Clinically relevant mutations that cause derepression of the Neisseria gonorrhoeae MtrC-MtrD-MtrE Efflux pump system confer different levels of antimicrobial resistance and in vivo fitness

Molecular Microbiology

Volumn 70, Issue 2, 2008, Pages 462-478

  Warner, Douglas M ^a,d   Shafer, William M ^b,c   Jerse, Ann E ^a  

^a Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c ATLANTA VA MEDICAL CENTER   (United States)

^d TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZITHROMYCIN; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; CRAMP 38; ERYTHROMYCIN; KANAMYCIN; POLYPEPTIDE ANTIBIOTIC AGENT; PROGESTERONE; TRITON X 100; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BINDING SITE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE LOCUS; GENE MUTATION; GENETIC TRANSCRIPTION; IN VIVO STUDY; MINIMUM INHIBITORY CONCENTRATION; MOUSE; MTRC GENE; MTRD GENE; MTRE GENE; NEISSERIA GONORRHOEAE; NONHUMAN; OPERON; PHENOTYPE; PRIORITY JOURNAL; RNA STABILITY; WILD TYPE;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; AZITHROMYCIN; BACTERIAL OUTER MEMBRANE PROTEINS; BACTERIAL PROTEINS; DRUG RESISTANCE, BACTERIAL; ERYTHROMYCIN; FEMALE; GENE EXPRESSION PROFILING; GONORRHEA; LIPOPROTEINS; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; MICE; MICE, INBRED BALB C; MUTATION; NEISSERIA GONORRHOEAE; PROGESTERONE; PROMOTER REGIONS, GENETIC; REPRESSOR PROTEINS; RNA STABILITY; VIRULENCE;

MURINAE; NEISSERIA GONORRHOEAE;

EID: 52649131941     PISSN: 0950382X     EISSN: 13652958     Source Type: Journal    
DOI: 10.1111/j.1365-2958.2008.06424.x     Document Type: Article

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