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Volumn 189, Issue 17, 2007, Pages 6118-6127

Assembly of the MexAB-OprM multidrug pump of Pseudomonas aeruginosa: Component interactions defined by the study of pump mutant suppressors

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; MUTANT PROTEIN; PROTEIN MEXA; PROTEIN MEXAB; PROTEIN OPRM; UNCLASSIFIED DRUG;

EID: 34548491825     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.00718-07     Document Type: Article
Times cited : (39)

References (53)
  • 1
    • 11144222920 scopus 로고    scopus 로고
    • Crystal structure of the drug-discharge outer membrane protein, OprM, of Pseudomonas aeruginosa: Dual modes of membrane anchoring and occluded cavity end
    • Akama, H., M. Kanemaki, M. Yoshimura, T. Tsukihara, T. Kashiwagi, H. Yoneyama, S. I. Narita, A. Nakagawa, and T. Nakae. 2004. Crystal structure of the drug-discharge outer membrane protein, OprM, of Pseudomonas aeruginosa: dual modes of membrane anchoring and occluded cavity end. J. Biol. Chem. 17:52816-52819.
    • (2004) J. Biol. Chem , vol.17 , pp. 52816-52819
    • Akama, H.1    Kanemaki, M.2    Yoshimura, M.3    Tsukihara, T.4    Kashiwagi, T.5    Yoneyama, H.6    Narita, S.I.7    Nakagawa, A.8    Nakae, T.9
  • 2
    • 2942731519 scopus 로고    scopus 로고
    • Crystal structure of the membrane fusion protein, MexA, of the multidrug transporter in Pseudomonas aeruginosa
    • Akama, H., T. Matsuura, S. Kashiwagi, H. Yoneyama, S. Narita, T. Tsukihara, A. Nakagawa, and T. Nakae. 2004. Crystal structure of the membrane fusion protein, MexA, of the multidrug transporter in Pseudomonas aeruginosa. J. Biol. Chem. 279:25939-25942.
    • (2004) J. Biol. Chem , vol.279 , pp. 25939-25942
    • Akama, H.1    Matsuura, T.2    Kashiwagi, S.3    Yoneyama, H.4    Narita, S.5    Tsukihara, T.6    Nakagawa, A.7    Nakae, T.8
  • 5
    • 33748759588 scopus 로고    scopus 로고
    • Directed evolution of a bacterial efflux pump: Adaptation of the E. coli TolC exit duct to the Pseudomonas MexAB translocase
    • Bokma, E., E. Koronakis, S. Lobedanz, C. Hughes, and V. Koronakis. 2006. Directed evolution of a bacterial efflux pump: adaptation of the E. coli TolC exit duct to the Pseudomonas MexAB translocase. FEBS Lett. 580:5339-5343.
    • (2006) FEBS Lett , vol.580 , pp. 5339-5343
    • Bokma, E.1    Koronakis, E.2    Lobedanz, S.3    Hughes, C.4    Koronakis, V.5
  • 6
    • 4444317855 scopus 로고    scopus 로고
    • MexAB-OprM hyperexpression in NalC type multidrug resistant Pseudomonas aeruginosa: Identification and characterization of the nalC gene encoding a repressor of PA3720-PA3719
    • Cao, L., R. Srikumar, and K. Poole. 2004. MexAB-OprM hyperexpression in NalC type multidrug resistant Pseudomonas aeruginosa: identification and characterization of the nalC gene encoding a repressor of PA3720-PA3719. Mol. Microbiol. 53:1423-1436.
    • (2004) Mol. Microbiol , vol.53 , pp. 1423-1436
    • Cao, L.1    Srikumar, R.2    Poole, K.3
  • 7
    • 0042838181 scopus 로고    scopus 로고
    • Chimeric analysis of AcrA function reveals the importance of its C-terminal domain in its interaction with the AcrB multidrug efflux pump
    • Elkins, C. A., and H. Nikaido. 2003. Chimeric analysis of AcrA function reveals the importance of its C-terminal domain in its interaction with the AcrB multidrug efflux pump. J. Bacteriol. 185:5349-5356.
