Hyperproduction of Proinflammatory Cytokines by WSX-1-Deficient NKT Cells in Concanavalin A-Induced Hepatitis

Journal of Immunology

Volumn 172, Issue 6, 2004, Pages 3590-3596

  Yamanaka, Atsushi ^a,c   Hamano, Shinjiro ^b   Miyazaki, Yoshiyuki ^a,c   Ishii, Kazunari ^b   Takeda, Atsunobu ^a,b   Mak, Tak W ^d   Himeno, Kunisuke ^b   Yoshimura, Akihiko ^a   Yoshida, Hiroki ^a,c,e  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d UNIVERSITY OF TORONTO   (Canada)

^e SAGA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CONCANAVALIN A; CYTOKINE; CYTOKINE RECEPTOR; GAMMA INTERFERON; INTERLEUKIN 1; INTERLEUKIN 12 RECEPTOR; INTERLEUKIN 4; INTERLEUKIN 6; PROTEIN WSX 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE HEPATITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; HEPATITIS; IMMUNOPATHOLOGY; IN VITRO STUDY; INFLAMMATION; KNOCKOUT MOUSE; LIVER INJURY; LIVER NECROSIS; LYMPHOCYTE ACTIVATION; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; WILD TYPE;

EID: 1542409969     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.172.6.3590     Document Type: Article

References (39)

