IL-27 is expressed in chronic human eczematous skin lesions and stimulates human keratinocytes

Journal of Allergy and Clinical Immunology

Volumn 124, Issue 1, 2009, Pages 81-89

  Wittmann, Miriam ^a   Zeitvogel, Jana ^a   Wang, Dong ^a   Werfel, Thomas ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

chemokines; eczema; Human primary keratinocytes; IL 6 IL 12 family; inflammation

Indexed keywords

GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 12; INTERLEUKIN 23; INTERLEUKIN 27; INTERLEUKIN 6; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PROTEIN SUBUNIT; STAT1 PROTEIN; STAT3 PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; ARTICLE; CELL STIMULATION; CHEMOTAXIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; ECZEMA; ENZYME LINKED IMMUNOSORBENT ASSAY; EPIDERMIS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; KERATINOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN INFLAMMATION; UPREGULATION; WESTERN BLOTTING;

BLOTTING, WESTERN; CELLS, CULTURED; CHEMOKINE CXCL10; ECZEMA; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; INTERLEUKIN-18 RECEPTOR ALPHA SUBUNIT; INTERLEUKINS; KERATINOCYTES; RECEPTORS, INTERLEUKIN; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR; UP-REGULATION;

EID: 67649233028     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2009.04.026     Document Type: Article

References (41)

