Interplay between chromosomal β-lactamase and the MexAB-OprM efflux system in intrinsic resistance to β-lactams in Pseudomonas aeruginosa

Antimicrobial Agents and Chemotherapy

Volumn 43, Issue 2, 1999, Pages 400-402

  Masuda, Nobuhisa ^a   Gotoh, Naomasa ^b   Ishii, Chie ^a   Sakagawa, Eiko ^a   Ohya, Satoshi ^a   Nishino, Takeshi ^b  

^a DAIICHI SANKYO CO   (Japan)

^b KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AZTREONAM; BETA LACTAMASE; CARBAPENEM; CEPHEM DERIVATIVE; LATAMOXEF; MONOBACTAM DERIVATIVE; PENICILLIN DERIVATIVE;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL INFECTION; CHROMOSOME ANALYSIS; ENZYME ACTIVITY; MEMBRANE PERMEABILITY; MINIMUM INHIBITORY CONCENTRATION; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA;

EID: 0033060792     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.43.2.400     Document Type: Article

References (26)

1. Angus, B. L., A. M. Carey, D. A. Caron, A. M. B. Kropinski, and R. E. W. Hancock. 1982. Outer membrane permeability in Pseudomonas aeruginosa: comparison of a wild-type with an antibiotic-supersusceptible mutant. Antimicrob. Agents Chemother. 21:299-309.
2. Burns, J. L., C. D. Wadsworth, J. J. Barry, and C. P. Goodall. 1996. Nucleotide sequence analysis of a gene from Burkholderia (Pseudomonas) cepacia encoding an outer membrane lipoprotein involved in multiple antibiotic resistance. Antimicrob. Agents Chemother. 40:307-313.
3. Chen, H. Y., and D. M. Livermore. 1994. In-vitro activity of biapenem, compared with imipenem and mecopenem, against Pseudomonas aeruginosa strains and mutants with known resistance mechanisms. J. Antimicrob. Chemother. 33:949-958.
4. Fleischmann, R. D., M. D. Adams, O. White, R. A. Clayton, E. F. Kirkness, A. R. Kerlavage, C. J. Bult, J. F. Tomb, B. A. Dougherty, J. M. Merrick, K. McKenney, G. Sutton, W. FitzHugh, C. Fields, J. D. Gocayne, J. Scott, R. Shirley, L.-I. Liu, A. Glodek, J. M. Kelley, J. F. Weidmann, C. A. Phillips, T. Spriggs, E. Hedblom, M. D. Cotton, T. R. Utterback, M. C. Hanna, L. D. Nguyen, D. M. Saudek, R. C. Brandon, L. D. Fine, J. L. Fritchman, N. S. M. Geoghagen, C. L. Gnehm, L. A. McDonald, K. V. Small, C. M. Fraser, H. O. Smith, and J. C. Venter. 1995. Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science 269:446-512.
5. Gotoh, N., N. Itoh, H. Tsujimoto, J. Yamagishi, Y. Oyamada, and T. Nishino. 1994. Isolation of OprM-deficient mutants of Pseudomonas aeruginosa by transposon insertion mutagenesis: evidence of involvement in multiple antibiotic resistance. FEMS Microbiol. Lett. 122:267-274.
6. Gotoh, N., H. Tsujimoto, K. Poole, J. Yamagishi, and T. Nishino. 1995. The outer membrane protein OprM of Pseudomonas aeruginosa is encoded by oprK of the mexA-mexB-oprK multidrug resistance operon. Antimicrob. Agents Chemother. 39:2567-2569.
7. Gotoh, N., H. Tsujimoto, M. Tsuda, K. Okamoto, A. Nomura, T. Wada, M. Nakahashi, and T. Nishino. 1998. Characterization of the MexC-MexD-OprJ multidrug efflux system in ΔmexA-mexB-oprM mutants of Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 42:1938-1943.
8. Gotoh, N., H. Tsujimoto, A. Nomura, K. Okamoto, M. Tsuda, and T. Nishino. 1998. Functional replacement of OprJ by OprM in the MexCD-OprJ multidrug efflux system of Pseudomonas aeruginosa. FEMS Microbiol. Lett. 165:21-27.
