메뉴 건너뛰기




Volumn 115, Issue , 2012, Pages 1-44

The Immunobiology of IL-27

Author keywords

Adaptive Immunity; Cytokine; Immune regulation; Immunobiology; Innate Immunity; Receptors; Signaling; Subunits; T cells

Indexed keywords

ADENOVIRUS VECTOR; CD8 ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 27; INTERLEUKIN 27 RECEPTOR ALPHA; INTERLEUKIN RECEPTOR; NANOPARTICLE; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG;

EID: 84861170066     PISSN: 00652776     EISSN: 15578445     Source Type: Book Series    
DOI: 10.1016/B978-0-12-394299-9.00001-1     Document Type: Chapter
Times cited : (113)

References (194)
  • 1
    • 70449732757 scopus 로고    scopus 로고
    • IL-27 regulates IL-10 and IL-17 from CD4+ cells in nonhealing Leishmania major infection
    • Anderson C.F., Stumhofer J.S., Hunter C.A., Sacks D. IL-27 regulates IL-10 and IL-17 from CD4+ cells in nonhealing Leishmania major infection. J. Immunol. 2009, 183:4619-4627.
    • (2009) J. Immunol. , vol.183 , pp. 4619-4627
    • Anderson, C.F.1    Stumhofer, J.S.2    Hunter, C.A.3    Sacks, D.4
  • 4
    • 1842477302 scopus 로고    scopus 로고
    • Cutting edge: Early IL-4 production governs the requirement for IL-27-WSX-1 signaling in the development of protective Th1 cytokine responses following Leishmania major infection
    • Artis D., Johnson L.M., Joyce K., Saris C., Villarino A., Hunter C.A., Scott P. Cutting edge: Early IL-4 production governs the requirement for IL-27-WSX-1 signaling in the development of protective Th1 cytokine responses following Leishmania major infection. J. Immunol. 2004, 172:4672-4675.
    • (2004) J. Immunol. , vol.172 , pp. 4672-4675
    • Artis, D.1    Johnson, L.M.2    Joyce, K.3    Saris, C.4    Villarino, A.5    Hunter, C.A.6    Scott, P.7
  • 8
    • 34447345406 scopus 로고    scopus 로고
    • The biology and therapeutic potential of interleukin 27
    • Batten M., Ghilardi N. The biology and therapeutic potential of interleukin 27. J. Mol. Med. (Berl.) 2007, 85:661-672.
    • (2007) J. Mol. Med. (Berl.) , vol.85 , pp. 661-672
    • Batten, M.1    Ghilardi, N.2
  • 9
    • 49149119535 scopus 로고    scopus 로고
    • Cutting edge: IL-27 is a potent inducer of IL-10 but not FoxP3 in murine T cells
    • Batten M., Kljavin N.M., Li J., Walter M.J., de Sauvage F.J., Ghilardi N. Cutting edge: IL-27 is a potent inducer of IL-10 but not FoxP3 in murine T cells. J. Immunol. 2008, 180:2752-2756.
    • (2008) J. Immunol. , vol.180 , pp. 2752-2756
    • Batten, M.1    Kljavin, N.M.2    Li, J.3    Walter, M.J.4    de Sauvage, F.J.5    Ghilardi, N.6
  • 12
    • 0025102756 scopus 로고
    • Haemopoietic receptors and helical cytokines
    • Bazan J.F. Haemopoietic receptors and helical cytokines. Immunol. Today 1990, 11:350-354.
    • (1990) Immunol. Today , vol.11 , pp. 350-354
    • Bazan, J.F.1
  • 13
    • 0025162844 scopus 로고
    • Structural design and molecular evolution of a cytokine receptor superfamily
    • Bazan J.F. Structural design and molecular evolution of a cytokine receptor superfamily. Proc. Natl. Acad. Sci. USA 1990, 87:6934-6938.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 6934-6938
    • Bazan, J.F.1
  • 14
    • 0031903792 scopus 로고    scopus 로고
    • Regulated expression of gp130 and IL-6 receptor alpha chain in T cell maturation and activation
    • Betz U.A., Muller W. Regulated expression of gp130 and IL-6 receptor alpha chain in T cell maturation and activation. Int. Immunol. 1998, 10:1175-1184.
