An aspartate ring at the TolC tunnel entrance determines ion selectivity and presents a target for blocking by large cations

Molecular Microbiology

Volumn 44, Issue 5, 2002, Pages 1131-1139

  Andersen, Christian ^a   Koronakis, Eva ^a   Hughes, Colin ^a   Koronakis, Vassilis ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ANION; ASPARTIC ACID; BACTERIAL PROTEIN; CATION; CHROMIUM; COBALT DERIVATIVE; DIVALENT CATION; ION; MONOMER; MUTANT PROTEIN; TOLC PROTEIN; UNCLASSIFIED DRUG; CARRIER PROTEIN; CHLORIDE; CHROMIUM CHLORIDE; CHROMIUM DERIVATIVE; COBALT; ESCHERICHIA COLI PROTEIN; OUTER MEMBRANE PROTEIN; PROTEIN SUBUNIT; TOLC PROTEIN, E COLI; ZINC CHLORIDE; ZINC DERIVATIVE;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CHANNEL GATING; CHEMICAL BOND; CONTROLLED STUDY; CYTOPLASM; DRUG TARGETING; EFFUSION; ELECTROPHYSIOLOGY; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; ION CURRENT; LIPID MEMBRANE; MEMBRANE CHANNEL; NONHUMAN; OUTER MEMBRANE; PH; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN TRANSPORT; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; LIPID BILAYER; METABOLISM; PROTEIN QUATERNARY STRUCTURE; PROTEIN TERTIARY STRUCTURE;

ASPARTIC ACID; BACTERIAL OUTER MEMBRANE PROTEINS; CATIONS, DIVALENT; CHLORIDES; CHROMIUM COMPOUNDS; COBALT; ELECTROPHYSIOLOGY; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HYDROGEN-ION CONCENTRATION; LIPID BILAYERS; MODELS, MOLECULAR; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; SUPPORT, NON-U.S. GOV'T; ZINC COMPOUNDS; MEMBRANE TRANSPORT PROTEINS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA;

EID: 0036015627     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.2002.02898.x     Document Type: Article

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