Cefuroxime non-susceptibility in multidrug-resistant Klebsiella pneumoniae overexpressing ramA and acrA and expressing ompK35 at reduced levels

Journal of Antimicrobial Chemotherapy

Volumn 62, Issue 5, 2008, Pages 986-990

  Källman, Owe ^a   Motakefi, Alma ^a   Wretlind, Bengt ^a   Kalin, Mats ^a   Olsson Liljequist, Barbro ^b   Giske, Christian G ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b SWEDISH INSTITUTE FOR INFECTIOUS DISEASE CONTROL   (Sweden)

Author keywords

Bacterial; Cephalosporins; Drug resistance; Efflux; MDR; Porins

Indexed keywords

2 NAPHTHYLAMINE; ANTIBIOTIC AGENT; ARGININE; BACTERIAL PROTEIN; CEFOTAXIME; CEFTAZIDIME; CEFUROXIME; CHLORAMPHENICOL; CIPROFLOXACIN; CLAVULANIC ACID; COTRIMOXAZOLE; GENE PRODUCT; NALIDIXIC ACID; PHENYLALANINE; PORIN; PROTEIN ACRA; PROTEIN OMPK35; PROTEIN RAMA; PROTEIN SOXS; TETRACYCLINE; TIGECYCLINE; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL STRAIN; BACTERIUM ISOLATE; BLOOD CULTURE; CONTROLLED STUDY; DNA SEQUENCE; DOWN REGULATION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; HUMAN; KLEBSIELLA PNEUMONIAE; MULTIDRUG RESISTANCE; NONHUMAN; NUCLEOTIDE SEQUENCE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BLOOD; CEFUROXIME; DRUG RESISTANCE, MULTIPLE, BACTERIAL; GENE EXPRESSION PROFILING; GENES, BACTERIAL; HUMANS; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; PORINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION, GENETIC;

EID: 54549118261     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkn296     Document Type: Article

References (11)

1. Poole K. Resistance to β-lactam antibiotics. Cell Mol Life Sci 2004; 61: 2200-23.
2. Lee CH, Chia JH, Chu C et al. In vivo selection of OmpK35-deficient mutant after cefuroxime therapy for primary liver abscess caused by Klebsiella pneumoniae. J Antimicrob Chemother 2006; 58: 857-60.
3. Källman O, Fendukly F, Karlsson I et al. Contribution of efflux to cefuroxime resistance in clinical isolates of Escherichia coli. Scand J Infect Dis 2003; 35: 464-70.
4. Schneiders T, Amyes SG, Levy SB. Role of AcrR and RamA in fluoroquinolone resistance in clinical Klebsiella pneumoniae isolates from Singapore. Antimicrob Agents Chemother 2003; 47 2831-7.
5. George AM, Hall RM, Stokes HW. Multidrug resistance in Klebsiella pneumoniae: A novel gene, ramA, confers a multidrug resistance phenotype in Escherichia coli. Microbiology 1995; 141: 1909-20.
6. Ruzin A, Visalli MA, Keeney D et al. Influence of transcriptional activator RamA on expression of multidrug efflux pump AcrAB and tigecycline susceptibility in Klebsiella pneumoniae. Antimicrob Agents Chemother 2005; 49: 1017-22.
7. George AM, Levy SB. Amplifiable resistance to tetracycline, chloramphenicol, and other antibiotics in Escherichia coli: involvement of a non-plasmid-determined efflux of tetracycline. J Bacteriol 1983; 155: 531-40.
8. El Amin N, Giske CG, Jalal S et al. Carbapenem resistance mechanisms in Pseudomonas aeruginosa: Alterations of porin OprD and efflux proteins do not fully explain resistance patterns observed in clinical isolates. APMIS 2005; 113: 187-96.
9. Tullus K, Burman LG, Haeggman S et al. Epidemiologic typing of international collections of Klebsiella spp.: Computerized biochemical fingerprinting compared with serotyping, phage typing and pulsed-field gel electrophoresis. Clin Microbiol Infect 1999; 5 184-9.
10. Gutmann L, Williamson R, Moreau N et al. Cross-resistance to nalidixic acid, trimethoprim, and chloramphenicol associated with alterations in outer membrane proteins of Klebsiella, Enterobacter and Serratia. J Infect Dis 1985; 151: 501-7.
11. Schumacher H, Scheibel J, Moller JK. Cross-resistance patterns among clinical isolates of Klebsiella pneumoniae with decreased susceptibility to cefuroxime. J Antimicrob Chemother 2000; 46 215-21.