Macrolide antibiotic-mediated downregulation of MexAB-OprM efflux pump expression in Pseudomonas aeruginosa

Antimicrobial Agents and Chemotherapy

Volumn 52, Issue 11, 2008, Pages 4141-4144

  Sugimura, Makoto ^a,c   Maseda, Hideaki ^b   Hanaki, Hideaki ^a   Nakae, Taiji ^a  

^a KITASATO INSTITUTE   (Japan)

^b Faculty of Engineering   (Japan)

^c Miroku Medical Laboratory Inc   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AZITHROMYCIN; AZTREONAM; CARBENICILLIN; CARRIER PROTEIN; CHLORAMPHENICOL; MEXAB OPRM EFFLUX PUMP; NOVOBIOCIN; TETRACYCLINE; UNCLASSIFIED DRUG;

ANTIBIOTIC SENSITIVITY; ARTICLE; DOWN REGULATION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSEUDOMONAS AERUGINOSA;

ANTI-BACTERIAL AGENTS; AZITHROMYCIN; BACTERIAL OUTER MEMBRANE PROTEINS; DOWN-REGULATION; HUMANS; MACROLIDES; MEMBRANE TRANSPORT PROTEINS; MICROBIAL SENSITIVITY TESTS; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; QUORUM SENSING;

EID: 55849146287     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00511-08     Document Type: Article

References (32)

