Role of the AcrAB-TolC efflux pump in determining susceptibility of Haemophilus influenzae to the novel peptide deformylase inhibitor LBM415

Antimicrobial Agents and Chemotherapy

Volumn 49, Issue 8, 2005, Pages 3129-3135

  Dean, Charles R ^a   Narayan, Shubha ^a   Daigle, Denis M ^a   Dzink Fox, JoAnn L ^a   Puyang, Xiaoling ^a   Bracken, Kathryn R ^a   Dean, Karl E ^a   Weidmann, Beat ^a   Yuan, Zhengyu ^b   Jain, Rakesh ^b   Ryder, Neil S ^a  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^b Vicuron Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACRAB PROTEIN; BACTERIAL PROTEIN; LBK 611; N (5 FLUORO 1 OXIDO 2 PYRIDINYL) 1 [2 (N FORMYL N HYDROXYAMINOMETHYL)HEXANOYL]PROLINAMIDE; PEPTIDE DEFORMYLASE INHIBITOR; TOLC PROTEIN; UNCLASSIFIED DRUG;

ACRA GENE; ACRAB GENE; ACRB GENE; AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIUM ISOLATE; DNA FLANKING REGION; FRAMESHIFT MUTATION; GENE EXPRESSION; GENE INACTIVATION; GENE INSERTION; GENE SEQUENCE; GRAM POSITIVE BACTERIUM; HAEMOPHILUS INFLUENZAE; MINIMUM INHIBITORY CONCENTRATION; MUTANT; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REPRESSOR GENE; STAPHYLOCOCCUS AUREUS; STOP CODON; STREPTOCOCCUS PNEUMONIAE; TOLC GENE;

AMIDOHYDROLASES; ANTI-BACTERIAL AGENTS; BACTERIAL OUTER MEMBRANE PROTEINS; BACTERIAL PROTEINS; CARRIER PROTEINS; DRUG RESISTANCE, BACTERIAL; ENZYME INHIBITORS; ESCHERICHIA COLI PROTEINS; GENE EXPRESSION REGULATION, BACTERIAL; HAEMOPHILUS INFLUENZAE; HUMANS; MEMBRANE TRANSPORT PROTEINS; MICROBIAL SENSITIVITY TESTS; MUTAGENESIS, INSERTIONAL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PEPTIDES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 23044442679     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.49.8.3129-3135.2005     Document Type: Article

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