Deletion of TolC orthologs in Francisella tularensis identifies roles in multidrug resistance and virulence

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 34, 2006, Pages 12897-12902

  Gil, Horacio ^a,c   Platz, Gabrielle J ^a   Forestal, Colin A ^a   Monfett, Michael ^a   Bakshi, Chandra Shekhar ^b   Sellati, Timothy J ^b   Furie, Martha B ^a   Benach, Jorge L ^a   Thanassi, David G ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b ALBANY MEDICAL COLLEGE   (United States)

^c INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

Bacterial pathogenesis; Multidrug efflux; Type I secretion

Indexed keywords

BACTERIAL PROTEIN; DETERGENT; DYE; OUTER MEMBRANE PROTEIN; TOLC PROTEIN; VIRULENCE FACTOR;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIAL GENOME; BACTERIAL MUTATION; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BIOLOGICAL WARFARE; ESCHERICHIA COLI; FRANCISELLA TULARENSIS; FTLC GENE; GENE DELETION; GENE MUTATION; GENETIC COMPLEMENTATION; MACROPHAGE; MULTIDRUG RESISTANCE; NONHUMAN; NUCLEOTIDE SEQUENCE; ORTHOLOGY; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; TOLC GENE; TULAREMIA;

ANIMALS; BACTERIAL OUTER MEMBRANE PROTEINS; BACTERIAL VACCINES; DRUG RESISTANCE, MULTIPLE; FRANCISELLA TULARENSIS; GENE DELETION; MACROPHAGES; MICE; MICE, INBRED C3H; MOLECULAR SEQUENCE DATA; MUTATION; SURVIVAL RATE;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; FRANCISELLA TULARENSIS; MURINAE; NEGIBACTERIA;

EID: 33748068465     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0602582103     Document Type: Article

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