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Volumn 33, Issue , 2015, Pages 417-443

The immunobiology of interleukin-27

Author keywords

Autoimmunity; IL 10; IL 17; Infectious disease; Inflammation

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 27; INTERLEUKIN 27 RECEPTOR; INTERLEUKIN 27P28; UNCLASSIFIED DRUG;

EID: 84927662065     PISSN: 07320582     EISSN: 15453278     Source Type: Book Series    
DOI: 10.1146/annurev-immunol-032414-112134     Document Type: Review
Times cited : (357)

References (229)
  • 1
    • 18444385868 scopus 로고    scopus 로고
    • IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells
    • Pflanz S, Timans JC, Cheung J, Rosales R, Kanzler H, et al. 2002. IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells. Immunity 16:779-90
    • (2002) Immunity , vol.16 , pp. 779-790
    • Pflanz, S.1    Timans, J.C.2    Cheung, J.3    Rosales, R.4    Kanzler, H.5
  • 2
    • 10744222574 scopus 로고    scopus 로고
    • WSX-1and glycoprotein 130 constitute a signal-transducing receptor for IL-27
    • Pflanz S,Hibbert L, Mattson J, RosalesR, Vaisberg E, et al. 2004. WSX-1and glycoprotein 130 constitute a signal-transducing receptor for IL-27. J. Immunol. 172:2225-31
    • (2004) J. Immunol. , vol.172 , pp. 2225-2231
    • Pflanz, S.1    Hibbert, L.2    Mattson, J.3    Rosales, R.4    Vaisberg, E.5
  • 3
    • 34247523141 scopus 로고    scopus 로고
    • Discovery and biology of IL-23 and IL-27: Related but functionally distinct regulators of inflammation
    • Kastelein RA, Hunter CA, Cua DJ. 2007. Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation. Annu. Rev. Immunol. 25:221-42
    • (2007) Annu. Rev. Immunol. , vol.25 , pp. 221-242
    • Kastelein, R.A.1    Hunter, C.A.2    Cua, D.J.3
  • 4
    • 0037168543 scopus 로고    scopus 로고
    • Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient mice
    • Nieuwenhuis EE, Neurath MF, Corazza N, Iijima H, Trgovcich J, et al. 2002. Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient mice. PNAS 99:16951-56
    • (2002) PNAS , vol.99 , pp. 16951-16956
    • Nieuwenhuis, E.E.1    Neurath, M.F.2    Corazza, N.3    Iijima, H.4    Trgovcich, J.5
  • 5
    • 0034687402 scopus 로고    scopus 로고
    • Development of Th1-type immune responses requires the type i cytokine receptor TCCR
    • Chen Q, Ghilardi N, Wang H, Baker T, Xie MH, et al. 2000. Development of Th1-type immune responses requires the type I cytokine receptor TCCR. Nature 407:916-20
    • (2000) Nature , vol.407 , pp. 916-920
    • Chen, Q.1    Ghilardi, N.2    Wang, H.3    Baker, T.4    Xie, M.H.5
  • 7
    • 0038326688 scopus 로고    scopus 로고
    • Cutting Edge: Role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment
    • Takeda A, Hamano S, Yamanaka A, Hanada T, Ishibashi T, et al. 2003. Cutting Edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment. J. Immunol. 170:4886-90
    • (2003) J. Immunol. , vol.170 , pp. 4886-4890
    • Takeda, A.1    Hamano, S.2    Yamanaka, A.3    Hanada, T.4    Ishibashi, T.5
  • 8
    • 0344304399 scopus 로고    scopus 로고
    • IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and-independent mechanisms
    • Lucas S, Ghilardi N, Li J, de Sauvage FJ. 2003. IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and-independent mechanisms. PNAS 100:15047-52
    • (2003) PNAS , vol.100 , pp. 15047-15052
    • Lucas, S.1    Ghilardi, N.2    Li, J.3    De Sauvage, F.J.4
  • 9
    • 0345570521 scopus 로고    scopus 로고
    • The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection
    • Villarino A, Hibbert L, Lieberman L,Wilson E, Mak T, et al. 2003. The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection. Immunity 19:645-55
    • (2003) Immunity , vol.19 , pp. 645-655
    • Villarino, A.1    Hibbert, L.2    Lieberman, L.3    Wilson, E.4    Mak, T.5
  • 10
    • 1842477302 scopus 로고    scopus 로고
    • Cutting Edge: Early IL-4 production governs the requirement for IL-27-WSX-1 signaling in the development of protective Th1 cytokine responses following Leishmania major infection
    • Artis D, Johnson LM, Joyce K, Saris C, Villarino A, et al. 2004. Cutting Edge: early IL-4 production governs the requirement for IL-27-WSX-1 signaling in the development of protective Th1 cytokine responses following Leishmania major infection. J. Immunol. 172:4672-75
    • (2004) J. Immunol. , vol.172 , pp. 4672-4675
    • Artis, D.1    Johnson, L.M.2    Joyce, K.3    Saris, C.4    Villarino, A.5
  • 11
    • 10744221849 scopus 로고    scopus 로고
    • WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of proinflammatory cytokine production
    • Hamano S, Himeno K, Miyazaki Y, Ishii K, Yamanaka A, et al. 2003. WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of proinflammatory cytokine production. Immunity 19:657-67
    • (2003) Immunity , vol.19 , pp. 657-667
    • Hamano, S.1    Himeno, K.2    Miyazaki, Y.3    Ishii, K.4    Yamanaka, A.5
  • 12
    • 6344274850 scopus 로고    scopus 로고
    • The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity
    • Artis D, Villarino A, Silverman M, He W, Thornton EM, et al. 2004. The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity. J. Immunol. 173:5626-34
    • (2004) J. Immunol. , vol.173 , pp. 5626-5634
    • Artis, D.1    Villarino, A.2    Silverman, M.3    He, W.4    Thornton, E.M.5
  • 13
    • 14844355133 scopus 로고    scopus 로고
    • The IL-27 receptor chain WSX-1 differentially regulates antibacterial immunity and survival during experimental tuberculosis
    • Holscher C, Holscher A, Ruckerl D, Yoshimoto T, Yoshida H, et al. 2005. The IL-27 receptor chain WSX-1 differentially regulates antibacterial immunity and survival during experimental tuberculosis. J. Immunol. 174:3534-44
    • (2005) J. Immunol. , vol.174 , pp. 3534-3544
    • Holscher, C.1    Holscher, A.2    Ruckerl, D.3    Yoshimoto, T.4    Yoshida, H.5
  • 14
    • 30344488706 scopus 로고    scopus 로고
    • Interleukin-27R (WSX-1/T-cell cytokine receptor) gene-deficient mice display enhanced resistance to Leishmania donovani infection but develop severe liver immunopathology
    • Rosas LE, Satoskar AA, Roth KM, Keiser TL, Barbi J, et al. 2006. Interleukin-27R (WSX-1/T-cell cytokine receptor) gene-deficient mice display enhanced resistance to Leishmania donovani infection but develop severe liver immunopathology. Am. J. Pathol. 168:158-69
    • (2006) Am. J. Pathol. , vol.168 , pp. 158-169
    • Rosas, L.E.1    Satoskar, A.A.2    Roth, K.M.3    Keiser, T.L.4    Barbi, J.5
  • 15
    • 70449732757 scopus 로고    scopus 로고
    • IL-27 regulates IL-10 and IL-17 from CD4+ cells in nonhealing Leishmania major infection
    • Anderson CF, Stumhofer JS, Hunter CA, Sacks D. 2009. IL-27 regulates IL-10 and IL-17 from CD4+ cells in nonhealing Leishmania major infection. J. Immunol. 183:4619-27
    • (2009) J. Immunol. , vol.183 , pp. 4619-4627
    • Anderson, C.F.1    Stumhofer, J.S.2    Hunter, C.A.3    Sacks, D.4
  • 16
    • 48749121088 scopus 로고    scopus 로고
    • Interleukin-12 and interleukin-27 regulate macrophage control of Mycobacterium tuberculosis
    • Robinson CM, Nau GJ. 2008. Interleukin-12 and interleukin-27 regulate macrophage control of Mycobacterium tuberculosis. J. Infect. Dis. 198:359-66
    • (2008) J. Infect. Dis. , vol.198 , pp. 359-366
    • Robinson, C.M.1    Nau, G.J.2
  • 17
    • 84903648169 scopus 로고    scopus 로고
    • IL-27 limits central nervous system viral clearance by promoting IL-10 and enhances demyelination
    • de Aquino MT, Kapil P, Hinton DR, Phares TW, Puntambekar SS, et al. 2014. IL-27 limits central nervous system viral clearance by promoting IL-10 and enhances demyelination. J. Immunol. 193:285-94
    • (2014) J. Immunol. , vol.193 , pp. 285-294
    • De Aquino, M.T.1    Kapil, P.2    Hinton, D.R.3    Phares, T.W.4    Puntambekar, S.S.5
  • 18
    • 84871707047 scopus 로고    scopus 로고
    • Epstein-Barr virus-induced gene 3 negatively regulates neuroinflammation and T cell activation following coronavirus-induced encephalomyelitis
    • Tirotta E, Duncker P, Oak J, Klaus S, Tsukamoto MR, et al. 2013. Epstein-Barr virus-induced gene 3 negatively regulates neuroinflammation and T cell activation following coronavirus-induced encephalomyelitis. J. Neuroimmunol. 254:110-16
    • (2013) J. Neuroimmunol. , vol.254 , pp. 110-116
    • Tirotta, E.1    Duncker, P.2    Oak, J.3    Klaus, S.4    Tsukamoto, M.R.5
  • 19
    • 79952994082 scopus 로고    scopus 로고
    • CD4+ T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs
    • Sun J, Dodd H, Moser EK, Sharma R, Braciale TJ. 2011. CD4+ T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs. Nat. Immunol. 12:327-34
    • (2011) Nat. Immunol. , vol.12 , pp. 327-334
    • Sun, J.1    Dodd, H.2    Moser, E.K.3    Sharma, R.4    Braciale, T.J.5
  • 20
    • 84901653175 scopus 로고    scopus 로고
    • Timed action of IL-27 protects from immunopathology while preserving defense in influenza
    • Liu FD, Kenngott EE, Schroter MF, Kuhl A, Jennrich S, et al. 2014. Timed action of IL-27 protects from immunopathology while preserving defense in influenza. PLOS Pathog. 10:e1004110
    • (2014) PLOS Pathog. , vol.10 , pp. e1004110
    • Liu, F.D.1    Kenngott, E.E.2    Schroter, M.F.3    Kuhl, A.4    Jennrich, S.5
  • 21
    • 77956899787 scopus 로고    scopus 로고
    • Essential role for IL-27 receptor signaling in prevention of Th1-mediated immunopathology during malaria infection
    • Findlay EG, Greig R, Stumhofer JS, Hafalla JC, de Souza JB, et al. 2011. Essential role for IL-27 receptor signaling in prevention of Th1-mediated immunopathology during malaria infection. J. Immunol. 185:2482-92
    • (2011) J. Immunol. , vol.185 , pp. 2482-2492
    • Findlay, E.G.1    Greig, R.2    Stumhofer, J.S.3    Hafalla, J.C.4    De Souza, J.B.5
  • 23
    • 47049114262 scopus 로고    scopus 로고
    • Epstein-Barr virus-induced gene 3 negatively regulates IL-17, IL-22 and RORγt
    • Yang J, Yang M, Htut TM, Ouyang X, Hanidu A, et al. 2008. Epstein-Barr virus-induced gene 3 negatively regulates IL-17, IL-22 and RORγt. Eur. J. Immunol. 38:1204-14
    • (2008) Eur. J. Immunol. , vol.38 , pp. 1204-1214
    • Yang, J.1    Yang, M.2    Htut, T.M.3    Ouyang, X.4    Hanidu, A.5
  • 24
    • 28244474156 scopus 로고    scopus 로고
    • Membranous glomerulonephritis developmentwithTh2-type immune deviations in MRL/lprmice deficient for IL-27 receptor (WSX-1)
    • Shimizu S, Sugiyama N, Masutani K, Sadanaga A, Miyazaki Y, et al. 2005. Membranous glomerulonephritis developmentwithTh2-type immune deviations in MRL/lprmice deficient for IL-27 receptor (WSX-1). J. Immunol. 175:7185-92
    • (2005) J. Immunol. , vol.175 , pp. 7185-7192
    • Shimizu, S.1    Sugiyama, N.2    Masutani, K.3    Sadanaga, A.4    Miyazaki, Y.5
  • 25
    • 33747588291 scopus 로고    scopus 로고
    • Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells
    • Batten M, Li J, Yi S, Kljavin NM, Danilenko DM, et al. 2006. Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nat. Immunol. 7:929-36
    • (2006) Nat. Immunol. , vol.7 , pp. 929-936
    • Batten, M.1    Li, J.2    Yi, S.3    Kljavin, N.M.4    Danilenko, D.M.5
  • 26
    • 68149163187 scopus 로고    scopus 로고
    • IL-27 regulates homeostasis of the intestinal CD4+ effector T cell pool and limits intestinal inflammation in a murine model of colitis
    • Troy AE, Zaph C, Du Y, Taylor BC, Guild KJ, et al. 2009. IL-27 regulates homeostasis of the intestinal CD4+ effector T cell pool and limits intestinal inflammation in a murine model of colitis. J. Immunol. 183:2037-44
