EBI3 deficiency leads to diminished T helper type 1 and increased T helper type 2 mediated airway inflammation

Immunology

Volumn 132, Issue 4, 2011, Pages 559-566

  Dokmeci, Elif ^a   Xu, Lan ^a   Robinson, Eve ^a   Golubets, Kseniya ^a   Bottomly, Kim ^b   Herrick, Christina A ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WELLESLEY COLLEGE   (United States)

Author keywords

Allergic asthma; CD4 helper T cells; Cytokines; EBI3; Mice

Indexed keywords

ANTIGEN; CD66L ANTIGEN; GAMMA INTERFERON; HERMES ANTIGEN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G2A; INTERLEUKIN 13; INTERLEUKIN 27; INTERLEUKIN 4; INTERLEUKIN 5; LIPOPOLYSACCHARIDE; OVALBUMIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; EOSINOPHIL; EPSTEIN BARR VIRUS; FEMALE; IMMUNOCOMPETENT CELL; IMMUNOGLOBULIN PRODUCTION; LYMPH NODE CELL; MEDIASTINUM LYMPH NODE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY TRACT INFLAMMATION; SENSITIZATION; TH1 CELL; TH2 CELL; WILD TYPE;

ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CYTOKINES; EOSINOPHILS; FEMALE; IMMUNOASSAY; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; INTERFERON-GAMMA; INTERLEUKIN-12; LIPOPOLYSACCHARIDES; LYMPH NODES; MALE; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; NEUTROPHILS; OVALBUMIN; PNEUMONIA; RECEPTORS, CYTOKINE; TH1 CELLS; TH2 CELLS;

EID: 79952535373     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2010.03401.x     Document Type: Article

References (38)

