Tetracycline antibiotics: Mode of action, applications, molecular biology, and epidemiology of bacterial resistance

Microbiology and Molecular Biology Reviews

Volumn 65, Issue 2, 2001, Pages 232-260

  Chopra, I ^a   Roberts, M ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; DOXYCYCLINE; RIBOSOME PROTEIN; ROLITETRACYCLINE; TETRACYCLINE;

ANTIBIOTIC RESISTANCE; BACTERIAL GENE; BACTERIAL INFECTION; DRUG ABSORPTION; DRUG ELIMINATION; DRUG HALF LIFE; GENE EXPRESSION; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HUMAN; NONHUMAN; POINT MUTATION; PROPHYLAXIS; REVIEW; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; TET GENE; VETERINARY MEDICINE;

ANIMAL HUSBANDRY; ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIAL INFECTIONS; HUMANS; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; TETRACYCLINE RESISTANCE; TETRACYCLINES;

ANIMALIA; BACTERIA (MICROORGANISMS); CHLAMYDIAE; MYCOPLASMATALES; NEGIBACTERIA; POSIBACTERIA; PROTOZOA; SHIGELLA DYSENTERIAE;

EID: 0034973583     PISSN: 10922172     EISSN: None     Source Type: Journal    
DOI: 10.1128/MMBR.65.2.232-260.2001     Document Type: Review