    • (2009) J. Immunol. , vol.183 , pp. 2037-2044
    • Troy, A.E.1    Zaph, C.2    Du, Y.3    Taylor, B.C.4    Guild, K.J.5
  • 27
    • 60149106103 scopus 로고    scopus 로고
    • Deficiency in EBV-induced gene 3 (EBI3) in MRL/lpr mice results in pathological alteration of autoimmune glomerulonephritis and sialadenitis
    • Igawa T, Nakashima H, Sadanaga A, Masutani K, Miyake K, et al. 2009. Deficiency in EBV-induced gene 3 (EBI3) in MRL/lpr mice results in pathological alteration of autoimmune glomerulonephritis and sialadenitis. Mod. Rheumatol. 19:33-41
    • (2009) Mod. Rheumatol. , vol.19 , pp. 33-41
    • Igawa, T.1    Nakashima, H.2    Sadanaga, A.3    Masutani, K.4    Miyake, K.5
  • 28
    • 38149045608 scopus 로고    scopus 로고
    • IL-27 suppresses Th2 cell development and Th2 cytokines production from polarized Th2 cells: A novel therapeutic way for Th2-mediated allergic inflammation
    • Yoshimoto T, Yasuda K, Mizuguchi J, Nakanishi K. 2007. IL-27 suppresses Th2 cell development and Th2 cytokines production from polarized Th2 cells: a novel therapeutic way for Th2-mediated allergic inflammation. J. Immunol. 179:4415-23
    • (2007) J. Immunol. , vol.179 , pp. 4415-4423
    • Yoshimoto, T.1    Yasuda, K.2    Mizuguchi, J.3    Nakanishi, K.4
  • 29
    • 66949157620 scopus 로고    scopus 로고
    • IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells
    • Diveu C, McGeachyMJ, Boniface K, Stumhofer JS, SatheM, et al. 2009. IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells. J. Immunol. 182:5748-56
    • (2009) J. Immunol. , vol.182 , pp. 5748-5756
    • Diveu, C.1    McGeachy, M.J.2    Boniface, K.3    Stumhofer, J.S.4    Sathe, M.5
  • 30
    • 1542409969 scopus 로고    scopus 로고
    • Hyperproduction of proinflammatory cytokines byWSX-1-deficient NKT cells in concanavalin A-induced hepatitis
    • Yamanaka A, Hamano S, MiyazakiY, Ishii K, Takeda A, et al. 2004. Hyperproduction of proinflammatory cytokines byWSX-1-deficient NKT cells in concanavalin A-induced hepatitis. J. Immunol. 172:3590-96
    • (2004) J. Immunol. , vol.172 , pp. 3590-3596
    • Yamanaka, A.1    Hamano, S.2    Miyazaki, Y.3    Ishii, K.4    Takeda, A.5
  • 31
    • 84876129756 scopus 로고    scopus 로고
    • High susceptibility to liver injury in IL-27 p28 conditional knockout mice involves intrinsic interferon-γ dysregulation of CD4+ T cells
    • Zhang S, Liang R, Luo W, Liu C, Wu X, et al. 2013. High susceptibility to liver injury in IL-27 p28 conditional knockout mice involves intrinsic interferon-γ dysregulation of CD4+ T cells. Hepatology 57:1620-31
    • (2013) Hepatology , vol.57 , pp. 1620-1631
    • Zhang, S.1    Liang, R.2    Luo, W.3    Liu, C.4    Wu, X.5
  • 32
    • 84873543730 scopus 로고    scopus 로고
    • A novel role for IL-27 in mediating the survival of activated mouse CD4 T lymphocytes
    • Kim G, Shinnakasu R, Saris CJ, Cheroutre H, Kronenberg M. 2013. A novel role for IL-27 in mediating the survival of activated mouse CD4 T lymphocytes. J. Immunol. 190:1510-18
    • (2013) J. Immunol. , vol.190 , pp. 1510-1518
    • Kim, G.1    Shinnakasu, R.2    Saris, C.J.3    Cheroutre, H.4    Kronenberg, M.5
  • 33
    • 0030067819 scopus 로고    scopus 로고
    • A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes
    • Devergne O, HummelM, Koeppen H, Le Beau MM, Nathnson EC, et al. 1996. A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes. J. Virol. 70:1143-53
    • (1996) J. Virol. , vol.70 , pp. 1143-1153
    • Devergne, O.1    Hummel, M.2    Koeppen, H.3    Le Beau, M.M.4    Nathnson, E.C.5
  • 34
    • 0030700003 scopus 로고    scopus 로고
    • Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin
    • Devergne O, Birkenbach M, Kieff E. 1997. Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin. PNAS 94:12041-46
    • (1997) PNAS , vol.94 , pp. 12041-12046
    • Devergne, O.1    Birkenbach, M.2    Kieff, E.3
  • 35
    • 36549030784 scopus 로고    scopus 로고
    • The inhibitory cytokine IL-35 contributes to regulatory T-cell function
    • Collison LW, Workman CJ, Kuo TT, Boyd K, Wang Y, et al. 2007. The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature 450:566-69
    • (2007) Nature , vol.450 , pp. 566-569
    • Collison, L.W.1    Workman, C.J.2    Kuo, T.T.3    Boyd, K.4    Wang, Y.5
  • 36
    • 76249108969 scopus 로고    scopus 로고
    • The IL-27 p28 subunit binds cytokine-like factor 1 to form a cytokine regulatingNKandTcell activities requiring IL-6R for signaling
    • Crabe S, Guay-Giroux A, Tormo AJ, Duluc D, Lissilaa R, et al. 2009. The IL-27 p28 subunit binds cytokine-like factor 1 to form a cytokine regulatingNKandTcell activities requiring IL-6R for signaling. J. Immunol. 183:7692-702
    • (2009) J. Immunol. , vol.183 , pp. 7692-7702
    • Crabe, S.1    Guay-Giroux, A.2    Tormo, A.J.3    Duluc, D.4    Lissilaa, R.5
  • 37
    • 84867755894 scopus 로고    scopus 로고
    • Novel IL27p28/IL12p40 cytokine suppressed experimental autoimmune uveitis by inhibiting autoreactive Th1/Th17 cells and promoting expansion of regulatory T cells
    • Wang RX, Yu CR, Mahdi RM, Egwuagu CE. 2012. Novel IL27p28/IL12p40 cytokine suppressed experimental autoimmune uveitis by inhibiting autoreactive Th1/Th17 cells and promoting expansion of regulatory T cells. J. Biol. Chem. 287:36012-21
    • (2012) J. Biol. Chem. , vol.287 , pp. 36012-36021
    • Wang, R.X.1    Yu, C.R.2    Mahdi, R.M.3    Egwuagu, C.E.4
  • 38
    • 78449300568 scopus 로고    scopus 로고
    • A role for IL-27p28 as an antagonist of gp130-mediated signaling
    • Stumhofer JS, Tait ED, Quinn WJ III, Hosken N, Spudy B, et al. 2010. A role for IL-27p28 as an antagonist of gp130-mediated signaling. Nat. Immunol. 11:1119-26
    • (2010) Nat. Immunol. , vol.11 , pp. 1119-1126
    • Stumhofer, J.S.1    Tait, E.D.2    Quinn, W.J.3    Hosken, N.4    Spudy, B.5
  • 39
    • 68249142908 scopus 로고    scopus 로고
    • The secreted form of p28 subunit of interleukin (IL)-27 inhibits biological functions of IL-27 and suppresses anti-allogeneic immune responses
    • Shimozato O, Sato A, Kawamura K, Chiyo M, Ma G, et al. 2009. The secreted form of p28 subunit of interleukin (IL)-27 inhibits biological functions of IL-27 and suppresses anti-allogeneic immune responses. Immunology 128:e816-25
    • (2009) Immunology , vol.128 , pp. e816-e825
    • Shimozato, O.1    Sato, A.2    Kawamura, K.3    Chiyo, M.4    Ma, G.5
  • 40
    • 84862777838 scopus 로고    scopus 로고
    • Interleukin-30: A novel antiinflammatory cytokine candidate for prevention and treatment of inflammatory cytokine-induced liver injury
    • Dibra D, Cutrera J, Xia X, Kallakury B, Mishra L, Li S. 2012. Interleukin-30: a novel antiinflammatory cytokine candidate for prevention and treatment of inflammatory cytokine-induced liver injury. Hepatology 55:1204-14
    • (2012) Hepatology , vol.55 , pp. 1204-1214
    • Dibra, D.1    Cutrera, J.2    Xia, X.3    Kallakury, B.4    Mishra, L.5    Li, S.6
  • 41
    • 78650602324 scopus 로고    scopus 로고
    • IL-27 structural analysis demonstrates similarities with ciliary neurotrophic factor (CNTF) and leads to the identification of antagonistic variants
    • Rousseau F, Basset L, Froger J, Dinguirard N, Chevalier S, Gascan H. 2010. IL-27 structural analysis demonstrates similarities with ciliary neurotrophic factor (CNTF) and leads to the identification of antagonistic variants. PNAS 107:19420-25
    • (2010) PNAS , vol.107 , pp. 19420-19425
    • Rousseau, F.1    Basset, L.2    Froger, J.3    Dinguirard, N.4    Chevalier, S.5    Gascan, H.6
  • 42
    • 84873624088 scopus 로고    scopus 로고
    • An interleukin-6 receptor-dependent molecular switch mediates signal transduction of the IL-27 cytokine subunit p28 (IL-30) via a gp130 protein receptor homodimer
    • Garbers C, Spudy B, Aparicio-Siegmund S, Waetzig GH, Sommer J, et al. 2013. An interleukin-6 receptor-dependent molecular switch mediates signal transduction of the IL-27 cytokine subunit p28 (IL-30) via a gp130 protein receptor homodimer. J. Biol. Chem. 288:4346-54
    • (2013) J. Biol. Chem. , vol.288 , pp. 4346-4354
    • Garbers, C.1    Spudy, B.2    Aparicio-Siegmund, S.3    Waetzig, G.H.4    Sommer, J.5
  • 44
    • 84878648242 scopus 로고    scopus 로고
    • Systemic 4-1BB activation induces a novel T cell phenotype driven by high expression of Eomesodermin
    • CurranMA, Geiger TL,MontalvoW,Kim M, Reiner SL, et al. 2013. Systemic 4-1BB activation induces a novel T cell phenotype driven by high expression of Eomesodermin. J. Exp. Med. 210:743-55
    • (2013) J. Exp. Med. , vol.210 , pp. 743-755
    • Curran, M.A.1    Geiger, T.L.2    Montalvo, W.3    Kim, M.4    Reiner, S.L.5
  • 45
    • 84860338292 scopus 로고    scopus 로고
    • Coordination between TLR9 signaling in macrophages and CD3 signaling in T cells induces robust expression of IL-30
    • Dibra D, Cutrera JJ, Li S. 2012. Coordination between TLR9 signaling in macrophages and CD3 signaling in T cells induces robust expression of IL-30. J. Immunol. 188:3709-15
    • (2012) J. Immunol. , vol.188 , pp. 3709-3715
    • Dibra, D.1    Cutrera, J.J.2    Li, S.3
  • 46
    • 0036890125 scopus 로고    scopus 로고
    • Interferon-β differentially regulates expression of the IL-12 family members p35, p40, p19 and EBI3 in activated human dendritic cells
    • van Seventer JM, Nagai T, van Seventer GA. 2002. Interferon-β differentially regulates expression of the IL-12 family members p35, p40, p19 and EBI3 in activated human dendritic cells. J. Neuroimmunol. 133:60-71
    • (2002) J. Neuroimmunol. , vol.133 , pp. 60-71
    • Van Seventer, J.M.1    Nagai, T.2    Van Seventer, G.A.3
  • 47
    • 37549011741 scopus 로고    scopus 로고
    • IFN-βmodulates the response to TLR stimulation in human DC: Involvement of IFN regulatory factor-1 (IRF-1) in IL-27 gene expression
    • Remoli ME,GafaV,Giacomini E, SeveraM, Lande R, Coccia EM. 2007. IFN-βmodulates the response to TLR stimulation in human DC: Involvement of IFN regulatory factor-1 (IRF-1) in IL-27 gene expression. Eur. J. Immunol. 37:3499-508
    • (2007) Eur. J. Immunol. , vol.37 , pp. 3499-3508
    • Remoli, M.E.1    Gafa, V.2    Giacomini, E.3    Severa, M.4    Lande, R.5    Coccia, E.M.6
  • 48
    • 34250167871 scopus 로고    scopus 로고
    • IL-27 synthesis induced by TLR ligation critically depends on IFN regulatory factor
    • Molle C, Nguyen M, Flamand V, Renneson J, Trottein F, et al. 2007. IL-27 synthesis induced by TLR ligation critically depends on IFN regulatory factor. J. Immunol. 178:7607-15
    • (2007) J. Immunol. , vol.178 , pp. 7607-7615
    • Molle, C.1    Nguyen, M.2    Flamand, V.3    Renneson, J.4    Trottein, F.5
  • 49
    • 33846440515 scopus 로고    scopus 로고
    • Regulation of IL-27 p28 gene expression in macrophages through MyD88-and interferon-γ-mediated pathways
    • Liu J, Guan X,Ma X. 2007. Regulation of IL-27 p28 gene expression in macrophages through MyD88-and interferon-γ-mediated pathways. J. Exp. Med. 204:141-52
    • (2007) J. Exp. Med. , vol.204 , pp. 141-152
    • Liu, J.1    Guan, X.2    Ma, X.3
  • 50
    • 36249017932 scopus 로고    scopus 로고
    • IFN-αregulates Toll-like receptor-mediated IL-27 gene expression in human macrophages
    • Pirhonen J, Siren J, Julkunen I,Matikainen S. 2007. IFN-αregulates Toll-like receptor-mediated IL-27 gene expression in human macrophages. J. Leukoc. Biol. 82:1185-92
    • (2007) J. Leukoc. Biol. , vol.82 , pp. 1185-1192
    • Pirhonen, J.1    Siren, J.2    Julkunen, I.3    Matikainen, S.4
  • 51
