SmeC, an outer membrane multidrug efflux protein of Stenotrophomonas maltophilia

Antimicrobial Agents and Chemotherapy

Volumn 46, Issue 2, 2002, Pages 333-343

  Li, Xian Zhi ^a   Zhang, Li ^a   Poole, Keith ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; AMINOGLYCOSIDE ANTIBIOTIC AGENT; AMPICILLIN; BACTERIAL ENZYME; BACTERIAL PROTEIN; BETA LACTAM ANTIBIOTIC; BETA LACTAMASE; CARBENICILLIN; CEFEPIME; CEFOPERAZONE; CEFOTAXIME; CEFPIROME; CEFSULODIN; CHLORAMPHENICOL; CIPROFLOXACIN; GENTAMICIN; HYBRID PROTEIN; IMIPENEM; KANAMYCIN; NALIDIXIC ACID; NORFLOXACIN; OUTER MEMBRANE PROTEIN; PENICILLIN G; PROTEIN SMEC; QUINOLINE DERIVED ANTIINFECTIVE AGENT; STREPTOMYCIN; TETRACYCLINE; TOBRAMYCIN; TROVAFLOXACIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BACTERIUM MUTANT; DRUG TRANSPORT; ENZYME ACTIVITY; GENE DELETION; GENE OVEREXPRESSION; MOLECULAR CLONING; MULTIDRUG RESISTANCE; NONHUMAN; NUCLEOTIDE SEQUENCE; OPERON; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PSEUDOMONAS AERUGINOSA; SEQUENCE HOMOLOGY; STENOTROPHOMONAS MALTOPHILIA;

BACTERIAL OUTER MEMBRANE PROTEINS; BACTERIAL PROTEINS; BETA-LACTAMASES; BIOLOGICAL TRANSPORT; CLONING, MOLECULAR; DRUG RESISTANCE, MULTIPLE; GENE EXPRESSION REGULATION, BACTERIAL; OPERON; SEQUENCE ANALYSIS, DNA; STENOTROPHOMONAS MALTOPHILIA;

EID: 0036148599     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.46.2.333-343.2002     Document Type: Article

References (57)