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199. Characterization of the Tn916-like transposon Tn3872 on a strain of Abiotrophia defectiva (Streptococcus defectivus) causing sequential episodes of endocarditis in a child
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202. Comparative analysis of five related staphylococcal plasmids
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207. Tn5381, a conjugative transposon identifiable as a circular form in Enterococcus faecalis
208. A novel tetracycline-resistant determinant, tet(U), is encoded on the plasmid pKQ10 in Enterococcus faecium
209. Ciprofloxacin does not inhibit mitochondrial functions but other antibiotics do
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211. Plasmids of Neisseria gonorrhoeae and other Neisseria species
212. Plasmid-mediated Tet M in Haemophilus ducreyi
213. Characterization of the Tet M determinant in urogenital and respiratory bacteria
214. Tetracycline resistance in Peptostreptococcus species
215. Epidemiology of tetracycline resistance determinants
216. Tetracycline resistant determinants: Mechanisms of action, regulation of expression, genetic mobility and distribution
217. Genetic mobility and distribution of tetracycline resistance determinants
218. Oral bacteria: Reservoirs for antibiotic resistance traits
219. APUA - Alliance for the prudent use of antibiotics
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221. Characterization of tetracycline and erythromycin determinants in Treponema denticola
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231. Characterization of the genetic basis of antibiotic resistance in Clostridium difficile
232. Characterization of unusual tetracycline-resistant gram-positive bacteria
233. Detection of Tet M and Tet O tetracycline resistance genes by polymerase chain reaction
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237. Characterization of erythromycin resistance in Campylobacter (Wolinella) rectus
238. Chemical modification of the tetracyclines
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249. The effect of changes in the consumption of macrolide antibiotics on erythromycin resistance in group A streptococci in Finland
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251. Tetracyclines: Antibiotic action, uptake, and resistance mechanisms
252. Primaquine as prophylaxis for malaria for nonimmune travelers: A comparison with mefloquine and doxycycline
253. Nucleotide sequence and phylogeny of tet(L) tetracycline resistance determinant encoded by plasmid pSTE1 from Staphylococcus hyicus
254. Tetracycline resistance in Staphylococcus spp. from domestic and pet animals
255. Occurrence of the new tetracycline resistance gene tet(W) in bacteria from the human gut
256. Sex and the single circle: Conjugative transposition
257. Origin of tetracycline efflux proteins: Conclusions from nucleotide sequence analysis
258. Comparative in-vitro activities of RP59500 (quinupristin/dalfopristin), CL 329,998, CL 331,002, trovafloxacin, clinafloxacin, teicoplanin and vancomycin against Gram-positive bacteria
259. Mechanism of transferable resistance to chloramphenicol in Haemophilus parainfluenzae
260. Tetracycline enhances Tn916-mediated conjugal transfer
261. The Clostridium perfringens Tet P determinant comprises two overlapping genes: TetA(P), which mediates active tetracycline efflux, and tetB(P), which is related to the ribosomal protection family of tetracycline-resistance determinants
262. Random transposition by Tn916 in Desulfitobacterium dehalogenans allows for isolation and characterization of halorespiration-deficient mutants
263. The tetracyclines
264. The effect of the continuous administration of diets containing low levels of tetracyclines on the incidence of drug-resistant Bacterium coli in the faeces of pigs and chickens: The sensitivity of the Bacterium coli to other chemotherapeutic agents
265. Multiple drug-resistant Chlamydia trachomatis associated with clinical treatment failure
266. + antiporter
267. + antiporter of Escherichia coli
268. Identification and cloning of a tetracycline resistance gene from the fish pathogen Vibrio salmonicida
269. Evidence that a novel tetracycline resistance gene found on two Bacteroides transposons encodes an NADP-requiring oxidoreductase
270. Amplification of resistance genes in Haemophilus influenzae plasmids
271. Bacillus subtilis tetA(L) gene expression: Evidence for regulation by translational reinitiation
272. The multiple nature of the animal protein factor
273. Characterization of the tet(M) determinant of Tn916: Evidence for regulation by transcription attenuation
274. Glycylcyclines. 1. A new generation of potent antibacterial agents through modification of 9-aminotetracyclines
275. Synthesis and structure-activity relationship of novel glycylcycline derivatives leading to the discovery of GAR-936
276. Dissemination of a chloramphenicol-and tetracycline-resistant but penicillin-susceptible invasive clone of serotype 5 Streptococcus pneumoniae in Colombia
277. Molecular characterization of a plasmid-borne (pGT633) erythromycin resistance determinant (ermGT) from Lactobacillus reuteri 100-63
278. TetZ, a new tetracycline resistance determinant discovered in gram-positive bacteria, shows high homology, to gram-negative regulated efflux systems
279. Tetracycline resistance mediated by ribosomal protection
280. Mechanisms of antibiotic resistance in Campylobacter species
281. Host mutations (miaA and rpsL) reduce tetracycline resistance mediated by Tet(O) and Tet(M)
282. In vitro and in vivo antibacterial activities of the glycylcyclines, a new class of semisynthetic tetracyclines
283. Epidemic in cattle and humans of Salmonella typhimurium DT104 with chromsomally integrated multiple drug resistance
284. The conjugative transposon Tn925: Enhancement of conjugal transfer by tetracycline in Enterococcus faecalis and mobilization of chromosomal genes in Bacillus subtilis and E. faecalis
285. Ribosomal protection from tetracycline mediated by Tet(O): Tet(O) interaction with ribosomes is GTP-dependent
286. Novel tetracycline glycosides active against tetracycline-resistant bacteria
287. Topical antimicrobials: New horizons for management of periodontal disease in general practice?
288. Tissue distribution and effects on mitochondrial protein synthesis of tetracyclines after prolonged continuous intravenous administration to rats
289. Treatment of Helicobacter pylori infection: A review of the world literature
290. Plasmid-mediated chloramphenicol resistance in Haemophilus influenzae
291. A 15-month evaluation of the effects of repeated subgingival minocycline in chronic adult periodontitis
292. A DNA sequence upstream of the tet(O) gene is required for full expression of tetracycline resistance
293. Characterization of antibiotic resistance in Streptococcus suis
294. Infectious heredity of multiple drug resistance in bacteria
295. Endemic emergence of cephalosporin-resistant enterobacter: Relation to prior therapy
296. Susceptibility of enterococci, methicillin-resistant Staphylococcus aureus and Streptococcus pneumoniae to the glycylcyclines
297. Structural alterations in the translational attenuator of constitutively expressed ermC genes
298. In vitro activities of two new glycylcyclines, N,N-dimethylglycylamido derivatives of minocycline and 6-demethyl-6-deoxytetracycline, against 339 strains of anaerobic bacteria
299. Susceptibilities of Neisseria gonorrhoeae to the glycylcyclines
300. Tetracyclines
301. Decreased susceptibility to penicillin G and Tet M plasmids in genital and anorectal isolates of Neisseria meningitidis
302. In vitro activities of two glycylcyclines
303. Medical consequences of antibiotic use in agriculture
304. Detection of two groups of 25.2 Mda Tet M plasmids by polymerase chain reaction of the downstream region
305. + antiporter of Escherichia coli encoded by a transposon, Tn10
306. Nucleotide sequence analysis of the class G tetracycline resistance determinant from Vibrio anguillarum