    • 84888802126 scopus 로고    scopus 로고
    • Modulation of inflammation by interleukin-27
    • Bosmann M, Ward PA. 2013. Modulation of inflammation by interleukin-27. J. Leukoc. Biol. 94:1159-65
    • (2013) J. Leukoc. Biol. , vol.94 , pp. 1159-1165
    • Bosmann, M.1    Ward, P.A.2
  • 52
    • 13544251389 scopus 로고    scopus 로고
    • Extracellular nucleotide signaling by P2 receptors inhibits IL-12 and enhances IL-23 expression in human dendritic cells: A novel role for the cAMP pathway
    • Schnurr M, ToyT, Shin A,WagnerM,Cebon J, MaraskovskyE. 2005. Extracellular nucleotide signaling by P2 receptors inhibits IL-12 and enhances IL-23 expression in human dendritic cells: a novel role for the cAMP pathway. Blood 105:1582-89
    • (2005) Blood , vol.105 , pp. 1582-1589
    • Schnurr, M.1    Toy, T.2    Shin, A.3    Wagner, M.4    Cebon, J.5    Maraskovsky, E.6
  • 54
    • 23844434887 scopus 로고    scopus 로고
    • Gi-protein-dependent inhibition of IL-12 production is mediated by activation of the phosphatidylinositol 3-kinase-protein 3 kinase B/Akt pathway and JNK
    • la Sala A, Gadina M, Kelsall BL. 2005. Gi-protein-dependent inhibition of IL-12 production is mediated by activation of the phosphatidylinositol 3-kinase-protein 3 kinase B/Akt pathway and JNK. J. Immunol. 175:2994-99
    • (2005) J. Immunol. , vol.175 , pp. 2994-2999
    • La Sala, A.1    Gadina, M.2    Kelsall, B.L.3
  • 55
    • 84861137551 scopus 로고    scopus 로고
    • Complement activation product C5a is a selective suppressor of TLR4-induced, but not TLR3-induced, production of IL-27(p28) from macrophages
    • Bosmann M, Haggadone MD, Hemmila MR, Zetoune FS, Sarma JV, Ward PA. 2012. Complement activation product C5a is a selective suppressor of TLR4-induced, but not TLR3-induced, production of IL-27(p28) from macrophages. J. Immunol. 188:5086-93
    • (2012) J. Immunol. , vol.188 , pp. 5086-5093
    • Bosmann, M.1    Haggadone, M.D.2    Hemmila, M.R.3    Zetoune, F.S.4    Sarma, J.V.5    Ward, P.A.6
  • 56
    • 84907192190 scopus 로고    scopus 로고
    • Complement component C5a permits the coexistence of pathogenic Th17 Cells and type i IFN in lupus
    • Pawaria S, Ramani K, Maers K, Liu Y, Kane LP, et al. 2014. Complement component C5a permits the coexistence of pathogenic Th17 Cells and type I IFN in lupus. J. Immunol. 193:3179-80
    • (2014) J. Immunol. , vol.193 , pp. 3179-3180
    • Pawaria, S.1    Ramani, K.2    Maers, K.3    Liu, Y.4    Kane, L.P.5
  • 57
    • 79960800539 scopus 로고    scopus 로고
    • Mutations in the transmembrane and juxtamembrane domains enhance IL27R transforming activity
    • LambertQT, Pradhan A, Roll JD, Reuther GW. 2011. Mutations in the transmembrane and juxtamembrane domains enhance IL27R transforming activity. Biochem. J. 438:155-64
    • (2011) Biochem. J. , vol.438 , pp. 155-164
    • Lambert, Q.T.1    Pradhan, A.2    Roll, J.D.3    Reuther, G.W.4
  • 58
    • 36749024030 scopus 로고    scopus 로고
    • Transformation of hematopoietic cells and activation of JAK2-V617F by IL-27R, a component of a heterodimeric type i cytokine receptor
    • Pradhan A, Lambert QT, Reuther GW. 2007. Transformation of hematopoietic cells and activation of JAK2-V617F by IL-27R, a component of a heterodimeric type I cytokine receptor. PNAS 104:18502-7
    • (2007) PNAS , vol.104 , pp. 18502-18507
    • Pradhan, A.1    Lambert, Q.T.2    Reuther, G.W.3
  • 60
    • 84868521662 scopus 로고    scopus 로고
    • Persistent loss of IL-27 responsiveness in CD8+ memory T cells abrogates IL-10 expression in a recall response
    • Perona-Wright G, Kohlmeier JE, Bassity E, Freitas TC, Mohrs K, et al. 2012. Persistent loss of IL-27 responsiveness in CD8+ memory T cells abrogates IL-10 expression in a recall response. PNAS 109:18535-40
    • (2012) PNAS , vol.109 , pp. 18535-18540
    • Perona-Wright, G.1    Kohlmeier, J.E.2    Bassity, E.3    Freitas, T.C.4    Mohrs, K.5
  • 61
    • 67449124590 scopus 로고    scopus 로고
    • Humanin inhibits neuronal cell death by interacting with a cytokine receptor complex or complexes involving CNTF receptor α/WSX-1/gp130
    • HashimotoY,KuritaM,Aiso S,Nishimoto I, MatsuokaM. 2009. Humanin inhibits neuronal cell death by interacting with a cytokine receptor complex or complexes involving CNTF receptor α/WSX-1/gp130. Mol. Biol. Cell 20:2864-73
    • (2009) Mol. Biol. Cell , vol.20 , pp. 2864-2873
    • Hashimoto, Y.1    Kurita, M.2    Aiso, S.3    Nishimoto, I.4    Matsuoka, M.5
  • 63
    • 84902078796 scopus 로고    scopus 로고
    • Interleukin-35 induces regulatory B cells that suppress autoimmune disease
    • WangRX,YuCR, Dambuza IM, MahdiRM, DolinskaMB, et al. 2014. Interleukin-35 induces regulatory B cells that suppress autoimmune disease. Nat. Med. 20:633-41
    • (2014) Nat. Med. , vol.20 , pp. 633-641
    • Wang, R.X.1    Yu, C.R.2    Dambuza, I.M.3    Mahdi, R.M.4    Dolinska, M.B.5
  • 64
    • 84901264863 scopus 로고    scopus 로고
    • A soluble form of IL-27Rαis a natural IL-27 antagonist
    • Dietrich C, Candon S, Ruemmele FM, Devergne O. 2014. A soluble form of IL-27Rαis a natural IL-27 antagonist. J. Immunol. 192:5382-89
    • (2014) J. Immunol. , vol.192 , pp. 5382-5389
    • Dietrich, C.1    Candon, S.2    Ruemmele, F.M.3    Devergne, O.4
  • 65
    • 84862776988 scopus 로고    scopus 로고
    • Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'
    • Levin AM, Bates DL, Ring AM, Krieg C, Lin JT, et al. 2012. Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'. Nature 484:529-33
    • (2012) Nature , vol.484 , pp. 529-533
    • Levin, A.M.1    Bates, D.L.2    Ring, A.M.3    Krieg, C.4    Lin, J.T.5
  • 67
    • 33747593830 scopus 로고    scopus 로고
    • Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system
    • Stumhofer JS, Laurence A, Wilson EH, Huang E, Tato CM, et al. 2006. Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nat. Immunol. 7:937-45
    • (2006) Nat. Immunol. , vol.7 , pp. 937-945
    • Stumhofer, J.S.1    Laurence, A.2    Wilson, E.H.3    Huang, E.4    Tato, C.M.5
  • 69
    • 84866483591 scopus 로고    scopus 로고
    • The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology
    • Hall AO, Beiting DP, Tato C, John B, Oldenhove G, et al. 2012. The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology. Immunity 37:511-23
    • (2012) Immunity , vol.37 , pp. 511-523
    • Hall, A.O.1    Beiting, D.P.2    Tato, C.3    John, B.4    Oldenhove, G.5
  • 70
    • 84865412454 scopus 로고    scopus 로고
    • Cutting Edge: Suppression of GM-CSF expression in murine and human T cells by IL-27
    • Young A, Linehan E, Hams E, O'Hara Hall AC, McClurg A, et al. 2012. Cutting Edge: suppression of GM-CSF expression in murine and human T cells by IL-27. J. Immunol. 189:2079-83
    • (2012) J. Immunol. , vol.189 , pp. 2079-2083
    • Young, A.1    Linehan, E.2    Hams, E.3    O'hara Hall, A.C.4    McClurg, A.5
  • 72
    • 44849096815 scopus 로고    scopus 로고
    • IL-27R deficiency delays the onset of colitis and protects from helminth-induced pathology in a model of chronic IBD
    • Villarino AV, Artis D, Bezbradica JS, Miller O, Saris CJ, et al. 2008. IL-27R deficiency delays the onset of colitis and protects from helminth-induced pathology in a model of chronic IBD. Int. Immunol. 20:739-52
    • (2008) Int. Immunol. , vol.20 , pp. 739-752
    • Villarino, A.V.1    Artis, D.2    Bezbradica, J.S.3    Miller, O.4    Saris, C.J.5
  • 73
    • 0346962972 scopus 로고    scopus 로고
    • Divergent pro-and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation
    • Murphy CA, Langrish CL, Chen Y, Blumenschein W, McClanahan T, et al. 2003. Divergent pro-and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J. Exp. Med. 198:1951-57
    • (2003) J. Exp. Med. , vol.198 , pp. 1951-1957
    • Murphy, C.A.1    Langrish, C.L.2    Chen, Y.3    Blumenschein, W.4    McClanahan, T.5
  • 74
    • 84866532132 scopus 로고    scopus 로고
    • Induction and molecular signature of pathogenic TH17 cells
    • Lee Y, Awasthi A, Yosef N, Quintana FJ, Xiao S, et al. 2012. Induction and molecular signature of pathogenic TH17 cells. Nat. Immunol. 13:991-99
    • (2012) Nat. Immunol. , vol.13 , pp. 991-999
    • Lee, Y.1    Awasthi, A.2    Yosef, N.3    Quintana, F.J.4    Xiao, S.5
  • 77
    • 79955756479 scopus 로고    scopus 로고
    • Interleukin-27-mediated suppression of human Th17 cells is associated with activation of STAT1 and suppressor of cytokine signaling protein
    • Liu H, Rohowsky-Kochan C. 2011. Interleukin-27-mediated suppression of human Th17 cells is associated with activation of STAT1 and suppressor of cytokine signaling protein. J. Interferon Cytokine Res. 31:459-69
    • (2011) J. Interferon Cytokine Res. , vol.31 , pp. 459-469
    • Liu, H.1    Rohowsky-Kochan, C.2
  • 78
    • 78650671831 scopus 로고    scopus 로고
    • STAT1-activating cytokines limit Th17 responses through both T-bet-dependent and-independent mechanisms
    • Villarino AV, Gallo E, Abbas AK. 2010. STAT1-activating cytokines limit Th17 responses through both T-bet-dependent and-independent mechanisms. J. Immunol. 185:6461-71
    • (2010) J. Immunol. , vol.185 , pp. 6461-6471
    • Villarino, A.V.1    Gallo, E.2    Abbas, A.K.3
  • 79
    • 84862981070 scopus 로고    scopus 로고
    • Interleukin-27 priming of T cells controls IL-17 production in trans via induction of the ligand PD-L1
    • Hirahara K, Ghoreschi K, Yang XP, Takahashi H, Laurence A, et al. 2012. Interleukin-27 priming of T cells controls IL-17 production in trans via induction of the ligand PD-L1. Immunity 36:1017-30
    • (2012) Immunity , vol.36 , pp. 1017-1030
    • Hirahara, K.1    Ghoreschi, K.2    Yang, X.P.3    Takahashi, H.4    Laurence, A.5
  • 80
    • 32544459770 scopus 로고    scopus 로고
    • Restoring function in exhausted CD8 T cells during chronic viral infection
    • Barber DL, Wherry EJ, Masopust D, Zhu B, Allison JP, et al. 2006. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 439:682-87
    • (2006) Nature , vol.439 , pp. 682-687
    • Barber, D.L.1    Wherry, E.J.2    Masopust, D.3    Zhu, B.4    Allison, J.P.5
  • 81
    • 84859158384 scopus 로고    scopus 로고
    • Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity
    • Topalian SL, Drake CG, Pardoll DM. 2012. Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity. Curr. Opin. Immunol. 24:207-12
    • (2012) Curr. Opin. Immunol. , vol.24 , pp. 207-212
    • Topalian, S.L.1    Drake, C.G.2    Pardoll, D.M.3
  • 82
    • 44449096726 scopus 로고    scopus 로고
    • IL-10: The master regulator of immunity to infection
    • Couper KN, Blount DG, Riley EM. 2008. IL-10: the master regulator of immunity to infection. J. Immunol. 180:5771-77
    • (2008) J. Immunol. , vol.180 , pp. 5771-5777
    • Couper, K.N.1    Blount, D.G.2    Riley, E.M.3
  • 83
    • 0029813545 scopus 로고    scopus 로고
    • Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4+ TH1-like responses
    • Berg DJ, Davidson N, Kuhn R, Muller W, Menon S, et al. 1996. Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4+ TH1-like responses. J. Clin. Investig. 98:1010-20
    • (1996) J. Clin. Investig. , vol.98 , pp. 1010-1020
    • Berg, D.J.1    Davidson, N.2    Kuhn, R.3    Muller, W.4    Menon, S.5
  • 84
    • 36248970701 scopus 로고    scopus 로고
    • A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells
    • Awasthi A, Carrier Y, Peron JP, Bettelli E, Kamanaka M, et al. 2007. A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells. Nat. Immunol. 8:1380-89
    • (2007) Nat. Immunol. , vol.8 , pp. 1380-1389
