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Volumn 185, Issue 11, 2010, Pages 7047-7056

Suppression of TNF-α and IL-1 signaling identifies a mechanism of homeostatic regulation of macrophages by IL-27

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1BETA; INTERLEUKIN 27; PROTEIN P55; PROTEIN P75; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

EID: 78650663329     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1001290     Document Type: Article
Times cited : (68)

References (57)
  • 3
    • 0344304399 scopus 로고    scopus 로고
    • IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and-independent mechanisms
    • Lucas, S., N. Ghilardi, J. Li, and F. J. de Sauvage. 2003. IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and-independent mechanisms. Proc. Natl. Acad. Sci. USA 100:15047-15052.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 15047-15052
    • Lucas, S.1    Ghilardi, N.2    Li, J.3    De Sauvage, F.J.4
  • 4
    • 44449140104 scopus 로고    scopus 로고
    • IL-27 activates human monocytes via STAT1 and suppresses IL-10 production but the inflammatory functions of IL-27 are abrogated by TLRs and p38
    • Kalliolias, G. D., and L. B. Ivashkiv. 2008. IL-27 activates human monocytes via STAT1 and suppresses IL-10 production but the inflammatory functions of IL-27 are abrogated by TLRs and p38. J. Immunol. 180:6325-6333.
    • (2008) J. Immunol. , vol.180 , pp. 6325-6333
    • Kalliolias, G.D.1    Ivashkiv, L.B.2
  • 5
    • 41449113342 scopus 로고    scopus 로고
    • Advances in understanding the antiinflammatory properties of IL-27
    • Stumhofer, J. S., and C. A. Hunter. 2008. Advances in understanding the antiinflammatory properties of IL-27. Immunol. Lett. 117:123-130.
    • (2008) Immunol. Lett. , vol.117 , pp. 123-130
    • Stumhofer, J.S.1    Hunter, C.A.2
  • 6
    • 33846440515 scopus 로고    scopus 로고
    • Regulation of IL-27 p28 gene expression in macrophages through MyD88-and interferon-gamma-mediated pathways
    • Liu, J., X. Guan, and X. Ma. 2007. Regulation of IL-27 p28 gene expression in macrophages through MyD88-and interferon-gamma-mediated pathways. J. Exp. Med. 204:141-152.
    • (2007) J. Exp. Med. , vol.204 , pp. 141-152
    • Liu, J.1    Guan, X.2    Ma, X.3
  • 7
    • 36249017932 scopus 로고    scopus 로고
    • IFN-alpha regulates Toll-like receptor-mediated IL-27 gene expression in human macrophages
    • Pirhonen, J., J. Sirén, I. Julkunen, and S. Matikainen. 2007. IFN-alpha regulates Toll-like receptor-mediated IL-27 gene expression in human macrophages. J. Leukoc. Biol. 82:1185-1192.
    • (2007) J. Leukoc. Biol. , vol.82 , pp. 1185-1192
    • Pirhonen, J.1    Sirén, J.2    Julkunen, I.3    Matikainen, S.4
  • 9
    • 77949891800 scopus 로고    scopus 로고
    • Critical role of the IFN-stimulated gene factor 3 complex in TLR-mediated IL-27p28 gene expression revealing a two-step activation process
    • Molle, C., M. Goldman, and S. Goriely. 2010. Critical role of the IFN-stimulated gene factor 3 complex in TLR-mediated IL-27p28 gene expression revealing a two-step activation process. J. Immunol. 184:1784-1792.
    • (2010) J. Immunol. , vol.184 , pp. 1784-1792
    • Molle, C.1    Goldman, M.2    Goriely, S.3
  • 10
    • 44449146212 scopus 로고    scopus 로고
    • Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: Role of intracellular osteopontin
    • Shinohara, M. L., J. H. Kim, V. A. Garcia, and H. Cantor. 2008. Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: role of intracellular osteopontin. Immunity 29:68-78.
    • (2008) Immunity , vol.29 , pp. 68-78
    • Shinohara, M.L.1    Kim, J.H.2    Garcia, V.A.3    Cantor, H.4
  • 14
    • 34247523141 scopus 로고    scopus 로고
    • Discovery and biology of IL-23 and IL-27: Related but functionally distinct regulators of inflammation
    • Kastelein, R. A., C. A. Hunter, and D. J. Cua. 2007. Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation. Annu. Rev. Immunol. 25:221-242.
