Cutting edge: T-bet and IL-27R are critical for in vivo IFN-γ production by CD8 T cells during infection

Journal of Immunology

Volumn 180, Issue 2, 2008, Pages 693-697

  Mayer, Katrin D ^a,b   Mohrs, Katja ^a   Reiley, William ^a   Wittmer, Susan ^a   Kohlmeier, Jacob E ^a   Pearl, John E ^a   Cooper, Andrea M ^a   Johnson, Lawrence L ^a   Woodland, David L ^a   Mohrs, Markus ^a  

^a TRUDEAU INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EOMESODERMIN; GAMMA INTERFERON; IL 27 RECEPTOR ALPHA; INTERLEUKIN 27; STAT1 PROTEIN; TRANSCRIPTION FACTOR T BET; UNCLASSIFIED DRUG; CYTOKINE RECEPTOR; IL27RA PROTEIN, MOUSE; STAT1 PROTEIN, MOUSE; T BOX TRANSCRIPTION FACTOR; T BOX TRANSCRIPTION FACTOR TBX21; T-BOX TRANSCRIPTION FACTOR TBX21;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL SELECTION; CYTOKINE PRODUCTION; FLOW CYTOMETRY; IMMUNE RESPONSE; IN VIVO STUDY; INFLUENZA; MOUSE; NONHUMAN; PATHOGENESIS; POSITIVE FEEDBACK; PRIORITY JOURNAL; ANIMAL; GENETICS; HUMAN; IMMUNOLOGY; INFECTION; METABOLISM; MICROBIOLOGY; MOUSE MUTANT; PARASITOLOGY; PHYSIOLOGY; TOXOPLASMOSIS;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; HUMANS; INFECTION; INFLUENZA, HUMAN; INTERFERON TYPE II; MICE; MICE, MUTANT STRAINS; RECEPTORS, CYTOKINE; STAT1 TRANSCRIPTION FACTOR; T-BOX DOMAIN PROTEINS; TOXOPLASMOSIS;

EID: 40449137091     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.180.2.693     Document Type: Article

References (29)