    • Awasthi, A.1    Carrier, Y.2    Peron, J.P.3    Bettelli, E.4    Kamanaka, M.5
  • 85
    • 36248970702 scopus 로고    scopus 로고
    • Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells
    • Fitzgerald DC, Zhang GX, El-Behi M, Fonseca-Kelly Z, Li H, et al. 2007. Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells. Nat. Immunol. 8:1372-79
    • (2007) Nat. Immunol. , vol.8 , pp. 1372-1379
    • Fitzgerald, D.C.1    Zhang, G.X.2    El-Behi, M.3    Fonseca-Kelly, Z.4    Li, H.5
  • 86
    • 84856567798 scopus 로고    scopus 로고
    • IL-27 promotes IL-10 production by effector Th1 CD4+ T cells: A critical mechanism for protection from severe immunopathology during malaria infection
    • Freitas doRosario AP,LambT, Spence P, StephensR,LangA, et al. 2012. IL-27 promotes IL-10 production by effector Th1 CD4+ T cells: a critical mechanism for protection from severe immunopathology during malaria infection. J. Immunol. 188:1178-90
    • (2012) J. Immunol. , vol.188 , pp. 1178-1190
    • Freitas Dorosario, A.P.1    Lamb, T.2    Spence, P.3    Stephens, R.4    Lang, A.5
  • 87
    • 79955000536 scopus 로고    scopus 로고
    • IL-27 and IL-21 are associated with T cell IL-10 responses in human visceral leishmaniasis
    • Ansari NA, Kumar R, Gautam S, Nylen S, Singh OP, et al. 2011. IL-27 and IL-21 are associated with T cell IL-10 responses in human visceral leishmaniasis. J. Immunol. 186:3977-85
    • (2011) J. Immunol. , vol.186 , pp. 3977-3985
    • Ansari, N.A.1    Kumar, R.2    Gautam, S.3    Nylen, S.4    Singh, O.P.5
  • 88
    • 79952317431 scopus 로고    scopus 로고
    • IL-27 induces the differentiation ofTr1-like cells from human naive CD4+ T cells via the phosphorylation of STAT1 and STAT3
    • Wang H, Meng R, Li Z, Yang B, LiuY, et al. 2011. IL-27 induces the differentiation ofTr1-like cells from human naive CD4+ T cells via the phosphorylation of STAT1 and STAT3. Immunol. Lett. 136:21-28
    • (2011) Immunol. Lett. , vol.136 , pp. 21-28
    • Wang, H.1    Meng, R.2    Li, Z.3    Yang, B.4    Liu, Y.5
  • 89
    • 69249083836 scopus 로고    scopus 로고
    • Cutting Edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells
    • Pot C, Jin H, Awasthi A, Liu SM, Lai CY, et al. 2009. Cutting Edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells. J. Immunol. 183:797-801
    • (2009) J. Immunol. , vol.183 , pp. 797-801
    • Pot, C.1    Jin, H.2    Awasthi, A.3    Liu, S.M.4    Lai, C.Y.5
  • 90
    • 73249149628 scopus 로고    scopus 로고
    • C-Maf regulates IL-10 expression during Th17 polarization
    • Xu J, Yang Y, Qiu G, Lal G, Wu Z, et al. 2009. c-Maf regulates IL-10 expression during Th17 polarization. J. Immunol. 182:6226-36
    • (2009) J. Immunol. , vol.182 , pp. 6226-6236
    • Xu, J.1    Yang, Y.2    Qiu, G.3    Lal, G.4    Wu, Z.5
  • 91
    • 77955903212 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27
    • Apetoh L, Quintana FJ, Pot C, Joller N, Xiao S, et al. 2010. The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27. Nat. Immunol. 11:854-61
    • (2010) Nat. Immunol. , vol.11 , pp. 854-861
    • Apetoh, L.1    Quintana, F.J.2    Pot, C.3    Joller, N.4    Xiao, S.5
  • 92
    • 84877103820 scopus 로고    scopus 로고
    • IL-21 is required for optimal antibody production and T cell responses during chronic Toxoplasma gondii infection
    • Stumhofer JS, Silver JS, Hunter CA. 2013. IL-21 is required for optimal antibody production and T cell responses during chronic Toxoplasma gondii infection. PLOS ONE 8:e62889
    • (2013) PLOS ONE , vol.8 , pp. e62889
    • Stumhofer, J.S.1    Silver, J.S.2    Hunter, C.A.3
  • 93
    • 84877321163 scopus 로고    scopus 로고
    • Metallothioneins negatively regulate IL-27-induced type 1 regulatory T-cell differentiation
    • Wu C, Pot C, Apetoh L, Thalhamer T, Zhu B, et al. 2013. Metallothioneins negatively regulate IL-27-induced type 1 regulatory T-cell differentiation. PNAS 110:7802-7
    • (2013) PNAS , vol.110 , pp. 7802-7807
    • Wu, C.1    Pot, C.2    Apetoh, L.3    Thalhamer, T.4    Zhu, B.5
  • 94
    • 41349099625 scopus 로고    scopus 로고
    • Interleukin-27 directly induces differentiation in hematopoietic stem cells
    • Seita J, Asakawa M, Ooehara J, Takayanagi S, Morita Y, et al. 2008. Interleukin-27 directly induces differentiation in hematopoietic stem cells. Blood 111:1903-12
    • (2008) Blood , vol.111 , pp. 1903-1912
    • Seita, J.1    Asakawa, M.2    Ooehara, J.3    Takayanagi, S.4    Morita, Y.5
  • 96
    • 34447567140 scopus 로고    scopus 로고
    • IL-27 controls the development of inducible regulatoryTcells andTh17 cells via differential effects on STAT1
    • Neufert C, Becker C,Wirtz S, FantiniMC, Weigmann B, et al. 2007. IL-27 controls the development of inducible regulatoryTcells andTh17 cells via differential effects on STAT1. Eur. J. Immunol. 37:1809-16
    • (2007) Eur. J. Immunol. , vol.37 , pp. 1809-1816
    • Neufert, C.1    Becker, C.2    Wirtz, S.3    Fantini, M.C.4    Weigmann, B.5
  • 99
    • 20444375878 scopus 로고    scopus 로고
    • Positive and negative regulation of the IL-27 receptor during lymphoid cell activation
    • Villarino AV, Larkin J 3rd, Saris CJ, Caton AJ, Lucas S, et al. 2005. Positive and negative regulation of the IL-27 receptor during lymphoid cell activation. J. Immunol. 174:7684-91
    • (2005) J. Immunol. , vol.174 , pp. 7684-7691
    • Villarino, A.V.1    Larkin, J.2    Saris, C.J.3    Caton, A.J.4    Lucas, S.5
  • 100
    • 65749103365 scopus 로고    scopus 로고
    • The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
    • Koch MA, Tucker-Heard G, Perdue NR, Killebrew JR, Urdahl KB, Campbell DJ. 2009. The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nat. Immunol. 10:595-602
    • (2009) Nat. Immunol. , vol.10 , pp. 595-602
    • Koch, M.A.1    Tucker-Heard, G.2    Perdue, N.R.3    Killebrew, J.R.4    Urdahl, K.B.5    Campbell, D.J.6
  • 101
    • 70449532980 scopus 로고    scopus 로고
    • Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection
    • Oldenhove G, Bouladoux N, Wohlfert EA, Hall JA, Chou D, et al. 2009. Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection. Immunity 31:772-86
    • (2009) Immunity , vol.31 , pp. 772-786
    • Oldenhove, G.1    Bouladoux, N.2    Wohlfert, E.A.3    Hall, J.A.4    Chou, D.5
  • 102
    • 84892421982 scopus 로고    scopus 로고
    • In vivo action of IL-27: Reciprocal regulation of Th17 and Treg cells in collagen-induced arthritis
    • Moon SJ, Park JS, Heo YJ, Kang CM, Kim EK, et al. 2013. In vivo action of IL-27: reciprocal regulation of Th17 and Treg cells in collagen-induced arthritis. Exp. Mol. Med. 45:e46
    • (2013) Exp. Mol. Med. , vol.45 , pp. e46
    • Moon, S.J.1    Park, J.S.2    Heo, Y.J.3    Kang, C.M.4    Kim, E.K.5
  • 103
    • 33751568890 scopus 로고    scopus 로고
    • IL-27 Induces Th1 differentiation via p38 MAPK/T-bet-and intercellular adhesion molecule-1/LFA-1/ERK1/2-dependent pathways
    • Owaki T, Asakawa M, Fukai F, Mizuguchi J, Yoshimoto T. 2006. IL-27 Induces Th1 differentiation via p38 MAPK/T-bet-and intercellular adhesion molecule-1/LFA-1/ERK1/2-dependent pathways. J. Immunol. 177:7579-87
    • (2006) J. Immunol. , vol.177 , pp. 7579-7587
    • Owaki, T.1    Asakawa, M.2    Fukai, F.3    Mizuguchi, J.4    Yoshimoto, T.5
  • 104
    • 34247575723 scopus 로고    scopus 로고
    • Cutting Edge: Alternative signaling of Th17 cell development by sphingosine 1-phosphate
    • Liao JJ, Huang MC, Goetzl EJ. 2007. Cutting Edge: alternative signaling of Th17 cell development by sphingosine 1-phosphate. J. Immunol. 178:5425-28
    • (2007) J. Immunol. , vol.178 , pp. 5425-5428
    • Liao, J.J.1    Huang, M.C.2    Goetzl, E.J.3
  • 106
    • 22544433708 scopus 로고    scopus 로고
    • Augmentation of effector CD8+T cell generation with enhanced granzyme B expression by IL-27
    • Morishima N, Owaki T, Asakawa M, Kamiya S, Mizuguchi J, Yoshimoto T. 2005. Augmentation of effector CD8+T cell generation with enhanced granzyme B expression by IL-27. J. Immunol. 175:1686-93
    • (2005) J. Immunol. , vol.175 , pp. 1686-1693
    • Morishima, N.1    Owaki, T.2    Asakawa, M.3    Kamiya, S.4    Mizuguchi, J.5    Yoshimoto, T.6
  • 107
    • 78650338317 scopus 로고    scopus 로고
    • IL-27 increases the proliferation and effector functions of human naive CD8+ T lymphocytes and promotes their development into Tc1 cells
    • Schneider R, Yaneva T, Beauseigle D, El-Khoury L, Arbour N. 2011. IL-27 increases the proliferation and effector functions of human naive CD8+ T lymphocytes and promotes their development into Tc1 cells. Eur. J. Immunol. 41:47-59
    • (2011) Eur. J. Immunol. , vol.41 , pp. 47-59
    • Schneider, R.1    Yaneva, T.2    Beauseigle, D.3    El-Khoury, L.4    Arbour, N.5
  • 108
    • 34948904840 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling 3 regulates CD8 T-cell proliferation by inhibition of interleukins 6 and 8
    • Brender C, Tannahill GM, Jenkins BJ, Fletcher J, Columbus R, et al. 2007. Suppressor of cytokine signaling 3 regulates CD8 T-cell proliferation by inhibition of interleukins 6 and 8. Blood 110:2528-36
    • (2007) Blood , vol.110 , pp. 2528-2536
    • Brender, C.1    Tannahill, G.M.2    Jenkins, B.J.3    Fletcher, J.4    Columbus, R.5
  • 109
    • 18644381517 scopus 로고    scopus 로고
    • Expression of IL-27 in murine carcinoma cells produces antitumor effects and induces protective immunity in inoculated host animals
    • Chiyo M, Shimozato O, Yu L, Kawamura K, Iizasa T, et al. 2005. Expression of IL-27 in murine carcinoma cells produces antitumor effects and induces protective immunity in inoculated host animals. Int. J. Cancer 115:437-42
    • (2005) Int. J. Cancer , vol.115 , pp. 437-442
    • Chiyo, M.1    Shimozato, O.2    Yu, L.3    Kawamura, K.4    Iizasa, T.5
  • 110
    • 14944367061 scopus 로고    scopus 로고
    • Antitumor effects produced by transduction of dendritic cells-derived heterodimeric cytokine genes in murine colon carcinoma cells
    • ChiyoM, ShimozatoO, IizasaT, Fujisawa T, TagawaM. 2004. Antitumor effects produced by transduction of dendritic cells-derived heterodimeric cytokine genes in murine colon carcinoma cells. Anticancer Res. 24:3763-67
    • (2004) Anticancer Res. , vol.24 , pp. 3763-3767
    • Chiyo, M.1    Shimozato, O.2    Iizasa, T.3    Fujisawa, T.4    Tagawa, M.5
  • 112
    • 64249118418 scopus 로고    scopus 로고
    • Immunologic and therapeutic synergy of IL-27 and IL-2: Enhancement of T cell sensitization, tumor-specific CTL reactivity and complete regression of disseminated neuroblastoma metastases in the liver and bone marrow
    • Salcedo R, Hixon JA, Stauffer JK, Jalah R, Brooks AD, et al. 2009. Immunologic and therapeutic synergy of IL-27 and IL-2: enhancement of T cell sensitization, tumor-specific CTL reactivity and complete regression of disseminated neuroblastoma metastases in the liver and bone marrow. J. Immunol. 182:4328-38
    • (2009) J. Immunol. , vol.182 , pp. 4328-4338
    • Salcedo, R.1    Hixon, J.A.2    Stauffer, J.K.3    Jalah, R.4    Brooks, A.D.5
  • 113
    • 10344228778 scopus 로고    scopus 로고
    • IL-27 mediates complete regression of orthotopic primary and metastatic murine neuroblastoma tumors: Role for CD8+ T cells
    • Salcedo R, Stauffer JK, Lincoln E, Back TC, Hixon JA, et al. 2004. IL-27 mediates complete regression of orthotopic primary and metastatic murine neuroblastoma tumors: role for CD8+ T cells. J. Immunol. 173:7170-82
    • (2004) J. Immunol. , vol.173 , pp. 7170-7182