    • (2003) J. Bacteriol , vol.185 , pp. 5349-5356
    • Elkins, C.A.1    Nikaido, H.2
  • 8
    • 7644244749 scopus 로고    scopus 로고
    • Genetic evidence for functional interactions between TolC and AcrA proteins of a major antibiotic efflux pump of Escherichia coli
    • Gerken, H., and R. Misra. 2004. Genetic evidence for functional interactions between TolC and AcrA proteins of a major antibiotic efflux pump of Escherichia coli. Mol. Microbiol. 54:620-631.
    • (2004) Mol. Microbiol , vol.54 , pp. 620-631
    • Gerken, H.1    Misra, R.2
  • 10
    • 0033826385 scopus 로고    scopus 로고
    • Antibiotic resistance in Pseudomonas aeruginosa: Mechanisms and impact on treatment
    • Hancock, R. E. W., and D. P. Speert. 2000. Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and impact on treatment. Drug Resist. Updat. 3:247-255.
    • (2000) Drug Resist. Updat , vol.3 , pp. 247-255
    • Hancock, R.E.W.1    Speert, D.P.2
  • 13
    • 0032575051 scopus 로고    scopus 로고
    • A broad-host-range Flp-FRT recombination system for site-specific excision of chromosomally located DNA sequences: Application for isolation of unmarked Pseudomonas aeruginosa mutants
    • Hoang, T. T., R. R. Karkhoff-Schweizer, A. J. Kutchma, and H. P. Schweizer. 1998. A broad-host-range Flp-FRT recombination system for site-specific excision of chromosomally located DNA sequences: application for isolation of unmarked Pseudomonas aeruginosa mutants. Gene 212:77-86.
    • (1998) Gene , vol.212 , pp. 77-86
    • Hoang, T.T.1    Karkhoff-Schweizer, R.R.2    Kutchma, A.J.3    Schweizer, H.P.4
  • 14
    • 10044231647 scopus 로고    scopus 로고
    • Interaction between the TolC and AcrA proteins of a multidrug efflux system of Escherichia coli
    • Husain, F., M. Humbard, and R. Misra. 2004. Interaction between the TolC and AcrA proteins of a multidrug efflux system of Escherichia coli. J. Bacteriol. 186:8533-8536.
    • (2004) J. Bacteriol , vol.186 , pp. 8533-8536
    • Husain, F.1    Humbard, M.2    Misra, R.3
  • 15
    • 0025675856 scopus 로고
    • High efficiency transformation of Escherichia coli with plasmids
    • Inoue, H., H. Nojima, and H. Okayama. 1991. High efficiency transformation of Escherichia coli with plasmids. Gene 96:23-28.
    • (1991) Gene , vol.96 , pp. 23-28
    • Inoue, H.1    Nojima, H.2    Okayama, H.3
  • 16
    • 0037417031 scopus 로고    scopus 로고
    • Aminoglycoside efflux in Pseudomonas aeruginosa: Involvement of novel outer membrane proteins
    • Jo, J. T., F. S. Brinkman, and R. E. Hancock. 2003. Aminoglycoside efflux in Pseudomonas aeruginosa: involvement of novel outer membrane proteins. Antimicrob. Agents Chemother. 47:1101-1111.
    • (2003) Antimicrob. Agents Chemother , vol.47 , pp. 1101-1111
    • Jo, J.T.1    Brinkman, F.S.2    Hancock, R.E.3
  • 17
    • 0023715368 scopus 로고
    • Improved broad-host-range plasmids for DNA cloning in gram-negative bacteria
    • Keen, N. T., S. Tamaki, D. Kobayashi, and D. Trollinger. 1988. Improved broad-host-range plasmids for DNA cloning in gram-negative bacteria. Gene 70:191-197.
    • (1988) Gene , vol.70 , pp. 191-197
    • Keen, N.T.1    Tamaki, S.2    Kobayashi, D.3    Trollinger, D.4
  • 18
    • 0034702177 scopus 로고    scopus 로고
    • Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export
    • Koronakis, V., A. Sharff, E. Koronakis, B. Luisi, and C. Hughes. 2000. Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export. Nature 405:914-919.