    • (2007) Annu. Rev. Immunol. , vol.25 , pp. 221-242
    • Kastelein, R.A.1    Hunter, C.A.2    Cua, D.J.3
  • 15
    • 73149111975 scopus 로고    scopus 로고
    • Interleukin 27: A double-edged sword for offense and defense
    • Yoshida, H., M. Nakaya, and Y. Miyazaki. 2009. Interleukin 27: a double-edged sword for offense and defense. J. Leukoc. Biol. 86:1295-1303.
    • (2009) J. Leukoc. Biol. , vol.86 , pp. 1295-1303
    • Yoshida, H.1    Nakaya, M.2    Miyazaki, Y.3
  • 16
    • 55149126024 scopus 로고    scopus 로고
    • Regulation of immune responses by interleukin-27
    • Yoshida, H., Y. Miyazaki, and M. Yoshiyuki. 2008. Regulation of immune responses by interleukin-27. Immunol. Rev. 226:234-247.
    • (2008) Immunol. Rev. , vol.226 , pp. 234-247
    • Yoshida, H.1    Miyazaki, Y.2    Yoshiyuki, M.3
  • 17
    • 58049215515 scopus 로고    scopus 로고
    • Published erratum appears in
    • [Published erratum appears in 2009 Immunol. Rev. 227:283.]
    • (2009) Immunol. Rev. , vol.227 , pp. 283
  • 18
    • 34447345406 scopus 로고    scopus 로고
    • The biology and therapeutic potential of interleukin 27
    • Batten, M., and N. Ghilardi. 2007. The biology and therapeutic potential of interleukin 27. J. Mol. Med. 85:661-672.
    • (2007) J. Mol. Med. , vol.85 , pp. 661-672
    • Batten, M.1    Ghilardi, N.2
  • 20
    • 0038326688 scopus 로고    scopus 로고
    • Cutting edge: Role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment
    • Takeda, A., S. Hamano, A. Yamanaka, T. Hanada, T. Ishibashi, T. W. Mak, A. Yoshimura, and H. Yoshida. 2003. Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment. J. Immunol. 170:4886-4890.
    • (2003) J. Immunol. , vol.170 , pp. 4886-4890
    • Takeda, A.1    Hamano, S.2    Yamanaka, A.3    Hanada, T.4    Ishibashi, T.5    Mak, T.W.6    Yoshimura, A.7    Yoshida, H.8
  • 21
    • 75749091859 scopus 로고    scopus 로고
    • Interleukin-27 inhibits human osteoclastogenesis by abrogating RANKL-mediated induction of nuclear factor of activated T cells c1 and suppressing proximal RANK signaling
    • Kalliolias, G. D., B. Zhao, A. Triantafyllopoulou, K. H. Park-Min, and L. B. Ivashkiv. 2010. Interleukin-27 inhibits human osteoclastogenesis by abrogating RANKL-mediated induction of nuclear factor of activated T cells c1 and suppressing proximal RANK signaling. Arthritis Rheum. 62:402-413.
    • (2010) Arthritis Rheum , vol.62 , pp. 402-413
    • Kalliolias, G.D.1    Zhao, B.2    Triantafyllopoulou, A.3    Park-Min, K.H.4    Ivashkiv, L.B.5
  • 22
    • 70149083341 scopus 로고    scopus 로고
    • IL-27 abrogates receptor activator of NF-kappa B ligand-mediated osteoclastogenesis of human granulocyte-macrophage colony-forming unit cells through STAT1-dependent inhibition of c-Fos
    • Furukawa, M., H. Takaishi, J. Takito, M. Yoda, S. Sakai, T. Hikata, A. Hakozaki, S. Uchikawa, M. Matsumoto, K. Chiba, et al. 2009. IL-27 abrogates receptor activator of NF-kappa B ligand-mediated osteoclastogenesis of human granulocyte-macrophage colony-forming unit cells through STAT1-dependent inhibition of c-Fos. J. Immunol. 183:2397-2406.
    • (2009) J. Immunol. , vol.183 , pp. 2397-2406
    • Furukawa, M.1    Takaishi, H.2    Takito, J.3    Yoda, M.4    Sakai, S.5    Hikata, T.6    Hakozaki, A.7    Uchikawa, S.8    Matsumoto, M.9    Chiba, K.10
  • 23
    • 14844355133 scopus 로고    scopus 로고
    • The IL-27 receptor chain WSX-1 differentially regulates antibacterial immunity and survival during experimental tuberculosis
    • Hölscher, C., A. Hölscher, D. Rückerl, T. Yoshimoto, H. Yoshida, T. Mak, C. Saris, and S. Ehlers. 2005. The IL-27 receptor chain WSX-1 differentially regulates antibacterial immunity and survival during experimental tuberculosis. J. Immunol. 174:3534-3544.
    • (2005) J. Immunol. , vol.174 , pp. 3534-3544
    • Hölscher, C.1    Hölscher, A.2    Rückerl, D.3    Yoshimoto, T.4    Yoshida, H.5    Mak, T.6    Saris, C.7    Ehlers, S.8
  • 24
    • 38449098843 scopus 로고    scopus 로고
    • Augmentation of antigen-presenting and Th1-promoting functions of dendritic cells by WSX-1 (IL-27R) deficiency
    • Wang, S., Y. Miyazaki, Y. Shinozaki, and H. Yoshida. 2007. Augmentation of antigen-presenting and Th1-promoting functions of dendritic cells by WSX-1 (IL-27R) deficiency. J. Immunol. 179:6421-6428.
    • (2007) J. Immunol. , vol.179 , pp. 6421-6428
    • Wang, S.1    Miyazaki, Y.2    Shinozaki, Y.3    Yoshida, H.4
  • 26
    • 3142709474 scopus 로고    scopus 로고
    • Understanding the pro-and anti-inflammatory properties of IL-27
    • Villarino, A. V., E. Huang, and C. A. Hunter. 2004. Understanding the pro-and anti-inflammatory properties of IL-27. J. Immunol. 173:715-720.
    • (2004) J. Immunol. , vol.173 , pp. 715-720
    • Villarino, A.V.1    Huang, E.2    Hunter, C.A.3
  • 27
    • 3142719733 scopus 로고    scopus 로고
    • Suppression of ongoing adjuvant-induced arthritis by neutralizing the function of the p28 subunit of IL-27
    • Goldberg, R., G. Wildbaum, Y. Zohar, G. Maor, and N. Karin. 2004. Suppression of ongoing adjuvant-induced arthritis by neutralizing the function of the p28 subunit of IL-27. J. Immunol. 173:1171-1178. (Pubitemid 38924293)
    • (2004) Journal of Immunology , vol.173 , Issue.2 , pp. 1171-1178
    • Goldberg, R.1    Wildbaum, G.2    Zohar, Y.3    Maor, G.4    Karin, N.5
  • 28
    • 40449100736 scopus 로고    scopus 로고
    • IL-27 induces a Th1 immune response and susceptibility to experimental arthritis
    • Cao, Y., P. D. Doodes, T. T. Glant, and A. Finnegan. 2008. IL-27 induces a Th1 immune response and susceptibility to experimental arthritis. J. Immunol. 180:922-930.
    • (2008) J. Immunol. , vol.180 , pp. 922-930
    • Cao, Y.1    Doodes, P.D.2    Glant, T.T.3    Finnegan, A.4
  • 30
    • 33747588291 scopus 로고    scopus 로고
    • Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells
    • Batten, M., J. Li, S. Yi, N. M. Kljavin, D. M. Danilenko, S. Lucas, J. Lee, F. J. de Sauvage, and N. Ghilardi. 2006. Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nat. Immunol. 7:929-936.
    • (2006) Nat. Immunol. , vol.7 , pp. 929-936
    • Batten, M.1    Li, J.2    Yi, S.3    Kljavin, N.M.4    Danilenko, D.M.5    Lucas, S.6    Lee, J.7    De Sauvage, F.J.8    Ghilardi, N.9
  • 32
    • 61849104903 scopus 로고    scopus 로고
    • Published erratum appears in
    • [Published erratum appears in 2008. J. Immunol. 180:3612.]
