Canle, D.2    Latasa, C.3
  • 263
    • 0037417016 scopus 로고    scopus 로고
    • Effects of an efflux mechanism and ribosomal mutations on macrolide susceptibility of Haemophilus influenzae clinical isolates
    • Peric M, Bozdogan B, Jacobs MR et al (2003) Effects of an efflux mechanism and ribosomal mutations on macrolide susceptibility of Haemophilus influenzae clinical isolates. Antimicrob Agents Chemother 47:1017-1022
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 1017-1022
    • Peric, M.1    Bozdogan, B.2    Jacobs, M.R.3
  • 264
    • 4444270519 scopus 로고    scopus 로고
    • Inability of L22 ribosomal protein alteration to increase macrolide MICs in the absence of efflux mechanism in Haemophilus influenzae HMC-S
    • Peric M, Bozdogan B, Galderisi C et al (2004) Inability of L22 ribosomal protein alteration to increase macrolide MICs in the absence of efflux mechanism in Haemophilus influenzae HMC-S. J Antimicrob Chemother 54:393-400
    • (2004) J Antimicrob Chemother , vol.54 , pp. 393-400
    • Peric, M.1    Bozdogan, B.2    Galderisi, C.3
  • 265
    • 34447264727 scopus 로고    scopus 로고
    • Transferable resistance to aminoglycosides by methylation of G1405 in 16 S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli
    • Perichon B, Courvalin P, Galimand M (2007) Transferable resistance to aminoglycosides by methylation of G1405 in 16 S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli. Antimicrob Agents Chemother 51:2464-2469
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 2464-2469
    • Perichon, B.1    Courvalin, P.2    Galimand, M.3
  • 266
    • 33747154459 scopus 로고    scopus 로고
    • Multidrug-resistance efflux pumps - Not just for resistance
    • Piddock LJ (2006) Multidrug-resistance efflux pumps - not just for resistance. Nat Rev Microbiol 4:629-636
    • (2006) Nat Rev Microbiol , vol.4 , pp. 629-636
    • Piddock, L.J.1
  • 267
    • 0026777171 scopus 로고
    • A pleiotropic, posttherapy, enoxacin-resistant mutant of Pseudomonas aeruginosa
    • Piddock LJV, Hall MC, Bellido F et al (1992) A pleiotropic, posttherapy, enoxacin-resistant mutant of Pseudomonas aeruginosa. Antimicrob Agents Chemother 36:1057-1061
    • (1992) Antimicrob Agents Chemother , vol.36 , pp. 1057-1061
    • Piddock, L.J.V.1    Hall, M.C.2    Bellido, F.3
  • 268
    • 35348985921 scopus 로고    scopus 로고
    • Gene cloning and characterization of KdeA, a multidrug efflux pump from Klebsiella pneumoniae
    • Ping Y, Ogawa W, Kuroda T et al (2007) Gene cloning and characterization of KdeA, a multidrug efflux pump from Klebsiella pneumoniae. Biol Pharm Bull 30:1962-1964
    • (2007) Biol Pharm Bull , vol.30 , pp. 1962-1964
    • Ping, Y.1    Ogawa, W.2    Kuroda, T.3
  • 269
    • 0037055994 scopus 로고    scopus 로고
    • Multidrug transporters and antibiotic resistance in Lactococcus lactis
    • Poelarends G, Mazurkiewicz P, Konings W (2002) Multidrug transporters and antibiotic resistance in Lactococcus lactis. Biochim Biophys Acta 1555:1
    • (2002) Biochim Biophys Acta , vol.1555 , pp. 1
    • Poelarends, G.1    Mazurkiewicz, P.2    Konings, W.3
  • 270
    • 0035087832 scopus 로고    scopus 로고
    • Multidrug efflux pumps and antimicrobial resistance in Pseudomonas aeruginosa and related organisms
    • Poole K (2001) Multidrug efflux pumps and antimicrobial resistance in Pseudomonas aeruginosa and related organisms. J Mol Microbiol Biotechnol 3:255-264
    • (2001) J Mol Microbiol Biotechnol , vol.3 , pp. 255-264
    • Poole, K.1
  • 271
    • 18244381325 scopus 로고    scopus 로고
    • Efflux pumps
    • In: Ramos J-L (ed), Genomics, life style and molecular architecture. Kluwer Academic/Plenum, New York
    • Poole K (2004) Efflux pumps. In: Ramos J-L (ed) Pseudomonas, vol I, Genomics, life style and molecular architecture. Kluwer Academic/Plenum, New York, pp 635-674
    • (2004) Pseudomonas , vol.1 , pp. 635-674
    • Poole, K.1
  • 272
    • 1642422948 scopus 로고    scopus 로고
    • Efflux-mediated multiresistance in Gram-negative bacteria
    • Poole K (2004) Efflux-mediated multiresistance in Gram-negative bacteria. Clin Microbiol Infect 10:12-26
    • (2004) Clin Microbiol Infect , vol.10 , pp. 12-26
    • Poole, K.1
  • 273
    • 4644301876 scopus 로고    scopus 로고
    • Resistance to b -lactam antibiotics
    • Poole K (2004) Resistance to b -lactam antibiotics. Cell Mol Life Sci 61:2200-2223
    • (2004) Cell Mol Life Sci , vol.61 , pp. 2200-2223
    • Poole, K.1
  • 274
    • 11144321435 scopus 로고    scopus 로고
    • Uninhibited antibiotic target discovery via chemical genetics
    • Poole K (2004) Uninhibited antibiotic target discovery via chemical genetics. Nat Biotechnol 22:1528-1529
    • (2004) Nat Biotechnol , vol.22 , pp. 1528-1529
    • Poole, K.1
  • 275
    • 12944262276 scopus 로고    scopus 로고
    • Aminoglycoside resistance in Pseudomonas aeruginosa
    • Poole K (2005) Aminoglycoside resistance in Pseudomonas aeruginosa. Antimicrob Agents Chemother 49:479-487
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 479-487
    • Poole, K.1
  • 276
    • 24044514016 scopus 로고    scopus 로고
    • Efflux-mediated antimicrobial resistance
    • Poole K (2005) Efflux-mediated antimicrobial resistance. J Antimicrob Chemother 56:20-51
    • (2005) J Antimicrob Chemother , vol.56 , pp. 20-51
    • Poole, K.1
  • 277
    • 34247568394 scopus 로고    scopus 로고
    • Efflux pumps as antimicrobial resistance mechanisms
    • Poole K (2007) Efflux pumps as antimicrobial resistance mechanisms. Ann Med 39:162-176
    • (2007) Ann Med , vol.39 , pp. 162-176
    • Poole, K.1
  • 278
    • 42249097293 scopus 로고    scopus 로고
    • Bacteria multidrug efflux pumps serve other functions
    • Poole K (2008) Bacteria multidrug efflux pumps serve other functions. Microbe 3:179-185
    • (2008) Microbe , vol.3 , pp. 179-185
    • Poole, K.1
  • 280
    • 0035353081 scopus 로고    scopus 로고
    • Multidrug efflux in Pseudomonas aeruginosa: Components, mechanisms and clinical significance
    • Poole K, Srikumar R (2001) Multidrug efflux in Pseudomonas aeruginosa: components, mechanisms and clinical significance. Curr Top Med Chem 1:59-71
    • (2001) Curr Top Med Chem , vol.1 , pp. 59-71
    • Poole, K.1    Srikumar, R.2
  • 281
    • 27144451383 scopus 로고    scopus 로고
    • Spread of efflux pump-overexpressing, nonmetallo- b -lactamase-producing, meropenem-resistant but ceftazidime-susceptible Pseudomonas aeruginosa in a region with bla VIM endemicity
    • Pournaras S, Maniati M, Spanakis N et al (2005) Spread of efflux pump-overexpressing, nonmetallo- b -lactamase-producing, meropenem-resistant but ceftazidime-susceptible Pseudomonas aeruginosa in a region with bla VIM endemicity. J Antimicrob Chemother 56:761-764
    • (2005) J Antimicrob Chemother , vol.56 , pp. 761-764
    • Pournaras, S.1    Maniati, M.2    Spanakis, N.3
  • 282
    • 0035991982 scopus 로고    scopus 로고
    • The AcrAB-TolC efflux pump contributes to multidrug resistance in the nosocomial pathogen Enterobacter aerogenes
    • Pradel E, Pages JM (2002) The AcrAB-TolC efflux pump contributes to multidrug resistance in the nosocomial pathogen Enterobacter aerogenes. Antimicrob Agents Chemother 46:2640-2643
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 2640-2643
    • Pradel, E.1    Pages, J.M.2
  • 283
    • 1942537625 scopus 로고    scopus 로고
