Enhanced active efflux, repression of porin synthesis and development of Mar phenotype by diazepam in two enterobacteria strains

Journal of Medical Microbiology

Volumn 53, Issue 11, 2004, Pages 1119-1122

  Tavío, María M ^a   Vila, Jordi ^b   Perilli, Mariagrazia ^c   Casañas, Lucia T ^a   Maciá, Laura ^a   Amicosante, Gianfranco ^c   Jiménez De Anta, María T ^b  

^a UNIVERSITY OF LAS PALMAS DE GRAN CANARIA   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

^c UNIVERSITY OF L'AQUILA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOIC ACID; BETA LACTAM ANTIBIOTIC; CHLORAMPHENICOL; DIAZEPAM; NALIDIXIC ACID; NORFLOXACIN; PORIN; SALICYLATE SODIUM; TETRACYCLINE;

ACTIVE TRANSPORT; ANTIBIOTIC RESISTANCE; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL INFECTION; ENTEROBACTER; GENETIC SUSCEPTIBILITY; IMMUNE RESPONSE; MULTIDRUG RESISTANCE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRAIN DIFFERENCE; SURVIVAL;

ANTI-BACTERIAL AGENTS; BACTERIAL OUTER MEMBRANE PROTEINS; BIOLOGICAL TRANSPORT, ACTIVE; CYTOPLASM; DIAZEPAM; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ENZYME ACTIVATORS; ESCHERICHIA COLI; GENE EXPRESSION REGULATION, BACTERIAL; KLEBSIELLA PNEUMONIAE; MICROBIAL SENSITIVITY TESTS; NORFLOXACIN; PORINS; SODIUM BENZOATE; SODIUM SALICYLATE;

EID: 11144231757     PISSN: 00222615     EISSN: None     Source Type: Journal    
DOI: 10.1099/jmm.0.45613-0     Document Type: Article

References (16)

1. Alekshun, M. N. & Levy, S. B. (1997), Regulation of chromosomally mediated multiple antibiotic resistance: the mar regulon. Antimicrob Agents Chemother 41, 2067-2075.
2. Balaguė, C. & Vescovi, E. G. (2001). Activation of multiple antibiotic resistance in uropathogenic Escherichia coli strains by aryloxoalcanoic acid compounds. Antimicrob Agents Chemother 45, 1815-1822.
3. Covelli, V., Munno, I., Decandia, P., Altamura, M., Cannuscio, B., Maffione, A. B. & Jirillo, E. (1891). Effects of benzodiazepines on the immune system. Acta Neurol (Napoli) 13, 418-423.
4. Doménech-Sánchez, A., Martínez-Martínez, L., Hernández-Allés, S., Conejo, M. C., Pascual, A., Tomás, J. M., Alberti, S. & Benedí, V. J. (2003). Role of Klebsiella pneumoniae OmpK35 porin in antimicrobial resistance. Antimicrob Agents Chemother 47, 3332-3335.
5. Galdiero, F., Bentivoglio, C., Nuzzo, I., Ianniello, R., Capasso, C., Mattera, S., Nazzaro, C., Galdiero, M. & Romano Carratelli, C. (1995). Effects of benzodiazepines on immunodeficiency and resistance in mice. Life Sci 57, 2413-2423.
6. George, A. M., Hall, R. M. & Stokes, H. W. (1995). Multidrug resistance in Klebsiella pneumoniae: a novel gene, ramA, confers a multidrug resistance phenotype in Escherichia coli. Microbiology 141, 1909-1920.
7. Kern, W. V., Oethinger, M., Jellen-Ritter, A. S. & Levy, S. B. (2000). Non-target gene mutations in the development of fluoroquinolone resistance in Escherichia coli. Antimicrob Agents Chemother 44, 814-820.
8. Laschi, A., Descotes, J., Tachon, P. & Evreux, J. C. (1983). Adverse influence of diazepam upon resistance to Klebsiella pneumoniae infection in mice. Toxicol Lett 16, 281-284.
9. Martínez-Martínez, L, García, I., Ballesta, S, Benedí, V. J., Hernández-Allés, S. & Pascual, A. (1998). Energy-dependent accumulation of fluoroquinolones in quinolone-resistant Klebsiella pneumoniae strains. Antimicrob Agents Chemother 42, 1850-1852.
10. Martínez-Martínez, L., Pascual, A., Conejo, M. C., García, I., Joyanes, P., Doménech-Sánchez, A. & Benedí, V. J. (2002). Energy-dependent accumulation of norfloxacin and porin expression in clinical isolates of Klebsiella pneumoniae and relationship to extended-spectrum β-lactamase production. Antimicrob Agents Chemother 46, 3926-3932.
11. Mortimer, P. G. & Piddock, L. J. (1993). The accumulation of five antibacterial agents in porin-deficient mutants of Escherichia coli. J Antimicrob Chemother 32, 195-213.
12. NCCLS, (2003a). Methods for dilution susceptibility for bacteria that grow aerobically; approved standard 6th edn. M07-A6. Wayne, PA: National Committee for Clinical Laboratory Standards.
13. NCCLS, (2003b). Performance standards for antimicrobial disk susceptibility tests; approved standard 8th edn. M02-A8. Wayne, PA: National Committee for Clinical Laboratory Standards.
14. Oethinger, M., Kern, W. V., Jellen-Ritter, A. S., McMurry, L. M. & Levy, S. B. (2000). Ineffectiveness of topoisomerase mutations in mediating clinically significant fluoroquinolone resistance in Escherichia coli in the absence of the AcrAB efflux pump. Antimicrob Agents Chemother 44, 10-13.
15. Schneiders, T., Amyes, S. G. B. & Levy, S. B. (2003). Role of AcrR and RamA in fluoroquinolone resistance in clinical Klebsiella pneumoniae isolates from Singapore. Antimicrob Agents Chemother 47, 2831-2837.
16. Tavio, M. M., Vila, J., Ruiz, J., Ruiz, J., Martin-Sänchez, A. M. & Jiménez de Anta, M. T. (1999). Mechanisms involved in the development of resistance to fluoroquinolones in Escherichia coli isolates. J Antimicrob Chemother 44, 735-742.