1. Koziel, M. J. 1999. Cytokines in viral hepatitis. Semin. Liver Dis. 19:157.
2. McFarlane, I. G. 1999. Pathogenesis of autoimmune hepatitis. Biomed. Pharmacother. 53:255.
3. Tiegs, G., J. Barsig, B. Matiba, S. Uhlig, and A. Wendel. 1994. Potentiation by granulocyte macrophage colony-stimulating factor of lipopolysaccharide toxicity in mice. J. Clin. Invest. 93:2616.
4. Lohr, H. F., J. F. Schlaak, G. Gerken, B. Fleischer, H. P. Dienes, and K. H. Meyer zum Buschenfelde. 1994. Phenotypical analysis and cytokine release of liver-infiltrating and peripheral blood T lymphocytes from patients with chronic hepatitis of different etiology. Liver 14:161.
5. + surface phenotype and a T helper type 1 profile of cytokine secretion in the liver of patients chronically infected with hepatitis B virus. J. Immunol. 152:3074.
6. Tiegs, G., J. Hentschel, and A. Wendel. 1992. A T cell-dependent experimental liver injury in mice inducible by concanavalin A. J. Clin. Invest. 90:196.
7. Tiegs, G. 1997. Experimental hepatitis and role of cytokines. Acta Gastroenterol. Belg. 60:176.
8. Schumann, J., D. Wolf, A. Pahl, K. Brune, T. Papadopoulos, N. van Rooijen, and G. Tiegs. 2000. Importance of Kupffer cells for T-cell-dependent liver injury in mice. Am. J. Pathol. 157:1671.
9. + T cells for concanavalin A-induced hepatic injury in mice. J. Immunol. 159:1537.
10. Takeda, K., Y. Hayakawa, L. Van Kaer, H. Matsuda, H. Yagita, and K. Okumura. 2000. Critical contribution of liver natural killer T cells to a murine model of hepatitis. Proc. Natl. Acad. Sci. USA 97:5498.
11. Kaneko, Y., M. Harada, T. Kawano, M. Yamashita, Y. Shibata, F. Gejyo, T. Nakayama, and M. Taniguchi. 2000. Augmentation of Vα14 NKT cell-mediated cytotoxicity by interleukin 4 in an autocrine mechanism resulting in the development of concanavalin A-induced hepatitis. J. Exp. Med. 191:105.
12. + T cells produce large amounts of IL-4 and IFN-γ upon activation by anti-CD3 or CD1. J. Immunol. 159:2240.
13. + NK T lymphocytes. J. Immunol. 161:3271.
14. Cao, Q., R. Batey, G. Pang, A. Russell, and R. Clancy. 1998. IL-6, IFN-γ and TNF-α production by liver-associated T cells and acute liver injury in rats administered concanavalin A. Immunol Cell Biol. 76:542.
15. Kim, K. M., Y. M. Kim, M. Park, K. Park, H. K. Chang, T. K. Park, H. H. Chung, and C. Y. Kang. 2000. A broad-spectrum caspase inhibitor blocks concanavalin A-induced hepatitis in mice. Clin. Immunol. 97:221.
16. Tagawa, Y., P. Matthys, H. Heremans, C. Dillen, Z. Zaman, Y. Iwakura, and A. Billiau. 2000. Bimodal role of endogenous interleukin-6 in concanavalin A-induced hepatitis in mice. J. Leukocyte Biol. 67:90.
17. Wolf, D., R. Hallmann, G. Sass, M. Sixt, S. Kusters, B. Fregien, C. Trautwein, and G. Tiegs. 2001. TNF-α-induced expression of adhesion molecules in the liver is under the control of TNFR1: relevance for concanavalin A-induced hepatitis. J. Immunol. 166:1300.
18. Kato, M., N. Ikeda, E. Matsushita, S. Kaneko, and K. Kobayashi. 2001. Involvement of IL-10, an anti-inflammatory cytokine in murine liver injury induced by concanavalin A. Hepatol. Res. 20:232.
19. Louis, H., A. Le Moine, V. Flamand, N. Nagy, E. Quertinmont, F. Paulart, D. Abramowicz, O. Le Moine, M. Goldman, and J. Deviere. 2002. Critical role of interleukin 5 and eosinophils in concanavalin A-induced hepatitis in mice. Gastroenterology 122:2001.
20. Sprecher, C. A., F. J. Grant, J. W. Baumgartner, S. R. Presnell, S. K. Schrader, T. Yamagiwa, T. E. Whitmore, P. J. O'Hara, and D. F. Foster. 1998. Cloning and characterization of a novel class I cytokine receptor. Biochem. Biophys. Res. Commun. 246:82.
21. Chen, Q., N. Ghilardi, H. Wang, T. Baker, M. H. Xie, A. Gurney, I. S. Grewal, and F. J. de Sauvage. 2000. Development of Th1-type immune responses requires the type I cytokine receptor TCCR. Nature 407:916.
22. Yoshida, H., S. Hamano, G. Senaldi, T. Covey, R. Faggioni, S. Mu, M. Xia, A. C. Wakeham, H. Nishina, J. Potter, et al. 2001. WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection. Immunity 15:569.
23. Takeda, A., S. Hamano, A. Yamanaka, T. Hanada, T. Ishibashi, T. W. Mak, A. Yoshimura, and H. Yoshida. 2003. Role of IL-27/WSX-1 signaling for induction of T-Bet through activation of STAT1 during initial Th1 commitment. J. Immunol. 170:4886.
24. + T cells. Immunity 16:779.
25. Villarino, A., L. Hibbert, L. Lieberman, E. Wilson, T. Mak, H. Yoshida, R. A. Kastelein, C. Saris, and C. A. Hunter. 2003. The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection. Immunity 19:645.
26. Hamano, S., K. Himeno, Y. Miyazaki, K. Ishii, A. Yamanaka, A. Takeda, M. Zhang, H. Hisaeda, T. W. Mak, A. Yoshimura, et al. 2003. WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of proinflammatory cytokine production. Immunity 19:657.
27. Sonoda, K. H., M. Exley, S. Snapper, S. P. Balk, and J. Stein-Streilein. 1999. CD1-reactive natural killer T cells are required for development of systemic tolerance through an immune-privileged site. J. Exp. Med. 190:1215.
28. Yoshida, H., H. Nishina, H. Takimoto, L. E. Marengere, A. C. Wakeham, D. Bouchard, Y. Y. Kong, T. Ohteki, A. Shahinian, M. Bachmann, et al. 1998. The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production. Immunity 8:115.
29. Kusters, S., F. Gantner, G. Kunstle, and G. Tiegs. 1996. Interferon γ plays a critical role in T cell-dependent liver injury in mice initiated by concanavalin A. Gastroenterology 111:462.
30. Mizuhara, H., M. Uno, N. Seki, M. Yamashita, M. Yamaoka, T. Ogawa, K. Kaneda, T. Fujii, H. Senoh, and H. Fujiwara. 1996. Critical involvement of interferon γ in the pathogenesis of T-cell activation-associated hepatitis and regulatory mechanisms of interleukin-6 for the manifestations of hepatitis. Hepatology 23:1608.
31. Nieuwenhuis, E. E., M. F. Neurath, N. Corazza, H. Iijima, J. Trgovcich, S. Wirtz, J. Glickman, D. Bailey, M. Yoshida, P. R. Galle, et al. 2002. Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient mice. Proc. Natl. Acad. Sci. USA 99:16951.
32. Sass, G., S. Heinlein, A. Agli, R. Bang, J. Schumann, and G. Tiegs. 2002. Cytokine expression in three mouse models of experimental hepatitis. Cytokine 19:115.
33. Parham, C., M. Chirica, J. Timans, E. Vaisberg, M. Travis, J. Cheung, S. Pflanz, R. Zhang, K. P. Singh, F. Vega, et al. 2002. A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rβ1 and a novel cytokine receptor subunit, IL-23R. J. Immunol. 168:5699.
34. Devergne, O., M. Birkenbach, and E. Kieff. 1997. Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin. Proc. Natl. Acad. Sci. USA 94:12041.
35. Brombacher, F., R. A. Kastelein, and G. Alber. 2003. Novel IL-12 family members shed light on the orchestration of Th1 responses. Trends Immunol. 24:207.
36. Robinson, D. S., and A. O'Garra. 2002. Further checkpoints in Th1 development. Immunity 16:755.
37. Szabo, S. J., B. M. Sullivan, S. L. Peng, and L. H. Glimcher. 2003. Molecular mechanisms regulating Th1 immune responses. Annu. Rev. Immunol. 21:713.
38. Wiekowski, M. T., M. W. Leach, E. W. Evans, L. Sullivan, S. C. Chen, G. Vassileva, J. F. Bazan, D. M. Gorman, R. A. Kastelein, S. Narula, et al. 2001. Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death. J. Immunol. 166:7563.
39. Fairweather, D., S. Yusung, S. Frisancho, M. Barrett, S. Gatewood, R. Steele, and N. R. Rose. 2003. IL-12 receptor β1 and Toll-like receptor 4 increase IL-1β- and IL-18-associated myocarditis and coxsackievirus replication. J. Immunol. 170:4731.