    • Bile-salt-mediated induction of antimicrobial and bile resistance in Salmonella typhimurium
    • Prouty AM, Brodsky IE, Falkow S et al (2004) Bile-salt-mediated induction of antimicrobial and bile resistance in Salmonella typhimurium. Microbiology 150:775-783
    • (2004) Microbiology , vol.150 , pp. 775-783
    • Prouty, A.M.1    Brodsky, I.E.2    Falkow, S.3
  • 284
    • 4444336144 scopus 로고    scopus 로고
    • Expression of the efflux pump genes cmeB, cmeF and the porin gene porA in multiple-antibiotic-resistant Campylobacter jejuni
    • Pumbwe L, Randall LP, Woodward MJ et al (2004) Expression of the efflux pump genes cmeB, cmeF and the porin gene porA in multiple-antibiotic-resistant Campylobacter jejuni. J Antimicrob Chemother 54:341-347
    • (2004) J Antimicrob Chemother , vol.54 , pp. 341-347
    • Pumbwe, L.1    Randall, L.P.2    Woodward, M.J.3
  • 285
    • 33747878184 scopus 로고    scopus 로고
    • Clinical significance of overexpression of multiple RND-family efflux pumps in Bacteroides fragilis isolates
    • Pumbwe L, Chang A, Smith RL et al (2006) Clinical significance of overexpression of multiple RND-family efflux pumps in Bacteroides fragilis isolates. J Antimicrob Chemother 58:543-548
    • (2006) J Antimicrob Chemother , vol.58 , pp. 543-548
    • Pumbwe, L.1    Chang, A.2    Smith, R.L.3
  • 286
    • 33747876462 scopus 로고    scopus 로고
    • Bacteroides fragilis BmeABC efflux systems additively confer intrinsic antimicrobial resistance
    • Pumbwe L, Ueda O, Yoshimura F et al (2006) Bacteroides fragilis BmeABC efflux systems additively confer intrinsic antimicrobial resistance. J Antimicrob Chemother 58:37-46
    • (2006) J Antimicrob Chemother , vol.58 , pp. 37-46
    • Pumbwe, L.1    Ueda, O.2    Yoshimura, F.3
  • 287
    • 34250865692 scopus 로고    scopus 로고
    • Bile salts enhance bacterial co-aggregation, bacterial-intestinal epithelial cell adhesion, biofilm formation and antimicrobial resistance of Bacteroides fragilis
    • Pumbwe L, Skilbeck CA, Nakano V et al (2007) Bile salts enhance bacterial co-aggregation, bacterial-intestinal epithelial cell adhesion, biofilm formation and antimicrobial resistance of Bacteroides fragilis. Microb Pathog 43:78-87
    • (2007) Microb Pathog , vol.43 , pp. 78-87
    • Pumbwe, L.1    Skilbeck, C.A.2    Nakano, V.3
  • 288
    • 36448942927 scopus 로고    scopus 로고
    • Induction of multiple antibiotic resistance in Bacteroides fragilis by benzene and benzene-derived active compounds of commonly used analgesics, antiseptics and cleaning agents
    • Pumbwe L, Skilbeck CA, Wexler HM (2007) Induction of multiple antibiotic resistance in Bacteroides fragilis by benzene and benzene-derived active compounds of commonly used analgesics, antiseptics and cleaning agents. J Antimicrob Chemother 60:1288-1297
    • (2007) J Antimicrob Chemother , vol.60 , pp. 1288-1297
    • Pumbwe, L.1    Skilbeck, C.A.2    Wexler, H.M.3
  • 289
    • 34547561708 scopus 로고    scopus 로고
    • BmeRABC5 is a multidrug efflux system that can confer metronidazole resistance in Bacteroides fragilis
    • Pumbwe L, Chang A, Smith RL et al (2007) BmeRABC5 is a multidrug efflux system that can confer metronidazole resistance in Bacteroides fragilis. Microb Drug Resist 13:96-101
    • (2007) Microb Drug Resist , vol.13 , pp. 96-101
    • Pumbwe, L.1    Chang, A.2    Smith, R.L.3
  • 291
    • 33646453620 scopus 로고    scopus 로고
    • Interplay of efflux system, ampC, and oprD expression in carbapenem resistance of Pseudomonas aeruginosa clinical isolates
    • Quale J, Bratu S, Gupta J et al (2006) Interplay of efflux system, ampC, and oprD expression in carbapenem resistance of Pseudomonas aeruginosa clinical isolates. Antimicrob Agents Chemother 50:1633-1641
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 1633-1641
    • Quale, J.1    Bratu, S.2    Gupta, J.3
  • 292
    • 52449114776 scopus 로고    scopus 로고
    • Detection and characterization of an ABC transporter in Clostridium hathewayi
    • Rafii F, Park M (2008) Detection and characterization of an ABC transporter in Clostridium hathewayi. Arch Microbiol 190:417-426
    • (2008) Arch Microbiol , vol.190 , pp. 417-426
    • Rafii, F.1    Park, M.2
  • 293
    • 36349032975 scopus 로고    scopus 로고
    • Molecular cloning and characterization of all RND-type efflux transporters in Vibrio cholerae non-O1
    • Rahman MM, Matsuo T, Ogawa W et al (2007) Molecular cloning and characterization of all RND-type efflux transporters in Vibrio cholerae non-O1. Microbiol Immunol 51:1061-1070
    • (2007) Microbiol Immunol , vol.51 , pp. 1061-1070
    • Rahman, M.M.1    Matsuo, T.2    Ogawa, W.3
  • 294
    • 34248189172 scopus 로고    scopus 로고
    • Contribution of the Rv2333c efflux pump (the Stp protein) from Mycobacterium tuberculosis to intrinsic antibiotic resistance in Mycobacterium bovis BCG
    • Ramon-Garcia S, Martin C, De Rossi E et al (2007) Contribution of the Rv2333c efflux pump (the Stp protein) from Mycobacterium tuberculosis to intrinsic antibiotic resistance in Mycobacterium bovis BCG. J Antimicrob Chemother 59:544-547
    • (2007) J Antimicrob Chemother , vol.59 , pp. 544-547
    • Ramon-Garcia, S.1    Martin, C.2    De Rossi, E.3
  • 295
    • 0034802153 scopus 로고    scopus 로고
    • Association between cyclohexane resistance in Salmonella of different serovars and increased resistance to multiple antibiotics, disinfectants and dyes
    • Randall LP, Cooles SW, Sayers AR et al (2001) Association between cyclohexane resistance in Salmonella of different serovars and increased resistance to multiple antibiotics, disinfectants and dyes. J Med Microbiol 50:919-924
    • (2001) J Med Microbiol , vol.50 , pp. 919-924
    • Randall, L.P.1    Cooles, S.W.2    Sayers, A.R.3
  • 296
    • 0141741157 scopus 로고    scopus 로고
    • Prevalence of multiple antibiotic resistance in 443 Campylobacter spp. isolated from humans and animals
    • Randall LP, Ridley AM, Cooles SW et al (2003) Prevalence of multiple antibiotic resistance in 443 Campylobacter spp. isolated from humans and animals. J Antimicrob Chemother 52:507-510
    • (2003) J Antimicrob Chemother , vol.52 , pp. 507-510
    • Randall, L.P.1    Ridley, A.M.2    Cooles, S.W.3
  • 297
    • 4644258833 scopus 로고    scopus 로고
    • Effect of triclosan or a phenolic farm disinfectant on the selection of antibiotic-resistant Salmonella enterica
    • Randall LP, Cooles SW, Piddock LJ et al (2004) Effect of triclosan or a phenolic farm disinfectant on the selection of antibiotic-resistant Salmonella enterica. J Antimicrob Chemother 54:621-627
    • (2004) J Antimicrob Chemother , vol.54 , pp. 621-627
    • Randall, L.P.1    Cooles, S.W.2    Piddock, L.J.3
  • 298
    • 36448995401 scopus 로고    scopus 로고
    • Commonly used farm disinfectants can select for mutant Salmonella enterica serovar Typhimurium with decreased susceptibility to biocides and antibiotics without compromising virulence
    • Randall LP, Cooles SW, Coldham NG et al (2007) Commonly used farm disinfectants can select for mutant Salmonella enterica serovar Typhimurium with decreased susceptibility to biocides and antibiotics without compromising virulence. J Antimicrob Chemother 60: 1273-1280
    • (2007) J Antimicrob Chemother , vol.60 , pp. 1273-1280
    • Randall, L.P.1    Cooles, S.W.2    Coldham, N.G.3
  • 299
    • 36248971286 scopus 로고    scopus 로고
