Common variants at five new loci associated with early-onset inflammatory bowel disease

Nature Genetics

Volumn 41, Issue 12, 2009, Pages 1335-1340

  Imielinski, Marcin ^a   Baldassano, Robert N ^a,b   Griffiths, Anne ^c   Russell, Richard K ^d   Annese, Vito ^e   Dubinsky, Marla ^f   Kugathasan, Subra ^g   Bradfield, Jonathan P ^a   Walters, Thomas D ^c   Sleiman, Patrick ^a   Kim, Cecilia E ^a   Muise, Aleixo ^c   Wang, Kai ^a   Glessner, Joseph T ^a   Saeed, Shehzad ^h   Zhang, Haitao ^a   Frackelton, Edward C ^a   Hou, Cuiping ^a   Flory, James H ^a   Otieno, George ^a   Chiavacci, Rosetta M ^a   Grundmeier, Robert ^a,b   Castro, Massimo ⁱ   Latiano, Anna ⁱ   Dallapiccola, Bruno ^j   Stempak, Joanne ^k   Abrams, Debra J ^a   Taylor, Kent ^f   McGovern, Dermot ^f   Heyman, Melvin B ^l   Ferry, George D ^m   Kirschner, Barbara ⁿ   Lee, Jessica ^o   Essers, Jonah ^o   Grand, Richard ^o   Stephens, Michael ^p   Levine, Arie ^q   Piccoli, David ^a,b   Van Limbergen, Johan ^r   Cucchiara, Salvatore ^j   Monos, Dimitri S ^a   Guthery, Stephen L ^s   Denson, Lee ^t   Wilson, David C ^u   Grant, Struan F A ^a,b   Daly, Mark ^v   Silverberg, Mark S ^k   Satsangi, Jack ^r   Hakonarson, Hakon ^a,b   more..

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

^d ROYAL HOSPITAL FOR SICK CHILDREN   (United Kingdom)

^e CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

^f CEDARS SINAI MEDICAL CENTER   (United States)

^g EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h University of Alabama at Birmingham   (United States)

ⁱ BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

^j SAPIENZA UNIVERSITY OF ROME   (Italy)

^k UNIVERSITY OF TORONTO   (Canada)

^l UNIVERSITY OF CALIFORNIA   (United States)

^m BAYLOR COLLEGE OF MEDICINE   (United States)

ⁿ UNIVERSITY OF CHICAGO   (United States)

^o BOSTON CHILDREN S HOSPITAL   (United States)

^p MEDICAL COLLEGE OF WISCONSIN   (United States)

^q TEL AVIV UNIVERSITY   (Israel)

^r WESTERN GENERAL HOSPITAL   (United Kingdom)

^s UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^t CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^u UNIVERSITY OF EDINBURGH   (United Kingdom)

^v MASSACHUSETTS GENERAL HOSPITAL   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CHROMOSOME 16P; CHROMOSOME 19Q; CHROMOSOME 22Q; CONTROLLED STUDY; CROHN DISEASE; DISEASE PREDISPOSITION; ENTERITIS; GENE; GENE ASSIGNMENT; GENE LOCUS; GENETIC ASSOCIATION; GENETIC VARIABILITY; HUMAN; IL2 GENE; MAJOR CLINICAL STUDY; NORTH AMERICA; PRIORITY JOURNAL; ULCERATIVE COLITIS;

AGE OF ONSET; CHROMOSOME MAPPING; COLITIS, ULCERATIVE; GENETIC VARIATION; GENOME, HUMAN; GENOME-WIDE ASSOCIATION STUDY; HUMANS; INFLAMMATORY BOWEL DISEASES;

EID: 70649113728     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.489     Document Type: Article

References (24)

1. Kugathasan, S. et al. Loci on 20q13 and 21q22 are associated with pediatric-onset infammatory bowel disease. Nat. Genet. 40, 1211-1215 (2008).
2. Van Limbergen, J., Wilson, D.C. & Satsangi, J. The genetics of Crohn's disease. Annu. Rev. Genomics Hum. Genet. 10, 89-116 (2009).
3. Cho, J.H. The genetics and immunopathogenesis of infammatory bowel disease. Nat. Rev. Immunol. 8, 458-466 (2008).
4. Fisher, S.A. et al. Genetic determinants of ulcerative colitis include the ECM1 locus and fve loci implicated in Crohn's disease. Nat. Genet. 40, 710-712 (2008).
5. Barrett, J.C. et al. Genome-wide association defnes more than 30 distinct susceptibility loci for Crohn's disease. Nat. Genet. 40, 955-962 (2008).
6. Franke, A. et al. Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility. Nat. Genet. 40, 1319-1323 (2008).
7. Silverberg, M.S. et al. Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. Nat. Genet. 41, 216-220 (2009).
8. Vernier-Massouille, G. et al. Natural history of pediatric Crohn's disease: a population-based cohort study. Gastroenterology 135, 1106-1113 (2008).
9. Van Limbergen, J. et al. Defnition of phenotypic characteristics of childhood-onset infammatory bowel disease. Gastroenterology 135, 1114-1122 (2008).
10. Rioux, J.D. et al. Genome-wide association study identifes new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat. Genet. 39, 596-604 (2007).
11. The Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447, 661-678 (2007).
12. Libioulle, C. et al. Novel Crohn disease locus identifed by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4. PLoS Genet. 3, e58 (2007).
13. Barrett, J.C. et al. Genome-wide association study and meta-analysis fnd that over 40 loci affect risk of type 1 diabetes. Nat. Genet. 41, 703-707 (2009).
14. Dixon, A.L. et al. A genome-wide association study of global gene expression. Nat. Genet. 39, 1202-1207 (2007).
15. Li, X., Thyssen, G., Beliakoff, J. & Sun, Z. The novel PIAS-like protein hZimp10 enhances Smad transcriptional activity. J. Biol. Chem. 281, 23748-23756 (2006).
16. Steinman, L. A brief history of TH17, the frst major revision in the TH1/TH2 hypothesis of T cell-mediated tissue damage. Nat. Med. 13, 139-145 (2007).
17. Bettelli, E., Oukka, M. & Kuchroo, V.K.T. TH-17 cells in the circle of immunity and autoimmunity. Nat. Immunol. 8, 345-350 (2007).
18. Hakonarson, H. et al. A genome-wide association study identifes KIAA0350 as a type 1 diabetes gene. Nature 448, 591-594 (2007).
19. Pritchard, J.K., Stephens, M. & Donnelly, P. Inference of population structure using multilocus genotype data. Genetics 155, 945-959 (2000).
20. Luca, D. et al. On the use of general control samples for genome-wide association studies: genetic matching highlights causal variants. Am. J. Hum. Genet. 82, 453-463 (2008).
21. Patterson, N., Price, A.L. & Reich, D. Population structure and eigenanalysis. PLoS Genet. 2, e190 (2006).
22. Duerr, R.H. et al. A genome-wide association study identifes IL23R as an infammatory bowel disease gene. Science 314, 1461-1463 (2006).
23. Parkes, M. et al. Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nat. Genet. 39, 830-832 (2007).
24. Purcell, S. et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet. 81, 559-575 (2007).