IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+T cells

Immunity

Volumn 16, Issue 6, 2002, Pages 779-790

  Pflanz, Stefan ^a   Timans, Jackie C ^a   Cheung, Jeanne ^a   Rosales, Rency ^a   Kanzler, Holger ^a   Gilbert, Jonathan ^a   Hibbert, Linda ^a   Churakova, Tatyana ^a   Travis, Marilyn ^a   Vaisberg, Elena ^a   Blumenschein, Wendy M ^a   Mattson, Jeanine D ^a   Wagner, Janet L ^a   To, Wayne ^a   Zurawski, Sandra ^a   McClanahan, Terrill K ^a   Gorman, Daniel M ^a   Bazan, J Fernando ^a   De Waal Malefyt, Rene ^a   Rennick, Donna ^a   Kastelein, Robert A ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 12; POLYPEPTIDE; PROTEIN P28; PROTEIN P35; PROTEIN P40; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN PRESENTING CELL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; MEMORY CELL; MOUSE; NONHUMAN; POLARIZATION; PRIORITY JOURNAL; PROTEIN SECRETION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TH1 CELL;

EID: 18444385868     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(02)00324-2     Document Type: Article

References (31)

1. Construction and biological characterization of an interleukin-12 fusion protein (Flexi-12): Delivery to acute myeloid leukemic blasts using adeno-associated virus
2. Haemopoietic receptors and helical cytokines
3. HNMP-1: A novel hematopoietic and neural membrane protein differentially regulated in neural development and injury
4. Development of Th1-type immune responses requires the type I cytokine receptor TCCR
5. IL-12, but not IFN-gamma, plays a major role in sustaining the chronic phase of colitis in IL-10 deficient mice
6. A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes
7. Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin
8. Expression of Epstein-Barr virus-induced gene 3, an interleukin-12 p40-related molecule, throughout human pregnancy
9. CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complex
10. A bioactive designer cytokine for human hematopoietic progenitor cell expansion
11. The interleukin-12/interleukin-12-receptor system: Role in normal and pathologic immune responses
12. Profile analysis: Detection of distantly related proteins
13. The enigmatic plasmacytoid T cells develop into dendritic cells with interleukin (IL)-3 and CD40-ligand
14. Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor
15. Identification of genes specifically expressed in human activated and mature dendritic cells through serial analysis of gene expression
16. Detection of specific polymerase chain reaction product by utilizing the 5′-3′ exonuclease activity of Thermus aquaticus DNA polymerase
17. Touring protein fold space with Dali/FSSP
18. -/-setting
19. Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity
20. The expanding universe of T-cell subsets: Th1, Th2 and more
21. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
22. IGIF does not drive Th1 development but synergizes with IL-12 for interferon-γ production and activates IRAK and NFκB
23. Structural comparisons among the short-chain helical cytokines
24. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha
25. Cloning and characterization of a novel class I cytokine receptor
26. Clustal w: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
27. The CLUSTAL_X windows interface: Flexible strategies for multiple sequence alignment aided by quality analysis tools
28. Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity
29. Interleukin-12: A cytokine at the interface of inflammation and immunity
30. Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells
31. WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection