Prevalence, mechanisms, and risk factors of carbapenem resistance in bloodstream isolates of Pseudomonas aeruginosa

Diagnostic Microbiology and Infectious Disease

Volumn 58, Issue 3, 2007, Pages 309-314

  Tam, Vincent H ^a,b   Chang, Kai Tai ^a   LaRocco, Mark T ^b   Schilling, Amy N ^a   McCauley, Shana K ^a   Poole, Keith ^c   Garey, Kevin W ^a,b  

^a UNIVERSITY OF HOUSTON   (United States)

^b ST LUKE S EPISCOPAL HOSPITAL   (United States)

^c QUEEN S UNIVERSITY   (Canada)

Author keywords

Bloodstream infection; Carbapenem resistance; Prevalence; Pseudomonas aeruginosa

Indexed keywords

AMIKACIN; AMINOGLYCOSIDE ANTIBIOTIC AGENT; CARBAPENEM; CEFEPIME; CEFTAZIDIME; CEPHALOSPORIN; CLOXACILLIN; GENOMIC DNA; IMIPENEM; LEVOFLOXACIN; MEROPENEM; OUTER MEMBRANE PROTEIN; PIPERACILLIN PLUS TAZOBACTAM; QUINOLINE DERIVED ANTIINFECTIVE AGENT; TOBRAMYCIN;

ADULT; AGED; ANTIBIOTIC RESISTANCE; ANTIBIOTIC THERAPY; ARTICLE; BACTEREMIA; BACTERIUM CULTURE; BACTERIUM ISOLATE; BLOOD CULTURE; CEREBROVASCULAR ACCIDENT; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; COMORBIDITY; CONGESTIVE HEART FAILURE; CORONARY ARTERY DISEASE; DIABETES MELLITUS; DRUG CHOICE; FEMALE; GENOTYPE; HOSPITAL INFECTION; HOSPITAL PATIENT; HUMAN; HYPERTENSION; KIDNEY FAILURE; LENGTH OF STAY; MALE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PERIPHERAL VASCULAR DISEASE; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PREVALENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PSEUDOMONAS AERUGINOSA; RISK FACTOR; SEX DIFFERENCE; SOLID TUMOR; SPECTROPHOTOMETRY; TREATMENT PLANNING; UNIVERSITY HOSPITAL; WESTERN BLOTTING;

AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; BACTEREMIA; BACTERIAL OUTER MEMBRANE PROTEINS; BETA-LACTAMASES; BLOTTING, WESTERN; CARBAPENEMS; CARRIER PROTEINS; CLUSTER ANALYSIS; DNA FINGERPRINTING; DRUG RESISTANCE, BACTERIAL; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FEMALE; HOSPITALS, UNIVERSITY; HUMANS; LENGTH OF STAY; MALE; MICROBIAL SENSITIVITY TESTS; MIDDLE AGED; PREVALENCE; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; RISK FACTORS;

EID: 34347324927     PISSN: 07328893     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.diagmicrobio.2007.05.006     Document Type: Article

References (24)