    • (1998) Int. Immunol. , vol.10 , pp. 1175-1184
    • Betz, U.A.1    Muller, W.2
  • 15
    • 77951440735 scopus 로고    scopus 로고
    • Type I interferon therapy and its role in autoimmunity
    • Biggioggero M., Gabbriellini L., Meroni P.L. Type I interferon therapy and its role in autoimmunity. Autoimmunity 2010, 43:248-254.
    • (2010) Autoimmunity , vol.43 , pp. 248-254
    • Biggioggero, M.1    Gabbriellini, L.2    Meroni, P.L.3
  • 17
    • 0028964995 scopus 로고
    • Modification of acute experimental autoimmune encephalomyelitis in the Lewis rat by oral administration of type 1 interferons
    • Brod S.A., Scott M., Burns D.K., Phillips J.T. Modification of acute experimental autoimmune encephalomyelitis in the Lewis rat by oral administration of type 1 interferons. J. Interferon Cytokine Res. 1995, 15:115-122.
    • (1995) J. Interferon Cytokine Res. , vol.15 , pp. 115-122
    • Brod, S.A.1    Scott, M.2    Burns, D.K.3    Phillips, J.T.4
  • 18
    • 40449100736 scopus 로고    scopus 로고
    • IL-27 induces a Th1 immune response and susceptibility to experimental arthritis
    • Cao Y., Doodes P.D., Glant T.T., Finnegan A. IL-27 induces a Th1 immune response and susceptibility to experimental arthritis. J. Immunol. 2008, 180:922-930.
    • (2008) J. Immunol. , vol.180 , pp. 922-930
    • Cao, Y.1    Doodes, P.D.2    Glant, T.T.3    Finnegan, A.4
  • 19
    • 33947626493 scopus 로고    scopus 로고
    • Identification of polymorphisms in human interleukin-27 and their association with asthma in a Korean population
    • Chae S.C., Li C.S., Kim K.M., Yang J.Y., Zhang Q., Lee Y.C., Yang Y.S., Chung H.T. Identification of polymorphisms in human interleukin-27 and their association with asthma in a Korean population. J. Hum. Genet. 2007, 52:355-361.
    • (2007) J. Hum. Genet. , vol.52 , pp. 355-361
    • Chae, S.C.1    Li, C.S.2    Kim, K.M.3    Yang, J.Y.4    Zhang, Q.5    Lee, Y.C.6    Yang, Y.S.7    Chung, H.T.8
  • 20
    • 79960993671 scopus 로고    scopus 로고
    • Signaling events involved in interleukin 27 (IL-27)-induced proliferation of human naive CD4+ T cells and B cells
    • Charlot-Rabiega P., Bardel E., Dietrich C., Kastelein R., Devergne O. Signaling events involved in interleukin 27 (IL-27)-induced proliferation of human naive CD4+ T cells and B cells. J. Biol. Chem. 2011, 286:27350-27362.
    • (2011) J. Biol. Chem. , vol.286 , pp. 27350-27362
    • Charlot-Rabiega, P.1    Bardel, E.2    Dietrich, C.3    Kastelein, R.4    Devergne, O.5
  • 22
    • 14944367061 scopus 로고    scopus 로고
    • Antitumor effects produced by transduction of dendritic cells-derived heterodimeric cytokine genes in murine colon carcinoma cells
    • Chiyo M., Shimozato O., Iizasa T., Fujisawa T., Tagawa M. Antitumor effects produced by transduction of dendritic cells-derived heterodimeric cytokine genes in murine colon carcinoma cells. Anticancer Res. 2004, 24:3763-3767.
    • (2004) Anticancer Res. , vol.24 , pp. 3763-3767
    • Chiyo, M.1    Shimozato, O.2    Iizasa, T.3    Fujisawa, T.4    Tagawa, M.5
  • 23
    • 18644381517 scopus 로고    scopus 로고
    • Expression of IL-27 in murine carcinoma cells produces antitumor effects and induces protective immunity in inoculated host animals
    • Chiyo M., Shimozato O., Yu L., Kawamura K., Iizasa T., Fujisawa T., Tagawa M. Expression of IL-27 in murine carcinoma cells produces antitumor effects and induces protective immunity in inoculated host animals. Int. J. Cancer 2005, 115:437-442.