1. Wittmann M., Purwar R., Hartmann C., Gutzmer R., and Werfel T. Human keratinocytes respond to interleukin-18: implication for the course of chronic inflammatory skin diseases. J Invest Dermatol 124 (2005) 1225-1233
2. Wittmann M., and Werfel T. Interaction of keratinocytes with infiltrating lymphocytes in allergic eczematous skin diseases. Curr Opin Allergy Clin Immunol 6 (2006) 329-334
3. Purwar R., Werfel T., and Wittmann M. IL-13-stimulated human keratinocytes preferentially attract CD4+CCR4+ T cells: possible role in atopic dermatitis. J Invest Dermatol 26 (2006) 1043-1051
4. Kamiya S., Owaki T., Morishima N., Fukai F., Mizuguchi J., and Yoshimoto T. An indispensable role for STAT1 in IL-27-induced T-bet expression but not proliferation of naive CD4+ T cells. J Immunol 173 (2004) 3871-3877
5. Lucas S., Ghilardi N., Li J., and de Sauvage F.J. IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms. Proc Natl Acad Sci U S A 100 (2003) 15047-15052
6. Pflanz S., Timans J.C., Cheung J., Rosales R., Kanzler H., Gilbert J., et al. IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells. Immunity 16 (2002) 779-790
7. Takeda A., Hamano S., Yamanaka A., Hanada T., Ishibashi T., Mak T.W., et al. Cutting edge: role of IL-27/WSX-1 signaling for induction of T-Bet through activation of STAT1 during initial Th1 commitment. J Immunol 170 (2003) 4886-4890
8. Pflanz S., Hibbert L., Mattson J., Rosales R., Vaisberg E., Bazan J.F., et al. WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27. J Immunol 172 (2004) 2225-2231
9. Hibbert L., Pflanz S., de Waal M.R., and Kastelein R.A. IL-27 and IFN-alpha signal via Stat1 and Stat3 and induce T-Bet and IL-12Rbeta2 in naive T cells. J Interferon Cytokine Res 23 (2003) 513-522
10. Villarino A.V., Larkin III J., Saris C.J., Caton A.J., Lucas S., Wong T., et al. Positive and negative regulation of the IL-27 receptor during lymphoid cell activation. J Immunol 174 (2005) 7684-7691
11. Kanda N., and Watanabe T. IL-12, IL-23, and IL-27 enhance human β-defensin-2 production in human keratinocytes. Eur J Immunol 38 (2008) 1287-1296
12. Purwar R., Kraus M., Werfel T., and Wittmann M. Modulation of keratinocyte derived MMP-9 by IL-13: a possible role for the pathogenesis of epidermal inflammation. J Invest Dermatol 128 (2008) 59-66
13. Purwar R., Wittmann M., Zwirner J., Oppermann M., Kracht M., Dittrich-Breiholz O., et al. Induction of C3 and CCL2 by C3a in keratinocytes: a novel autocrine amplification loop of inflammatory skin reactions. J Immunol 177 (2006) 4444-4450
14. Gutzmer R., Diestel C., Mommert S., Köther B., Stark H., Wittmann M., et al. Histamine H4 receptor stimulation suppresses IL-12p70 production and mediates chemotaxis in human monocyte-derived dendritic cells. J Immunol 174 (2005) 5224-5232
15. Larousserie F., Pflanz S., Coulomb-L'Hermine A., Brousse N., Kastelein R., and Devergne O. Expression of IL-27 in human Th1-associated granulomatous diseases. J Pathol 202 (2004) 164-171
16. Schwarz A., Stander S., Berneburg M., Bohm M., Kulms D., van Steeg H., et al. Interleukin-12 suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair. Nat Cell Biol 4 (2002) 26-31
17. Werfel T., and Wittmann M. Regulatory role of T lymphocytes in atopic dermatitis. Chem Immunol Allergy 94 (2008) 101-111
18. Wirtz S., Becker C., Fantini M.C., Nieuwenhuis E.E., Tubbe I., Galle P.R., et al. EBV-induced gene 3 transcription is induced by TLR signaling in primary dendritic cells via NF-kappa B activation. J Immunol 174 (2005) 2814-2824
19. Smits H.H., van Beelen A.J., Hessle C., Westland R., de Jong E., Soeteman E., et al. Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 development. Eur J Immunol 34 (2004) 1371-1380
20. Maaser C., Egan L.J., Birkenbach M.P., Eckmann L., and Kagnoff M.F. Expression of Epstein-Barr virus-induced gene 3 and other interleukin-12-related molecules by human intestinal epithelium. Immunology 112 (2004) 437-445
21. Shimizu M., Shimamura M., Owaki T., Asakawa M., Fujita K., Kudo M., et al. Antiangiogenic and antitumor activities of IL-27. J Immunol 176 (2006) 7317-7324
22. Artis D., Villarino A., Silverman M., He W., Thornton E.M., Mu S., et al. The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity. J Immunol 173 (2004) 5626-5634
23. Hölscher C., Hölscher A., Rückerl D., Yoshimoto T., Yoshida H., Mak T., et al. The IL-27 receptor chain WSX-1 differentially regulates antibacterial immunity and survival during experimental tuberculosis. J Immunol 174 (2005) 3534-3544
24. Larousserie F., Charlot P., Bardel E., Froger J., Kastelein R.A., and Devergne O. Differential effects of IL-27 on human B cell subsets. J Immunol 176 (2006) 5890-5897
25. Rückerl D., Hessmann M., Yoshimoto T., Ehlers S., and Hölscher C. Alternatively activated macrophages express the IL-27 receptor alpha chain WSX-1. Immunobiology 211 (2006) 427-436
26. Yoshimoto T., Okada K., Morishima N., Kamiya S., Owaki T., Asakawa M., et al. Induction of IgG2a class switching in B cells by IL-27. J Immunol 173 (2004) 2479-2485
27. Chen Q., Ghilardi N., Wang H., Baker T., Xie M.H., Gurney A., et al. Development of Th1-type immune responses requires the type I cytokine receptor TCCR. Nature 407 (2000) 916-920
28. Owaki T., Asakawa M., Kamiya S., Takeda K., Fukai F., Mizuguchi J., et al. IL-27 suppresses CD28-mediated IL-2 production through suppressor of cytokine signaling 3. J Immunol 176 (2006) 2773-2780
29. Yoshimura T., Takeda A., Hamano S., Miyazaki Y., Kinjyo I., Ishibashi T., et al. Two-sided roles of IL-27: induction of Th1 differentiation on naive CD4+ T cells versus suppression of proinflammatory cytokine production including IL-23-induced IL-17 on activated CD4+ T cells partially through STAT3-dependent mechanism. J Immunol 177 (2006) 5377-5385
30. Batten M., and Ghilardi N. The biology and therapeutic potential of interleukin 27. J Mol Med 85 (2007) 661-672
31. Sonoda K.H., Yoshimura T., Takeda A., Ishibashi T., Hamano S., and Yoshida H. WSX-1 plays a significant role for the initiation of experimental autoimmune uveitis. Int Immunol 19 (2007) 93-98
32. Wittmann M., Alter M., Stunkel T., Kapp A., and Werfel T. Cell-to-cell contact between activated CD4+ T lymphocytes and unprimed monocytes interferes with a TH1 response. J Allergy Clin Immunol 114 (2004) 965-973
33. Owaki T., Asakawa M., Morishima N., Hata K., Fukai F., Matsui M., et al. A role for IL-27 in early regulation of Th1 differentiation. J Immunol 175 (2005) 2191-2200
34. Trautmann A., Altznauer F., Akdis M., Simon H.U., Disch R., Brocker E.B., et al. The differential fate of cadherins during T-cell-induced keratinocyte apoptosis leads to spongiosis in eczematous dermatitis. J Invest Dermatol 117 (2001) 927-934
35. Villarino A., Hibbert L., Lieberman L., Wilson E., Mak T., Yoshida H., et al. The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection. Immunity 19 (2003) 645-655
36. Hamano S., Himeno K., Miyazaki Y., Ishii K., Yamanaka A., Takeda A., et al. WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of proinflammatory cytokine production. Immunity 19 (2003) 657-667
37. Yoshimoto T., Yoshimoto T., Yasuda K., Mizuguchi J., and Nakanishi K. IL-27 suppresses Th2 cell development and Th2 cytokines production from polarized Th2 cells: a novel therapeutic way for Th2-mediated allergic inflammation. J Immunol 179 (2007) 4415-4423
38. Batten M., Li J., Yi S., Kljavin N.M., Danilenko D.M., Lucas S., et al. Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nat Immunol 7 (2006) 929-936
39. Stumhofer J.S., Laurence A., Wilson E.H., Huang E., Tato C.M., Johnson L.M., et al. Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nat Immunol 7 (2006) 937-945
40. Kastelein R.A., Hunter C.A., and Cua D.J. Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation. Annu Rev Immunol 25 (2007) 221-242
41. Villarino A.V., Stumhofer J.S., Saris C.J., Kastelein R.A., de Sauvage F.J., and Hunter C.A. IL-27 limits IL-2 production during Th1 differentiation. J Immunol 176 (2006) 237-247