A novel role for interleukin-27 (IL-27) as mediator of intestinal epithelial barrier protection mediated via differential signal transducer and activator of transcription (STAT) protein signaling and induction of antibacterial and anti-inflammatory proteins

Journal of Biological Chemistry

Volumn 287, Issue 1, 2012, Pages 286-298

  Diegelmann, Julia ^a   Olszak, Torsten ^a,b   Göke, Burkhard ^a   Blumberg, Richard S ^b   Brand, Stephan ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-BACTERIAL; ANTI-INFLAMMATORIES; ANTI-INFLAMMATORY PROTEINS; BACTERIAL INFECTIONS; BRAIN TUMORS; CYTOKINES; DEXTRAN SULFATE SODIUM; DIFFERENTIAL SIGNAL; DIOXYGENASES; ENZYMATIC ACTIVITIES; EPITHELIAL BARRIER; GROWTH INHIBITION; INDOLEAMINE 2 ,3-DIOXYGENASE; INFLAMMATORY BOWEL DISEASE; INTESTINAL BACTERIA; INTESTINAL EPITHELIAL CELLS; INTESTINAL INFLAMMATION; PROTEIN SIGNALING; RECEPTOR EXPRESSION; SIGNALING PATHWAYS; TARGET GENES; TRANSCRIPTIONAL ACTIVATIONS;

AMINO ACIDS; CELL PROLIFERATION; CELLS; CHEMICAL ACTIVATION; GENES; SIGNAL TRANSDUCTION; SODIUM; SODIUM SULFATE; TISSUE;

TRANSCRIPTION;

DEXTRAN SULFATE; GLYCOPROTEIN GP 130; INDOLEAMINE 2,3 DIOXYGENASE; INTERLEUKIN 27; INTERLEUKIN 27RA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; STAT PROTEIN; STAT1 PROTEIN; STAT3 PROTEIN; STAT6 PROTEIN; TRANSCRIPTION FACTOR RELA; TRYPTOPHAN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL GROWTH; BACTERIAL INFECTION; CELL PROLIFERATION; COLITIS; COLON MUCOSA; CONTROLLED STUDY; CROHN DISEASE; DELETED IN MALIGNANT BRAIN TUMOR 1 GENE; ESCHERICHIA COLI; GENE; GENE EXPRESSION REGULATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; INDOLEAMINE 2,3 DIOXYGENASE GENE; INTERLEUKIN 27 GENE; INTESTINE EPITHELIUM CELL; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; COLITIS; CROHN DISEASE; DEXTRAN SULFATE; HUMANS; INDOLEAMINE-PYRROLE 2,3,-DIOXYGENASE; INTERLEUKIN-17; INTESTINAL MUCOSA; MICE; MUCINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RECEPTORS, CELL SURFACE; RECEPTORS, INTERLEUKIN; REPRODUCIBILITY OF RESULTS; RNA, MESSENGER; SIGNAL TRANSDUCTION; STAT TRANSCRIPTION FACTORS; TRANSCRIPTOME; UP-REGULATION;

BACTERIA (MICROORGANISMS); MUS;

EID: 84855272274     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.294355     Document Type: Article

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