    • In vitro activities of 'new' and 'conventional' antibiotics against multi-drug resistant Gram negative bacteria from patients in the intensive care unit
    • Ratnam I, Franklin C, Spelman DW (2007) In vitro activities of 'new' and 'conventional' antibiotics against multi-drug resistant Gram negative bacteria from patients in the intensive care unit. Pathology 39:586-588
    • (2007) Pathology , vol.39 , pp. 586-588
    • Ratnam, I.1    Franklin, C.2    Spelman, D.W.3
  • 300
    • 12444345510 scopus 로고    scopus 로고
    • Conformationally-restricted analogues of efflux pump inhibitors that potentiate the activity of levofloxacin in Pseudomonas aeruginosa
    • Renau TE, Leger R, Filonova L et al (2003) Conformationally-restricted analogues of efflux pump inhibitors that potentiate the activity of levofloxacin in Pseudomonas aeruginosa. Bioorg Med Chem Lett 13:2755-2758
    • (2003) Bioorg Med Chem Lett , vol.13 , pp. 2755-2758
    • Renau, T.E.1    Leger, R.2    Filonova, L.3
  • 301
    • 34250851528 scopus 로고    scopus 로고
    • Characterization of macrolide resistance in Grampositive cocci from Colombian hospitals: A countrywide surveillance
    • Reyes J, Hidalgo M, Diaz L et al (2007) Characterization of macrolide resistance in Grampositive cocci from Colombian hospitals: a countrywide surveillance. Int J Infect Dis 11: 329-336
    • (2007) Int J Infect Dis , vol.11 , pp. 329-336
    • Reyes, J.1    Hidalgo, M.2    Diaz, L.3
  • 302
    • 29944433409 scopus 로고    scopus 로고
    • Ciprofloxacin-resistant Salmonella enterica serovar Typhimurium strains are difficult to select in the absence of AcrB and TolC
    • Ricci V, Tzakas P, Buckley A et al (2006) Ciprofloxacin-resistant Salmonella enterica serovar Typhimurium strains are difficult to select in the absence of AcrB and TolC. Antimicrob Agents Chemother 50:38-42
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 38-42
    • Ricci, V.1    Tzakas, P.2    Buckley, A.3
  • 303
    • 4544242799 scopus 로고    scopus 로고
    • Distribution of macrolide, lincosamide, streptogramin, ketolide and oxazolidinone (MLSKO) resistance genes in Gram-negative bacteria
    • Roberts MC (2004) Distribution of macrolide, lincosamide, streptogramin, ketolide and oxazolidinone (MLSKO) resistance genes in Gram-negative bacteria. Curr Drug Targets Infect Disord 4:207-215
    • (2004) Curr Drug Targets Infect Disord , vol.4 , pp. 207-215
    • Roberts, M.C.1
  • 304
    • 21644438529 scopus 로고    scopus 로고
    • Resistance to macrolide, lincosamide, streptogramin, ketolide, and oxazolidinone antibiotics
    • Roberts MC (2004) Resistance to macrolide, lincosamide, streptogramin, ketolide, and oxazolidinone antibiotics. Mol Biotechnol 28:47-62
    • (2004) Mol Biotechnol , vol.28 , pp. 47-62
    • Roberts, M.C.1
  • 305
    • 17144412507 scopus 로고    scopus 로고
    • Update on acquired tetracycline resistance genes
    • Roberts MC (2005) Update on acquired tetracycline resistance genes. FEMS Microbiol Lett 245:195-203
    • (2005) FEMS Microbiol Lett , vol.245 , pp. 195-203
    • Roberts, M.C.1
  • 306
    • 42449112810 scopus 로고    scopus 로고
    • Update on macrolide-lincosamide-streptogramin, ketolide, and oxazolidinone resistance genes
    • Roberts MC (2008) Update on macrolide-lincosamide-streptogramin, ketolide, and oxazolidinone resistance genes. FEMS Microbiol Lett 282:147-159
    • (2008) FEMS Microbiol Lett , vol.282 , pp. 147-159
    • Roberts, M.C.1
  • 307
    • 34948893955 scopus 로고    scopus 로고
    • A Novel indole compound that inhibits Pseudomonas aeruginosa growth by targeting MreB is a substrate for MexAB-OprM
    • Robertson GT, Doyle TB, Du Q et al (2007) A Novel indole compound that inhibits Pseudomonas aeruginosa growth by targeting MreB is a substrate for MexAB-OprM. J Bacteriol 189:6870-6881
    • (2007) J Bacteriol , vol.189 , pp. 6870-6881
    • Robertson, G.T.1    Doyle, T.B.2    Du, Q.3
  • 308
    • 0037898916 scopus 로고    scopus 로고
    • Bile salts and fatty acids induce the expression of Escherichia coli AcrAB multidrug efflux pump through their interaction with Rob regulatory protein
    • Rosenberg EY, Bertenthal D, Nilles ML et al (2003) Bile salts and fatty acids induce the expression of Escherichia coli AcrAB multidrug efflux pump through their interaction with Rob regulatory protein. Mol Microbiol 48:1609-1619
    • (2003) Mol Microbiol , vol.48 , pp. 1609-1619
    • Rosenberg, E.Y.1    Bertenthal, D.2    Nilles, M.L.3
  • 310
    • 12944289673 scopus 로고    scopus 로고
    • AcrAB efflux pump plays a role in decreased susceptibility to tigecycline in Morganella morganii
    • Ruzin A, Keeney D, Bradford PA (2005) AcrAB efflux pump plays a role in decreased susceptibility to tigecycline in Morganella morganii. Antimicrob Agents Chemother 49:791-793
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 791-793
    • Ruzin, A.1    Keeney, D.2    Bradford, P.A.3
  • 311
    • 14744267574 scopus 로고    scopus 로고
    • Influence of transcriptional activator RamA on expression of multidrug efflux pump AcrAB and tigecycline susceptibility in Klebsiella pneumoniae
    • Ruzin A, Visalli MA, Keeney D et al (2005) Influence of transcriptional activator RamA on expression of multidrug efflux pump AcrAB and tigecycline susceptibility in Klebsiella pneumoniae. Antimicrob Agents Chemother 49:1017-1022
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 1017-1022
    • Ruzin, A.1    Visalli, M.A.2    Keeney, D.3
  • 312
    • 34250861565 scopus 로고    scopus 로고
    • AdeABC multidrug efflux pump is associated with decreased susceptibility to tigecycline in Acinetobacter calcoaceticus-Acinetobacter baumannii complex
    • Ruzin A, Keeney D, Bradford PA (2007) AdeABC multidrug efflux pump is associated with decreased susceptibility to tigecycline in Acinetobacter calcoaceticus-Acinetobacter baumannii complex. J Antimicrob Chemother 59:1001-1004
    • (2007) J Antimicrob Chemother , vol.59 , pp. 1001-1004
    • Ruzin, A.1    Keeney, D.2    Bradford, P.A.3
  • 313
    • 1642358394 scopus 로고    scopus 로고
    • Effect of the efflux pump inhibitor Phe-Arg- b - Naphthylamide on the MIC values of the quinolones, tetracycline and chloramphenicol, in Escherichia coli isolates of different origin
    • Saenz Y, Ruiz J, Zarazaga M et al (2004) Effect of the efflux pump inhibitor Phe-Arg- b - naphthylamide on the MIC values of the quinolones, tetracycline and chloramphenicol, in Escherichia coli isolates of different origin. J Antimicrob Chemother 53:544-545
    • (2004) J Antimicrob Chemother , vol.53 , pp. 544-545
    • Saenz, Y.1    Ruiz, J.2    Zarazaga, M.3
  • 314
    • 33747892583 scopus 로고    scopus 로고
    • Role of type II topoisomerase mutations and AcrAB efflux pump in fluoroquinolone-resistant clinical isolates of Proteus mirabilis
    • Saito R, Sato K, Kumita W et al (2006) Role of type II topoisomerase mutations and AcrAB efflux pump in fluoroquinolone-resistant clinical isolates of Proteus mirabilis. J Antimicrob Chemother 58:673-677
    • (2006) J Antimicrob Chemother , vol.58 , pp. 673-677
    • Saito, R.1    Sato, K.2    Kumita, W.3
  • 315
    • 0037397295 scopus 로고    scopus 로고
    • The efflux pump inhibitor Phe-Arg- b -naphthylamide does not abolish the activity of the Stenotrophomonas maltophilia SmeDEF multidrug efflux pump