1. Carvalho A.P., Albano R.M., de Oliveira D.N., Cidade D.A., Teixeira L.M., and Marques Ede A. Characterization of an epidemic carbapenem-resistant Pseudomonas aeruginosa producing SPM-1 metallo-beta-lactamase in a hospital located in Rio de Janeiro, Brazil. Microb. Drug. Resist. 12 (2006) 103-108
2. Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Testing: Seventeenth Informational Supplement. CLSI Document M100-S17 (2007) (Clinical and Laboratory Standards Institute, Wayne, PA)
3. El Amin N., Giske C.G., Jalal S., Keijser B., Kronvall G., and Wretlind B. Carbapenem resistance mechanisms in Pseudomonas aeruginosa: alterations of porin OprD and efflux proteins do not fully explain resistance patterns observed in clinical isolates. APMIS 113 (2005) 187-196
4. Gales A.C., Sader H.H., and Jones R.N. Respiratory tract pathogens isolated from patients hospitalized with suspected pneumonia in Latin America: frequency of occurrence and antimicrobial susceptibility profile: results from the SENTRY Antimicrobial Surveillance Program (1997-2000). Diagn. Microbiol. Infect. Dis. 44 (2002) 301-311
5. Gaynes R., and Edwards J.R. Overview of nosocomial infections caused by gram-negative bacilli. Clin. Infect. Dis. 41 (2005) 848-854
6. Landman D., Quale J.M., Mayorga D., Adedeji A., Vangala K., Ravishankar J., Flores C., and Brooks S. Citywide clonal outbreak of multiresistant Acinetobacter baumannii and Pseudomonas aeruginosa in Brooklyn, NY: the preantibiotic era has returned. Arch. Intern. Med. 162 (2002) 1515-1520
7. Lauretti L., Riccio M.L., Mazzariol A., Cornaglia G., Amicosante G., Fontana R., and Rossolini G.M. Cloning and characterization of blaVIM, a new integron-borne metallo-beta-lactamase gene from a Pseudomonas aeruginosa clinical isolate. Antimicrob. Agents Chemother. 43 (1999) 1584-1590
8. Livermore D.M. Multiple mechanisms of antimicrobial resistance in Pseudomonas aeruginosa: our worst nightmare?. Clin. Infect. Dis. 34 (2002) 634-640
9. Lolans K., Queenan A.M., Bush K., Sahud A., and Quinn J.P. First nosocomial outbreak of Pseudomonas aeruginosa producing an integron-borne metallo-beta-lactamase (VIM-2) in the United States. Antimicrob. Agents Chemother. 49 (2005) 3538-3540
10. Lomovskaya O., Warren M.S., Lee A., Galazzo J., Fronko R., Lee M., Blais J., Cho D., Chamberland S., Renau T., Leger R., Hecker S., Watkins W., Hoshino K., Ishida H., and Lee V.J. Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: novel agents for combination therapy. Antimicrob. Agents Chemother. 45 (2001) 105-116
11. Masuda N., Sakagawa E., Ohya S., Gotoh N., Tsujimoto H., and Nishino T. Substrate specificities of MexAB-OprM, MexCD-OprJ, and MexXY-oprM efflux pumps in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 44 (2000) 3322-3327
12. Middlemiss J.K., and Poole K. Differential impact of MexB mutations on substrate selectivity of the MexAB-OprM multidrug efflux pump of Pseudomonas aeruginosa. J. Bacteriol. 186 (2004) 1258-1269
13. Pai H., Kim J., Lee J.H., Choe K.W., and Gotoh N. Carbapenem resistance mechanisms in Pseudomonas aeruginosa clinical isolates. Antimicrob. Agents Chemother. 45 (2001) 480-484
14. Patzer J., Toleman M.A., Deshpande L.M., Kaminska W., Dzierzanowska D., Bennett P.M., Jones R.N., and Walsh T.R. Pseudomonas aeruginosa strains harbouring an unusual blaVIM-4 gene cassette isolated from hospitalized children in Poland (1998-2001). J. Antimicrob. Chemother. 53 (2004) 451-456
15. Poirel L., Naas T., Nicolas D., Collet L., Bellais S., Cavallo J.D., and Nordmann P. Characterization of VIM-2, a carbapenem-hydrolyzing metallo-beta-lactamase and its plasmid- and integron-borne gene from a Pseudomonas aeruginosa clinical isolate in France. Antimicrob. Agents Chemother. 44 (2000) 891-897
16. Quale J., Bratu S., Gupta J., and Landman D. Interplay of efflux system, ampC, and oprD expression in carbapenem resistance of Pseudomonas aeruginosa clinical isolates. Antimicrob. Agents Chemother. 50 (2006) 1633-1641
17. Quinn J.P., Darzins A., Miyashiro D., Ripp S., and Miller R.V. Imipenem resistance in Pseudomonas aeruginosa PAO: mapping of the OprD2 gene. Antimicrob. Agents Chemother. 35 (1991) 753-755
18. Saeed S., Fakih M.G., Riederer K., Shah A.R., and Khatib R. Interinstitutional and intrainstitutional transmission of a strain of Acinetobacter baumannii detected by molecular analysis: comparison of pulsed-field gel electrophoresis and repetitive sequence-based polymerase chain reaction. Infect. Control. Hosp. Epidemiol. 27 (2006) 981-983
19. Srikumar R., Paul C.J., and Poole K. Influence of mutations in the mexR repressor gene on expression of the MexA-MexB-oprM multidrug efflux system of Pseudomonas aeruginosa. J. Bacteriol. 182 (2000) 1410-1414
20. Syrmis M.W., O'Carroll M.R., Sloots T.P., Coulter C., Wainwright C.E., Bell S.C., and Nissen M.D. Rapid genotyping of Pseudomonas aeruginosa isolates harboured by adult and paediatric patients with cystic fibrosis using repetitive-element-based PCR assays. J. Med. Microbiol. 53 (2004) 1089-1096
21. Tam V.H., Schilling A.N., Melnick D.A., and Coyle E.A. Comparison of beta-lactams in counter-selecting resistance of Pseudomonas aeruginosa. Diagn. Microbiol. Infect. Dis. 52 (2005) 145-151
22. Tam V.H., Schilling A.N., Neshat S., Poole K., Melnick D.A., and Coyle E.A. Optimization of meropenem minimum concentration/MIC ratio to suppress in vitro resistance of Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 49 (2005) 4920-4927
23. Tam V.H., Schilling A.N., LaRocco M.T., Gentry L.O., Lolans K., Quinn J.P., and Garey K.W. Prevalence of AmpC over-expression in bloodstream isolates of Pseudomonas aeruginosa. Clin. Microbiol. Infect. 13 (2007) 413-418
24. Vidal F., Mensa J., Almela M., Martinez J.A., Marco F., Casals C., Gatell J.M., Soriano E., and Jimenez de Anta M.T. Epidemiology and outcome of Pseudomonas aeruginosa bacteremia, with special emphasis on the influence of antibiotic treatment. Analysis of 189 episodes. Arch. Intern. Med. 156 (1996) 2121-2126