    • (2008) J. Immunol. , vol.180 , pp. 3612
  • 34
    • 44849116504 scopus 로고    scopus 로고
    • Primer: Toll-like receptor signaling pathways-what do rheumatologists need to know?
    • O'Neill, L. A. 2008. Primer: Toll-like receptor signaling pathways-what do rheumatologists need to know? Nat. Clin. Pract. Rheumatol. 4:319-327.
    • (2008) Nat. Clin. Pract. Rheumatol , vol.4 , pp. 319-327
    • O'Neill, L.A.1
  • 35
    • 47249153519 scopus 로고    scopus 로고
    • Role of cytokines in rheumatoid arthritis: An education in pathophysiology and therapeutics
    • Feldmann, M., and S. R. Maini. 2008. Role of cytokines in rheumatoid arthritis: an education in pathophysiology and therapeutics. Immunol. Rev. 223:7-19.
    • (2008) Immunol. Rev. , vol.223 , pp. 7-19
    • Feldmann, M.1    Maini, S.R.2
  • 36
    • 85047692516 scopus 로고    scopus 로고
    • Signalling pathways of the TNF superfamily: A doubleedged sword
    • Aggarwal, B. B. 2003. Signalling pathways of the TNF superfamily: a doubleedged sword. Nat. Rev. Immunol. 3:745-756.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 745-756
    • Aggarwal, B.B.1
  • 37
    • 62649139025 scopus 로고    scopus 로고
    • Immunological and inflammatory functions of the interleukin-1 family
    • Dinarello, C. A. 2009. Immunological and inflammatory functions of the interleukin-1 family. Annu. Rev. Immunol. 27:519-550.
    • (2009) Annu. Rev. Immunol. , vol.27 , pp. 519-550
    • Dinarello, C.A.1
  • 38
  • 39
    • 9644279571 scopus 로고    scopus 로고
    • The role of IL-27 in the development of T-cell responses during parasitic infections
    • Hunter, C. A., A. Villarino, D. Artis, and P. Scott. 2004. The role of IL-27 in the development of T-cell responses during parasitic infections. Immunol. Rev. 202:106-114.
    • (2004) Immunol. Rev. , vol.202 , pp. 106-114
    • Hunter, C.A.1    Villarino, A.2    Artis, D.3    Scott, P.4
  • 42
    • 33747593830 scopus 로고    scopus 로고
    • Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system
    • Stumhofer, J. S., A. Laurence, E. H. Wilson, E. Huang, C. M. Tato, L. M. Johnson, A. V. Villarino, Q. Huang, A. Yoshimura, D. Sehy, et al. 2006. Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nat. Immunol. 7:937-945.
    • (2006) Nat. Immunol. , vol.7 , pp. 937-945
    • Stumhofer, J.S.1    Laurence, A.2    Wilson, E.H.3    Huang, E.4    Tato, C.M.5    Johnson, L.M.6    Villarino, A.V.7    Huang, Q.8    Yoshimura, A.9    Sehy, D.10
  • 43
    • 43049101640 scopus 로고    scopus 로고
    • The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice
    • Guo, B., E. Y. Chang, and G. Cheng. 2008. The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice. J. Clin. Invest. 118:1680-1690.
    • (2008) J. Clin. Invest. , vol.118 , pp. 1680-1690
    • Guo, B.1    Chang, E.Y.2    Cheng, G.3
  • 44
    • 77949655330 scopus 로고    scopus 로고
    • Th17 cytokines and arthritis
    • Lubberts, E. 2010. Th17 cytokines and arthritis. Semin. Immunopathol. 32:43-53.
    • (2010) Semin. Immunopathol , vol.32 , pp. 43-53
    • Lubberts, E.1
  • 45
    • 67650224449 scopus 로고    scopus 로고
    • Crohn's disease: Th1, Th17 or both? The change of a paradigm: New immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease
    • Brand, S. 2009. Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease. Gut 58:1152-1167.