    • Sanchez P, Le U, Martinez JL (2003) The efflux pump inhibitor Phe-Arg- b -naphthylamide does not abolish the activity of the Stenotrophomonas maltophilia SmeDEF multidrug efflux pump. J Antimicrob Chemother 51:1042-1045
    • (2003) J Antimicrob Chemother , vol.51 , pp. 1042-1045
    • Sanchez, P.1    Le, U.2    Martinez, J.L.3
  • 316
    • 12944270423 scopus 로고    scopus 로고
    • The biocide triclosan selects Stenotrophomonas maltophilia mutants that overproduce the SmeDEF multidrug efflux pump
    • Sanchez P, Moreno E, Martinez JL (2005) The biocide triclosan selects Stenotrophomonas maltophilia mutants that overproduce the SmeDEF multidrug efflux pump. Antimicrob Agents Chemother 49:781-782
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 781-782
    • Sanchez, P.1    Moreno, E.2    Martinez, J.L.3
  • 317
    • 34547406680 scopus 로고    scopus 로고
    • Partial characterisation of the acrAB locus in two Citrobacter freundii clinical isolates
    • Sanchez-Cespedes J, Vila J (2007) Partial characterisation of the acrAB locus in two Citrobacter freundii clinical isolates. Int J Antimicrob Agents 30:259-263
    • (2007) Int J Antimicrob Agents , vol.30 , pp. 259-263
    • Sanchez-Cespedes, J.1    Vila, J.2
  • 318
    • 23944467566 scopus 로고    scopus 로고
    • Plasmid pB8 is closely related to the prototype IncP-1beta plasmid R751 but transfers poorly to Escherichia coli and carries a new transposon encoding a small multidrug resistance efflux protein
    • Schluter A, Heuer H, Szczepanowski R et al (2005) Plasmid pB8 is closely related to the prototype IncP-1beta plasmid R751 but transfers poorly to Escherichia coli and carries a new transposon encoding a small multidrug resistance efflux protein. Plasmid 54:135-148
    • (2005) Plasmid , vol.54 , pp. 135-148
    • Schluter, A.1    Heuer, H.2    Szczepanowski, R.3
  • 319
    • 0041422177 scopus 로고    scopus 로고
    • Role of AcrR and RamA in fluoroquinolone resistance in clinical Klebsiella pneumoniae isolates from Singapore
    • Schneiders T, Amyes SG, Levy SB (2003) Role of AcrR and RamA in fluoroquinolone resistance in clinical Klebsiella pneumoniae isolates from Singapore. Antimicrob Agents Chemother 47:2831-2837
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 2831-2837
    • Schneiders, T.1    Amyes, S.G.2    Levy, S.B.3
  • 320
    • 31544464121 scopus 로고    scopus 로고
    • Effect of 1-(1-naphthylmethyl)-piperazine, a novel putative efflux pump inhibitor, on antimicrobial drug susceptibility in clinical isolates of Enterobacteriaceae other than Escherichia coli
    • Schumacher A, Steinke P, Bohnert JA et al (2006) Effect of 1-(1-naphthylmethyl)-piperazine, a novel putative efflux pump inhibitor, on antimicrobial drug susceptibility in clinical isolates of Enterobacteriaceae other than Escherichia coli. J Antimicrob Chemother 57:344-348
    • (2006) J Antimicrob Chemother , vol.57 , pp. 344-348
    • Schumacher, A.1    Steinke, P.2    Bohnert, J.A.3
  • 321
    • 34447553357 scopus 로고    scopus 로고
    • Intracellular accumulation of linezolid in Escherichia coli, Citrobacter freundii and Enterobacter aerogenes: Role of enhanced efflux pump activity and inactivation
    • Schumacher A, Trittler R, Bohnert JA et al (2006) Intracellular accumulation of linezolid in Escherichia coli, Citrobacter freundii and Enterobacter aerogenes: role of enhanced efflux pump activity and inactivation. J Antimicrob Chemother 59:1261-1264
    • (2006) J Antimicrob Chemother , vol.59 , pp. 1261-1264
    • Schumacher, A.1    Trittler, R.2    Bohnert, J.A.3
  • 322
    • 6344291118 scopus 로고    scopus 로고
    • Molecular basis of bacterial resistance to chloramphenicol and florfenicol
    • Schwarz S, Kehrenberg C, Doublet B et al (2004) Molecular basis of bacterial resistance to chloramphenicol and florfenicol. FEMS Microbiol Rev 28:519-542
    • (2004) FEMS Microbiol Rev , vol.28 , pp. 519-542
    • Schwarz, S.1    Kehrenberg, C.2    Doublet, B.3
  • 323
    • 0031918573 scopus 로고    scopus 로고
    • Intrinsic resistance to inhibitors of fatty acid biosynthesis in Pseudomonas aeruginosa is due to efflux: Application of a novel technique for generation of unmarked chromosomal mutations for the study of efflux systems
    • Schweizer HP (1998) Intrinsic resistance to inhibitors of fatty acid biosynthesis in Pseudomonas aeruginosa is due to efflux: application of a novel technique for generation of unmarked chromosomal mutations for the study of efflux systems. Antimicrob Agents Chemother 42:394-398
    • (1998) Antimicrob Agents Chemother , vol.42 , pp. 394-398
    • Schweizer, H.P.1
  • 324
    • 0035822555 scopus 로고    scopus 로고
    • Triclosan: A widely used biocide and its link to antibiotics
    • Schweizer HP (2001) Triclosan: a widely used biocide and its link to antibiotics. FEMS Microbiol Lett 202:1-7
    • (2001) FEMS Microbiol Lett , vol.202 , pp. 1-7
    • Schweizer, H.P.1
  • 325
    • 33748310520 scopus 로고    scopus 로고
    • Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism
    • Seeger MA, Schiefner A, Eicher T et al (2006) Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism. Science 313:1295-1298
    • (2006) Science , vol.313 , pp. 1295-1298
    • Seeger, M.A.1    Schiefner, A.2    Eicher, T.3
  • 326
    • 52449109122 scopus 로고    scopus 로고
    • The AcrB efflux pump: Conformational cycling and peristalsis lead to multidrug resistance
    • Seeger MA, Diederichs K, Eicher T et al (2008) The AcrB efflux pump: conformational cycling and peristalsis lead to multidrug resistance. Curr Drug Targets 9:729-749
    • (2008) Curr Drug Targets , vol.9 , pp. 729-749
    • Seeger, M.A.1    Diederichs, K.2    Eicher, T.3
  • 327
    • 0028997376 scopus 로고
    • Missense mutations that alter the DNAbinding domain of the MtrR protein occur frequently in rectal isolates of Nesseria gonorrhoeae that are resistant to fecal lipids
    • Shafer WM, Balthazar JT, Hagman KE et al (1995) Missense mutations that alter the DNAbinding domain of the MtrR protein occur frequently in rectal isolates of Nesseria gonorrhoeae that are resistant to fecal lipids. Microbiology 141:907-911
    • (1995) Microbiology , vol.141 , pp. 907-911
    • Shafer, W.M.1    Balthazar, J.T.2    Hagman, K.E.3
  • 328
    • 34147127625 scopus 로고    scopus 로고
    • Molecular cloning and characterization of a multidrug efflux pump, SmfY, from Serratia marcescens
    • Shahcheraghi F, Minato Y, Chen J et al (2007) Molecular cloning and characterization of a multidrug efflux pump, SmfY, from Serratia marcescens. Biol Pharm Bull 30:798-800
    • (2007) Biol Pharm Bull , vol.30 , pp. 798-800
    • Shahcheraghi, F.1    Minato, Y.2    Chen, J.3
  • 329
    • 40949121607 scopus 로고    scopus 로고
    • ABC multidrug transporters: Structure, function and role in chemoresistance
    • Sharom FJ (2008) ABC multidrug transporters: structure, function and role in chemoresistance. Pharmacogenomics 9:105-127
    • (2008) Pharmacogenomics , vol.9 , pp. 105-127
    • Sharom, F.J.1
  • 330
    • 1842451933 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis isolate with a distinct genomic identity overexpresses a Tap-like efflux pump
    • Siddiqi N, Das R, Pathak N et al (2004) Mycobacterium tuberculosis isolate with a distinct genomic identity overexpresses a Tap-like efflux pump. Infection 32:109-111
    • (2004) Infection , vol.32 , pp. 109-111
    • Siddiqi, N.1    Das, R.2    Pathak, N.3