    • (2000) Nature , vol.405 , pp. 914-919
    • Koronakis, V.1    Sharff, A.2    Koronakis, E.3    Luisi, B.4    Hughes, C.5
  • 19
    • 0029129966 scopus 로고
    • Role of MexA-MexB-OprM in antibiotic efflux in Pseudomonas aeruginosa
    • Li, X. Z., H. Nikaido, and K. Poole. 1995. Role of MexA-MexB-OprM in antibiotic efflux in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 39:1948-1953.
    • (1995) Antimicrob. Agents Chemother , vol.39 , pp. 1948-1953
    • Li, X.Z.1    Nikaido, H.2    Poole, K.3
  • 20
    • 0035185376 scopus 로고    scopus 로고
    • Mutational analysis of the OprM outer membrane component of the MexA-MexB-OprM multidrug efflux system of Pseudomonas aeruginosa
    • Li, X. Z., and K. Poole. 2001. Mutational analysis of the OprM outer membrane component of the MexA-MexB-OprM multidrug efflux system of Pseudomonas aeruginosa. J. Bacteriol. 183:12-27.
    • (2001) J. Bacteriol , vol.183 , pp. 12-27
    • Li, X.Z.1    Poole, K.2
  • 21
  • 22
    • 34248359106 scopus 로고    scopus 로고
    • A periplasmic coiled-coil interface underlying TolC recruitment and the assembly of bacterial drug efflux pumps
    • Lobedanz, S., E. Bokma, M. F. Symmons, E. Koronakis, C. Hughes, and V. Koronakis. 2007. A periplasmic coiled-coil interface underlying TolC recruitment and the assembly of bacterial drug efflux pumps. Proc. Natl. Acad. Sci. USA 104:4612-4617.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 4612-4617
    • Lobedanz, S.1    Bokma, E.2    Symmons, M.F.3    Koronakis, E.4    Hughes, C.5    Koronakis, V.6
  • 23
    • 0026722581 scopus 로고
    • Cross-resistance to meropenem, cephems, and quinolones in Pseudomonas aeruginosa
    • Masuda, N., and S. Ohya. 1992. Cross-resistance to meropenem, cephems, and quinolones in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 36:1847-1851.
    • (1992) Antimicrob. Agents Chemother , vol.36 , pp. 1847-1851
    • Masuda, N.1    Ohya, S.2
  • 24
    • 1342325470 scopus 로고    scopus 로고
    • Differential impact of MexB mutations on substrate selectivity of the MexAB-OprM multidrug efflux pump of Pseudomonas aeruginosa
    • Middlemiss, J. K., and K. Poole. 2004. Differential impact of MexB mutations on substrate selectivity of the MexAB-OprM multidrug efflux pump of Pseudomonas aeruginosa. J. Bacteriol. 186:1258-1269.
    • (2004) J. Bacteriol , vol.186 , pp. 1258-1269
    • Middlemiss, J.K.1    Poole, K.2
  • 25
    • 6044233423 scopus 로고    scopus 로고
    • Role of the membrane fusion protein in the assembly of resistance-nodulation- cell division multidrug efflux pump in Pseudomonas aeruginosa
    • Mokhonov, V. V., E. I. Mokhonova, H. Akama, and T. Nakae. 2004. Role of the membrane fusion protein in the assembly of resistance-nodulation- cell division multidrug efflux pump in Pseudomonas aeruginosa. Biochem. Biophys. Res. Commun. 322:483-489.
    • (2004) Biochem. Biophys. Res. Commun , vol.322 , pp. 483-489
    • Mokhonov, V.V.1    Mokhonova, E.I.2    Akama, H.3    Nakae, T.4
  • 26
    • 0026019764 scopus 로고
    • A series of wide-host-range low-copy-number vectors that allow direct screening for recombinants
    • Morales, V. M., A. Backman, and M. Bagdasarian. 1991. A series of wide-host-range low-copy-number vectors that allow direct screening for recombinants. Gene 97:39-47.
