Expression of the efflux pump genes cmeB, cmeF and the porin gene porA in multiple-antibiotic-resistant Campylobacter jejuni

Journal of Antimicrobial Chemotherapy

Volumn 54, Issue 2, 2004, Pages 341-347

  Pumbwe, Lilian ^a   Randall, Luke P ^b   Woodward, Martin J ^b   Piddock, Laura J V ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b VETERINARY LABORATORIES AGENCY   (United Kingdom)

Author keywords

Antibiotic resistance; Transporter

Indexed keywords

ACRIDINE ORANGE; ALANINE; AMPICILLIN; ANTIBIOTIC AGENT; CARBONYL CYANIDE CHLOROPHENYLHYDRAZONE; CHLORAMPHENICOL; CIPROFLOXACIN; DEOXYCHOLATE SODIUM; DODECYL SULFATE SODIUM; ERYTHROMYCIN; ETHIDIUM BROMIDE; GLYCINE; KANAMYCIN; MEMBRANE PROTEIN; OUTER MEMBRANE PROTEIN F; PORIN; PORIN A; PROTEIN CMEB; PROTEIN MARA; PROTEIN SOXS; REGULATOR PROTEIN; TETRACYCLINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL STRAIN; BACTERIUM ISOLATE; CAMPYLOBACTER JEJUNI; CONTROLLED STUDY; DENATURING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; GENE EXPRESSION; GENE MUTATION; GENE OVEREXPRESSION; MULTIDRUG RESISTANCE; NONHUMAN; POULTRY; REGULATOR GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY; WILD TYPE;

ANTI-INFECTIVE AGENTS; BACTERIAL PROTEINS; BETA-LACTAMASES; CAMPYLOBACTER JEJUNI; CIPROFLOXACIN; CULTURE MEDIA; DNA GYRASE; DNA PRIMERS; DNA-BINDING PROTEINS; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GENE EXPRESSION REGULATION, BACTERIAL; MEMBRANE TRANSPORT PROTEINS; MICROBIAL SENSITIVITY TESTS; PORINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANS-ACTIVATORS;

EID: 4444336144     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/dkh331     Document Type: Article

References (21)

1. Aarestrup, F. M. & Engberg, J. (2001). Antimicrobial resistance of thermophilic Campylobacter. Veterinary Research 32, 311-21.
2. Allos, B. M. (2001). Campylobacter jejuni infections: update on emerging issues and trends. Clinical Infectious Diseases 32, 1201-6.
3. Tam, C. C., Rodrigues, L. C. & O'Brien, S. J. (2003). Guillain-Barre syndrome associated with Campylobacter jejuni infection in England, 2000-2001. Clinical Infectious Diseases 37, 307-10.
4. Webber, M. A. & Piddock, L. J. V. (2003). The importance of efflux pumps in bacterial antibiotic resistance. Journal of Antimicrobial Chemotherapy 51, 9-11.
5. Pumbwe, L. & Piddock, L. J. V. (2002). Identification and molecular characterisation of CmeB, a Campylobacter jejuni multidrug efflux pump. FEMS Microbiology Letters 206, 185-9.
6. Lin, J., Michel, L. O. & Zhang, Q. (2002). CmeABC functions as a multidrug efflux system in Campylobacter jejuni. Antimicrobial Agents and Chemotherapy 46, 2124-31.
7. Lin, J., Sahin, O., Michel, L. O. et al. (2003). Critical role of the multidrug efflux pump CmeABC in bile resistance and in vivo colonization of Campylobacter jejuni. Infection and Immunity 8, 4250-9.
8. Cohen, S. P., McMurray, L. M. & Levy, S. B. (1988). marA locus causes decreased expression of OmpF porin in multiple-antibiotic-resistant (Mar) mutants of Escherichia coli. Journal of Bacteriology 170, 5416-22.
9. Bolla, J. M., De, E., Dorez, A. et al. (2000). Purification, characterization and sequence analysis of Omp50 a new porin isolated from Campylobacter jejuni. Biochemical Journal 352, 637-43.
10. Schroder, W. & Morger, I. (1997). Primary structure analysis and adhesion studies on the major outer membrane protein of Campylobacter jejuni. FEMS Microbiology Letters 150, 141-7.
11. Page, W., Huyer, G., Huyer, M. et al. (1989). Characterization of the porins of Campylobacter jejuni and Campylobacter coli and implications for antibiotic susceptibility. Antimicrobial Agents and Chemotherapy 33, 297-303.
12. Randall, I. P., Ridley, A. M., Cooles, S. W. et al. (2003). Prevalence of multiple antibiotic resistance in 443 Campylobacter spp. isolated from humans and animals. Journal of Antimicrobial Chemotherapy 52, 507-10.
13. McDermott, P., Bodeis, S., Aarestrup, F. et al. (2004). Development of a standardized susceptibility, test for Campylobacter with quality control ranges for ciprofloxacin, moxifloxacin, erythromycin, gentamicin and meropenem. Microbial Drug Resistance 10, in press.
14. Piddock, L. J. V., Ricci, V., Pumbwe, L. et al. (2003). Fluoroquinolone resistance in Campylobacter species from man and animals: detection of mutations in topoisomerase genes. Journal of Antimicrobial Chemotherapy 51, 19-26.
15. Parkhill, J., Wren, B. W., Mungall, K. et al. (2000). The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences. Nature 403, 665-8.
16. Eaves, D. J. V., Liebana, E., Woodward, M. J. et al. (2002). Detection of gyrA mutations in quinolone resistant Salmonella enterica by denaturing high performance liquid chromatography. Journal of Clinical Microbiology 40, 4121 -5.
17. Eaves, D. J., Ricci, V. & Piddock, L. J. V. (2004). Expression of acrB, acrF, marA and soxS in efflux pump mutants of Salmonella Typhimurium. Antimicrobial Agents and Chemotherapy 48,1145-50.
18. Everett, M., Jin, Y. F., Ricci, V. et al. (1996). Contribution of individual mechanisms to fluoroquinolone resistance in Escherichia coli strains isolated from humans and animals. Antimicrobial Agents and Chemotherapy 40, 2380-6.
19. Stintzi, A. (2003). Gene expression profile for Campylobacter jejuni in response to growth temperature variation. Journal of Bacteriology 185, 2009-16.
20. Gaynor, E. C., Cawthraw, S., Manning, G. et al. (2004). The genome-sequence variant of Campylobacter jejuni NCTC 11168 and the original clonal clinical isolate differ markedly in colonization, gene expression and virulence-associated phenotypes. Journal of Bacteriology 186, 503-17.
21. Lin, J., Sahin, O., Zhang, Q. et al. (2003). Regulatory mechanisms of the efflux pump CmeABC in Campylobacter jejuni. In Program and Abstracts of the 12th International Workshop on Campylobacter, Helicobacter and Related Organisms, 6-10 September 2003, Aarhus, Denmark. Abstract F44 p. 20. Urban and Fisher Verlag.