  • 331
    • 18144394737 scopus 로고    scopus 로고
    • Design and structure of peptide and peptidomimetic antagonists of protein-protein interaction
    • Sillerud LO, Larson RS (2005) Design and structure of peptide and peptidomimetic antagonists of protein-protein interaction. Curr Protein Pept Sci 6:151-169
    • (2005) Curr Protein Pept Sci , vol.6 , pp. 151-169
    • Sillerud, L.O.1    Larson, R.S.2
  • 332
    • 34250842647 scopus 로고    scopus 로고
    • Mechanisms of resistance to carbapenems in meropenem- resistant Acinetobacter isolates from clinical samples
    • Sinha M, Srinivasa H (2007) Mechanisms of resistance to carbapenems in meropenem- resistant Acinetobacter isolates from clinical samples. Indian J Med Microbiol 25:121-125
    • (2007) Indian J Med Microbiol , vol.25 , pp. 121-125
    • Sinha, M.1    Srinivasa, H.2
  • 333
    • 33744814106 scopus 로고    scopus 로고
    • Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients
    • Smith EE, Buckley DG, Wu Z et al (2006) Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients. Proc Natl Acad Sci USA 103:8487-8492
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 8487-8492
    • Smith, E.E.1    Buckley, D.G.2    Wu, Z.3
  • 334
    • 0141959305 scopus 로고    scopus 로고
    • Contribution of the MexXY multidrug transporter to aminoglycoside resistance in Pseudomonas aeruginosa clinical isolates
    • Sobel ML, McKay GA, Poole K (2003) Contribution of the MexXY multidrug transporter to aminoglycoside resistance in Pseudomonas aeruginosa clinical isolates. Antimicrob Agents Chemother 47:3202-3207
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 3202-3207
    • Sobel, M.L.1    McKay, G.A.2    Poole, K.3
  • 335
    • 18244399839 scopus 로고    scopus 로고
    • Mutations in PA3574 ( nalD ) lead to increased MexAB-OprM expression and multidrug resistance in lab and clinical isolates of Pseudomonas aeruginosa
    • Sobel ML, Hocquet D, Cao L et al (2005) Mutations in PA3574 ( nalD ) lead to increased MexAB-OprM expression and multidrug resistance in lab and clinical isolates of Pseudomonas aeruginosa. Antimicrob Agents Chemother 49:1782-1786
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 1782-1786
    • Sobel, M.L.1    Hocquet, D.2    Cao, L.3
  • 336
    • 14544299583 scopus 로고    scopus 로고
    • Mutations in PA2491 ( mexS ) promote MexT-dependent mexEF-oprN expression and multidrug resistance in a clinical strain of Pseudomonas aeruginosa
    • Sobel ML, Poole K, Neshat S (2005) Mutations in PA2491 ( mexS ) promote MexT-dependent mexEF-oprN expression and multidrug resistance in a clinical strain of Pseudomonas aeruginosa. J Bacteriol 187:1246-1253
    • (2005) J Bacteriol , vol.187 , pp. 1246-1253
    • Sobel, M.L.1    Poole, K.2    Neshat, S.3
  • 337
    • 34548071428 scopus 로고    scopus 로고
    • Quinolone resistance of Salmonella enterica serovar Virchow isolates from humans and poultry in Israel: Evidence for clonal expansion
    • Solnik-Isaac H, Weinberger M, Tabak M et al (2007) Quinolone resistance of Salmonella enterica serovar Virchow isolates from humans and poultry in Israel: evidence for clonal expansion. J Clin Microbiol 45:2575-2579
    • (2007) J Clin Microbiol , vol.45 , pp. 2575-2579
    • Solnik-Isaac, H.1    Weinberger, M.2    Tabak, M.3
  • 338
    • 48749090737 scopus 로고    scopus 로고
    • Identification of mutations related to streptomycin resistance in clinical isolates of Mycobacterium tuberculosis and possible involvement of efflux mechanism
    • Spies FS, da Silva PE, Ribeiro MO et al (2008) Identification of mutations related to streptomycin resistance in clinical isolates of Mycobacterium tuberculosis and possible involvement of efflux mechanism. Antimicrob Agents Chemother 52:2947-2949
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 2947-2949
    • Spies, F.S.1    Da Silva, P.E.2    Ribeiro, M.O.3
  • 339
    • 33745588086 scopus 로고    scopus 로고
    • Mechanism of drug resistance in clonally related clinical isolates of Vibrio fluvialis isolated in Kolkata, India
    • Srinivasan VB, Virk RK, Kaundal A et al (2006) Mechanism of drug resistance in clonally related clinical isolates of Vibrio fluvialis isolated in Kolkata, India. Antimicrob Agents Chemother 50:2428-2432
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 2428-2432
    • Srinivasan, V.B.1    Virk, R.K.2    Kaundal, A.3
  • 340
    • 34447545604 scopus 로고    scopus 로고
    • Bacterial efflux pump inhibitors from natural sources
    • Stavri M, Piddock LJ, Gibbons S (2007) Bacterial efflux pump inhibitors from natural sources. J Antimicrob Chemother 59:1247-1260
    • (2007) J Antimicrob Chemother , vol.59 , pp. 1247-1260
    • Stavri, M.1    Piddock, L.J.2    Gibbons, S.3
  • 341
    • 33748638824 scopus 로고    scopus 로고
    • Importance of the adaptor (membrane fusion) protein hairpin domain for the functionality of multidrug efflux pumps
    • Stegmeier JF, Polleichtner G, Brandes N et al (2006) Importance of the adaptor (membrane fusion) protein hairpin domain for the functionality of multidrug efflux pumps. Biochemistry 45:10303-10312
    • (2006) Biochemistry , vol.45 , pp. 10303-10312
    • Stegmeier, J.F.1    Polleichtner, G.2    Brandes, N.3
  • 342
    • 44949200391 scopus 로고    scopus 로고
    • Characterization of the RND-type multidrug efflux pump MexAB-OprM from the plant pathogen Pseudomonas syringae
    • Stoitsova SO, Braun Y, Ullrich MS et al (2008) Characterization of the RND-type multidrug efflux pump MexAB-OprM from the plant pathogen Pseudomonas syringae. Appl Environ Microbiol 74:3387-3393
    • (2008) Appl Environ Microbiol , vol.74 , pp. 3387-3393
    • Stoitsova, S.O.1    Braun, Y.2    Ullrich, M.S.3
  • 343
    • 28844493047 scopus 로고    scopus 로고
    • DX-619, a novel des-fluoro(6) quinolone manifesting low frequency of selection of resistant Staphylococcus aureus mutants: Quinolone resistance beyond modification of type II topoisomerases
    • Strahilevitz J, Truong-Bolduc QC, Hooper DC (2005) DX-619, a novel des-fluoro(6) quinolone manifesting low frequency of selection of resistant Staphylococcus aureus mutants: quinolone resistance beyond modification of type II topoisomerases. Antimicrob Agents Chemother 49:5051-5057
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 5051-5057
    • Strahilevitz, J.1    Truong-Bolduc, Q.C.2    Hooper, D.C.3
  • 344
    • 33751202419 scopus 로고    scopus 로고
    • In vitro susceptibility testing versus in vivo effectiveness
    • Stratton CW (2006) In vitro susceptibility testing versus in vivo effectiveness. Med Clin North Am 90:1077-1088
    • (2006) Med Clin North Am , vol.90 , pp. 1077-1088
    • Stratton, C.W.1
  • 345
    • 55849146287 scopus 로고    scopus 로고
    • Macrolide antibiotic-mediated down regulation of MexAB-OprM efflux pump expression in Pseudomonas aeruginosa
    • Sugimura M, Maseda H, Hanaki H et al (2008) Macrolide antibiotic-mediated down regulation of MexAB-OprM efflux pump expression in Pseudomonas aeruginosa. Antimicrob Agents Chemother 52:4141-4144
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 4141-4144
    • Sugimura, M.1    Maseda, H.2    Hanaki, H.3
  • 346
    • 33746928431 scopus 로고    scopus 로고
    • Outer membrane protein changes and efflux pump expression together may confer resistance to ertapenem in Enterobacter cloacae