    • (1991) Gene , vol.97 , pp. 39-47
    • Morales, V.M.1    Backman, A.2    Bagdasarian, M.3
  • 27
    • 33748670458 scopus 로고    scopus 로고
    • Crystal structures of a multidrug transporter reveal a functionally rotating mechanism
    • Murakami, S., R. Nakashima, E. Yamashita, T. Matsumoto, and A. Yamaguchi. 2006. Crystal structures of a multidrug transporter reveal a functionally rotating mechanism. Nature 143:173-179.
    • (2006) Nature , vol.143 , pp. 173-179
    • Murakami, S.1    Nakashima, R.2    Yamashita, E.3    Matsumoto, T.4    Yamaguchi, A.5
  • 28
    • 0037057652 scopus 로고    scopus 로고
    • Crystal structure of bacterial multidrug efflux transporter AcrB
    • Murakami, S., R. Nakashima, E. Yamashita, and A. Yamaguchi. 2002. Crystal structure of bacterial multidrug efflux transporter AcrB. Nature 419:587-593.
    • (2002) Nature , vol.419 , pp. 587-593
    • Murakami, S.1    Nakashima, R.2    Yamashita, E.3    Yamaguchi, A.4
  • 29
    • 2342664171 scopus 로고    scopus 로고
    • Assembly of the MexAB-OprM multidrug efflux system of Pseudomonas aeruginosa: Identification and characterization of mutations in mexA compromising MexA multimerization and interaction with MexB
    • Nehme, D., X. Z. Li, R. Elliot, and K. Poole. 2004. Assembly of the MexAB-OprM multidrug efflux system of Pseudomonas aeruginosa: identification and characterization of mutations in mexA compromising MexA multimerization and interaction with MexB. J. Bacteriol. 186:2973-2983.
    • (2004) J. Bacteriol , vol.186 , pp. 2973-2983
    • Nehme, D.1    Li, X.Z.2    Elliot, R.3    Poole, K.4
  • 30
    • 25844457479 scopus 로고    scopus 로고
    • Interaction of the MexA and MexB components of the MexAB-OprM multidrug efflux system of Pseudomonas aeruginosa: Identification of MexA extragenic suppressors of a T578I mutation in MexB
    • Nehme, D., and K. Poole. 2005. Interaction of the MexA and MexB components of the MexAB-OprM multidrug efflux system of Pseudomonas aeruginosa: identification of MexA extragenic suppressors of a T578I mutation in MexB. Antimicrob. Agents Chemother. 49:4375-4378.
    • (2005) Antimicrob. Agents Chemother , vol.49 , pp. 4375-4378
    • Nehme, D.1    Poole, K.2
  • 31
    • 0020512939 scopus 로고
    • Mapping of the gene specifying aminoglycoside 3′-phosphotransferase II on the Pseudomonas aeruginosa chromosome
    • Okii, M., S. Iyobe, and S. Mitsuhashi. 1983. Mapping of the gene specifying aminoglycoside 3′-phosphotransferase II on the Pseudomonas aeruginosa chromosome. J. Bacteriol. 155:643-649.
    • (1983) J. Bacteriol , vol.155 , pp. 643-649
    • Okii, M.1    Iyobe, S.2    Mitsuhashi, S.3
  • 32
    • 0035087832 scopus 로고    scopus 로고
    • Multidrug efflux pumps and antimicrobial resistance in Pseudomonas aeruginosa and related organisms
    • Poole, K. 2001. Multidrug efflux pumps and antimicrobial resistance in Pseudomonas aeruginosa and related organisms. J. Mol. Microbiol. Biotechnol. 3:255-264.
    • (2001) J. Mol. Microbiol. Biotechnol , vol.3 , pp. 255-264
    • Poole, K.1
  • 33
    • 7944229426 scopus 로고    scopus 로고
    • Multidrug efflux pumps and antimicrobial resistance in Pseudomonas aeruginosa and related organisms
    • I. T. Paulsen and K. Lewis ed, Horizon Scientific Press, Norfolk, United Kingdom
    • Poole, K. 2003. Multidrug efflux pumps and antimicrobial resistance in Pseudomonas aeruginosa and related organisms, p. 273-298. In I. T. Paulsen and K. Lewis (ed.), Microbial multidrug efflux. Horizon Scientific Press, Norfolk, United Kingdom.
