Conformationally-restricted analogues of efflux pump inhibitors that potentiate the activity of levofloxacin in Pseudomonas aeruginosa

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 16, 2003, Pages 2755-2758

  Renau, Thomas E ^a   Léger, Roger ^a   Filonova, Lubov ^a   Flamme, Eric M ^a   Wang, Michael ^a   Yen, Rose ^a   Madsen, Deidre ^a   Griffith, David ^a   Chamberland, Suzanne ^a   Dudley, Michael N ^a   Lee, Ving J ^a   Lomovskaya, Olga ^a   Watkins, William J ^a   Ohta, Toshiharu ^b   Nakayama, Kiyoshi ^b   Ishida, Yohei ^b  

^a Essential Therapeutics Inc   (United States)

^b DAIICHI SANKYO CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOQUINOLINE DERIVATIVE; BLOCKING AGENT; DEXTRO ORNITHINE DEXTRO HOMOPHENYLALANINE 3 AMINOQUINOLINE; EFFLUX PUMP INHIBITOR; LEVOFLOXACIN; MC 02595; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CONFORMATION; DRUG ACTIVITY; DRUG POTENTIATION; NONHUMAN; PSEUDOMONAS AERUGINOSA;

PSEUDOMONAS; PSEUDOMONAS AERUGINOSA;

EID: 12444345510     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(03)00556-0     Document Type: Article

References (8)

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2. Renau T.E., Léger R., Flamme E.M., She M.W., Gannon C.L., Mathias K.M., Lomovskaya O., Chamberland S., Lee V.J., Ohta T., Nakayama K., Ishiada Y. Bioorg. Med. Chem. Lett. 11:2001;663.
3. Renau T.E., Léger R., Yen R., She M.W., Flamme E.M., Sangalang J., Gannon C.L., Chamberland S., Lomovskaya O., Lee V.J. Bioorg. Med. Chem. Lett. 12:2002;763.
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6. Lomovskaya O., Warren M.S., Lee A., Galazzo J., Fronko R., Lee M., Blais J., Cho D., Chamberland S., Renau T., Léger R., Hecker S., Watkins W., Hoshino K., Ishida H., Lee V. Antimicrob. Agents Chemother. 45:2001;105.
7. Griffith, D.; Corcoran, E.; Sorenson, K.; Cho, D.; Lomovskaya, O.; Dudley, M. N. In: 41st Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, Dec. 16-19, 2001; Abstr. 340.
8. Webb T.R., Eigenbrot C. J. Org. Chem. 56:1991;3009.