    • Szabo D, Silveira F, Hujer AM et al (2006) Outer membrane protein changes and efflux pump expression together may confer resistance to ertapenem in Enterobacter cloacae. Antimicrob Agents Chemother 50:2833-2835
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 2833-2835
    • Szabo, D.1    Silveira, F.2    Hujer, A.M.3
  • 347
    • 33847621194 scopus 로고    scopus 로고
    • In vitro and in vivo activities of a new cephalosporin, FR264205, against Pseudomonas aeruginosa
    • Takeda S, Nakai T, Wakai Y et al (2007) In vitro and in vivo activities of a new cephalosporin, FR264205, against Pseudomonas aeruginosa. Antimicrob Agents Chemother 51:826-830
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 826-830
    • Takeda, S.1    Nakai, T.2    Wakai, Y.3
  • 348
    • 34347324927 scopus 로고    scopus 로고
    • Prevalence, mechanisms, and risk factors of carbapenem resistance in bloodstream isolates of Pseudomonas aeruginosa
    • Tam VH, Chang KT, LaRocco MT et al (2007) Prevalence, mechanisms, and risk factors of carbapenem resistance in bloodstream isolates of Pseudomonas aeruginosa. Diagn Microbiol Infect Dis 58:309-314
    • (2007) Diagn Microbiol Infect Dis , vol.58 , pp. 309-314
    • Tam, V.H.1    Chang, K.T.2    Larocco, M.T.3
  • 349
    • 0037293014 scopus 로고    scopus 로고
    • The 79,370-bp conjugative plasmid pB4 consists of an IncP-1 b backbone loaded with a chromate resistance transposon, the strA-strB streptomycin resistance gene pair, the oxacillinase gene bla (NPS-1), and a tripartite antibiotic efflux system of the resistance-nodulation-division family
    • Tauch A, Schluter A, Bischoff N et al (2003) The 79,370-bp conjugative plasmid pB4 consists of an IncP-1 b backbone loaded with a chromate resistance transposon, the strA-strB streptomycin resistance gene pair, the oxacillinase gene bla (NPS-1), and a tripartite antibiotic efflux system of the resistance-nodulation-division family. Mol Genet Genomics 268: 570-584
    • (2003) Mol Genet Genomics , vol.268 , pp. 570-584
    • Tauch, A.1    Schluter, A.2    Bischoff, N.3
  • 350
    • 11144231757 scopus 로고    scopus 로고
    • Enhanced active efflux, repression of porin synthesis and development of Mar phenotype by diazepam in two enterobacteria strains
    • Tavio MM, Vila J, Perilli M et al (2004) Enhanced active efflux, repression of porin synthesis and development of Mar phenotype by diazepam in two enterobacteria strains. J Med Microbiol 53:1119-1122
    • (2004) J Med Microbiol , vol.53 , pp. 1119-1122
    • Tavio, M.M.1    Vila, J.2    Perilli, M.3
  • 351
    • 34247547843 scopus 로고    scopus 로고
    • Novel tetracycline resistance determinant isolated from an environmental strain of Serratia marcescens
    • Thompson SA, Maani EV, Lindell AH et al (2007) Novel tetracycline resistance determinant isolated from an environmental strain of Serratia marcescens. Appl Environ Microbiol 73:2199-2206
    • (2007) Appl Environ Microbiol , vol.73 , pp. 2199-2206
    • Thompson, S.A.1    Maani, E.V.2    Lindell, A.H.3
  • 352
  • 353
    • 3242890387 scopus 로고    scopus 로고
    • Interactions underlying assembly of the Escherichia coli AcrAB-TolC multidrug efflux system
    • Touze T, Eswaran J, Bokma E et al (2004) Interactions underlying assembly of the Escherichia coli AcrAB-TolC multidrug efflux system. Mol Microbiol 53:697-706
    • (2004) Mol Microbiol , vol.53 , pp. 697-706
    • Touze, T.1    Eswaran, J.2    Bokma, E.3
  • 355
    • 48949101533 scopus 로고    scopus 로고
    • Campylobacter jejuni response to human mucin MUC2: Modulation of colonization and pathogenicity determinants
    • Tu QV, McGuckin MA, Mendz GL (2008) Campylobacter jejuni response to human mucin MUC2: modulation of colonization and pathogenicity determinants. J Med Microbiol 57:795-802
    • (2008) J Med Microbiol , vol.57 , pp. 795-802
    • Tu, Q.V.1    McGuckin, M.A.2    Mendz, G.L.3
  • 356
    • 22544486843 scopus 로고    scopus 로고
    • Cationic antimicrobial peptide resistance in Neisseria meningitidis
    • Tzeng YL, Ambrose KD, Zughaier S et al (2005) Cationic antimicrobial peptide resistance in Neisseria meningitidis. J Bacteriol 187:5387-5396
    • (2005) J Bacteriol , vol.187 , pp. 5387-5396
    • Tzeng, Y.L.1    Ambrose, K.D.2    Zughaier, S.3
  • 357
    • 33748710888 scopus 로고    scopus 로고
    • MarA-like regulator of multidrug resistance in Yersinia pestis
    • Udani RA, Levy SB (2006) MarA-like regulator of multidrug resistance in Yersinia pestis. Antimicrob Agents Chemother 50:2971-2975
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 2971-2975
    • Udani, R.A.1    Levy, S.B.2
  • 358
    • 21444454081 scopus 로고    scopus 로고
    • Sixteen homologs of the mex-type multidrug resistance efflux pump in Bacteroides fragilis
    • Ueda O, Wexler HM, Hirai K et al (2005) Sixteen homologs of the mex-type multidrug resistance efflux pump in Bacteroides fragilis. Antimicrob Agents Chemother 49:2807-2815
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 2807-2815
    • Ueda, O.1    Wexler, H.M.2    Hirai, K.3
  • 359
    • 53149149471 scopus 로고    scopus 로고
    • Phenotypic and molecular characterization of Acinetobacter baumannii clinical isolates from nosocomial outbreaks in Los Angeles County
    • Valentine SC, Contreras D, Tan S et al (2008) Phenotypic and molecular characterization of Acinetobacter baumannii clinical isolates from nosocomial outbreaks in Los Angeles County. J Clin Microbiol 46:2499-2507
    • (2008) J Clin Microbiol , vol.46 , pp. 2499-2507
    • Valentine, S.C.1    Contreras, D.2    Tan, S.3
  • 360
    • 34248400414 scopus 로고    scopus 로고
    • Inhibitors of bacterial efflux pumps as adjuvants in antibiotic treatments and diagnostic tools for detection of resistance by efflux
    • Van Bambeke F, Pages JM, Lee VJ (2006) Inhibitors of bacterial efflux pumps as adjuvants in antibiotic treatments and diagnostic tools for detection of resistance by efflux. Recent Pat Antiinfect Drug Discov 1:157-175
    • (2006) Recent Pat Antiinfect Drug Discov , vol.1 , pp. 157-175
    • Van Bambeke, F.1    Pages, J.M.2    Lee, V.J.3
  • 361
    • 0036785342 scopus 로고    scopus 로고
    • Overexpression of the MtrC-MtrD-MtrE efflux pump due to an mtrR mutation is required for chromosomally mediated penicillin resistance in Neisseria gonorrhoeae
    • Veal WL, Nicholas RA, Shafer WM (2002) Overexpression of the MtrC-MtrD-MtrE efflux pump due to an mtrR mutation is required for chromosomally mediated penicillin resistance in Neisseria gonorrhoeae. J Bacteriol 184:5619-5624
    • (2002) J Bacteriol , vol.184 , pp. 5619-5624
    • Veal, W.L.1    Nicholas, R.A.2    Shafer, W.M.3
  • 362
    • 0037309748 scopus 로고    scopus 로고
    • AcrAB multidrug efflux pump is associated with reduced levels of susceptibility to tigecycline (GAR-936) in Proteus mirabilis
    • Visalli MA, Murphy E, Projan SJ et al (2003) AcrAB multidrug efflux pump is associated with reduced levels of susceptibility to tigecycline (GAR-936) in Proteus mirabilis. Antimicrob Agents Chemother 47:665-669
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 665-669
    • Visalli, M.A.1    Murphy, E.2    Projan, S.J.3
  • 363
    • 0036719989 scopus 로고    scopus 로고
    • Isoniazid-induced transient high-level resistance in Mycobacterium tuberculosis