    • (2005) Int. J. Cancer , vol.115 , pp. 437-442
    • Chiyo, M.1    Shimozato, O.2    Yu, L.3    Kawamura, K.4    Iizasa, T.5    Fujisawa, T.6    Tagawa, M.7
  • 24
    • 79955844662 scopus 로고    scopus 로고
    • Interleukin-27 and interleukin-23 modulate human plasmacell functions
    • Cocco C., Morandi F., Airoldi I. Interleukin-27 and interleukin-23 modulate human plasmacell functions. J. Leukoc. Biol. 2011, 89:729-734.
    • (2011) J. Leukoc. Biol. , vol.89 , pp. 729-734
    • Cocco, C.1    Morandi, F.2    Airoldi, I.3
  • 25
    • 0028824039 scopus 로고
    • IL-12 deaths: Explanation and a puzzle
    • Cohen J. IL-12 deaths: Explanation and a puzzle. Science 1995, 270:908.
    • (1995) Science , vol.270 , pp. 908
    • Cohen, J.1
  • 27
    • 70049118519 scopus 로고    scopus 로고
    • Regulatory T cell suppression is potentiated by target T cells in a cell contact, IL-35- and IL-10-dependent manner
    • Collison L.W., Pillai M.R., Chaturvedi V., Vignali D.A. Regulatory T cell suppression is potentiated by target T cells in a cell contact, IL-35- and IL-10-dependent manner. J. Immunol. 2009, 182:6121-6128.
    • (2009) J. Immunol. , vol.182 , pp. 6121-6128
    • Collison, L.W.1    Pillai, M.R.2    Chaturvedi, V.3    Vignali, D.A.4
  • 29
    • 44449096726 scopus 로고    scopus 로고
    • IL-10: The master regulator of immunity to infection
    • Couper K.N., Blount D.G., Riley E.M. IL-10: The master regulator of immunity to infection. J. Immunol. 2008, 180:5771-5777.
    • (2008) J. Immunol. , vol.180 , pp. 5771-5777
    • Couper, K.N.1    Blount, D.G.2    Riley, E.M.3
  • 33
    • 0030700003 scopus 로고    scopus 로고
    • Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin
    • Devergne O., Birkenbach M., Kieff E. Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin. Proc. Natl. Acad. Sci. USA 1997, 94:12041-12046.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 12041-12046
    • Devergne, O.1    Birkenbach, M.2    Kieff, E.3
  • 34
    • 0030067819 scopus 로고    scopus 로고
    • A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes
    • Devergne O., Hummel M., Koeppen H., Le Beau M.M., Nathanson E.C., Kieff E., Birkenbach M. A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes. J. Virol. 1996, 70:1143-1153.
    • (1996) J. Virol. , vol.70 , pp. 1143-1153
    • Devergne, O.1    Hummel, M.2    Koeppen, H.3    Le Beau, M.M.4    Nathanson, E.C.5    Kieff, E.6    Birkenbach, M.7
  • 35
    • 79955777815 scopus 로고    scopus 로고
    • WSX1 expression in tumors induces immune tolerance via suppression of effector immune cells
    • Dibra D., Cutrera J., Xia X., Li S. WSX1 expression in tumors induces immune tolerance via suppression of effector immune cells. PLoS One 2011, 6:e19072.
    • (2011) PLoS One , vol.6
    • Dibra, D.1    Cutrera, J.2    Xia, X.3    Li, S.4
  • 36
    • 67650462706 scopus 로고    scopus 로고
    • Expression of WSX1 in tumors sensitizes IL-27 signaling-independent natural killer cell surveillance
    • Dibra D., Cutrera J.J., Xia X., Birkenbach M.P., Li S. Expression of WSX1 in tumors sensitizes IL-27 signaling-independent natural killer cell surveillance. Cancer Res. 2009, 69:5505-5513.