    • Salcedo, R.1    Stauffer, J.K.2    Lincoln, E.3    Back, T.C.4    Hixon, J.A.5
  • 114
    • 60549117359 scopus 로고    scopus 로고
    • Tumor-specific cytotoxic T cell generation and dendritic cell function are differentially regulated by interleukin 27 during development of anti-tumor immunity
    • Shinozaki Y,Wang S, Miyazaki Y, Miyazaki K, Yamada H, et al. 2009. Tumor-specific cytotoxic T cell generation and dendritic cell function are differentially regulated by interleukin 27 during development of anti-tumor immunity. Int. J. Cancer 124:1372-78
    • (2009) Int. J. Cancer , vol.124 , pp. 1372-1378
    • Shinozaki, Y.1    Wang, S.2    Miyazaki, Y.3    Miyazaki, K.4    Yamada, H.5
  • 115
    • 40449137091 scopus 로고    scopus 로고
    • Cutting Edge: T-bet and IL-27R are critical for in vivo IFN-γproduction by CD8 T cells during infection
    • Mayer KD, Mohrs K, ReileyW,Wittmer S, Kohlmeier JE, et al. 2008. Cutting Edge: T-bet and IL-27R are critical for in vivo IFN-γproduction by CD8 T cells during infection. J. Immunol. 180:693-97
    • (2008) J. Immunol. , vol.180 , pp. 693-697
    • Mayer, K.D.1    Mohrs, K.2    Reiley, W.3    Wittmer, S.4    Kohlmeier, J.E.5
  • 116
    • 84912077479 scopus 로고    scopus 로고
    • IL-27 is required for shaping the magnitude, affinity distribution and memory of T cells responding to subunit immunization
    • Pennock ND,Gapin L, Kedl RM. 2014. IL-27 is required for shaping the magnitude, affinity distribution and memory of T cells responding to subunit immunization. PNAS 111:16472-77
    • (2014) PNAS , vol.111 , pp. 16472-16477
    • Pennock, N.D.1    Gapin, L.2    Kedl, R.M.3
  • 118
    • 33746889455 scopus 로고    scopus 로고
    • IL-10 is required for optimal CD8 T cell memory following Listeria monocytogenes infection
    • Foulds KE, Rotte MJ, Seder RA. 2006. IL-10 is required for optimal CD8 T cell memory following Listeria monocytogenes infection. J. Immunol. 177:2565-74
    • (2006) J. Immunol. , vol.177 , pp. 2565-2574
    • Foulds, K.E.1    Rotte, M.J.2    Seder, R.A.3
  • 119
    • 33846419491 scopus 로고    scopus 로고
    • Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals
    • Villarino AV, Tato CM, Stumhofer JS, Yao Z, Cui YK, et al. 2007. Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals. J. Exp. Med. 204:65-71
    • (2007) J. Exp. Med. , vol.204 , pp. 65-71
    • Villarino, A.V.1    Tato, C.M.2    Stumhofer, J.S.3    Yao, Z.4    Cui, Y.K.5
  • 120
    • 0037313578 scopus 로고    scopus 로고
    • Interleukin-12 and the regulation of innate resistance and adaptive immunity
    • Trinchieri G. 2003. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 3:133-46
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 133-146
    • Trinchieri, G.1
  • 121
    • 3142709474 scopus 로고    scopus 로고
    • Understanding the pro-and anti-inflammatory properties of IL-27
    • Villarino AV, Huang E, Hunter CA. 2004. Understanding the pro-and anti-inflammatory properties of IL-27. J. Immunol. 173:715-20
    • (2004) J. Immunol. , vol.173 , pp. 715-720
    • Villarino, A.V.1    Huang, E.2    Hunter, C.A.3
  • 122
    • 23444445743 scopus 로고    scopus 로고
    • Exacerbation of experimental allergic asthma by augmented Th2 responses inWSX-1-deficient mice
    • Miyazaki Y, Inoue H, MatsumuraM,Matsumoto K, Nakano T, et al. 2005. Exacerbation of experimental allergic asthma by augmented Th2 responses inWSX-1-deficient mice. J. Immunol. 175:2401-7
    • (2005) J. Immunol. , vol.175 , pp. 2401-2407
    • Miyazaki, Y.1    Inoue, H.2    Matsumura, M.3    Matsumoto, K.4    Nakano, T.5
  • 123
    • 1842477302 scopus 로고    scopus 로고
    • Cutting Edge: Early IL-4 production governs the requirement for IL-27-WSX-1 signaling in the development of protective Th1 cytokine responses following Leishmania major infection
    • Artis D, Johnson LM, Joyce K, Saris C, Villarino A, et al. 2004. Cutting Edge: early IL-4 production governs the requirement for IL-27-WSX-1 signaling in the development of protective Th1 cytokine responses following Leishmania major infection. J. Immunol. 172:4672-75
    • (2004) J. Immunol. , vol.172 , pp. 4672-4675
    • Artis, D.1    Johnson, L.M.2    Joyce, K.3    Saris, C.4    Villarino, A.5
  • 124
    • 23444445743 scopus 로고    scopus 로고
    • Exacerbation of experimental allergic asthma by augmented Th2 responses inWSX-1-deficient mice
    • Miyazaki Y, Inoue H, MatsumuraM,Matsumoto K, Nakano T, et al. 2005. Exacerbation of experimental allergic asthma by augmented Th2 responses inWSX-1-deficient mice. J. Immunol. 175:2401-7
    • (2005) J. Immunol. , vol.175 , pp. 2401-2407
    • Miyazaki, Y.1    Inoue, H.2    Matsumura, M.3    Matsumoto, K.4    Nakano, T.5
  • 125
    • 81055157812 scopus 로고    scopus 로고
    • Late interleukin-6 escalates T follicular helper cell responses and controls a chronic viral infection
    • Harker JA, Lewis GM, Mack L, Zuniga EI. 2012. Late interleukin-6 escalates T follicular helper cell responses and controls a chronic viral infection. Science 334:825-29
    • (2012) Science , vol.334 , pp. 825-829
    • Harker, J.A.1    Lewis, G.M.2    Mack, L.3    Zuniga, E.I.4
  • 126
    • 58449124804 scopus 로고    scopus 로고
    • The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells
    • Bauquet AT, Jin H, Paterson AM, Mitsdoerffer M, Ho IC, et al. 2009. The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells. Nat. Immunol. 10:167-75
    • (2009) Nat. Immunol. , vol.10 , pp. 167-175
    • Bauquet, A.T.1    Jin, H.2    Paterson, A.M.3    Mitsdoerffer, M.4    Ho, I.C.5
  • 127
    • 46749151286 scopus 로고    scopus 로고
    • Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages
    • Nurieva RI, Chung Y, Hwang D, Yang XO, Kang HS, et al. 2008. Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 29:138-49
    • (2008) Immunity , vol.29 , pp. 138-149
    • Nurieva, R.I.1    Chung, Y.2    Hwang, D.3    Yang, X.O.4    Kang, H.S.5
  • 128
    • 0037159687 scopus 로고    scopus 로고
    • A critical role for IL-21 in regulating immunoglobulin production
    • Ozaki K, Spolski R, Feng CG, Qi CF, Cheng J, et al. 2002. A critical role for IL-21 in regulating immunoglobulin production. Science 298:1630-34
    • (2002) Science , vol.298 , pp. 1630-1634
    • Ozaki, K.1    Spolski, R.2    Feng, C.G.3    Qi, C.F.4    Cheng, J.5
  • 129
    • 6344269331 scopus 로고    scopus 로고
    • Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6
    • Ozaki K, Spolski R, Ettinger R, Kim HP, Wang G, et al. 2004. Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6. J. Immunol. 173:5361-71
    • (2004) J. Immunol. , vol.173 , pp. 5361-5371
    • Ozaki, K.1    Spolski, R.2    Ettinger, R.3    Kim, H.P.4    Wang, G.5
  • 130
    • 40449100736 scopus 로고    scopus 로고
    • IL-27 induces a Th1 immune response and susceptibility to experimental arthritis
    • Cao Y, Doodes PD, Glant TT, Finnegan A. 2008. IL-27 induces a Th1 immune response and susceptibility to experimental arthritis. J. Immunol. 180:922-30
    • (2008) J. Immunol. , vol.180 , pp. 922-930
    • Cao, Y.1    Doodes, P.D.2    Glant, T.T.3    Finnegan, A.4
  • 131
    • 78650357814 scopus 로고    scopus 로고
    • IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells
    • Batten M, Ramamoorthi N, Kljavin NM, Ma CS, Cox JH, et al. 2010. IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells. J. Exp. Med. 207:2895-906
    • (2010) J. Exp. Med. , vol.207 , pp. 2895-2906
    • Batten, M.1    Ramamoorthi, N.2    Kljavin, N.M.3    Ma, C.S.4    Cox, J.H.5
  • 132
    • 84884351419 scopus 로고    scopus 로고
    • Cell-intrinsic IL-27 and gp130 cytokine receptor signaling regulates virus-specific CD4+ T cell responses and viral control during chronic infection
    • Harker JA, Dolgoter A, Zuniga EI. 2013. Cell-intrinsic IL-27 and gp130 cytokine receptor signaling regulates virus-specific CD4+ T cell responses and viral control during chronic infection. Immunity 39:548-59
    • (2013) Immunity , vol.39 , pp. 548-559
    • Harker, J.A.1    Dolgoter, A.2    Zuniga, E.I.3
  • 133
    • 84861423126 scopus 로고    scopus 로고
    • Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation
    • Ballesteros-Tato A, Leon B, Graf BA, Moquin A, Adams PS, et al. 2012. Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation. Immunity 36:847-56
    • (2012) Immunity , vol.36 , pp. 847-856
    • Ballesteros-Tato, A.1    Leon, B.2    Graf, B.A.3    Moquin, A.4    Adams, P.S.5
  • 135
    • 84859487740 scopus 로고    scopus 로고
    • STAT5 protein negatively regulates T follicular helper (Tfh) cell generation and function
    • Nurieva RI, Podd A, Chen Y, Alekseev AM, Yu M, et al. 2012. STAT5 protein negatively regulates T follicular helper (Tfh) cell generation and function. J. Biol. Chem. 287:11234-39
    • (2012) J. Biol. Chem. , vol.287 , pp. 11234-11239
    • Nurieva, R.I.1    Podd, A.2    Chen, Y.3    Alekseev, A.M.4    Yu, M.5
  • 139
    • 79960993671 scopus 로고    scopus 로고
    • Signaling events involved in interleukin 27 (IL-27)-induced proliferation of human naive CD4+ T cells and B cells
    • Charlot-Rabiega P, Bardel E, Dietrich C, Kastelein R, Devergne O. 2011. Signaling events involved in interleukin 27 (IL-27)-induced proliferation of human naive CD4+ T cells and B cells. J. Biol. Chem. 286:27350-62
    • (2011) J. Biol. Chem. , vol.286 , pp. 27350-27362
    • Charlot-Rabiega, P.1    Bardel, E.2    Dietrich, C.3    Kastelein, R.4    Devergne, O.5
  • 140
    • 79955844662 scopus 로고    scopus 로고
    • Interleukin-27 and interleukin-23 modulate human plasmacell functions
    • Cocco C, Morandi F, Airoldi I. 2011. Interleukin-27 and interleukin-23 modulate human plasmacell functions. J. Leukoc. Biol. 89:729-34
    • (2011) J. Leukoc. Biol. , vol.89 , pp. 729-734
    • Cocco, C.1    Morandi, F.2    Airoldi, I.3
  • 141
    • 67649197343 scopus 로고    scopus 로고
    • Interleukin 17 acts in synergy with B cell-activating factor to influence B cell biology and the pathophysiology of systemic lupus erythematosus
    • Doreau A, Belot A, Bastid J, Riche B, Trescol-Biemont MC, et al. 2009. Interleukin 17 acts in synergy with B cell-activating factor to influence B cell biology and the pathophysiology of systemic lupus erythematosus. Nat. Immunol. 10:778-85
    • (2009) Nat. Immunol. , vol.10 , pp. 778-785
    • Doreau, A.1    Belot, A.2    Bastid, J.3    Riche, B.4    Trescol-Biemont, M.C.5
  • 142
    • 67650462706 scopus 로고    scopus 로고
    • Expression of WSX1 in tumors sensitizes IL-27 signaling-independent natural killer cell surveillance
    • Dibra D, Cutrera JJ, Xia X, Birkenbach MP, Li S. 2009. Expression of WSX1 in tumors sensitizes IL-27 signaling-independent natural killer cell surveillance. Cancer Res. 69:5505-13
    • (2009) Cancer Res. , vol.69 , pp. 5505-5513
    • Dibra, D.1    Cutrera, J.J.2    Xia, X.3    Birkenbach, M.P.4    Li, S.5
  • 143
    • 79955777815 scopus 로고    scopus 로고
    • WSX1 expression in tumors induces immune tolerance via suppression of effector immune cells
    • Dibra D, Cutrera J, Xia X, Li S. 2011. WSX1 expression in tumors induces immune tolerance via suppression of effector immune cells. PLOS ONE 6:e19072
    • (2011) PLOS ONE , vol.6 , pp. e19072
    • Dibra, D.1    Cutrera, J.2    Xia, X.3    Li, S.4
  • 145
    • 84878232252 scopus 로고    scopus 로고
    • Synergy of IL-27 and TNF-αin regulating CXCL10 expression in lung fibroblasts
    • Dong S, Zhang X, He Y, Xu F, Li D, et al. 2013. Synergy of IL-27 and TNF-αin regulating CXCL10 expression in lung fibroblasts. Am. J. Respir. Cell Mol. Biol. 48:518-30