    • Viveiros M, Portugal I, Bettencourt R et al (2002) Isoniazid-induced transient high-level resistance in Mycobacterium tuberculosis. Antimicrob Agents Chemother 46:2804-2810
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 2804-2810
    • Viveiros, M.1    Portugal, I.2    Bettencourt, R.3
  • 364
    • 2142697190 scopus 로고    scopus 로고
    • Role of the multidrug efflux system MexXY in the emergence of moderate resistance to aminoglycosides among Pseudomonas aeruginosa isolates from patients with cystic fibrosis
    • Vogne C, Aires JR, Bailly C et al (2004) Role of the multidrug efflux system MexXY in the emergence of moderate resistance to aminoglycosides among Pseudomonas aeruginosa isolates from patients with cystic fibrosis. Antimicrob Agents Chemother 48:1676-1680
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 1676-1680
    • Vogne, C.1    Aires, J.R.2    Bailly, C.3
  • 365
    • 34547746867 scopus 로고    scopus 로고
    • Carbapenem resistance in clinical isolates of Pseudomonas aeruginosa
    • Walsh F, Amyes SG (2007) Carbapenem resistance in clinical isolates of Pseudomonas aeruginosa. J Chemother 19:376-381
    • (2007) J Chemother , vol.19 , pp. 376-381
    • Walsh, F.1    Amyes, S.G.2
  • 366
    • 52449101821 scopus 로고    scopus 로고
    • Antimicrobial resistance in foodborne pathogens-A cause for concern
    • Walsh C, Fanning S (2008) Antimicrobial resistance in foodborne pathogens-a cause for concern? Curr Drug Targets 9:808-815
    • (2008) Curr Drug Targets , vol.9 , pp. 808-815
    • Walsh, C.1    Fanning, S.2
  • 367
    • 39149112789 scopus 로고    scopus 로고
    • Regulation of the MtrC-MtrD-MtrE effluxpump system modulates the in vivo fitness of Neisseria gonorrhoeae
    • Warner DM, Folster JP, Shafer WM et al (2007) Regulation of the MtrC-MtrD-MtrE effluxpump system modulates the in vivo fitness of Neisseria gonorrhoeae. J Infect Dis 196:1804-1812
    • (2007) J Infect Dis , vol.196 , pp. 1804-1812
    • Warner, D.M.1    Folster, J.P.2    Shafer, W.M.3
  • 368
    • 52649131941 scopus 로고    scopus 로고
    • Clinically relevant mutations that cause derepression of the Neisseria gonorrhoeae MtrC-MtrD-MtrE efflux pump system confer different levels of antimicrobial resistance and in vivo fitness
    • Warner DM, Shafer WM, Jerse AE (2008) Clinically relevant mutations that cause derepression of the Neisseria gonorrhoeae MtrC-MtrD-MtrE efflux pump system confer different levels of antimicrobial resistance and in vivo fitness. Mol Microbiol 70:462-478
    • (2008) Mol Microbiol , vol.70 , pp. 462-478
    • Warner, D.M.1    Shafer, W.M.2    Jerse, A.E.3
  • 369
    • 10744228144 scopus 로고    scopus 로고
    • The relationship between physicochemical properties, in vitro activity and pharmacokinetic profiles of analogues of diamine-containing efflux pump inhibitors
    • Watkins WJ, Landaverry Y, Leger R et al (2003) The relationship between physicochemical properties, in vitro activity and pharmacokinetic profiles of analogues of diamine-containing efflux pump inhibitors. Bioorg Med Chem Lett 13:4241-4244
    • (2003) Bioorg Med Chem Lett , vol.13 , pp. 4241-4244
    • Watkins, W.J.1    Landaverry, Y.2    Leger, R.3
  • 370
    • 25844442529 scopus 로고    scopus 로고
    • Contribution of mutation at amino acid 45 of AcrR to acrB expression and ciprofloxacin resistance in clinical and veterinary Escherichia coli isolates
    • Webber MA, Talukder A, Piddock LJ (2005) Contribution of mutation at amino acid 45 of AcrR to acrB expression and ciprofloxacin resistance in clinical and veterinary Escherichia coli isolates. Antimicrob Agents Chemother 49:4390-4392
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 4390-4392
    • Webber, M.A.1    Talukder, A.2    Piddock, L.J.3
  • 371
    • 45749116550 scopus 로고    scopus 로고
    • Triclosan resistance in Salmonella enterica serovar Typhimurium
    • Webber MA, Randall LP, Cooles S et al (2008) Triclosan resistance in Salmonella enterica serovar Typhimurium. J Antimicrob Chemother 62:83-91
    • (2008) J Antimicrob Chemother , vol.62 , pp. 83-91
    • Webber, M.A.1    Randall, L.P.2    Cooles, S.3
  • 372
    • 33750565432 scopus 로고    scopus 로고
    • Use of germicides in the home and the healthcare setting: Is there a relationship between germicide use and antibiotic resistance
    • Weber DJ, Rutala WA (2006) Use of germicides in the home and the healthcare setting: is there a relationship between germicide use and antibiotic resistance? Infect Control Hosp Epidemiol 27:1107-1119
    • (2006) Infect Control Hosp Epidemiol , vol.27 , pp. 1107-1119
    • Weber, D.J.1    Rutala, W.A.2
  • 373
    • 35548995922 scopus 로고    scopus 로고
    • DNA microarray for genotyping multidrugresistant Pseudomonas aeruginosa clinical isolates
    • Weile J, Schmid RD, Bachmann TT et al (2007) DNA microarray for genotyping multidrugresistant Pseudomonas aeruginosa clinical isolates. Diagn Microbiol Infect Dis 59: 325-338
    • (2007) Diagn Microbiol Infect Dis , vol.59 , pp. 325-338
    • Weile, J.1    Schmid, R.D.2    Bachmann, T.T.3
  • 374
    • 0032762778 scopus 로고    scopus 로고
    • Characterization of a Pseudomonas aeruginosa efflux pump contributing to aminoglycoside impermeability
    • Westbrock-Wadman S, Sherman DR, Hickey MJ et al (1999) Characterization of a Pseudomonas aeruginosa efflux pump contributing to aminoglycoside impermeability. Antimicrob Agents Chemother 43:2975-2983
    • (1999) Antimicrob Agents Chemother , vol.43 , pp. 2975-2983
    • Westbrock-Wadman, S.1    Sherman, D.R.2    Hickey, M.J.3
  • 375
    • 34548716358 scopus 로고    scopus 로고
    • Macrolide resistance mechanisms among Streptococcus pneumoniae isolated over 6 years of Canadian Respiratory Organism Susceptibility Study (CROSS) (1998 2004)
    • Wierzbowski AK, Nichol K, Laing N et al (2007) Macrolide resistance mechanisms among Streptococcus pneumoniae isolated over 6 years of Canadian Respiratory Organism Susceptibility Study (CROSS) (1998 2004). J Antimicrob Chemother 60:733-740
    • (2007) J Antimicrob Chemother , vol.60 , pp. 733-740
    • Wierzbowski, A.K.1    Nichol, K.2    Laing, N.3
  • 376
    • 39149119645 scopus 로고    scopus 로고
    • Effect and mechanism of andrographolide on the recovery of Pseudomonas aeruginosa susceptibility to several antibiotics
    • Wu CM, Cao JL, Zheng MH et al (2008) Effect and mechanism of andrographolide on the recovery of Pseudomonas aeruginosa susceptibility to several antibiotics. J Int Med Res 36:178-186
    • (2008) J Int Med Res , vol.36 , pp. 178-186
    • Wu, C.M.1    Cao, J.L.2    Zheng, M.H.3
  • 377
    • 0346734230 scopus 로고    scopus 로고
    • Molecular cloning and characterization of the HmrM multidrug efflux pump from Haemophilus influenzae Rd
    • Xu XJ, Su XZ, Morita Y et al (2003) Molecular cloning and characterization of the HmrM multidrug efflux pump from Haemophilus influenzae Rd. Microbiol Immunol 47:937-943
    • (2003) Microbiol Immunol , vol.47 , pp. 937-943
    • Xu, X.J.1    Su, X.Z.2    Morita, Y.3
  • 378
    • 35348894748 scopus 로고    scopus 로고
    • New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate
    • Yamane K, Wachino J, Suzuki S et al (2007) New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate. Antimicrob Agents Chemother 51:3354-3360
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 3354-3360
    • Yamane, K.1    Wachino, J.2    Suzuki, S.3
  • 379
    • 42049086071 scopus 로고    scopus 로고
