BpeAB-OprB, a Multidrug Efflux Pump in Burkholderia pseudomallei

Antimicrobial Agents and Chemotherapy

Volumn 48, Issue 4, 2004, Pages 1128-1135

  Chan, Y Y ^a   Tan, T M C ^a   Ong, Y M ^a   Chua, K L ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ACRIFLAVINE; AMINOGLYCOSIDE ANTIBIOTIC AGENT; BETA LACTAM ANTIBIOTIC; ERYTHROMYCIN; GENTAMICIN; HYBRID PROTEIN; MACROLIDE; MEMBRANE PROTEIN; PHENYLALANYLARGININE 2 NAPHTHYLAMIDE; POLYMYXIN; STREPTOMYCIN; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ARTICLE; BPEAB OPRB GENE; BURKHOLDERIA PSEUDOMALLEI; CONTROLLED STUDY; DELETION MUTANT; DNA SEQUENCE; DRUG POTENTIATION; DRUG TRANSPORT; GENE CLUSTER; GENE EXPRESSION REGULATION; GENETIC CODE; GENETIC COMPLEMENTATION; GENETIC TRANSCRIPTION; MELIOIDOSIS; MINIMUM INHIBITORY CONCENTRATION; MULTIDRUG RESISTANCE; NONHUMAN; NUCLEOTIDE SEQUENCE; OPERON; PRIORITY JOURNAL; REGULATORY MECHANISM; REPRESSOR GENE;

AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; BACTERIAL OUTER MEMBRANE PROTEINS; BURKHOLDERIA PSEUDOMALLEI; CARRIER PROTEINS; DIPEPTIDES; DNA PRIMERS; DNA, BACTERIAL; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ERYTHROMYCIN; GENE DELETION; GENE LIBRARY; GENES, BACTERIAL; GENETIC COMPLEMENTATION TEST; MACROLIDES; MEMBRANE TRANSPORT MODULATORS; MEMBRANE TRANSPORT PROTEINS; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; MUTATION; OPERON; PERIPLASMIC PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SUBSTRATE SPECIFICITY;

EID: 1642543200     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.48.4.1128-1135.2004     Document Type: Article

References (34)