    • (2013) Am. J. Respir. Cell Mol. Biol. , vol.48 , pp. 518-530
    • Dong, S.1    Zhang, X.2    He, Y.3    Xu, F.4    Li, D.5
  • 146
    • 78649522921 scopus 로고    scopus 로고
    • Activation of eosinophils by IL-12 family cytokine IL-27: Implications of the pleiotropic roles of IL-27 in allergic responses
    • Hu S, Wong CK, LamCW. 2011. Activation of eosinophils by IL-12 family cytokine IL-27: implications of the pleiotropic roles of IL-27 in allergic responses. Immunobiology 216:54-65
    • (2011) Immunobiology , vol.216 , pp. 54-65
    • Hu, S.1    Wong, C.K.2    Lam, C.W.3
  • 147
    • 79957596746 scopus 로고    scopus 로고
    • T cell-specific overexpression of interleukin-27 receptor αsubunit (WSX-1) prevents spontaneous skin inflammation in MRL/lpr mice
    • Kido M, Takeuchi S, Sugiyama N, Esaki H, Nakashima H, et al. 2011. T cell-specific overexpression of interleukin-27 receptor αsubunit (WSX-1) prevents spontaneous skin inflammation in MRL/lpr mice. Br. J. Dermatol. 164:1214-20
    • (2011) Br. J. Dermatol. , vol.164 , pp. 1214-1220
    • Kido, M.1    Takeuchi, S.2    Sugiyama, N.3    Esaki, H.4    Nakashima, H.5
  • 148
    • 33746931178 scopus 로고    scopus 로고
    • Protection from lethal septic peritonitis by neutralizing the biological function of interleukin
    • Wirtz S,Tubbe I, Galle PR, Schild HJ,Birkenbach M, et al. 2006. Protection from lethal septic peritonitis by neutralizing the biological function of interleukin. J. Exp. Med. 203:1875-81
    • (2006) J. Exp. Med. , vol.203 , pp. 1875-1881
    • Wirtz, S.1    Tubbe, I.2    Galle, P.R.3    Schild, H.J.4    Birkenbach, M.5
  • 149
    • 84901049525 scopus 로고    scopus 로고
    • IL-27R-mediated regulation of IL-17 controls the development of respiratory syncytial virus-associated pathogenesis
    • de Almeida Nagata DE, Demoor T, Ptaschinski C, Ting HA, Jang S, et al. 2014. IL-27R-mediated regulation of IL-17 controls the development of respiratory syncytial virus-associated pathogenesis. Am. J. Pathol. 184:1807-18
    • (2014) Am. J. Pathol. , vol.184 , pp. 1807-1818
    • De Almeida Nagata, D.E.1    Demoor, T.2    Ptaschinski, C.3    Ting, H.A.4    Jang, S.5
  • 150
    • 84861394111 scopus 로고    scopus 로고
    • Interleukin-27 inhibits vaccine-enhanced pulmonary disease following respiratory syncytial virus infection by regulating cellular memory responses
    • Zeng R, ZhangH,Hai Y, Cui Y,Wei L, et al. 2012. Interleukin-27 inhibits vaccine-enhanced pulmonary disease following respiratory syncytial virus infection by regulating cellular memory responses. J. Virol. 86:4505-17
    • (2012) J. Virol. , vol.86 , pp. 4505-4517
    • Zeng, R.1    Zhang, H.2    Hai, Y.3    Cui, Y.4    Wei, L.5
  • 152
    • 84891939286 scopus 로고    scopus 로고
    • Activation of IL-27 signalling promotes development of postinfluenza pneumococcal pneumonia
    • Cao J,WangD,Xu F,GongY,WangH, et al. 2014. Activation of IL-27 signalling promotes development of postinfluenza pneumococcal pneumonia. EMBO Mol. Med. 6:120-40
    • (2014) EMBO Mol. Med. , vol.6 , pp. 120-140
    • Cao, J.1    Wang, D.2    Xu, F.3    Gong, Y.4    Wang, H.5
  • 153
    • 80054782482 scopus 로고    scopus 로고
    • IL-27 imparts immunoregulatory function to human NK cell subsets
    • Laroni A, Gandhi R, Beynon V, Weiner HL. 2011. IL-27 imparts immunoregulatory function to human NK cell subsets. PLOS ONE 6:e26173
    • (2011) PLOS ONE , vol.6 , pp. e26173
    • Laroni, A.1    Gandhi, R.2    Beynon, V.3    Weiner, H.L.4
  • 154
    • 84879620473 scopus 로고    scopus 로고
    • Critical role of dendritic cell-derived IL-27 in antitumor immunity through regulating the recruitment and activation ofNKandNKTcells
    • Wei J, Xia S, Sun H, Zhang S, Wang J, et al. 2013. Critical role of dendritic cell-derived IL-27 in antitumor immunity through regulating the recruitment and activation ofNKandNKTcells. J. Immunol. 191:500-8
    • (2013) J. Immunol. , vol.191 , pp. 500-508
    • Wei, J.1    Xia, S.2    Sun, H.3    Zhang, S.4    Wang, J.5
  • 155
    • 38449098843 scopus 로고    scopus 로고
    • Augmentation of antigen-presenting and Th1-promoting functions of dendritic cells by WSX-1(IL-27R) deficiency
    • Wang S, Miyazaki Y, Shinozaki Y, Yoshida H. 2007. Augmentation of antigen-presenting and Th1-promoting functions of dendritic cells by WSX-1(IL-27R) deficiency. J. Immunol. 179:6421-28
    • (2007) J. Immunol. , vol.179 , pp. 6421-6428
    • Wang, S.1    Miyazaki, Y.2    Shinozaki, Y.3    Yoshida, H.4
  • 156
    • 84886728752 scopus 로고    scopus 로고
    • IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39
    • Mascanfroni ID, Yeste A, Vieira SM, Burns EJ, Patel B, et al. 2013. IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39. Nat. Immunol. 14:1054-63
    • (2013) Nat. Immunol. , vol.14 , pp. 1054-1063
    • Mascanfroni, I.D.1    Yeste, A.2    Vieira, S.M.3    Burns, E.J.4    Patel, B.5
  • 158
    • 84897564889 scopus 로고    scopus 로고
    • IL-27 in human secondary lymphoid organs attractsmyeloid dendritic cells and impairsHLA class I-restricted antigen presentation
    • Morandi F, Di Carlo E, Ferrone S, Petretto A, Pistoia V, Airoldi I. 2014. IL-27 in human secondary lymphoid organs attractsmyeloid dendritic cells and impairsHLA class I-restricted antigen presentation. J. Immunol. 192:2634-42
    • (2014) J. Immunol. , vol.192 , pp. 2634-2642
    • Morandi, F.1    Di Carlo, E.2    Ferrone, S.3    Petretto, A.4    Pistoia, V.5    Airoldi, I.6
  • 159
    • 44449140104 scopus 로고    scopus 로고
    • IL-27 activates human monocytes via STAT1 and suppresses IL-10 production but the inflammatory functions of IL-27 are abrogated by TLRs and p38
    • Kalliolias GD, Ivashkiv LB. 2008. IL-27 activates human monocytes via STAT1 and suppresses IL-10 production but the inflammatory functions of IL-27 are abrogated by TLRs and p38. J. Immunol. 180:6325-33
    • (2008) J. Immunol. , vol.180 , pp. 6325-6333
    • Kalliolias, G.D.1    Ivashkiv, L.B.2
  • 160
    • 78650647259 scopus 로고    scopus 로고
    • Lipopolysaccharide-mediated IL-10 transcriptional regulation requires sequential induction of type i IFNs and IL-27 in macrophages
    • Iyer SS, Ghaffari AA, Cheng G. 2010. Lipopolysaccharide-mediated IL-10 transcriptional regulation requires sequential induction of type I IFNs and IL-27 in macrophages. J. Immunol. 185:6599-607
    • (2010) J. Immunol. , vol.185 , pp. 6599-6607
    • Iyer, S.S.1    Ghaffari, A.A.2    Cheng, G.3
  • 161
    • 37349034971 scopus 로고    scopus 로고
    • IL-27, a novel anti-HIV cytokine, activates multiple interferon-inducible genes in macrophages
    • Imamichi T, Yang J,Huang DW, Brann TW, Fullmer BA, et al. 2008. IL-27, a novel anti-HIV cytokine, activates multiple interferon-inducible genes in macrophages. AIDS 22:39-45
    • (2008) AIDS , vol.22 , pp. 39-45
    • Imamichi, T.1    Yang, J.2    Huang, D.W.3    Brann, T.W.4    Fullmer, B.A.5
  • 162
    • 84877045985 scopus 로고    scopus 로고
    • IL-27 inhibits HIV-1 infection in human macrophages by down-regulating host factor SPTBN1 during monocyte to macrophage differentiation
    • DaiL,Lidie KB,ChenQ,Adelsberger JW,Zheng X, et al. 2013. IL-27 inhibits HIV-1 infection in human macrophages by down-regulating host factor SPTBN1 during monocyte to macrophage differentiation. J. Exp. Med. 210:517-34
    • (2013) J. Exp. Med. , vol.210 , pp. 517-534
    • Dai, L.1    Lidie, K.B.2    Chen, Q.3    Adelsberger, J.W.4    Zheng, X.5
  • 163
    • 84892707316 scopus 로고    scopus 로고
    • IL-27, a cytokine, and IFN-λ1, a type III IFN, are coordinated to regulate virus replication through type i IFN
    • Cao Y, Zhang R, Zhang W, Zhu C, Yu Y, et al. 2014. IL-27, a cytokine, and IFN-λ1, a type III IFN, are coordinated to regulate virus replication through type I IFN. J. Immunol. 192:691-703
    • (2014) J. Immunol. , vol.192 , pp. 691-703
    • Cao, Y.1    Zhang, R.2    Zhang, W.3    Zhu, C.4    Yu, Y.5
  • 164
    • 84859485114 scopus 로고    scopus 로고
    • Influenza A virus induces interleukin-27 through cyclooxygenase-2 and protein kinase A signaling
    • Liu L, Cao Z, Chen J, Li R, Cao Y, et al. 2012. Influenza A virus induces interleukin-27 through cyclooxygenase-2 and protein kinase A signaling. J. Biol. Chem. 287:11899-910
    • (2012) J. Biol. Chem. , vol.287 , pp. 11899-11910
    • Liu, L.1    Cao, Z.2    Chen, J.3    Li, R.4    Cao, Y.5
  • 165
    • 84877080684 scopus 로고    scopus 로고
    • Interleukin-27 treated human macrophages induce the expression of novel microRNAs which may mediate anti-viral properties
    • Swaminathan S,HuX,Zheng X, KrigaY, Shetty J, et al. 2013. Interleukin-27 treated human macrophages induce the expression of novel microRNAs which may mediate anti-viral properties. Biochem. Biophys. Res. Commun. 434:228-34
    • (2013) Biochem. Biophys. Res. Commun. , vol.434 , pp. 228-234
    • Swaminathan, S.1    Hu, X.2    Zheng, X.3    Kriga, Y.4    Shetty, J.5
  • 166
    • 78650663329 scopus 로고    scopus 로고
    • Suppression of TNF-α and IL-1 signaling identifies a mechanism of homeostatic regulation of macrophages by IL-27
    • Kalliolias GD, Gordon RA, Ivashkiv LB. 2010. Suppression of TNF-α and IL-1 signaling identifies a mechanism of homeostatic regulation of macrophages by IL-27. J. Immunol. 185:7047-56
    • (2010) J. Immunol. , vol.185 , pp. 7047-7056
    • Kalliolias, G.D.1    Gordon, R.A.2    Ivashkiv, L.B.3
  • 167
    • 80053301608 scopus 로고    scopus 로고
    • Serum levels of interleukin (IL)-27 in patientswith ischemic heart disease
    • Jafarzadeh A, Nemati M, RezayatiMT. 2011. Serum levels of interleukin (IL)-27 in patientswith ischemic heart disease. Cytokine 56:153-56
    • (2011) Cytokine , vol.56 , pp. 153-156
    • Jafarzadeh, A.1    Nemati, M.2    Rezayati, M.T.3
  • 168
    • 84867897328 scopus 로고    scopus 로고
    • Interleukin-27 is a novel candidate diagnostic biomarker for bacterial infection in critically ill children
    • Wong HR, Cvijanovich NZ, Hall M, Allen GL, Thomas NJ, et al. 2012. Interleukin-27 is a novel candidate diagnostic biomarker for bacterial infection in critically ill children. Crit. Care 16:R213
    • (2012) Crit. Care , vol.16 , pp. R213
    • Wong, H.R.1    Cvijanovich, N.Z.2    Hall, M.3    Allen, G.L.4    Thomas, N.J.5
  • 169
    • 84887054338 scopus 로고    scopus 로고
    • Interleukin 27 as a sepsis diagnostic biomarker in critically ill adults
    • WongHR, Lindsell CJ,Lahni P, HartKW,Gibot S. 2013. Interleukin 27 as a sepsis diagnostic biomarker in critically ill adults. Shock 40:382-86
    • (2013) Shock , vol.40 , pp. 382-386
    • Wong, H.R.1    Lindsell, C.J.2    Lahni, P.3    Hart, K.W.4    Gibot, S.5
  • 170
    • 84879887612 scopus 로고    scopus 로고
    • Expression of IL-27, Th1 and Th17 in patients with aplastic anemia
    • Du HZ, Wang Q, Ji J, Shen BM, Wei SC, et al. 2013. Expression of IL-27, Th1 and Th17 in patients with aplastic anemia. J. Clin. Immunol. 33:436-45
    • (2013) J. Clin. Immunol. , vol.33 , pp. 436-445
    • Du, H.Z.1    Wang, Q.2    Ji, J.3    Shen, B.M.4    Wei, S.C.5
  • 171
    • 84897362475 scopus 로고    scopus 로고
    • Elevated serum level of IL-27 andVEGFin patients with ankylosing spondylitis and associate with disease activity
    • In press.
    • Lin TT, Lu J, Qi CY,YuanL,LiXL, et al. 2014. Elevated serum level of IL-27 andVEGFin patients with ankylosing spondylitis and associate with disease activity. Clin. Exp. Med. In press. doi: 10.1007/s10238-014-0281-x
    • (2014) Clin. Exp. Med.