1. Akama, H., M. Kanemaki, M. Yoshimura, T. Tsukihara, T. Kashiwagi, H. Yoneyama, S. Narita, A. Nakagawa, and T. Nakae. 2004. Crystal structure of the drug discharge outer membrane protein, OprM, of Pseudomonas aeruginosa. J. Biol. Chem. 279:52816-52819.
2. Akama, H., T. Matuura, S. Kashiwagi, H. Yoneyama, S. Narita, T. Tsukihara, A. Nakagawa, and T. Nakae. 2004. Crystal structure of the membrane fusion protein, MexA, of the multidrug transporter in Pseudomonas aeruginosa. J. Biol. Chem. 279:25939-25942.
3. Brooun, A., S. Liu, and K. Lewis. 2000. A dose-response study of antibiotic resistance in Pseudomonas aeruginosa biofilm. Antimicrob. Agents Chemother. 44:640-646.
4. Calfee, M.-W., J. P. Coleman, and E.-C. Pesci. 2001. Interference with Pseudomonas quinolone signal synthesis inhibits virulence factor expression by Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. USA 98:11633-11637.
5. Daigle, D. M., L. Cao, S. Fraud, M. S. Wilke, A. Pacey, R. Klinoski, N. C. Strynadka, C. R. Dean, and K. Poole. 2007. Protein modulator of multidrug efflux gene expression in Pseudomonas aeruginosa. J. Bacteriol. 189:5441-5451.
6. Dinh, T., I. T. Paulsen, and M. H. Saier, Jr. 1994. A family of extracytoplasmic proteins that allow transport of large molecules across the outer membranes of gram-negative bacteria. J. Bacteriol. 176:3825-3831.
7. Eda, S., H. Maseda, and T. Nakae. 2003. An elegant means of self-protection in Gram-negative bacteria by recognizing and extruding xenobiotics from the periplasmic space. J. Biol. Chem. 278:2085-2088.
8. Equi, A., I. M. Balfour-Lynn, A. Bush, and M. Rosenthal. 2002. Long term azithromycin in children with cystic fibrosis: a randomised placebo-controlled crossover trial. Lancet 360:978-984.
9. Favre-Bonte, S., T. Kohler, and C. van Delden. 2003. Biofilm formation by Pseudomonas aeruginosa: role of the C4-HSL cell-to-cell signal and inhibition by azithromycin. J. Antimicrob. Chemother. 52:598-604.
10. Guan, L., M. Ehrmann, H. Yoneyama, and T. Nakae. 1999. Membrane topology of the xenobiotic-exporting subunit, MexB, of the MexA,B-OprM extrusion pump in Pseudomonas aeruginosa. J. Biol. Chem. 274:10517-10522.
11. Higgins, M. K., E. Bokma, E. Koronakis, C. Hughes, and V. Koronakis. 2004. Structure of the periplasmic component of a bacterial drug efflux pump. Proc. Natl. Acad. Sci. USA 101:9994-9999.
12. Howe, R. A., and R. C. Spencer. 1997. Macrolides for the treatment of Pseudomonas aeruginosa infections? J. Antimicrob. Chemother. 40:153-155.
13. Jaffe, A., J. Francis, M. Rosenthal, and A. Bush. 1998. Long-term azithromycin may improve lung function in children with cystic fibrosis. Lancet 351:420.
14. Kudoh, S., H. Kimura, K. Uetake, et al. 1984. Clinical effect of low-dose long-term administration of macrolides on diffuse panbronchiolitis. Jpn. J. Thorac. Dis. 22:254. (In Japanese.)
15. Kudoh, S., T. Uetake, K. Hagiwara, et al. 1987. Clinical effects of low-dose longterm erythromycin chemotherapy on diffuse panbronchiolitis. Nippon Kyobu Shikkan Gakkai Zasshi 25:632-642. (In Japanese.)
16. Maseda, H., I. Sawada, K. Saito, H. Uchiyama, T. Nakae, and N. Nomura. 2004. Enhancement of the MexAB-OprM efflux pump expression by a quorum-sensing autoinducer and its cancellation by a regulator, MexT, of the MexEF-OprN efflux pump operon in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 48:1320-1328.
17. Maseda, H., H. Yoneyama, and T. Nakae. 2000. Assignment of the substrate-selective subunits of the MexEF-OprN multidrug efflux pump of Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 44:658-664.
18. Murakami, S., R. Nakashima, E. Yamashita, T. Matsumoto, and A. Yamaguchi. 2006. Crystal structures of a multidrug transporter reveal a functionally rotating mechanism. Nature 2006:173-179.
19. Nakae, T., E. Yoshihara, and H. Yoneyama. 1997. Multiantibiotic resistance caused by active drug extrusion in hospital pathogens. J. Infect. Chemother. 3:173-183.
20. Nikaido, H. 1996. Prevention of drug access to bacterial targets: permeability barriers and active efflux. Science 264:221-229.
21. Nouwens, A. S., S. A. Beatson, C. B. Whitchurch, B. J. Walsh, H. P. Schweizer, J. S. Mattick, and S. J. Cordwell. 2003. Proteome analysis of extracellular proteins regulated by the las and rhl quorum sensing systems in Pseudomonas aeruginosa PAO1. Microbiology 149:1311-1322.
22. Pearson, J. P., C. van Delden, and B. H. Iglewski. 1999. Active efflux and diffusion are involved in transport of Pseudomonas aeruginosa cell-to-cell signal. J. Bacteriol. 181:1203-1210.
23. Pesci, E. C., J. B. J. Milbank, J. P. Pearson, S. Mcknight, A. S. Kende, E. P. Greenberg, and B. H. Iglewski. 1999. Quinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. USA 96:11229-11234.
24. Poole, K. 2001. Multidrug efflux pumps and antimicrobial resistance in Pseudomonas aeruginosa and related organisms. J. Mol. Microbiol. Biotechnol. 3:255-263.
25. Saito, K., H. Yoneyama, and T. Nakae. 1999. nalB-type mutations causing the overexpression of the MexAB-OprM efflux pump are located in the mexR gene of the Pseudomonas aeruginosa chromosome. FEMS Microbiol. Lett. 179:67-72.
26. Sawada, I., H. Maseda, T. Nakae, H. Uchiyama, and N. Nomura. 2004. A quorum-sensing autoinducer enhances the mexAB-oprM efflux-pump expression without the MexR-mediated regulation in Pseudomonas aeruginosa. Microbiol. Immunol. 48:435-439.
27. Schuster, M., C. P. Lostroh, T. Ogi, and E. P. Greenberg. 2003. Identification, timing, and signal specificity of Pseudomonas aeruginosa quorum-controlled genes: a transcriptome analysis. J. Bacteriol. 185:2066-2079.
28. Schweizer, H. P. 1993. Two plasmids, X1918 and Z1918, for easy recovery of the xelE and lacZ reporter genes. Gene 134:89-91.
29. Sofer, D., N. Gilboa-Garber, A. Belz, and N. C. Garber. 1999. Subinhibitory erythromycin represses production of Pseudomonas aeruginosa lectins, autoinducer and virulence factors. Chemotherapy 45:335-341.
30. Tateda, K., T. J. Standiford, J. C. Pechere, and K. Yamaguchi. 2004. Regulatory effects of macrolides on bacterial virulence: potential role as quorumsensing inhibitors. Curr. Pharm. Design. 10:3055-3065.
31. Whitehead, N. A., A. M. Bernard, H. Slater, N. J. Simpson, and G. P. Salmond. 2001. Quorum-sensing in Gram-negative bacteria. FEMS Microbiol. Lett. 25:365-404.
32. Yoneyama, H., A. Ocaktan, M. Tsuda, and T. Nakae. 1997. The role of mex-gene products in antibiotic extrusion in Pseudomonas aeruginosa. Biochem. Biophys. Res. Commun. 233:611-618.