    • (2003) Microbial multidrug efflux , pp. 273-298
    • Poole, K.1
  • 34
    • 1642422948 scopus 로고    scopus 로고
    • Efflux-mediated multiresistance in gram-negative bacteria
    • Poole, K. 2004. Efflux-mediated multiresistance in gram-negative bacteria. Clin. Microbiol. Infect. 10:12-26.
    • (2004) Clin. Microbiol. Infect , vol.10 , pp. 12-26
    • Poole, K.1
  • 35
    • 34548514885 scopus 로고    scopus 로고
    • Poole, K. 2004. Efflux pumps, p. 635-674. In J.-L. Ramos (ed.), Pseudomonas, I. Genomics, lifestyle and molecular architecture. Kluwer Academic/Plenum Publishers, New York, NY.
    • Poole, K. 2004. Efflux pumps, p. 635-674. In J.-L. Ramos (ed.), Pseudomonas, vol. I. Genomics, lifestyle and molecular architecture. Kluwer Academic/Plenum Publishers, New York, NY.
  • 36
    • 0029815432 scopus 로고    scopus 로고
    • Expression of the multidrug resistance operon mexA-mexB-oprM in Pseudomonas aeruginosa: MexR encodes a regulator of operon expression
    • Poole, K., K. Tetro, Q. Zhao, S. Neshat, D. Heinrichs, and N. Bianco. 1996. Expression of the multidrug resistance operon mexA-mexB-oprM in Pseudomonas aeruginosa: mexR encodes a regulator of operon expression. Antimicrob. Agents Chemother. 40:2021-2028.
    • (1996) Antimicrob. Agents Chemother , vol.40 , pp. 2021-2028
    • Poole, K.1    Tetro, K.2    Zhao, Q.3    Neshat, S.4    Heinrichs, D.5    Bianco, N.6
  • 37
    • 0037312849 scopus 로고    scopus 로고
    • Pyoverdine-mediated regulation of FpvA synthesis in Pseudomonas aeruginosa: Involvement of a probable extracytoplasmic-function sigma factor, FpvI
    • Redly, G. A., and K. Poole. 2003. Pyoverdine-mediated regulation of FpvA synthesis in Pseudomonas aeruginosa: involvement of a probable extracytoplasmic-function sigma factor, FpvI. J. Bacteriol. 185:1261- 1265.
    • (2003) J. Bacteriol , vol.185 , pp. 1261-1265
    • Redly, G.A.1    Poole, K.2
  • 39
    • 33748310520 scopus 로고    scopus 로고
    • Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism
    • Seeger, M. A., A. Schiefner, T. Eicher, F. Verrey, K. Diederichs, and K. M. Pos. 2006. Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism. Science 313:1295-1298.
    • (2006) Science , vol.313 , pp. 1295-1298
    • Seeger, M.A.1    Schiefner, A.2    Eicher, T.3    Verrey, F.4    Diederichs, K.5    Pos, K.M.6
  • 40
    • 33846363597 scopus 로고    scopus 로고
    • Drug export pathway of multidrug exporter AcrB revealed by DARPin inhibitors
    • Sennhauser, G., P. Amstutz, C. Briand, O. Storchenegger, and M. G. Grutter. 2006. Drug export pathway of multidrug exporter AcrB revealed by DARPin inhibitors. PLOS Biol. 5:0106-0113.
    • (2006) PLOS Biol , vol.5 , pp. 0106-0113
    • Sennhauser, G.1    Amstutz, P.2    Briand, C.3    Storchenegger, O.4    Grutter, M.G.5
  • 41
    • 0021027842 scopus 로고
    • A broad host range mobilization system for in vivo genetic engineering: Transposon mutagenesis in gram-negative bacteria
    • Simon, R., U. Priefer, and A. Puehler. 1983. A broad host range mobilization system for in vivo genetic engineering: transposon mutagenesis in gram-negative bacteria. Biotechnology 1:784-791.