    • Lin, T.T.1    Lu, J.2    Qi, C.Y.3    Yuan, L.4    Li, X.L.5
  • 172
    • 34250005444 scopus 로고    scopus 로고
    • TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1
    • Amadi-Obi A, Yu CR, Liu X, Mahdi RM, Clarke GL, et al. 2007. TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1. Nat. Med. 13:711-18
    • (2007) Nat. Med. , vol.13 , pp. 711-718
    • Amadi-Obi, A.1    Yu, C.R.2    Liu, X.3    Mahdi, R.M.4    Clarke, G.L.5
  • 173
    • 0027159096 scopus 로고
    • In vivo cytokine profiles in patients with kala-azar. Marked elevation of both interleukin-10 and interferon-γ
    • Karp CL, el-Safi SH,WynnTA, SattiMM,KordofaniAM, et al. 1993. In vivo cytokine profiles in patients with kala-azar. Marked elevation of both interleukin-10 and interferon-γ. J. Clin. Investig. 91:1644-48
    • (1993) J. Clin. Investig. , vol.91 , pp. 1644-1648
    • Karp, C.L.1    El-Safi, S.H.2    Wynn, T.A.3    Satti, M.M.4    Kordofani, A.M.5
  • 174
    • 80052422191 scopus 로고    scopus 로고
    • IL-10 neutralization promotes parasite clearance in splenic aspirate cells from patients with visceral leishmaniasis
    • Gautam S, Kumar R, Maurya R, Nylen S, Ansari N, et al. 2011. IL-10 neutralization promotes parasite clearance in splenic aspirate cells from patients with visceral leishmaniasis. J. Infect. Dis. 204:1134-37
    • (2011) J. Infect. Dis. , vol.204 , pp. 1134-1137
    • Gautam, S.1    Kumar, R.2    Maurya, R.3    Nylen, S.4    Ansari, N.5
  • 175
    • 80053619549 scopus 로고    scopus 로고
    • Proinflammatory and regulatory cytokines and chemokines in infants with uncomplicated and severe Plasmodium falciparum malaria
    • Ayimba E, Hegewald J, Segbena AY, Gantin RG, Lechner CJ, et al. 2011. Proinflammatory and regulatory cytokines and chemokines in infants with uncomplicated and severe Plasmodium falciparum malaria. Clin. Exp. Immunol. 166:218-26
    • (2011) Clin. Exp. Immunol. , vol.166 , pp. 218-226
    • Ayimba, E.1    Hegewald, J.2    Segbena, A.Y.3    Gantin, R.G.4    Lechner, C.J.5
  • 176
    • 79961154447 scopus 로고    scopus 로고
    • Gain-of-function human STAT1mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis
    • LiuL,Okada S, Kong XF,Kreins AY, Cypowyj S, et al. 2011. Gain-of-function human STAT1mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis. J. Exp. Med. 208:1635-48
    • (2011) J. Exp. Med. , vol.208 , pp. 1635-1648
    • Liu, L.1    Okada, S.2    Kong, X.F.3    Kreins, A.Y.4    Cypowyj, S.5
  • 177
    • 16244363083 scopus 로고    scopus 로고
    • Production of IL-27 and other IL-12 family cytokines by microglia and their subpopulations
    • Sonobe Y, Yawata I, Kawanokuchi J, Takeuchi H, Mizuno T, Suzumura A. 2005. Production of IL-27 and other IL-12 family cytokines by microglia and their subpopulations. Brain Res. 1040:202-7
    • (2005) Brain Res. , vol.1040 , pp. 202-207
    • Sonobe, Y.1    Yawata, I.2    Kawanokuchi, J.3    Takeuchi, H.4    Mizuno, T.5    Suzumura, A.6
  • 178
    • 35648988381 scopus 로고    scopus 로고
    • Suppressive effect of IL-27 on encephalitogenic Th17 cells and the effector phase of experimental autoimmune encephalomyelitis
    • Fitzgerald DC, Ciric B, Touil T, Harle H, Grammatikopolou J, et al. 2007. Suppressive effect of IL-27 on encephalitogenic Th17 cells and the effector phase of experimental autoimmune encephalomyelitis. J. Immunol. 179:3268-75
    • (2007) J. Immunol. , vol.179 , pp. 3268-3275
    • Fitzgerald, D.C.1    Ciric, B.2    Touil, T.3    Harle, H.4    Grammatikopolou, J.5
  • 179
    • 84869806031 scopus 로고    scopus 로고
    • IFN-γlimits Th9-mediated autoimmune inflammation through dendritic cell modulation of IL-27
    • Murugaiyan G, Beynon V, Pires Da Cunha A, Joller N,Weiner HL. 2012. IFN-γlimits Th9-mediated autoimmune inflammation through dendritic cell modulation of IL-27. J. Immunol. 189:5277-83
    • (2012) J. Immunol. , vol.189 , pp. 5277-5283
    • Murugaiyan, G.1    Beynon, V.2    Pires Da Cunha, A.3    Joller, N.4    Weiner, H.L.5
  • 180
    • 36249017932 scopus 로고    scopus 로고
    • IFN-αregulates Toll-like receptor-mediated IL-27 gene expression in human macrophages
    • Pirhonen J, Siren J, Julkunen I,Matikainen S. 2007. IFN-αregulates Toll-like receptor-mediated IL-27 gene expression in human macrophages. J. Leukoc. Biol. 82:1185-92
    • (2007) J. Leukoc. Biol. , vol.82 , pp. 1185-1192
    • Pirhonen, J.1    Siren, J.2    Julkunen, I.3    Matikainen, S.4
  • 181
    • 43049101640 scopus 로고    scopus 로고
    • The type i IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice
    • Guo B, Chang EY, Cheng G. 2008. The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice. J. Clin. Investig. 118:1680-90
    • (2008) J. Clin. Investig. , vol.118 , pp. 1680-1690
    • Guo, B.1    Chang, E.Y.2    Cheng, G.3
  • 182
    • 44449146212 scopus 로고    scopus 로고
    • Engagement of the type i interferon receptor on dendritic cells inhibits T helper 17 cell development: Role of intracellular osteopontin
    • Shinohara ML, Kim JH, Garcia VA, Cantor H. 2008. Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: role of intracellular osteopontin. Immunity 29:68-78
    • (2008) Immunity , vol.29 , pp. 68-78
    • Shinohara, M.L.1    Kim, J.H.2    Garcia, V.A.3    Cantor, H.4
  • 183
    • 79960219135 scopus 로고    scopus 로고
    • IL-27 mediates the response to IFN-βtherapy inmultiple sclerosis patients by inhibiting Th17 cells
    • Sweeney CM, Lonergan R, Basdeo SA, Kinsella K, Dungan LS, et al. 2011. IL-27 mediates the response to IFN-βtherapy inmultiple sclerosis patients by inhibiting Th17 cells. Brain Behav. Immun. 25:1170-81
    • (2011) Brain Behav. Immun. , vol.25 , pp. 1170-1181
    • Sweeney, C.M.1    Lonergan, R.2    Basdeo, S.A.3    Kinsella, K.4    Dungan, L.S.5
  • 187
    • 79959547499 scopus 로고    scopus 로고
    • IL-27-producing CD14+ cells infiltrate inflamed joints of rheumatoid arthritis and regulate inflammation and chemotactic migration
    • Tanida S, Yoshitomi H, Ishikawa M, Kasahara T, Murata K, et al. 2011. IL-27-producing CD14+ cells infiltrate inflamed joints of rheumatoid arthritis and regulate inflammation and chemotactic migration. Cytokine 55:237-44
    • (2011) Cytokine , vol.55 , pp. 237-244
    • Tanida, S.1    Yoshitomi, H.2    Ishikawa, M.3    Kasahara, T.4    Murata, K.5
  • 189
    • 84863052299 scopus 로고    scopus 로고
    • Elevated levels of interleukin-27 in patients with Sjogren's syndrome
    • Xia L, ShenH, Zhao L, Lu J. 2012. Elevated levels of interleukin-27 in patients with Sjogren's syndrome. Scand. J. Rheumatol. 41:73-74
    • (2012) Scand. J. Rheumatol. , vol.41 , pp. 73-74
    • Xia, L.1    Shen, H.2    Zhao, L.3    Lu, J.4
  • 190
    • 79957596746 scopus 로고    scopus 로고
    • T cell-specific overexpression of interleukin-27 receptor αsubunit (WSX-1) prevents spontaneous skin inflammation in MRL/lpr mice
    • Kido M, Takeuchi S, Sugiyama N, Esaki H, Nakashima H, et al. 2011. T cell-specific overexpression of interleukin-27 receptor αsubunit (WSX-1) prevents spontaneous skin inflammation in MRL/lpr mice. Br. J. Dermatol. 164:1214-34
    • (2011) Br. J. Dermatol. , vol.164 , pp. 1214-1234
    • Kido, M.1    Takeuchi, S.2    Sugiyama, N.3    Esaki, H.4    Nakashima, H.5
  • 191
    • 53149133918 scopus 로고    scopus 로고
    • Amelioration of human lupus-like phenotypes in MRL/lpr mice by overexpression of interleukin 27 receptor α(WSX-1)
    • Sugiyama N, Nakashima H, Yoshimura T, Sadanaga A, Shimizu S, et al. 2008. Amelioration of human lupus-like phenotypes in MRL/lpr mice by overexpression of interleukin 27 receptor α(WSX-1). Ann. Rheum. Dis. 67:1461-68
    • (2008) Ann. Rheum. Dis. , vol.67 , pp. 1461-1468
    • Sugiyama, N.1    Nakashima, H.2    Yoshimura, T.3    Sadanaga, A.4    Shimizu, S.5
  • 192
    • 60149106103 scopus 로고    scopus 로고
    • Deficiency in EBV-induced gene 3 (EBI3) in MRL/lpr mice results in pathological alteration of autoimmune glomerulonephritis and sialadenitis
    • Igawa T, Nakashima H, Sadanaga A, Masutani K, Miyake K, et al. 2009. Deficiency in EBV-induced gene 3 (EBI3) in MRL/lpr mice results in pathological alteration of autoimmune glomerulonephritis and sialadenitis. Mod. Rheumatol. 19:33-41
    • (2009) Mod. Rheumatol. , vol.19 , pp. 33-41
    • Igawa, T.1    Nakashima, H.2    Sadanaga, A.3    Masutani, K.4    Miyake, K.5
  • 193
    • 33748447541 scopus 로고    scopus 로고
    • Type i interferon in systemic lupus erythematosus and other autoimmune diseases
    • Banchereau J, PascualV. 2006. Type I interferon in systemic lupus erythematosus and other autoimmune diseases. Immunity 25:383-92
    • (2006) Immunity , vol.25 , pp. 383-392
    • Banchereau, J.1    Pascual, V.2
  • 194
    • 77951117432 scopus 로고    scopus 로고
    • Low level of serum interleukin 27 in patients with systemic lupus erythematosus
    • Li TT, Zhang T, Chen GM, Zhu QQ, Tao JH, et al. 2010. Low level of serum interleukin 27 in patients with systemic lupus erythematosus. J. Investig. Med. 58:737-39
    • (2010) J. Investig. Med. , vol.58 , pp. 737-739
    • Li, T.T.1    Zhang, T.2    Chen, G.M.3    Zhu, Q.Q.4    Tao, J.H.5
  • 195
    • 67649233028 scopus 로고    scopus 로고
    • IL-27 is expressed in chronic human eczematous skin lesions and stimulates human keratinocytes
    • Wittmann M, Zeitvogel J,Wang D,Werfel T. 2009. IL-27 is expressed in chronic human eczematous skin lesions and stimulates human keratinocytes. J. Allergy Clin. Immunol. 124:81-89
    • (2009) J. Allergy Clin. Immunol. , vol.124 , pp. 81-89
    • Wittmann, M.1    Zeitvogel, J.2    Wang, D.3    Werfel, T.4
  • 197
    • 47049124548 scopus 로고    scopus 로고
    • IL-12, IL-23, and IL-27 enhance human β-defensin-2 production in human keratinocytes
    • Kanda N, Watanabe S. 2008. IL-12, IL-23, and IL-27 enhance human β-defensin-2 production in human keratinocytes. Eur. J. Immunol. 38:1287-96
    • (2008) Eur. J. Immunol. , vol.38 , pp. 1287-1296
    • Kanda, N.1    Watanabe, S.2
  • 198
    • 84872600320 scopus 로고    scopus 로고
    • IL-27 activates Th1-mediated responses in imiquimod-induced psoriasis-like skin lesions
    • Shibata S, Tada Y, Asano Y, Yanaba K, Sugaya M, et al. 2012. IL-27 activates Th1-mediated responses in imiquimod-induced psoriasis-like skin lesions. J. Investig. Dermatol. 133:479-88
    • (2012) J. Investig. Dermatol. , vol.133 , pp. 479-488
    • Shibata, S.1    Tada, Y.2    Asano, Y.3    Yanaba, K.4    Sugaya, M.5
  • 200
    • 78650658942 scopus 로고    scopus 로고
    • Elevated serum interleukin-27 levels in patients with systemic sclerosis: Association with T cell, B cell and fibroblast activation
    • Yoshizaki A, Yanaba K, Iwata Y, Komura K, Ogawa A, et al. 2011. Elevated serum interleukin-27 levels in patients with systemic sclerosis: association with T cell, B cell and fibroblast activation. Ann. Rheum. Dis. 70:194-200
    • (2011) Ann. Rheum. Dis. , vol.70 , pp. 194-200
    • Yoshizaki, A.1    Yanaba, K.2    Iwata, Y.3    Komura, K.4    Ogawa, A.5
  • 201
    • 27944495565 scopus 로고    scopus 로고
    • T helper 1-inducing property of IL-27/WSX-1 signaling is required for the induction of experimental colitis
    • Honda K, Nakamura K,Matsui N, Takahashi M, Kitamura Y, et al. 2005. T helper 1-inducing property of IL-27/WSX-1 signaling is required for the induction of experimental colitis. Inflamm. Bowel Dis. 11:1044-52
    • (2005) Inflamm. Bowel Dis. , vol.11 , pp. 1044-1052
    • Honda, K.1    Nakamura, K.2    Matsui, N.3    Takahashi, M.4    Kitamura, Y.5
  • 202
    • 79955064497 scopus 로고    scopus 로고
    • Treatment with IL-27 attenuates experimental colitis through the suppression of the development of IL-17-producing T helper cells