    • (2009) Cancer Res. , vol.69 , pp. 5505-5513
    • Dibra, D.1    Cutrera, J.J.2    Xia, X.3    Birkenbach, M.P.4    Li, S.5
  • 37
    • 84855272274 scopus 로고    scopus 로고
    • A novel role for IL-27 as mediator of intestinal epithelial barrier protection mediated via differential STAT signaling and induction of antibacterial and anti-inflammatory proteins
    • Diegelmann J., Olszak T., Goke B., Blumberg R.S., Brand S. A novel role for IL-27 as mediator of intestinal epithelial barrier protection mediated via differential STAT signaling and induction of antibacterial and anti-inflammatory proteins. J. Biol. Chem. 2011, 287:286-298.
    • (2011) J. Biol. Chem. , vol.287 , pp. 286-298
    • Diegelmann, J.1    Olszak, T.2    Goke, B.3    Blumberg, R.S.4    Brand, S.5
  • 39
    • 79952535373 scopus 로고    scopus 로고
    • EBI3 deficiency leads to diminished T helper type 1 and increased T helper type 2 mediated airway inflammation
    • Dokmeci E., Xu L., Robinson E., Golubets K., Bottomly K., Herrick C.A. EBI3 deficiency leads to diminished T helper type 1 and increased T helper type 2 mediated airway inflammation. Immunology 2011, 132:559-566.
    • (2011) Immunology , vol.132 , pp. 559-566
    • Dokmeci, E.1    Xu, L.2    Robinson, E.3    Golubets, K.4    Bottomly, K.5    Herrick, C.A.6
  • 42
    • 34447099218 scopus 로고    scopus 로고
    • Systemic lupus erythematosus: Multiple immunological phenotypes in a complex genetic disease
    • Fairhurst A., Wandstrat A., Wakeland E. Systemic lupus erythematosus: Multiple immunological phenotypes in a complex genetic disease. Adv. Immunol. 2006, 92:1-69.
    • (2006) Adv. Immunol. , vol.92 , pp. 1-69
    • Fairhurst, A.1    Wandstrat, A.2    Wakeland, E.3
  • 49
    • 68949127073 scopus 로고    scopus 로고
    • Production of both IL-27 and IFN-gamma after the treatment with a ligand for invariant NK T cells is responsible for the suppression of Th2 response and allergic inflammation in a mouse experimental asthma model
    • Fujita H., Teng A., Nozawa R., Takamoto-Matsui Y., Katagiri-Matsumura H., Ikezawa Z., Ishii Y. Production of both IL-27 and IFN-gamma after the treatment with a ligand for invariant NK T cells is responsible for the suppression of Th2 response and allergic inflammation in a mouse experimental asthma model. J. Immunol. 2009, 183:254-260.
    • (2009) J. Immunol. , vol.183 , pp. 254-260
    • Fujita, H.1    Teng, A.2    Nozawa, R.3    Takamoto-Matsui, Y.4    Katagiri-Matsumura, H.5    Ikezawa, Z.6    Ishii, Y.7
  • 50
    • 0029959459 scopus 로고    scopus 로고
    • In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha
    • Gazzinelli R.T., Wysocka M., Hieny S., Scharton-Kersten T., Cheever A., Kuhn R., Muller W., Trinchieri G., Sher A. In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha. J. Immunol. 1996, 157:798-805.
    • (1996) J. Immunol. , vol.157 , pp. 798-805
    • Gazzinelli, R.T.1    Wysocka, M.2    Hieny, S.3    Scharton-Kersten, T.4    Cheever, A.5    Kuhn, R.6    Muller, W.7    Trinchieri, G.8    Sher, A.9
  • 51
    • 70349251863 scopus 로고    scopus 로고
    • Interleukin-27 inhibition of HIV-1 involves an intermediate induction of type I interferon
    • Greenwell-Wild T., Vazquez N., Jin W., Rangel Z., Munson P.J., Wahl S.M. Interleukin-27 inhibition of HIV-1 involves an intermediate induction of type I interferon. Blood 2009, 114:1864-1874.
