Contribution of the Rv2333c efflux pump (the Stp protein) from Mycobacterium tuberculosis to intrinsic antibiotic resistance in Mycobacterium bovis BCG

Journal of Antimicrobial Chemotherapy

Volumn 59, Issue 3, 2007, Pages 544-547

  Ramón García, Santiago ^a   Martín, Carlos ^a   De Rossi, Edda ^b   Aínsa, José A ^a  

^a UNIVERSITY OF ZARAGOZA   (Spain)

^b UNIVERSITY OF PAVIA   (Italy)

Author keywords

Efflux; Mycobacteria; Spectinomycin; Tetracycline

Indexed keywords

ACRIFLAVINE; AMIKACIN; AMINOSALICYLIC ACID; BACTERIAL PROTEIN; CARBONYL CYANIDE CHLOROPHENYLHYDRAZONE; CHLORAMPHENICOL; CHLORPROMAZINE; CIPROFLOXACIN; CLOFAZIMINE; ECONAZOLE; ETHAMBUTOL; ETHIONAMIDE; FLUCONAZOLE; GENTAMICIN; ISONIAZID; OFLOXACIN; PROTEIN STP; RIFAMPICIN; SPECTINOMYCIN; SPECTINOMYCIN TETRACYCLINE EFFLUX PUMP; STREPTOMYCIN; TETRACYCLINE; TRICLOSAN; UNCLASSIFIED DRUG; VANCOMYCIN;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL CHROMOSOME; BACTERIAL STRAIN; BACTERIUM CULTURE; DRUG UPTAKE; GENE EXPRESSION REGULATION; GENE INACTIVATION; GENE OVEREXPRESSION; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PLASMID; PROTEIN FUNCTION; BACTERIAL GENE; DRUG EFFECT; GENETICS; METABOLISM; MICROBIOLOGICAL EXAMINATION; PHYSIOLOGY;

DRUG RESISTANCE, BACTERIAL; GENES, BACTERIAL; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; SPECTINOMYCIN; TETRACYCLINE;

EID: 34248189172     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkl510     Document Type: Article

References (10)

1. De Rossi E, Ainsa JA, Riccardi G. Role of mycobacterial efflux transporters in drug resistance: An unresolved question. FEMS Microbiol Rev 2006; 30: 36-52.
2. Piddock LJ. Multidrug-resistance efflux pumps - not just for resistance. Nat Rev Microbiol 2006; 4: 629-36.
3. Webber MA, Piddock LJ. The importance of efflux pumps in bacterial antibiotic resistance. J Antimicrob Chemother 2003; 51: 9-11.
4. De Rossi E, Arrigo P, Bellinzoni M et al. The multidrug transporters belonging to major facilitator superfamily in Mycobacterium tuberculosis. Mol Med 2002; 8: 714-24.
5. Ramon-Garcia S, Martin C, Ainsa JA et al. Characterization of tetracycline resistance mediated by the efflux pump Tap from Mycobacterium fortuitum. J Antimicrob Chemother 2006; 57: 252-9.
6. Ainsa JA, Martin C, Cabeza M et al. Construction of a family of Mycobacterium/Escherichia coli shuttle vectors derived from pAL5000 and pACYC184: Their use for cloning an antibiotic-resistance gene from Mycobacterium fortuitum. Gene 1996; 176: 23-6.
7. Blondelet-Rouault MH, Weiser J, Lebrihi A et al. Antibiotic resistance gene cassettes derived from the omega interposon for use in E. coli and Streptomyces. Gene 1997; 190: 315-7.
8. Parish T, Stoker NG. Use of a flexible cassette method to generate a double unmarked Mycobacterium tuberculosis tlyA plcABC mutant by gene replacement. Microbiology 2000; 146: 1969-75.
9. Lewinson O, Paden E, Bibi E. Alkalitolerance: A biological function for a multidrug transporter in pH homeostasis. Proc Natl Acad Sci USA 2004; 101: 14073-8.
10. Cappelli G, Volpe E, Grassi M et al. Profiling of Mycobacterium tuberculosis gene expression during human macrophage infection: upregulation of the alternative sigma factor G, a group of transcriptional regulators, and proteins with unknown function. Res Microbiol 2006; 157: 445-55.