    • Plasmid-mediated qepA gene among Escherichia coli clinical isolates from Japan
    • Yamane K, Wachino J, Suzuki S et al (2008) Plasmid-mediated qepA gene among Escherichia coli clinical isolates from Japan. Antimicrob Agents Chemother 52:1564-1566
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 1564-1566
    • Yamane, K.1    Wachino, J.2    Suzuki, S.3
  • 380
    • 33845353844 scopus 로고    scopus 로고
    • Role of the CmeABC efflux pump in the emergence of fluoroquinolone-resistant Campylobacter under selection pressure
    • Yan M, Sahin O, Lin J et al (2006) Role of the CmeABC efflux pump in the emergence of fluoroquinolone-resistant Campylobacter under selection pressure. J Antimicrob Chemother 58:1154-1159
    • (2006) J Antimicrob Chemother , vol.58 , pp. 1154-1159
    • Yan, M.1    Sahin, O.2    Lin, J.3
  • 381
    • 33746744346 scopus 로고    scopus 로고
    • Triclosan and antimicrobial resistance in bacteria: An overview
    • Yazdankhah SP, Scheie AA, Hoiby EA et al (2006) Triclosan and antimicrobial resistance in bacteria: an overview. Microb Drug Resist 12:83-90
    • (2006) Microb Drug Resist , vol.12 , pp. 83-90
    • Yazdankhah, S.P.1    Scheie, A.A.2    Hoiby, E.A.3
  • 382
    • 0028303739 scopus 로고
    • Mechanisms of high-level resistance to quinolones in urinary tract isolates of Pseudomonas aeruginosa
    • Yoshida T, Muratani T, Iyobe S et al (1994) Mechanisms of high-level resistance to quinolones in urinary tract isolates of Pseudomonas aeruginosa. Antimicrob Agents Chemother 38: 1466-1469
    • (1994) Antimicrob Agents Chemother , vol.38 , pp. 1466-1469
    • Yoshida, T.1    Muratani, T.2    Iyobe, S.3
  • 383
    • 32044469590 scopus 로고    scopus 로고
    • MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 5: Carbon-substituted analogues at the C-2 position
    • Yoshida K, Nakayama K, Kuru N et al (2006) MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 5: carbon-substituted analogues at the C-2 position. Bioorg Med Chem 14:1993-2004
    • (2006) Bioorg Med Chem , vol.14 , pp. 1993-2004
    • Yoshida, K.1    Nakayama, K.2    Kuru, N.3
  • 384
    • 33750533367 scopus 로고    scopus 로고
    • MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 6: Exploration of aromatic substituents
    • Yoshida K, Nakayama K, Yokomizo Y et al (2006) MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 6: exploration of aromatic substituents. Bioorg Med Chem 14:8506-8518
    • (2006) Bioorg Med Chem , vol.14 , pp. 8506-8518
    • Yoshida, K.1    Nakayama, K.2    Yokomizo, Y.3
  • 385
    • 34548828818 scopus 로고    scopus 로고
    • MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 7: Highly soluble and in vivo active quaternary ammonium analogue D13-9001, a potential preclinical candidate
    • Yoshida K, Nakayama K, Ohtsuka M et al (2007) MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 7: highly soluble and in vivo active quaternary ammonium analogue D13-9001, a potential preclinical candidate. Bioorg Med Chem 15:7087-7097
    • (2007) Bioorg Med Chem , vol.15 , pp. 7087-7097
    • Yoshida, K.1    Nakayama, K.2    Ohtsuka, M.3
  • 386
    • 0032842433 scopus 로고    scopus 로고
    • Decreased azithromycin susceptibility of Neisseria gonorrhoeae due to mtrR mutations
    • Zarantonelli L, Borthagaray G, Lee EH et al (1999) Decreased azithromycin susceptibility of Neisseria gonorrhoeae due to mtrR mutations. Antimicrob Agents Chemother 43: 2468-2472
    • (1999) Antimicrob Agents Chemother , vol.43 , pp. 2468-2472
    • Zarantonelli, L.1    Borthagaray, G.2    Lee, E.H.3
  • 387
    • 0035001928 scopus 로고    scopus 로고
    • Decreased susceptibility to azithromycin and erythromycin mediated by a novel mtr(R) promoter mutation in Neisseria gonorrhoeae
    • Zarantonelli L, Borthagaray G, Lee EH et al (2001) Decreased susceptibility to azithromycin and erythromycin mediated by a novel mtr(R) promoter mutation in Neisseria gonorrhoeae. J Antimicrob Chemother 47:651-654
    • (2001) J Antimicrob Chemother , vol.47 , pp. 651-654
    • Zarantonelli, L.1    Borthagaray, G.2    Lee, E.H.3
  • 388
    • 36448983944 scopus 로고    scopus 로고
    • Polymyxin B for the treatment of multidrugresistant pathogens: A critical review
    • Zavascki AP, Goldani LZ, Li J et al (2007) Polymyxin B for the treatment of multidrugresistant pathogens: a critical review. J Antimicrob Chemother 60:1206-1215
    • (2007) J Antimicrob Chemother , vol.60 , pp. 1206-1215
    • Zavascki, A.P.1    Goldani, L.Z.2    Li, J.3
  • 389
    • 0346367066 scopus 로고    scopus 로고
    • Ketolides: An emerging treatment for macrolide- resistant respiratory infections, focusing on Streptococcus pneumoniae
    • Zhanel GG, Hisanaga T, Nichol K et al (2003) Ketolides: an emerging treatment for macrolide- resistant respiratory infections, focusing on Streptococcus pneumoniae. Expert Opin Emerg Drugs 8:297-321
    • (2003) Expert Opin Emerg Drugs , vol.8 , pp. 297-321
    • Zhanel, G.G.1    Hisanaga, T.2    Nichol, K.3
  • 390
    • 46049083393 scopus 로고    scopus 로고
    • Involvement of a novel efflux system in biofilm-specific resistance to antibiotics
    • Zhang L, Mah TF (2008) Involvement of a novel efflux system in biofilm-specific resistance to antibiotics. J Bacteriol 190:4447-4452
    • (2008) J Bacteriol , vol.190 , pp. 4447-4452
    • Zhang, L.1    Mah, T.F.2
  • 391
    • 0034757528 scopus 로고    scopus 로고
    • Fluoroquinolone susceptibilities of efflux-mediated multidrug- resistant Pseudomonas aeruginosa, Stenotrophomonas maltophilia and Burkholderia cepacia
    • Zhang L, Li XZ, Poole K (2001) Fluoroquinolone susceptibilities of efflux-mediated multidrug- resistant Pseudomonas aeruginosa, Stenotrophomonas maltophilia and Burkholderia cepacia. J Antimicrob Chemother 48:549-552
    • (2001) J Antimicrob Chemother , vol.48 , pp. 549-552
    • Zhang, L.1    Li, X.Z.2    Poole, K.3
  • 392
    • 0035183854 scopus 로고    scopus 로고
    • The SmeDEF multidrug efflux pump contributes to intrinsic multidrug resistance in Stenotrophomonas maltophilia
    • Zhang L, Li X-Z, Poole K (2001) The SmeDEF multidrug efflux pump contributes to intrinsic multidrug resistance in Stenotrophomonas maltophilia. Antimicrob Agents Chemother 45: 3497-3503
    • (2001) Antimicrob Agents Chemother , vol.45 , pp. 3497-3503
    • Zhang, L.1    Li, X.-Z.2    Poole, K.3
  • 393
    • 33846188178 scopus 로고    scopus 로고
    • Design, synthesis, and evaluation of efflux substrate- metal chelator conjugates as potential antimicrobial agents
    • Zhang Y, Eric BC, Zheng SL et al (2007) Design, synthesis, and evaluation of efflux substrate- metal chelator conjugates as potential antimicrobial agents. Bioorg Med Chem Lett 17:707-711
    • (2007) Bioorg Med Chem Lett , vol.17 , pp. 707-711
    • Zhang, Y.1    Eric, B.C.2    Zheng, S.L.3
  • 394
    • 0031835556 scopus 로고    scopus 로고
    • Contribution of outer membrane efflux protein OprM to antibiotic resistance in Pseudomonas aeruginosa independent of MexAB
    • Zhao Q, Li X-Z, Srikumar R et al (1998) Contribution of outer membrane efflux protein OprM to antibiotic resistance in Pseudomonas aeruginosa independent of MexAB. Antimicrob Agents Chemother 42:1682-1688
    • (1998) Antimicrob Agents Chemother , vol.42 , pp. 1682-1688
    • Zhao, Q.1    Li, X.-Z.2    Srikumar, R.3


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