    • (2009) Blood , vol.114 , pp. 1864-1874
    • Greenwell-Wild, T.1    Vazquez, N.2    Jin, W.3    Rangel, Z.4    Munson, P.J.5    Wahl, S.M.6
  • 52
    • 43049101640 scopus 로고    scopus 로고
    • The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice
    • Guo B., Chang E.Y., Cheng G. The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice. J. Clin. Invest. 2008, 118:1680-1690.
    • (2008) J. Clin. Invest. , vol.118 , pp. 1680-1690
    • Guo, B.1    Chang, E.Y.2    Cheng, G.3
  • 54
    • 0034665759 scopus 로고    scopus 로고
    • Identification of genes specifically expressed in human activated and mature dendritic cells through serial analysis of gene expression
    • Hashimoto S.I., Suzuki T., Nagai S., Yamashita T., Toyoda N., Matsushima K. Identification of genes specifically expressed in human activated and mature dendritic cells through serial analysis of gene expression. Blood 2000, 96:2206-2214.
    • (2000) Blood , vol.96 , pp. 2206-2214
    • Hashimoto, S.I.1    Suzuki, T.2    Nagai, S.3    Yamashita, T.4    Toyoda, N.5    Matsushima, K.6
  • 55
    • 70349088973 scopus 로고    scopus 로고
    • Identification of soluble WSX-1 not as a dominant-negative but as an alternative functional subunit of a receptor for an anti-Alzheimer's disease rescue factor Humanin
    • Hashimoto Y., Kurita M., Matsuoka M. Identification of soluble WSX-1 not as a dominant-negative but as an alternative functional subunit of a receptor for an anti-Alzheimer's disease rescue factor Humanin. Biochem. Biophys. Res. Commun. 2009, 389:95-99.
    • (2009) Biochem. Biophys. Res. Commun. , vol.389 , pp. 95-99
    • Hashimoto, Y.1    Kurita, M.2    Matsuoka, M.3
  • 56
    • 0141519112 scopus 로고    scopus 로고
    • IL-27 and IFN-alpha signal via Stat1 and Stat3 and induce T-Bet and IL-12Rbeta2 in naive T cells
    • Hibbert L., Pflanz S., De Waal Malefyt R., Kastelein R.A. IL-27 and IFN-alpha signal via Stat1 and Stat3 and induce T-Bet and IL-12Rbeta2 in naive T cells. J. Interferon Cytokine Res. 2003, 23:513-522.
    • (2003) J. Interferon Cytokine Res. , vol.23 , pp. 513-522
    • Hibbert, L.1    Pflanz, S.2    De Waal Malefyt, R.3    Kastelein, R.A.4
  • 58
    • 33745022850 scopus 로고    scopus 로고
    • Cytokine gene polymorphism in human disease: On-line databases, Supplement 3
    • Hollegaard M.V., Bidwell J.L. Cytokine gene polymorphism in human disease: On-line databases, Supplement 3. Genes Immun. 2006, 7:269-276.
    • (2006) Genes Immun. , vol.7 , pp. 269-276
    • Hollegaard, M.V.1    Bidwell, J.L.2
  • 60
    • 14844355133 scopus 로고    scopus 로고
    • The IL-27 receptor chain WSX-1 differentially regulates antibacterial immunity and survival during experimental tuberculosis
    • Holscher C., Holscher A., Ruckerl D., Yoshimoto T., Yoshida H., Mak T., Saris C., Ehlers S. The IL-27 receptor chain WSX-1 differentially regulates antibacterial immunity and survival during experimental tuberculosis. J. Immunol. 2005, 174:3534-3544.
    • (2005) J. Immunol. , vol.174 , pp. 3534-3544
    • Holscher, C.1    Holscher, A.2    Ruckerl, D.3    Yoshimoto, T.4    Yoshida, H.5    Mak, T.6    Saris, C.7    Ehlers, S.8
  • 61
    • 78649522921 scopus 로고    scopus 로고
    • Activation of eosinophils by IL-12 family cytokine IL-27: Implications of the pleiotropic roles of IL-27 in allergic responses
    • Hu S., Wong C.K., Lam C.W. Activation of eosinophils by IL-12 family cytokine IL-27: Implications of the pleiotropic roles of IL-27 in allergic responses. Immunobiology 2010, 216:54-65.
