Complement activation product C5a is a selective suppressor of TLR4-induced, but not TLR3-induced, production of IL-27(p28) from macrophages

Journal of Immunology

Volumn 188, Issue 10, 2012, Pages 5086-5093

  Bosmann, Markus ^a   Haggadone, Mikel D ^a   Hemmila, Mark R ^a   Zetoune, Firas S ^a   Sarma, J Vidya ^a   Ward, Peter A ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C5A; COMPLEMENT COMPONENT C5A RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 27; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL INFECTION; CELL ACTIVITY; CELL FUNCTION; COMPLEMENT ACTIVATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENDOTOXEMIA; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME REGULATION; ENZYME REPRESSION; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; MALE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PHARMACOLOGICAL BLOCKING; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; T LYMPHOCYTE; TRANSCRIPTION INITIATION; VIRUS INFECTION;

ANIMALS; CELLS, CULTURED; COMPLEMENT ACTIVATION; COMPLEMENT C5A; DOWN-REGULATION; INTERLEUKINS; LIPOPOLYSACCHARIDES; MACROPHAGES, PERITONEAL; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, CHEMOKINE; TOLL-LIKE RECEPTOR 3; TOLL-LIKE RECEPTOR 4;

EID: 84861137551     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1102914     Document Type: Article

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