1. Involvement of an active efflux system in the natural resistance of Pseudomonas aeruginosa to aminoglycosides
2. Expression of the AsbA1, OXA-12, and AsbM1 β-lactamases in Aeromonas jandaei AER 14 is coordinated by a two-component regulon
3. Multiple antibiotic resistance in Stenotrophomonas maltophilia
4. Cloning and characterization of SmeDEF, a novel multidrug efflux pump from Stenotrophomonas maltophilia
5. Expression of multidrug efflux pump SmeDEF by clinical isolates of Stenotrophomonas maltophilia
6. Aeromonas hydrophila AmpH and CepH β-lactamases: Derepressed expression in mutants of Escherichia coli lacking creB
7. Comparative antimicrobial activity of FK037, cefpirome, ceftazidime and cefepime against aminoglycoside-sensitive and aminoglycoside-resistant Pseudomonas aeruginosa and Pseudomonas spp
8. Genetic systems in Haemophilus influenzae
9. Purification of β-lactamases by affinity chromatography on phenylboronic acid-agarose
10. Molecular epidemiology of Stenotrophomonas maltophilia isolated from clinical specimens from patients with cystic fibrosis and associated environmental samples
11. Microbiological and clinical aspects of infections associated with Stenotrophomonas maltophilia
12. Presence of the Cpx system in bacteria
13. In vitro activities of quinolones, β-lactams, tobramycin, and trimethoprim-sulfamethoxazole against nonfermentative gram-negative bacilli
14. Susceptibility of Pseudomonas maltophilia to antimicrobial agents, singly and in combination
15. An overview of the kinetic parameters of class B β-lactamases
16. A broad-host-range Flp-FRT recombination system for site-specific excision of chromosomally-located DNA sequences: Application for isolation of unmarked Pseudomonas aeruginosa mutants
17. Identification and molecular characterization of an efflux pump involved in Pseudomonas putida S12 solvent tolerance
18. Aminoglycoside 6′-N acetyltransferase production by an isolate of Pseudomonas maltophilia
19. Characterization of MexE-MexF-OprN, a positively regulated multidrug efflux system of Pseudomonas aeruginosa
20. Characterization of the chromosomal aac(6′)-lz gene of Stenotrophomonas maltophilia
21. Susceptibility of Xanthamonas maltophilia to six quinolones and study of outer membrane proteins in resistant mutants selected in vitro
22. Role of mexA-mexB-oprM in antibiotic efflux in Pseudomonas aeruginosa
23. Mutational analysis of the OprM outer membrane component of the MexA-MexB-OprM multidrug efflux system of Pseudomonas aeruginosa
24. β-lactamase inhibitors are substrates for the multidrug efflux pumps of Pseudomonas aeruginosa
25. Molecular cloning and characterization of acrA and acrE genes of Escherichia coli
26. Hypersusceptibility of the Pseudomonas aeruginosa nfxB mutant to β-lactams due to reduced expression of the AmpC β-lactamase
27. Outer membrane permeability and β-lactamase content in Pseudomonas maltophilia clinical isolates and laboratory mutants
28. Bacteremia due to Stenotrophomonas maltophilia in patients with hematologic malignancies
29. Expression in Escherichia coli of a new multidrug efflux pump, MexXY, from Pseudomonas aeruginosa
30. Bacteremia due to Stenotrophomonas (Xanthomonas) maltophilia: A prospective, multicenter study of 91 episodes
31. Novel members of the two-component signal transduction genes in Eschenchia coli
32. Release of surface enzymes in Enterobacteriaceae by osmotic shock
33. Multiple antibiotic resistance and efflux
34. How do exported proteins and antibiotics bypass the periplasm in gram-negative bacterial cells?
35. Stenotrophomonas, a new bacterial genus for Xanthomonas maltophilia (Hugh 1980) Swings et al. 1983
36. Rapid identification of metallo- and serine β-lactamses
37. Characterization of a putative RND-type efflux system in Agrobacterium tumefaciens
38. Efflux-mediated resistance to fluoroquinolones in gram-negative bacteria
39. Overexpression of the mexC-mexD-oprJ efflux operon in nfxB multidrug resistant strains of Pseudomonas aeruginosa
40. Cloning and sequence analysis of an EnvCD homologue in Pseudomonas aeruginosa: Regulation by iron and possible involvement in the secretion of the siderophore pyoverdine
41. Multiple antibiotic resistance in Pseudomonas aeruginosa: Evidence for involvement of an efflux operon
42. Clinical problems posed by multiresistant nonfermenting gram-negative pathogens
43. The Cpx envelope stress response is controlled by amplification and feedback inhibition
44. Efflux pumps involved in toluene tolerance in Pseudomonasputida DOT-TIE
45. A functional-phylogenetic classification system for transmembrane solute transporters
46. Molecular heterogeneity of the L-1 metallo-β-lactamase family from Stenotrophomonas maltophilia
47. The inner membrane efflux components are responsible for the β-lactam specificity of multidrug efflux pumps in Pseudomonas aeruginosa
48. Molecular characterization of cloned avirulence genes from race 0 and race 1 of Pseudomonas syringae pv. glycinea
49. The role of lipopolysaccharide anionic binding sites in aminoglycoside uptake in Stenotrophomonas (Xanthomonas) maltophilia
50. Sequence analysis and enzyme kinetics of the L2 serine β-lactamase from Stenotrophomonas maltophilia
51. Characterization of a Pseudomonas aeruginosa efflux pump contributing to aminoglycoside impermeability
52. Multiple antibiotic resistance in Stenotrophomonas maltophilia: Involvement of a multidrug efflux system
53. SmeDEF multidrug efflux pump contributes to intrinsic multidrug resistance in Stenotrophomonas maltophilia
54. Contribution of outer membrane efflux protein OprM on antibiotic resistance in Pseudomonas aeruginosa independent of MexAB