    • (1983) Biotechnology , vol.1 , pp. 784-791
    • Simon, R.1    Priefer, U.2    Puehler, A.3
  • 42
    • 18244399839 scopus 로고    scopus 로고
    • Mutations in PA3574 (nalD) lead to increased MexAB-OprM expression and multidrug resistance in laboratory and clinical isolates of Pseudomonas aeruginosa
    • Sobel, M. L., D. Hocquet, L. Cao, P. Plesiat, and K. Poole. 2005. Mutations in PA3574 (nalD) lead to increased MexAB-OprM expression and multidrug resistance in laboratory and clinical isolates of Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 49:1782-1786.
    • (2005) Antimicrob. Agents Chemother , vol.49 , pp. 1782-1786
    • Sobel, M.L.1    Hocquet, D.2    Cao, L.3    Plesiat, P.4    Poole, K.5
  • 43
    • 0141959305 scopus 로고    scopus 로고
    • Contribution of the MexXY multidrug transporter to aminoglycoside resistance in Pseudomonas aeruginosa clinical isolates
    • Sobel, M. L., G. A. McKay, and K. Poole. 2003. Contribution of the MexXY multidrug transporter to aminoglycoside resistance in Pseudomonas aeruginosa clinical isolates. Antimicrob. Agents Chemother. 47:3202-3207.
    • (2003) Antimicrob. Agents Chemother , vol.47 , pp. 3202-3207
    • Sobel, M.L.1    McKay, G.A.2    Poole, K.3
  • 44
    • 0031962577 scopus 로고    scopus 로고
    • Expression of Pseudomonas aeruginosa multidrug efflux pumps MexA-MexB-OprM and MexC-MexD-OprJ in a multidrug-sensitive Escherichia coli strain
    • Srikumar, R., T. Kon, N. Gotoh, and K. Poole. 1998. Expression of Pseudomonas aeruginosa multidrug efflux pumps MexA-MexB-OprM and MexC-MexD-OprJ in a multidrug-sensitive Escherichia coli strain. Antimicrob. Agents Chemother. 42:65-71.
    • (1998) Antimicrob. Agents Chemother , vol.42 , pp. 65-71
    • Srikumar, R.1    Kon, T.2    Gotoh, N.3    Poole, K.4
  • 45
    • 0033953970 scopus 로고    scopus 로고
    • Influence of mutations in the mexR repressor gene on expression of the MexA-MexB-OprM multidrug efflux system of Pseudomonas aeruginosa
    • Srikumar, R., C. J. Paul, and K. Poole. 2000. Influence of mutations in the mexR repressor gene on expression of the MexA-MexB-OprM multidrug efflux system of Pseudomonas aeruginosa. J. Bacteriol. 182:1410-1414.
    • (2000) J. Bacteriol , vol.182 , pp. 1410-1414
    • Srikumar, R.1    Paul, C.J.2    Poole, K.3
  • 46
    • 33748638824 scopus 로고    scopus 로고
    • Importance of the adaptor (membrane fusion) protein hairpin domain for the functionality of multidrug efflux pumps
    • Stegmeier, J. F., G. Polleichtner, N. Brandes, C. Hotz, and C. Andersen. 2006. Importance of the adaptor (membrane fusion) protein hairpin domain for the functionality of multidrug efflux pumps. Biochemistry 45:10303-10312.
    • (2006) Biochemistry , vol.45 , pp. 10303-10312
    • Stegmeier, J.F.1    Polleichtner, G.2    Brandes, N.3    Hotz, C.4    Andersen, C.5
  • 47
    • 23944509010 scopus 로고    scopus 로고
    • Direct interaction of multidrug efflux transporter AcrB and outer membrane channel TolC detected via site-directed disulfide cross-linking
    • Tamura, N., S. Murakami, Y. Oyama, M. Ishiguro, and A. Yamaguchi. 2005. Direct interaction of multidrug efflux transporter AcrB and outer membrane channel TolC detected via site-directed disulfide cross-linking. Biochemistry 44:11115-11121.