1. Devergne O, Hummel M, Koeppen H et al. A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes. J Virol 1996; 70:1143-53.
2. Devergne O, Coulomb-L'Hermine A, Capel F et al. Expression of Epstein-Barr virus-induced gene 3, an interleukin-12 p40-related molecule, throughout human pregnancy: involvement of syncytiotrophoblasts and extravillous trophoblasts. Am J Pathol 2001; 159:1763-76.
3. Hashimoto SI, Suzuki T, Nagai S et al. Identification of genes specifically expressed in human activated and mature dendritic cells through serial analysis of gene expression. Blood 2000; 96:2206-14.
4. Pflanz S, Timans JC, Cheung J et al. IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells. Immunity 2002; 16:779-90.
5. Hunter CA. New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions. Nat Rev Immunol 2005; 5:521-31.
6. Niedobitek G, Päzolt D, Teichmann M et al. Frequent expression of the Epstein-Barr virus (EBV)-induced gene, EBI3, an IL-12 p40-related cytokine, in Hodgkin and Reed-Sternberg cells. J Pathol 2002; 198:310-6.
7. Brombacher F, Kastelein RA, Alber G. Novel IL-12 family members shed light on the orchestration of Th1 responses. Trends Immunol 2003; 24:207-12.
8. Devergne O, Birkenbach M, Kieff E. Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin. Proc Natl Acad Sci U S A 1997; 94:12041-6.
9. Takeda A, Hamano S, Yamanaka A et al. Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment. J Immunol 2003; 170:4886-90.
10. Holscher C. The power of combinatorial immunology: IL-12 and IL-12-related dimeric cytokines in infectious diseases. Med Microbiol Immunol 2004; 193:1-17.
11. Pflanz S, Hibbert L, Mattson J et al. WSX-1 and glycoprotein 130 constitute a signal transducing receptor for IL-27. J Immunol 2004; 172:2225-31.
12. Villarino A, Hibbert L, Lieberman L et al. The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection. Immunity 2003; 19:645-55.
13. Yoshida H, Hamano S, Senaldi G et al. WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection. Immunity 2001; 15:569-78.
14. Christ AD, Stevens AC, Koeppen H et al. An interleukin 12-related cytokine is up-regulated in ulcerative colitis but not in Crohn's disease. Gastroenterology 1998; 115:307-13.
15. Omata F, Birkenbach M, Matsuzaki S et al. The expression of IL-12 p40 and its homologue, Epstein-Barr virus-induced gene 3, in inflammatory bowel disease. Inflamm Bowel Dis 2001; 7:215-20.
16. Nieuwenhuis EE, Neurath MF, Corazza N et al. Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient mice. Proc Natl Acad Sci U S A 2002; 99:16951-6.
17. Bochner BS, Undem BJ, Lichtenstein LM. Immunological aspects of allergic asthma. Annu Rev Immunol 1994; 12:295-335.
18. Prescott SL, Taylor A, King B. Neonatal interleukin-12 capacity is associated with variations in allergen-specific immune responses in the neonatal and postnatal periods. Clin Exp Allergy 2003; 3:566-72.
19. Bryan SA, O'Connor BJ, Matti S et al. Effects of recombinant human interleukin-12 on eosinophils, airway hyper-responsiveness, and the late asthmatic process. Lancet 2000; 356:2149-53.
20. Wills-Karp M. Immunologic basis of antigen-induced airway hyperresponsiveness. Annu Rev Immunol 1999; 17:255-81.
21. Hansen G, Berry G, DeKruyff RH et al. Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation. J Clin Invest 1999; 103:175-83.
22. Kopf M, LeGros G, Bachmann MC et al. Disruption of the murine IL-4 gene blocks Th2 cytokine responses. Nature 1993; 362:245-8.
23. Kuhn R, Rajewsky K, Muller W. Generation and analysis of interleukin-4 deficient mice. Science 1991; 254:707-10.
24. Postlethwaite AE, Holness MA, Katai H et al. Human fibroblasts synthesize elevated levels of extracellular matrix proteins in response to interleukin 4. J Clin Invest 1992; 90:1479-85.
25. Yamaguchi Y, Suda T, Suda J et al. Purified interleukin 5 supports the terminal differentiation and proliferation of murine eosinophilic precursors. J Exp Med 1988; 167:43-56.
26. Walsh GM, Hartnell A, Wardlaw AJ et al. IL-5 enhances the in vitro adhesion of human eosinophils, but not neutrophils, in a leucocyte integrin (CD11/18)-dependent manner. Immunology 1990; 71:258-65.
27. Schweizer RC, Welmers BA, Raaijmakers JA et al. RANTES- and interleukin-8-induced responses in normal human eosinophils: effects of priming with interleukin-5. Blood 1994; 83:3697-704.
28. Kuperman DA, Huang X, Koth LL et al. Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat Med 2002; 8:885-9.
29. Abbas AK, Murphy KM, Sher A. Functional diversity of helper T lymphocytes. Nature 1996; 383:787-93.
30. + T cells. J Exp Med 1993; 177:573-6.
31. Cohn L, Homer RJ, Niu N et al. T helper 1 cells and interferon-γ regulate allergic airway inflammation and mucus production. J Exp Med 1999; 190:1309-18.
32. Larousserie F, Pflanz S, Coulomb-L'Hermine A et al. Expression of IL-27 in human Th1-associated granulomatous diseases. J Pathol 2004; 202:164-71.
33. Artis D, Villarino A, Silverman M et al. The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity. J Immunol 2004; 173:5626-34.
34. Villarino AV, Stumhofer JS, Saris CJ et al. IL-27 limits IL-2 production during Th1 differentiation. J Immunol 2006; 176:237-47.
35. Eisenbarth SC, Piggott DA, Huleatt JW et al. Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen. J Exp Med 2002; 196:1645-51.
36. Herrick CA, MacLeod H, Glusac E et al. Th2 responses induced by epicutaneous or inhalational protein exposure are differentially dependent on IL-4. J Clin Invest 2000; 105:765-75.
37. Burrows B, Martinez FD, Halonen M et al. Association of asthma with serum IgE levels and skin-test reactivity to allergens. N Engl J Med 1989; 320:271-7.
38. Chen Q, Ghilardi N, Wang H et al. Development of Th1-type immune responses requires the type I cytokine receptor TCCR. Nature 2000; 407:916-20.