1. Huang, S., W. Hendriks, A. Althage, S. Hemmi, H. Bluethmann, R. Kamijo, J. Vilcek, R. M. Zinkernagel, and M. Aguet. 1993. Immune response in mice that lack the interferon-γ receptor. Science 259: 1742-1745.
2. Dalton, D. K., S. Pitts-Meek, S. Keshav, I. S. Figari, A. Bradley, and T. A. Stewart. 1993. Multiple defects of immune cell function in mice with disrupted interferon-γ genes. Science 259: 1739-1742.
3. Bach, E. A., M. Aguet, and R. D. Schreiber. 1997. The IFN γ receptor: a paradigm for cytokine receptor signaling. Annu. Rev. Immunol. 15: 563-591.
4. Suzuki, Y., M. A. Orellana, R. D. Schreiber, and J. S. Remington. 1988. Interferon-γ: the major mediator of resistance against Toxoplasma gondii. Science 240: 516-518.
5. Szabo, S. J., S. T. Kim, G. L. Costa, X. Zhang, C. G. Fathman, and L. H. Glimcher. 2000. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100: 655-669.
6. Szabo, S. J., B. M. Sullivan, C. Stemmann, A. R. Satoskar, B. P. Sleckman, and L. H. Glimcher. 2002. Distinct effects of T-bet in TH1 lineage commitment and IFN-γ production in CD4 and CD8 T cells. Science 295: 338-342.
7. + T cell function by the transcription factor eomesodermin. Science 302: 1041-1043.
8. + T cell fate coupled by T-bet and eomesodermin. Nat. Immunol. 6: 1236-1244.
9. + T cells. Nat. Immunol. 3: 549-557.
10. Lighvani, A. A., D. M. Frucht, D. Jankovic, H. Yamane, J. Aliberti, B. D. Hissong, B. V. Nguyen, M. Gadina, A. Sher, W. E. Paul, and J. J. O'Shea. 2001. T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells. Proc. Natl. Acad. Sci. USA 98: 15137-15142.
11. Batten, M., and N. Ghilardi. 2007. The biology and therapeutic potential of interleukin 27. J. Mol. Med. 85: 661-672.
12. Villarino, A., L. Hibbert, L. Lieberman, E. Wilson, T. Mak, H. Yoshida, R. A. Kastelein, C. Saris, and C. A. Hunter. 2003. The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection. Immunity 19: 645-655.
13. Batten, M., J. Li, S. Yi, N. M. Kljavin, D. M. Danilenko, S. Lucas, J. Lee, F. J. de Sauvage, and N. Ghilardi. 2006. Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nat. Immunol. 7: 929-936.
14. Takeda, A., S. Hamano, A. Yamanaka, T. Hanada, T. Ishibashi, T. W. Mak, A. Yoshimura, and H. Yoshida. 2003. Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment. J. Immunol. 170: 4886-4890.
15. + T cells. J. Immunol. 173: 3871-3877.
16. Sullivan, B. M., A. Juedes, S. J. Szabo, M. von Herrath, and L. H. Glimcher. 2003. Antigen-driven effector CD8 T cell function regulated by T-bet. Proc. Natl. Acad. Sci. USA 100: 15818-15823.
17. Stetson, D. B., M. Mohrs, R. L. Reinhardt, J. L. Baron, Z. E. Wang, L. Gapin, M. Kronenberg, and R. M. Locksley. 2003. Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector function. J. Exp. Med. 198: 1069-1076.
18. Mayer, K. D., K. Mohrs, S. R. Crowe, L. L. Johnson, P. Rhyne, D. L. Woodland, and M. Mohrs. 2005. The functional heterogeneity of type 1 effector T cells in response to infection is related to the potential for IFN-γ production. J. Immunol. 174: 7732-7739.
19. Chen, Q., N. Ghilardi, H. Wang, T. Baker, M. H. Xie, A. Gurney, I. S. Grewal, and F. J. de Sauvage. 2000. Development of Th1-type immune responses requires the type I cytokine receptor TCCR. Nature 407: 916-920.
20. + T cells during primary and secondary viral infections. J. Immunol. 174: 5936-5940.
21. Glimcher, L. H., M. J. Townsend, B. M. Sullivan, and G. M. Lord. 2004. Recent developments in the transcriptional regulation of cytolytic effector cells. Nat. Rev. Immunol. 4: 900-911.
22. Lugo-Villarino, G., R. Maldonado-Lopez, R. Possemato, C. Penaranda, and L. H. Glimcher. 2003. T-bet is required for optimal production of IFN-γ and antigen-specific T cell activation by dendritic cells. Proc. Natl. Acad. Sci. USA 100: 7749-7754.
23. Peng, S. L., S. J. Szabo, and L. H. Glimcher. 2002. T-bet regulates IgG class switching and pathogenic autoantibody production. Proc. Natl. Acad. Sci. USA 99: 5545-5550.
24. + T cells to increase their abundance during virus infection. J. Exp. Med. 201: 1053-1059.
25. Sher, A., C. Collazzo, C. Scanga, D. Jankovic, G. Yap, and J. Aliberti. 2003. Induction and regulation of IL-12-dependent host resistance to Toxoplasma gondii. Immunol. Res. 27: 521-528.
26. Juedes, A. E., E. Rodrigo, L. Togher, L. H. Glimcher, and M. G. von Herrath. 2004. T-bet controls autoaggressive CD8 lymphocyte responses in type 1 diabetes. J. Exp. Med. 199: 1153-1162.
27. Way, S. S., and C. B. Wilson. 2004. Cutting edge: immunity and IFN-γ production during Listeria monocytogenes infection in the absence of T-bet. J. Immunol. 173: 5918-5922.
28. + T cell generation with enhanced granzyme B expression by IL-27. J. Immunol. 175: 1686-1693.
29. + T cells through Stat1-dependent and -independent mechanisms. Proc. Natl. Acad. Sci. USA 100: 15047-15052.