    • (2005) Biochemistry , vol.44 , pp. 11115-11121
    • Tamura, N.1    Murakami, S.2    Oyama, Y.3    Ishiguro, M.4    Yamaguchi, A.5
  • 48
    • 3542998054 scopus 로고    scopus 로고
    • AcrA, AcrB, and TolC of Escherichia coli form a stable intermembrane multidrug efflux complex
    • Tikhonova, E. B., and H. I. Zgurskaya. 2004. AcrA, AcrB, and TolC of Escherichia coli form a stable intermembrane multidrug efflux complex. J. Biol. Chem. 279:32116-32124.
    • (2004) J. Biol. Chem , vol.279 , pp. 32116-32124
    • Tikhonova, E.B.1    Zgurskaya, H.I.2
  • 49
    • 3242890387 scopus 로고    scopus 로고
    • Interactions underlying assembly of the Escherichia coli AcrAB-TolC multidrug efflux system
    • Touze, T., J. Eswaran, E. Bokma, E. Koronakis, C. Hughes, and V. Koronakis. 2004. Interactions underlying assembly of the Escherichia coli AcrAB-TolC multidrug efflux system. Mol. Microbiol. 53:697-706.
    • (2004) Mol. Microbiol , vol.53 , pp. 697-706
    • Touze, T.1    Eswaran, J.2    Bokma, E.3    Koronakis, E.4    Hughes, C.5    Koronakis, V.6
  • 50
    • 33847758332 scopus 로고    scopus 로고
    • Membrane protein selectively oriented on solid support and reconstituted into a lipid membrane
    • Trepout, S., S. Mornet, H. Benabdelhak, A. Ducruix, A. R. Brisson, and O. Lambert. 2007. Membrane protein selectively oriented on solid support and reconstituted into a lipid membrane. Langmuir 23:2647-2654.
    • (2007) Langmuir , vol.23 , pp. 2647-2654
    • Trepout, S.1    Mornet, S.2    Benabdelhak, H.3    Ducruix, A.4    Brisson, A.R.5    Lambert, O.6
  • 51
    • 33744748622 scopus 로고    scopus 로고
    • Isolation and characterization of VceC gain-of-function mutants that can function with the AcrAB multiple-drug-resistant efflux pump of Escherichia coli
    • Vediyappan, G., T. Borisova, and J. A. Fralick. 2006. Isolation and characterization of VceC gain-of-function mutants that can function with the AcrAB multiple-drug-resistant efflux pump of Escherichia coli. J. Bacteriol. 188:3757-3762.
    • (2006) J. Bacteriol , vol.188 , pp. 3757-3762
    • Vediyappan, G.1    Borisova, T.2    Fralick, J.A.3
  • 52
    • 0033912430 scopus 로고    scopus 로고
    • Multidrug resistance mechanisms: Drug efflux across two membranes
    • Zgurskaya, H. I., and H. Nikaido. 2000. Multidrug resistance mechanisms: drug efflux across two membranes. Mol. Microbiol. 37:219-225.
    • (2000) Mol. Microbiol , vol.37 , pp. 219-225
    • Zgurskaya, H.I.1    Nikaido, H.2
  • 53
    • 0033039934 scopus 로고    scopus 로고
    • In vivo emergence of multidrug-resistant mutants of Pseudomonas aeruginosa overexpressing the active efflux system MexA-MexB-OprM
    • Ziha-Zarifi, I., C. Llanes, T. Koehler, J.-C. Pechere, and P. Plesiat. 1999. In vivo emergence of multidrug-resistant mutants of Pseudomonas aeruginosa overexpressing the active efflux system MexA-MexB-OprM. Antimicrob. Agents Chemother. 43:287-291.
    • (1999) Antimicrob. Agents Chemother , vol.43 , pp. 287-291
    • Ziha-Zarifi, I.1    Llanes, C.2    Koehler, T.3    Pechere, J.-C.4    Plesiat, P.5


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