Multiple antibiotic resistance (mar) locus protects Escherichia coli from rapid cell killing by fluoroquinolones

Antimicrobial Agents and Chemotherapy

Volumn 40, Issue 5, 1996, Pages 1266-1269

  Goldman, John D ^a   White, David G ^a   Levy, Stuart B ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

QUINOLINE DERIVED ANTIINFECTIVE AGENT;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERICIDAL ACTIVITY; CELL KILLING; COLONY FORMING UNIT; DELETION MUTANT; ESCHERICHIA COLI; GENE LOCUS; MINIMUM INHIBITORY CONCENTRATION; OPERON; PHENOTYPE; PRIORITY JOURNAL; REGULON;

EID: 0029966719     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.40.5.1266     Document Type: Article

References (22)

1. Aguiar, J. M., J. Chacon, R. Canton, and F. Baquero. 1992. The emergence of highly fluoroqumolone-resistant Escherichia coli in community-acquired urinary tract infections. J. Antimicrob. Chcmother. 29:349-350.
2. Barry, A. L., P. C. Fuchs, M. A. Pfaller, S. D. Allen, and E. H. Gerlach. 1990. Prevalence of fluoroquinolone-resistant bacterial isolates in four medical centers during the first quarter of 1990 Eur. J. Clin. Microbiol Infect. Dis. 9:906-908.
3. Black, D. S., B. Irwin, and H. S. Moyed. 1994. Autoregulation of hip. an operon that affects lethality due to inhibition of peptidoglycan or DNA synthesis J. Bacteriol. 176:4081-4091.
4. Black, D. S., A. J. Kelly, M. J. Mardis, and H. S. Moyed. 1991. Structure and organization of hip. an operon that affects, lethality due to inhibition of peptidoglycan or DNA synthesis. J. Bacteriol. 172:5732-5739.
5. Cohen, S., H. Hächler, and S. B. Levy. 1993. Genetic and functional analysis of the multiple antibiotic resistance (mar) locus in Escherichia coli. J. Bacteriol. 175:1484-1492
6. Cohen, S. P., L. McMurry, D. Hooper, J. Wolfson, and S. B. Levy. 1989. Cross resistance to fluoroquinolones in multiple antibiotic resistant (Mar) Escherichia coli selected by tetracycline or chloramphenicol: decreased drug accumulation associated with membrane changes in addition to OmpF reduction. Antimicrob. Agents Chemother. 33:1318-1325.
7. Cohen, S. P., L. McMurry, and S. B. Levy. 1988. marA locus causes decreased expression of the OmpF porin in multiple antibiotic resistant (mar) mutants of Escherichia coli. J. Bacteriol. 170:5416-5422.
8. Cohen, S. P., W. Yan, and S. B. Levy. 1993. A multidrug resistance regulatory chromosomal locus is widespread among enteric bacteria. J. Infect. Dis. 168:484-488.
9. Gambino, L., S. J. Gracheck, and P. F. Miller. 1993. Overexpression of the MarA positive regulator is sufficient to confer multiple antibiotic resistance in Eschencliia coh J. Bacteriol. 175:2888-2894.
10. George, A., and S. B. Levy. 1983. Amplifiable resistance to tetracycline, chloramphenicol. and other antibiotics in Escherichia coli' involvement of a non-plasmid-determined efflux of tetracychne. J. Bacteriol. 155:531-540
11. Hächler, H., S. P. Cohen, and S. B. Levy. 1991. mar A. a regulated locus which controls expression of chromosomal multiple antibiotic resistance in Escherichia coli. J. Bacteriol 173:5532-5538.
12. Hamilton, C. M., M. Aldema, B. K. Washburn, P. Babitzke, and S. Kushner. 1989. New method for generating deletions and gene replacements in Eschenchia coli. J. Bacteriol. 171:4617-1622.
13. Hooper, D., and J. Wolfson. 1993. Mechanisms ot quinolone action and bacterial killing, p. 53-75. In D Hooper and J. Wolfson (ed.). Quinolone antimicrobial agents.. 2nd ed. American Society for Microbiology. Washington. D C.
14. Lewin, C., J. Morrissey, and J. T. Smith. 1984 The mode of action of quinolones: the paradox in activity of low and high concentrations and activity in the anerobic environment. Eur. J Clin Microbiol. Infect Dis 10:240-248.
15. Maneewannakul, K., and S. B. Levy. Identification of mar mutants among quinolone-resistant clinical isolates of Escherichia coli. Submitted for publication
16. Martin, R. G., and J. L. Rosner. 1995. Binding of purified multiple antibiotic resistance repressor protein (MarR) to mar operator sequences. Proc. Natl. Acad. Sci. USA 92:5456-5460.
17. McMurry, L. M., A. M. George, and S. B. Levy. 1994 Active efflux of chloramphenicol in susceptible Escherichia coli strains and in multiple antibiotic resistance (Mar) mutants. Antimicrob. Agents Chemother. 38:542-546.
18. Perez-Trallero, E., M. Urbieta, D. Jimenez, J. M. Garcia-Arenzana, and G. Cilla. 1993. Ten-year surveys of quinolone resistance in Escherichia coli causing urinary tract infections Eur. J Clin. Microbiol. Infect. Dis. 12:349-351.
19. Seoane, A., and S. B. Levy. 1995. Characterization of MarR. the repressor of the multiple antibiotic resistance (mar) in Escherichia cali. J. Bacteriol 177:3414-3419.
20. White, D. G., W. Yan, and S. B. Levy. Contribution of both operons of the chromosomal multiple antibiotic resistance (mar) locus in Escherichia coli to the Mar phenotype. Submitted for publication.
21. Wolfson, J., D. Hooper, G. McHugh, M. Bozza, and M. Swartz. 1990. Mutants of Escherichia coli K-12 exhibiting reduced killing by both quinolone and β-lactam antibiotics. Antimicrob. Agents Chemother 34:1938-1943.
22. Yan, W., S. P. Cohen, and S. B. Levy. 1992 Three putative proteins in the mar operon mediate intrinsic multidrug resistance in Escherichia coli. abstr. A-26. p 5. In Abstracts of the 1992 General Meeting of the American Society for Microbioloyg 1992 American Society for Microbiology. Washington. D C.