    • (2009) Gut , vol.58 , pp. 1152-1167
    • Brand, S.1
  • 49
    • 30344488706 scopus 로고    scopus 로고
    • Interleukin-27R (WSX-1/T-cell cytokine receptor) gene-deficient mice display enhanced resistance to leishmania donovani infection but develop severe liver immunopathology
    • Rosas, L. E., A. A. Satoskar, K. M. Roth, T. L. Keiser, J. Barbi, C. Hunter, F. J. de Sauvage, and A. R. Satoskar. 2006. Interleukin-27R (WSX-1/T-cell cytokine receptor) gene-deficient mice display enhanced resistance to leishmania donovani infection but develop severe liver immunopathology. Am. J. Pathol. 168:158-169.
    • (2006) Am. J. Pathol. , vol.168 , pp. 158-169
    • Rosas, L.E.1    Satoskar, A.A.2    Roth, K.M.3    Keiser, T.L.4    Barbi, J.5    Hunter, C.6    De Sauvage, F.J.7    Satoskar, A.R.8
  • 50
    • 35648988381 scopus 로고    scopus 로고
    • Suppressive effect of IL-27 on encephalitogenic Th17 cells and the effector phase of experimental autoimmune encephalomyelitis
    • Fitzgerald, D. C., B. Ciric, T. Touil, H. Harle, J. Grammatikopolou, J. Das Sarma, B. Gran, G. X. Zhang, and A. Rostami. 2007. Suppressive effect of IL-27 on encephalitogenic Th17 cells and the effector phase of experimental autoimmune encephalomyelitis. J. Immunol. 179:3268-3275.
    • (2007) J. Immunol. , vol.179 , pp. 3268-3275
    • Fitzgerald, D.C.1    Ciric, B.2    Touil, T.3    Harle, H.4    Grammatikopolou, J.5    Sarma, J.D.6    Gran, B.7    Zhang, G.X.8    Rostami, A.9
  • 51
    • 36248970702 scopus 로고    scopus 로고
    • Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells
    • Fitzgerald, D. C., G. X. Zhang, M. El-Behi, Z. Fonseca-Kelly, H. Li, S. Yu, C. J. Saris, B. Gran, B. Ciric, and A. Rostami. 2007. Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells. Nat. Immunol. 8:1372-1379.
    • (2007) Nat. Immunol. , vol.8 , pp. 1372-1379
    • Fitzgerald, D.C.1    Zhang, G.X.2    El-Behi, M.3    Fonseca-Kelly, Z.4    Li, H.5    Yu, S.6    Saris, C.J.7    Gran, B.8    Ciric, B.9    Rostami, A.10
  • 54
    • 34547736572 scopus 로고    scopus 로고
    • Crosstalk among Jak-STAT, Toll-like receptor, and ITAM-dependent pathways in macrophage activation
    • Hu, X., J. Chen, L. Wang, and L. B. Ivashkiv. 2007. Crosstalk among Jak-STAT, Toll-like receptor, and ITAM-dependent pathways in macrophage activation. J. Leukoc. Biol. 82:237-243.
    • (2007) J. Leukoc. Biol. , vol.82 , pp. 237-243
    • Hu, X.1    Chen, J.2    Wang, L.3    Ivashkiv, L.B.4
  • 56
    • 0028815553 scopus 로고
    • Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance
    • Berg, D. J., R. Kühn, K. Rajewsky, W. Müller, S. Menon, N. Davidson, G. Grünig, and D. Rennick. 1995. Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance. J. Clin. Invest. 96:2339-2347.
    • (1995) J. Clin. Invest. , vol.96 , pp. 2339-2347
    • Berg, D.J.1    Kühn, R.2    Rajewsky, K.3    Müller, W.4    Menon, S.5    Davidson, N.6    Grünig, G.7    Rennick, D.8
  • 57
    • 77649184739 scopus 로고    scopus 로고
    • The regulation of IL-10 production by immune cells
    • Saraiva, M., and A. O'Garra. 2010. The regulation of IL-10 production by immune cells. Nat. Rev. Immunol. 10:170-181.
    • (2010) Nat. Rev. Immunol. , vol.10 , pp. 170-181
    • Saraiva, M.1    O'Garra, A.2


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