1. Altschul, S. F., T. L. Madden, A. A. Schaffer, J. Zhang, Z. Zhang, W. Miller, and D. J. Lipman. 1997. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 25:3389-3402.
2. Angus, B. J., M. D. Smith, Y. Suputtamongkol, H. Mattie, A. L. Walsh, V. Wuthiekanun, W. Chaowagul, and N. J. White. 2000. Pharmacokinetic-pharmacodynamic evaluation of ceftazidime continuous infusion vs intermittent bolus injection in septicaemic melioidosis. Br. J. Clin. Pharmacol. 49:445-452.
3. Chaowagul, W. 2000. Recent advances in the treatment of severe melioidosis. Acta Trop. 74:133-137.
4. Chetchotisakd, P., S. Porramatikul, P. Mootsikapun, S. Anunnatsiri, and B. Thinkhamrop. 2001. Randomized, double-blind, controlled study of cefoperazone-sulbactam plus cotrimoxazole versus ceftazidime plus cotrimoxazole for the treatment of severe melioidosis. Clin. Infect. Dis. 33:29-34.
5. Chua, K. L., Y. Y. Chan, and Y. H. Gan. 2003. Flagella are virulence determinants of Burkholderia pseudomallei. Infect. Immun. 71:1622-1629.
6. Dance, D. A. 2002. Melioidosis. Curr. Opin. Infect. Dis. 15:127-132.
7. Dance, D. A., V. Wuthiekanun, W. Chaowagul, and N. J. White. 1989. The antimicrobial susceptibility of Pseudomonas pseudomallei. Emergence of resistance in vitro and during treatment. J. Antimicrob. Chemother. 24:295-309.
8. de Lorenzo, V., M. Herrero, U. Jakubzik, and K. N. Timmis. 1990. Mini-Tn5 transposon derivatives for insertion mutagenesis, promoter probing, and chromosomal insertion of cloned DNA in gram-negative eubacteria. J. Bacteriol. 172:6568-6572.
9. Eda, S., H. Maseda, and T. Nakae. 2002. An elegant means of self-protection in gram-negative bacteria by recognizing and extruding xenobiotics from the periplasmic space. J. Biol. Chem. 278:2085-2088.
10. Eickhoff, T. C., J. V. Bennett, P. S. Hayes, and J. Feeley. 1970. Pseudomonas pseudomallei: susceptibility to chemotherapeutic agents. J. Infect. Dis. 121:95-102.
11. Gilbert, D. N., S. J. Kohlhepp, K. A. Slama, G. Grunkemeier, G. Lewis, R. J. Dworkin, S. E. Slaughter, and J. E. Leggett. 2001. Phenotypic resistance of Staphylococcus aureus, selected Enterobacteriaceae, and Pseudomonas aeruginosa after single and multiple in vitro exposures to ciprofloxacin, levofloxacin, and trovafloxacin. Antimicrob. Agents Chemother. 45:883-892.
12. Lee, A., W. Mao, M. S. Warren, A. Mistry, K. Hoshino, R. Okumura, H. Ishida, and O. Lomovskaya. 2000. Interplay between efflux pumps may provide either additive or multiplicative effects on drug resistance. J. Bacteriol. 182:3142-3150.
13. Lomovskaya, O., M. S. Warren, A. Lee, J. Galazzo, R. Fronko, M. Lee, J. Blais, D. Cho, S. Chamberland, T. Renau, R. Leger, S. Hecker, W. Watkins, K. Hoshino, H. Ishida, and V. J. Lee. 2001. Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: novel agents for combination therapy. Antimicrob. Agents Chemother. 45:105-116.
14. Masuda, N., E. Sakagawa, S. Ohya, N. Gotoh, H. Tsujimoto, and T. Nishino. 2000. Substrate specificities of MexAB-OprM, MexCD-OprJ, and MexXY-oprM efflux pumps in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 44:3322-3327.
15. McKeegan, K. S., M. I. Borges-Walmsley, and A. R. Walmsley. 2003. The structure and function of drug pumps: an update. Trends Microbiol. 11:21-29.
16. Miller, V. L., and J. J. Mekalanos. 1988. A novel suicide vector and its use in construction of insertion mutations: osmoregulation of outer membrane proteins and virulence determinants in Vibrio cholerae requires toxR. J. Bacteriol. 170:2575-2583.
17. Moller, S., M. D. Croning, and R. Apweiler. 2001. Evaluation of methods for the prediction of membrane spanning regions. Bioinformatics 17:646-653.
18. Moore, R. A., D. DeShazer, S. Reckseidler, A. Weissman, and D. E. Woods. 1999. Efflux-mediated aminoglycoside and macrolide resistance in Burkholderia pseudomallei. Antimicrob. Agents Chemother. 43:465-470.
19. National Committee for Clinical Laboratory Standards. 2003. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; approved standard M7-A6 and MIC testing supplemental tables M100-S13, 6th ed., vol. 23, no. 2. National Committee for Clinical Laboratory Standards, Wayne, Pa.
20. Nikaido, H. 1998. Antibiotic resistance caused by gram-negative multidrug efflux pumps. Clin. Infect. Dis. 27(Suppl. 1):S32-S41.
21. Pitcher, D. G., N. A. Saunders, and R. J. Owen. 1989. Rapid extraction of bacterial genomic DNA with guanidium thiocyanate. Lett. Appl. Microbiol. 8:151-156.
22. Poole, K. 2001. Multidrug resistance in gram-negative bacteria. Curr. Opin. Microbiol. 4:500-508.
23. Poole, K., K. Krebes, C. McNally, and S. Neshat. 1993. Multiple antibiotic resistance in Pseudomonas aeruginosa: evidence for involvement of an efflux operon. J. Bacteriol. 175:7363-7372.
24. Putman, M., H. W. Van Veen, J. E. Degener, and W. N. Konings. 2000. Antibiotic resistance: era of the multidrug pump. Mol. Microbiol. 36:772-773.
25. Quandt, J., and M. F. Hynes. 1993. Versatile suicide vectors which allow direct selection for gene replacement in gram-negative bacteria. Gene 127:15-21.
26. Reese, M. G. 2001. Application of a time-delay neural network to promoter annotation in the Drosophila melanogaster genome. Comput. Chem. 26:51-56.
27. Sambrook, J., and D. W. Russell. 2001. Molecular cloning: a laboratory manual, 3rd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
28. Sanchez, L., W. Pan, M. Vinas, and H. Nikaido. 1997. The acrAB homolog of Haemophilus influenzae codes for a functional multidrug efflux pump. J. Bacteriol. 179:6855-6857.
29. Sanger, F., S. Nicklen, and A. R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74:5463-5467.
30. Tikhonova, E. B., Q. Wang, and H. I. Zgurskaya. 2002. Chimeric analysis of the multicomponent multidrug efflux transporters from gram-negative bacteria. J. Bacteriol. 184:6499-6507.
31. Vorachit, M., P. Chongtrakool, S. Arkomsean, and S. Boonsong. 2000. Antimicrobial resistance in Burkholderia pseudomallei. Acta Trop. 74:139-144.
32. Vorachit, M., K. Lam, P. Jayanetra, and J. W. Costerton. 1995. Electron microscopy study of the mode of growth of Pseudomonas pseudomallei in vitro and in vivo. J. Trop. Med. Hyg. 98:379-391.
33. Vorachit, M., K. Lam, P. Jayanetra, and J. W. Costerton. 1993. Resistance of Pseudomonas pseudomallei growing as a biofilm on silastic discs to ceftazidime and co-trimoxazole. Antimicrob. Agents Chemother. 37:2000-2002.
34. West, S. E., H. P. Schweizer, C. Dall, A. K. Sample, and L. J. Runyen-Janecky. 1994. Construction of improved Escherichia-Pseudomonas shuttle vectors derived from pUC18/19 and sequence of the region required for their replication in Pseudomonas aeruginosa. Gene 148:81-86.