9. Hagman, K. E., W. Pan, B. G. Spratt, T. J. Balthazar, R. C. Judd, and W. M. Shafer. 1995. Resistance of Neisseria gonorrhoeae to antimicrobial hydrophobic agents is modulated by the mtrRCDE efflux system. Microbiology 141: 611-622.
10. Iso, Y., T. Irie, V. Nishino, K. Motokawa, and Y. Nishitani. 1996. A novel 1 beta-methylcarbapenem antibiotic, S-4661. Synthesis and structure-activity relationships of 2-(5-substituted pyrrolidin-3-ylthio)-1 beta-methylcarbapenems. J. Antibiot. (Tokyo) 49:199-209.
11. Kieboom, J., J. J. Dennis, J. A. M. de Bont, and G. J. Zylstra. 1998. Identification and molecular characterization of an efflux pump involved in Pseudomonas putida S12 solvent tolerance. J. Biol. Chem. 273:85-91.
12. Köler, T., M. Michéa-Hamzepour, U. Henze, N. Gotoh, L. K. Curty, and J.-C. Pechëre. 1997. Characterization of MexE-MexF-OprN, a positively regulated multidrug efflux system of Pseudomonas aeruginosa. Mol. Microbiol. 23:345-354.
13. Labia, R., P. Baron, and J.-M. Masson. 1985. Binding of latamoxef (moxalactam) and its decarboxylated derivative to Escherichia coli and Pseudomonas aeruginosa penicillin-binding proteins. J. Antimicrob. Chemother. 15:9-15.
14. Li, X.-Z., H. Nikaido, and K. Poole. 1995. Role of MexA-MexB-OprM in antibiotic efflux in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 39:1948-1953.
15. Ma, D., D. N. Cook, J. E. Hearst, and H. Nikaido. 1994. Efflux pumps and drug resistance in gram-negative bacteria. Trends Microbiol. 2:489-493.
16. Masuda, N., and S. Ohya. 1992. Cross-resistance to meropenem, cephems, and quinolones Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 36:1847-1851.
17. Masuda, N., and N. Gotoh. Unpublished data.
18. Murata, T., S. Minami, K. Yasuda, S. Iyobe, M. Inoue, and S. Mitsuhashi. 1981. Purification and properties of cephalosporinase from Pseudomonas aeruginosa. J. Antibiot. (Tokyo) 34:1164-1170.
19. Nikaido, H. 1985. Role of permeability barriers in resistance to β-lactam antibiotics. Pharmacol. Ther. 27:197-231.
20. Nikaido, H. 1989. Outer membrane barrier as a mechanism of antimicrobial resistance. Antimicrob. Agents Chemother. 33:1831-1836.
21. Nikaido, H. 1994. Prevention of drug access to bacterial targets: permeability barriers and active efflux. Science 264:382-388.
22. Okamoto, K., N. Gotoh, H. Tsujimoto, and T. Nishino. Unpublished data.
23. Poole, K., N. Gotoh, H. Tsujimoto, Q. Zhao, A. Wada, T. Yamasaki, S. Neshat, J. Yamagishi, X.-Z. Li, and T. Nishino. 1996. Overexpression of the mexC-mexD-oprJ efflux operon in nfxB-type multidrug-resistant strains of Pseudomonas aeruginosa. Mol. Microbiol. 21:713-724.
24. Poole, K., K. Krebes, C. McNally, and S. Neshat. 1993. Multiple antibiotic resistance in Pseudomonas aeruginosa: evidence for involvement of an efflux operon. J. Bacteriol. 175:7363-7372.
25. Vokota, T., E. Suzuki, and K. Arai. 1988. Cefpodoxime proxetil, its in vitro antibacterial activity, affinity to bacterial penicillin-binding proteins, and synergy of bactericidal activity with serum complement and mouse-cultured macrophages. Drugs Exp. Clin. Res. 14:495-500.
26. Yoshimura, F., and H. Nikaido. 1982. Permeability of Pseudomonas aeruginosa outer membrane to hydrophilic solutes. J. Bacteriol. 152:636-642.