Effect and mechanism of andrographolide on the recovery of pseudomonas aeruginosa susceptibility to several antibiotics

Journal of International Medical Research

Volumn 36, Issue 1, 2008, Pages 178-186

  Wu, C M ^a   Cao, J L ^a   Zheng, M H ^b   Ou, Y ^a   Zhang, L ^b   Zhu, X Q ^a   Song, Jiansing X ^c  

^a The Traditional Chinese Medical Hospital of Wenzhou   (China)

^b WENZHOU MEDICAL UNIVERSITY   (China)

^c HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Andrographolide; Antibiotics; Drug resistance; Efflux pump; Microbes; Pseudomonas aeruginosa

Indexed keywords

ANDROGRAPHOLIDE; BACTERIAL PROTEIN; CEFPIROME; CEFTAZIDIME; CHLORAMPHENICOL; IMIPENEM; KANAMYCIN; MEROPENEM; OFLOXACIN; PROTEIN MEXB; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; ENZYME INHIBITION; GENE OVEREXPRESSION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PROTEIN EXPRESSION; PSEUDOMONAS AERUGINOSA; REAL TIME POLYMERASE CHAIN REACTION; WILD TYPE;

EID: 39149119645     PISSN: 03000605     EISSN: None     Source Type: Journal    
DOI: 10.1177/147323000803600123     Document Type: Article

References (17)

1. Ma D, Cook DN, Nikaido H, et al: Efflux pumps and drug resistance in gram-negative bacteria. Trends Microbiol 1994; 2: 489-493.
2. Maseda H, Yoneyama H, Nakae T: Assignment of the substrate-selective subunits of the MexEF-OprN multidrug efflux pump of Pseudomonas aeruginosa. Antimicrob Agents Chemother 2000; 44: 658-664.
3. Masuda N, Sakagawa E, Ohya S, et al: Substrate specificities of MexAB-OprM, MexCD-OprJ, and MexXY-oprM efflux pumps in Pseudomonas aeruginosa. Antimicrob Agents Chemother 2000; 44: 3322-3327.
4. Xiao-Hong NX, William JB, Sophia VK, et al: Real-time probing of membrane transport in living microbial cells using single nanoparticle optics and living cell imaging. Biochemistry 2004; 43: 10400-10413.
5. Cao L, Srikumar R, Poole K: MexAB-OprM hyperexpression in NalC-type multidrug resistant Pseudomonas aeruginosa: identification and characterization of the nalC gene encoding a repressor of PA3720-PA3719. Mol Microbiol 2004; 53: 1423-1436.
6. Aeschlimann JR: The role of multidrug efflux pumps in the antibiotic resistance of Pseudomonas aeruginosa and other gram-negative bacteria. Insights from the Society of Infectious Diseases Pharmacists. Pharmacotherapy 2003; 23: 916-924.
7. Feng X, Zhao G, Cui L, et al: Interaction between biofilm formed by Pseudomonas aeruginosa and antibacterial agents Wei Sheng Wu Xue Bao 2000; 40: 210-213 [in Chinese].
8. Saito K, Yoneyama H, Nakae T: nalB-type mutations causing the overexpression of the MexAB-OprM efflux pump are located in the mexR gene of the Pseudomonas aeruginosa chromosome. FEMS Microbiol Lett 1999; 179: 67-72.
9. National Committee of Clinical Laboratory Standards: Performance standards for antimicrobial susceptibility testing: 14th Informational Supplement[S]. NCCLS document M100-S14. Wayne, PA: NCCLS, 2004; pp 1-159.
10. Zhang WJ, Hou YP, Wu J, et al: Allele frequencies and species specificity of six short tandem repeat loci in Chinese population. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2004; 21: 587-590.
11. Yoneda K, Chikumi H, Murata T, et al: Measurement of Pseudomonas aeruginosa multidrug efflux pumps by quantitative real-time polymerase chain reaction. FEMS Microbiol Lett 2005; 243: 125-131.
12. Li XZ, Zhang L, Poole K, et al: Interplay between the MexA-MexB-OprM multidrug efflux system and the outer membrane barrier in the multiple antibiotic resistance of Pseudomonas aeruginosa. J Antimicrob Chemother 2000; 45: 433-436.
13. Rahmati S, Yang S, Davidson AL, et al: Control of the AcrAB multidrug efflux pump by quorum-sensing regulator SdiA. Mol Microbiol 2002; 43: 677-685.
14. Maseda H, Sawada I, Saito K, et al: Enhancement of the mexAB-oprM efflux pump expression by a quorum-sensing autoinducer and its cancellation by a regulator, MexT, of the mexEF-oprN efflux pump operon in Pseudomonas aeruginosa. Antimicrob Agents Chemother 2004; 48: 1320-1328.
15. Sawada I, Maseda H, Nakae T, et al: A quorum-sensing autoinducer enhances the mexAB-oprM efflux-pump expression without the MexR-mediated regulation in Pseudomonas aeruginosa. Microbiol Immunol 2004; 48: 435-439.
16. Li HT, Qin HM, Song JX, et al: Effect of andrographolide on QS regulating virulence factors production in Pseudomonas aeruginosa. Zhongguo Zhong Yao Za Zhi 2006; 31: 1015-1017 [in Chinese].
17. Rasmussen TB, Givskov M: Quorum-sensing inhibitors as anti-pathogenic drugs. Int J Med Microbiol 2006; 296: 149-161.