    • Sasaoka T, Ito M, Yamashita J, Nakajima K, Tanaka I, et al. 2011. Treatment with IL-27 attenuates experimental colitis through the suppression of the development of IL-17-producing T helper cells. Am. J. Physiol. Gastrointest. Liver Physiol. 300:G568-76
    • (2011) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.300 , pp. G568-G576
    • Sasaoka, T.1    Ito, M.2    Yamashita, J.3    Nakajima, K.4    Tanaka, I.5
  • 203
    • 84855272274 scopus 로고    scopus 로고
    • A novel role for interleukin-27 (IL-27) as mediator of intestinal epithelial barrier protection mediated via differential signal transducer and activator of transcription (STAT) protein signaling and induction of antibacterial and anti-inflammatory proteins
    • Diegelmann J, Olszak T, Göke B, Blumberg RS, Brand S. 2011. A novel role for interleukin-27 (IL-27) as mediator of intestinal epithelial barrier protection mediated via differential signal transducer and activator of transcription (STAT) protein signaling and induction of antibacterial and anti-inflammatory proteins. J. Biol. Chem. 287:286-98
    • (2011) J. Biol. Chem. , vol.287 , pp. 286-298
    • Diegelmann, J.1    Olszak, T.2    Göke, B.3    Blumberg, R.S.4    Brand, S.5
  • 204
    • 70349659805 scopus 로고    scopus 로고
    • Interleukin-27 polymorphisms are associated with inflammatory bowel diseases in a Korean population
    • Li CS, Zhang Q, Lee KJ, Cho SW, Lee KM, et al. 2009. Interleukin-27 polymorphisms are associated with inflammatory bowel diseases in a Korean population. J. Gastroenterol. Hepatol. 24:1692-96
    • (2009) J. Gastroenterol. Hepatol. , vol.24 , pp. 1692-1696
    • Li, C.S.1    Zhang, Q.2    Lee, K.J.3    Cho, S.W.4    Lee, K.M.5
  • 205
    • 70649113728 scopus 로고    scopus 로고
    • Common variants at five new loci associated with early-onset inflammatory bowel disease
    • Imielinski M, Baldassano RN, Griffiths A, Russell RK, Annese V, et al. 2009. Common variants at five new loci associated with early-onset inflammatory bowel disease. Nat. Genet. 41:1335-40
    • (2009) Nat. Genet. , vol.41 , pp. 1335-1340
    • Imielinski, M.1    Baldassano, R.N.2    Griffiths, A.3    Russell, R.K.4    Annese, V.5
  • 206
    • 84898913683 scopus 로고    scopus 로고
    • Attenuation of intestinal inflammation in interleukin-10-deficient mice infected with Citrobacter rodentium
    • Dann SM,LeC,ChoudhuryBK, LiuH, SaldarriagaO, et al. 2014. Attenuation of intestinal inflammation in interleukin-10-deficient mice infected with Citrobacter rodentium. Infect. Immun. 82:1949-58
    • (2014) Infect. Immun. , vol.82 , pp. 1949-1958
    • Dann, S.M.1    Le, C.2    Choudhury, B.K.3    Liu, H.4    Saldarriaga, O.5
  • 207
    • 84890608517 scopus 로고    scopus 로고
    • Oral delivery of IL-27 recombinant bacteria attenuates immune colitis in mice
    • Hanson ML, Hixon JA, Li W, Felber BK, Anver MR, et al. 2014. Oral delivery of IL-27 recombinant bacteria attenuates immune colitis in mice. Gastroenterology 146:210-21.e13
    • (2014) Gastroenterology , vol.146 , pp. 210e13-221e13
    • Hanson, M.L.1    Hixon, J.A.2    Li, W.3    Felber, B.K.4    Anver, M.R.5
  • 208
    • 68949127073 scopus 로고    scopus 로고
    • Production of both IL-27 and IFN-γ after the treatment with a ligand for invariant NK T cells is responsible for the suppression of Th2 response and allergic inflammation in a mouse experimental asthma model
    • Fujita H, Teng A, Nozawa R, Takamoto-Matsui Y, Katagiri-Matsumura H, et al. 2009. Production of both IL-27 and IFN-γ after the treatment with a ligand for invariant NK T cells is responsible for the suppression of Th2 response and allergic inflammation in a mouse experimental asthma model. J. Immunol. 183:254-60
    • (2009) J. Immunol. , vol.183 , pp. 254-260
    • Fujita, H.1    Teng, A.2    Nozawa, R.3    Takamoto-Matsui, Y.4    Katagiri-Matsumura, H.5
  • 209
    • 79952535373 scopus 로고    scopus 로고
    • EBI3 deficiency leads to diminished T helper type 1 and increased T helper type 2 mediated airway inflammation
    • Dokmeci E, Xu L, Robinson E, Golubets K, Bottomly K, Herrick CA. 2011. EBI3 deficiency leads to diminished T helper type 1 and increased T helper type 2 mediated airway inflammation. Immunology 132:559-66
    • (2011) Immunology , vol.132 , pp. 559-566
    • Dokmeci, E.1    Xu, L.2    Robinson, E.3    Golubets, K.4    Bottomly, K.5    Herrick, C.A.6
  • 210
    • 77958117957 scopus 로고    scopus 로고
    • IL-27/IFN-γ induce MyD88-dependent steroid-resistant airway hyperresponsiveness by inhibiting glucocorticoid signaling in macrophages
    • Li JJ, Wang W, Baines KJ, Bowden NA, Hansbro PM, et al. 2010. IL-27/IFN-γ induce MyD88-dependent steroid-resistant airway hyperresponsiveness by inhibiting glucocorticoid signaling in macrophages. J. Immunol. 185:4401-9
    • (2010) J. Immunol. , vol.185 , pp. 4401-4409
    • Li, J.J.1    Wang, W.2    Baines, K.J.3    Bowden, N.A.4    Hansbro, P.M.5
  • 211
    • 77951223638 scopus 로고    scopus 로고
    • Activation of human bronchial epithelial cells by inflammatory cytokines IL-27 and TNF-α: Implications for immunopathophysiology of airway inflammation
    • Cao J,Wong CK, Yin Y, Lam CW. 2010. Activation of human bronchial epithelial cells by inflammatory cytokines IL-27 and TNF-α: implications for immunopathophysiology of airway inflammation. J. Cell. Physiol. 223:788-97
    • (2010) J. Cell. Physiol. , vol.223 , pp. 788-797
    • Cao, J.1    Wong, C.K.2    Yin, Y.3    Lam, C.W.4
  • 212
    • 84855416818 scopus 로고    scopus 로고
    • IL-27 is elevated in patients with COPD and patients with pulmonary TB and induces human bronchial epithelial cells to produce CXCL10
    • Cao J, Zhang L, Li D, Xu F, Huang S, et al. 2012. IL-27 is elevated in patients with COPD and patients with pulmonary TB and induces human bronchial epithelial cells to produce CXCL10. Chest 141:121-30
    • (2012) Chest , vol.141 , pp. 121-130
    • Cao, J.1    Zhang, L.2    Li, D.3    Xu, F.4    Huang, S.5
  • 214
    • 33947626493 scopus 로고    scopus 로고
    • Identification of polymorphisms in human interleukin-27 and their association with asthma in a Korean population
    • Chae SC, Li CS, Kim KM, Yang JY, Zhang Q, et al. 2007. Identification of polymorphisms in human interleukin-27 and their association with asthma in a Korean population. J. Hum. Genet. 52:355-61
    • (2007) J. Hum. Genet. , vol.52 , pp. 355-361
    • Chae, S.C.1    Li, C.S.2    Kim, K.M.3    Yang, J.Y.4    Zhang, Q.5
  • 215
    • 50849129534 scopus 로고    scopus 로고
    • Association of interleukin (IL)-12 and IL-27 gene polymorphisms with chronic obstructive pulmonary disease in a Chinese population
    • Huang N, Liu L, Wang XZ, Liu D, Yin SY, Yang XD. 2008. Association of interleukin (IL)-12 and IL-27 gene polymorphisms with chronic obstructive pulmonary disease in a Chinese population. DNA Cell Biol. 27:527-31
    • (2008) DNA Cell Biol. , vol.27 , pp. 527-531
    • Huang, N.1    Liu, L.2    Wang, X.Z.3    Liu, D.4    Yin, S.Y.5    Yang, X.D.6
  • 216
    • 84923942848 scopus 로고    scopus 로고
    • Association between Interleukin-27 gene polymorphisms and susceptibility to allergic rhinitis
    • Shen Y, Yuan XD, Hu D, Ke X, Wang XQ, et al. 2014. Association between Interleukin-27 gene polymorphisms and susceptibility to allergic rhinitis. Hum. Immunol. 75:991-95
    • (2014) Hum. Immunol. , vol.75 , pp. 991-995
    • Shen, Y.1    Yuan, X.D.2    Hu, D.3    Ke, X.4    Wang, X.Q.5
  • 219
    • 84888091506 scopus 로고    scopus 로고
    • IL-27 inhibits epithelial-mesenchymal transition and angiogenic factor production in a STAT1-dominant pathway in human non-small cell lung cancer
    • Kachroo P, Lee MH, Zhang L, Baratelli F, Lee G, et al. 2013. IL-27 inhibits epithelial-mesenchymal transition and angiogenic factor production in a STAT1-dominant pathway in human non-small cell lung cancer. J. Exp. Clin. Cancer Res. 32:97
    • (2013) J. Exp. Clin. Cancer Res. , vol.32 , pp. 97
    • Kachroo, P.1    Lee, M.H.2    Zhang, L.3    Baratelli, F.4    Lee, G.5
  • 220
    • 84881484241 scopus 로고    scopus 로고
    • IL-27 inhibits lymphatic endothelial cell proliferation by STAT1-regulated gene expression
    • Nielsen SR, Hammer T, Gibson J, Pepper MS, Nisato RE, et al. 2013. IL-27 inhibits lymphatic endothelial cell proliferation by STAT1-regulated gene expression. Microcirculation 20:555-64
    • (2013) Microcirculation , vol.20 , pp. 555-564
    • Nielsen, S.R.1    Hammer, T.2    Gibson, J.3    Pepper, M.S.4    Nisato, R.E.5
  • 221
    • 83555165176 scopus 로고    scopus 로고
    • Interleukin-27 inhibits pediatric B-acute lymphoblastic leukemia cell spreading in a preclinical model
    • Canale S, Cocco C, Frasson C, Seganfreddo E, Di Carlo E, et al. 2011. Interleukin-27 inhibits pediatric B-acute lymphoblastic leukemia cell spreading in a preclinical model. Leukemia 25:1815-24
    • (2011) Leukemia , vol.25 , pp. 1815-1824
    • Canale, S.1    Cocco, C.2    Frasson, C.3    Seganfreddo, E.4    Di Carlo, E.5
  • 222
    • 84874846166 scopus 로고    scopus 로고
    • Interleukin-27 signaling promotes immunity against endogenously arising murine tumors
    • Natividad KD, Junankar SR, Mohd Redzwan N, Nair R, Wirasinha RC, et al. 2013. Interleukin-27 signaling promotes immunity against endogenously arising murine tumors. PLOS ONE 8:e57469
    • (2013) PLOS ONE , vol.8 , pp. e57469
    • Natividad, K.D.1    Junankar, S.R.2    Mohd Redzwan, N.3    Nair, R.4    Wirasinha, R.C.5
  • 223
    • 84896764895 scopus 로고    scopus 로고
    • Clinical implications of the interleukin 27 serum level in breast cancer
    • Lu D, Zhou X, Yao L, Liu C, Jin F,Wu Y. 2014. Clinical implications of the interleukin 27 serum level in breast cancer. J. Investig. Med. 62:627-31
    • (2014) J. Investig. Med. , vol.62 , pp. 627-631
    • Lu, D.1    Zhou, X.2    Yao, L.3    Liu, C.4    Jin, F.5    Wu, Y.6
  • 224
    • 77952483010 scopus 로고    scopus 로고
    • IL-27 directly restrains lung tumorigenicity by suppressing cyclooxygenase-2-mediated activities
    • Ho MY, Leu SJ, Sun GH,Tao MH,Tang SJ, SunKH. 2009. IL-27 directly restrains lung tumorigenicity by suppressing cyclooxygenase-2-mediated activities. J. Immunol. 183:6217-26
    • (2009) J. Immunol. , vol.183 , pp. 6217-6226
    • Ho, M.Y.1    Leu, S.J.2    Sun, G.H.3    Tao, M.H.4    Tang, S.J.5    Sun, K.H.6
  • 225
    • 84858233334 scopus 로고    scopus 로고
    • Interleukin-27 inhibits the growth of pediatric acute myeloid leukemia in NOD/SCID/Il2rg-/-mice
    • Zorzoli A, Di Carlo E, Cocco C, Ognio E, Ribatti D, et al. 2012. Interleukin-27 inhibits the growth of pediatric acute myeloid leukemia in NOD/SCID/Il2rg-/-mice. Clin. Cancer Res. 18:1630-40
    • (2012) Clin. Cancer Res. , vol.18 , pp. 1630-1640
    • Zorzoli, A.1    Di Carlo, E.2    Cocco, C.3    Ognio, E.4    Ribatti, D.5
  • 228
    • 80055003184 scopus 로고    scopus 로고
    • IL-27 inhibits hyperglycemia and pancreatic islet inflammation induced by streptozotocin in mice
    • Fujimoto H, Hirase T, Miyazaki Y, Hara H, Ide-Iwata N, et al. 2011. IL-27 inhibits hyperglycemia and pancreatic islet inflammation induced by streptozotocin in mice. Am. J. Pathol. 179:2327-36
    • (2011) Am. J. Pathol. , vol.179 , pp. 2327-2336
    • Fujimoto, H.1    Hirase, T.2    Miyazaki, Y.3    Hara, H.4    Ide-Iwata, N.5
  • 229
    • 57349116921 scopus 로고    scopus 로고
    • The pathogenic role of interleukin-27 in autoimmune diabetes
    • Wang R, Han G,Wang J, Chen G, Xu R, et al. 2008. The pathogenic role of interleukin-27 in autoimmune diabetes. Cell. Mol. Life Sci. 65:3851-60
    • (2008) Cell. Mol. Life Sci. , vol.65 , pp. 3851-3860
    • Wang, R.1    Han, G.2    Wang, J.3    Chen, G.4    Xu, R.5


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