Outer membrane protein changes and efflux pump expression together may confer resistance to ertapenem in Enterobacter cloacae

Antimicrobial Agents and Chemotherapy

Volumn 50, Issue 8, 2006, Pages 2833-2835

  Szabó, Dóra ^a,b   Silveira, Fernanda ^a   Hujer, Andrea M ^c   Bonomo, Robert A ^c   Hujer, Kristine M ^c   Marsh, Jane W ^a   Bethel, Christopher R ^c   Doi, Yohei ^a   Deeley, Kathleen ^a   Paterson, David L ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

^c LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; BACTERIAL RNA; BETA LACTAMASE; CARBAPENEM DERIVATIVE; CIPROFLOXACIN; COMPLEMENTARY DNA; ERTAPENEM; IMIPENEM; MEROPENEM; NITROCEFIN; OUTER MEMBRANE PROTEIN; OUTER MEMBRANE PROTEIN D; OUTER MEMBRANE PROTEIN F; PHENYLALANINE DERIVATIVE; PHENYLALANYLARGINYL BETA NAPHTHYLAMIDE; UNCLASSIFIED DRUG;

ACRB GENE; ADULT; ANTIBIOTIC RESISTANCE; ARTICLE; BACTEREMIA; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIUM ISOLATE; BLOOD CULTURE; CASE REPORT; CATHETER INFECTION; CONTROLLED STUDY; DIALYSIS CATHETER; ENTEROBACTER CLOACAE; GENETIC TRANSCRIPTION; HUMAN; ISOELECTRIC FOCUSING; ISOELECTRIC POINT; MALE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; OMPD GENE; OMPF GENE; PRIORITY JOURNAL; PULSED FIELD GEL ELECTROPHORESIS; REAL TIME POLYMERASE CHAIN REACTION; RPOB GENE;

ANTI-BACTERIAL AGENTS; BACTERIAL OUTER MEMBRANE PROTEINS; BETA-LACTAMS; DRUG RESISTANCE, MICROBIAL; ENTEROBACTER CLOACAE; GENE EXPRESSION REGULATION, BACTERIAL; GENES, BACTERIAL; HUMANS; MEMBRANE TRANSPORT PROTEINS; MICROBIAL SENSITIVITY TESTS; TRANSCRIPTION, GENETIC;

EID: 33746928431     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.01591-05     Document Type: Article

References (15)

1. Bush, K., S. K. Tanaka, D. P. Bonner, and R. B. Sykes. 1985. Resistance caused by decreased penetration of β-lactam antibiotics into Enterobacter cloacae. Antimicrob. Agents Chemother. 27:555-560.
2. Chollet, R., J. Chevalier, C. Bollet, J.-M. Pages, and A. Davin-Regli. 2004. RamA is an alternate activator of the multidrug resistance cascade in Enterobacter aerogenes. Antimicrob. Agents Chemother. 48:2518-2523.
3. Jacoby, G., P. Han, and J. Tran. 1997. Comparative in vitro activities of carbapenem L-749,345 and other antimicrobials against multiresistant gram-negative clinical pathogens. Antimicrob. Agents Chemother. 41:1830-1831.
4. Jacoby, G. A., D. M. Mills, and N. Chow. 2004. Role of β-lactamases and porins in resistance to ertapenem and other β-lactams in Klebsiella pneumoniae. Antimicrob. Agents Chemother. 48:3203-3206.
5. Lee, E. H., E. Collatz, J. Trias, and L. Gutmann. 1992. Diffusion of beta-lactam antibiotics into proteoliposomes reconstituted with outer membranes of isogenic imipenem-susceptible and -resistant strains of Enterobacter cloacae. J. Gen. Microbiol. 138:2347-2351.
6. Lee, E. H., M. H. Nicolas, M. D. Kitzis, G. Pialoux, E. Collatz, and L. Gutmann. 1991. Association of two resistance mechanisms in a clinical isolate of Enterobacter cloacae with high-level resistance to imipenem. Antimicrob. Agents Chemother. 35:1093-1098.
7. Linde, H. J., F. Notka, C. Irtenkauf, J. Decker, J. Wild, H. H. Niller, P. Heisig, and N. Lehn. 2002. Increase in MICs of ciprofloxacin in vivo in two closely related clinical isolates of Enterobacter cloacae. J. Antimicrob. Chemother. 49:625-630.
8. T method. Methods 25:402-408.
9. Mahlen, S. D., S. S. Morrow, B. Abdalhamid, and N. D. Hanson. 2003. Analyses of ampC gene expression in Serratia marcescens reveal new regulatory properties. J. Antimicrob. Chemother. 51:791-502.
10. Pages, J. M., M. Masi, and J. Barbe. 2005. Inhibitors of efflux pumps in Gram-negative bacteria. Trends Mol. Med. 11:382-389.
11. Paterson, D. L., K. M. Hujer, A. M. Hujer, B. Yeiser, M. D. Bonomo, L. B. Rice, R. A. Bonomo, and the International Klebsiella Study Group. 2003. Extended-spectrum β-lactamases in Klebsiella pneumoniae bloodstream isolates from seven countries: dominance and widespread prevalence of SHV- and CTX-M-type β-lactamases. Antimicrob. Agents Chemother. 47:3554-3560.
12. Paterson, D. L., F. Rossi, F. Baquero, P. R. Hsueh, G. L. Woods, V. Satishchandran, T. A. Snyder, C. M. Harvey, H. Teppler, M. J. Dinubile, and J. W. Chow. 2005. In vitro susceptibilities of aerobic and facultative Gram-negative bacilli isolated from patients with intra-abdominal infections worldwide: the 2003 Study for Monitoring Antimicrobial Resistance Trends (SMART). J. Antimicrob. Chemother. 55:965-973.
13. Sanders, C. C., and W. E. Sanders, Jr. 1986. Type I beta-lactamases of gram-negative bacteria: interactions with beta-lactam antibiotics. J Infect. Dis. 154:792-800.
14. Szabó, D., R. A. Bonomo, F. Silveira, A. W. Pasculle, C. Baxter, P. K. Linden, A. M. Hujer, K. M. Hujer, K. Deeley, and D. L. Paterson. 2005. SHV-type extended-spectrum beta-lactamase production is associated with reduced cefepime susceptibility in Enterobacter cloacae. J. Clin. Microbiol. 43:5058-5064.
15. Tenover, F. C., R. D. Arbeit, R. V. Goering, P. A. Mickelsen, B. E. Murray, D. H. Persing, and B. Swaminathan. 1995. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J. Clin. Microbiol. 33:2233-2239.