    • (2010) Immunobiology , vol.216 , pp. 54-65
    • Hu, S.1    Wong, C.K.2    Lam, C.W.3
  • 62
    • 50849129534 scopus 로고    scopus 로고
    • Association of interleukin (IL)-12 and IL-27 gene polymorphisms with chronic obstructive pulmonary disease in a Chinese population
    • Huang N., Liu L., Wang X.Z., Liu D., Yin S.Y., Yang X.D. Association of interleukin (IL)-12 and IL-27 gene polymorphisms with chronic obstructive pulmonary disease in a Chinese population. DNA Cell Biol. 2008, 27:527-531.
    • (2008) DNA Cell Biol. , vol.27 , pp. 527-531
    • Huang, N.1    Liu, L.2    Wang, X.Z.3    Liu, D.4    Yin, S.Y.5    Yang, X.D.6
  • 64
    • 33646383859 scopus 로고    scopus 로고
    • Phylogeny and evolution of class-I helical cytokines
    • Huising M.O. Phylogeny and evolution of class-I helical cytokines. J. Endocrinol. 2006, 189:1-25.
    • (2006) J. Endocrinol. , vol.189 , pp. 1-25
    • Huising, M.O.1
  • 66
    • 60149106103 scopus 로고    scopus 로고
    • Deficiency in EBV-induced gene 3 (EBI3) in MRL/lpr mice results in pathological alteration of autoimmune glomerulonephritis and sialadenitis
    • Igawa T., Nakashima H., Sadanaga A., Masutani K., Miyake K., Shimizu S., Takeda A., Hamano S., Yoshida H. Deficiency in EBV-induced gene 3 (EBI3) in MRL/lpr mice results in pathological alteration of autoimmune glomerulonephritis and sialadenitis. Mod. Rheumatol. 2009, 19:33-41.
    • (2009) Mod. Rheumatol. , vol.19 , pp. 33-41
    • Igawa, T.1    Nakashima, H.2    Sadanaga, A.3    Masutani, K.4    Miyake, K.5    Shimizu, S.6    Takeda, A.7    Hamano, S.8    Yoshida, H.9
  • 69
    • 78650647259 scopus 로고    scopus 로고
    • Lipopolysaccharide-mediated IL-10 transcriptional regulation requires sequential induction of type I IFNs and IL-27 in macrophages
    • Iyer S.S., Ghaffari A.A., Cheng G. Lipopolysaccharide-mediated IL-10 transcriptional regulation requires sequential induction of type I IFNs and IL-27 in macrophages. J. Immunol. 2010, 185:6599-6607.
    • (2010) J. Immunol. , vol.185 , pp. 6599-6607
    • Iyer, S.S.1    Ghaffari, A.A.2    Cheng, G.3
  • 71
    • 78650663329 scopus 로고    scopus 로고
    • Suppression of TNF-{alpha} and IL-1 signaling identifies a mechanism of homeostatic regulation of macrophages by IL-27
    • Kalliolias G.D., Gordon R.A., Ivashkiv L.B. Suppression of TNF-{alpha} and IL-1 signaling identifies a mechanism of homeostatic regulation of macrophages by IL-27. J. Immunol. 2010, 185:7047-7056.
    • (2010) J. Immunol. , vol.185 , pp. 7047-7056
    • Kalliolias, G.D.1    Gordon, R.A.2    Ivashkiv, L.B.3
  • 72
    • 44449140104 scopus 로고    scopus 로고
    • IL-27 activates human monocytes via STAT1 and suppresses IL-10 production but the inflammatory functions of IL-27 are abrogated by TLRs and p38
    • Kalliolias G.D., Ivashkiv L.B. IL-27 activates human monocytes via STAT1 and suppresses IL-10 production but the inflammatory functions of IL-27 are abrogated by TLRs and p38. J. Immunol. 2008, 180:6325-6333.
    • (2008) J. Immunol. , vol.180 , pp. 6325-6333
    • Kalliolias, G.D.1    Ivashkiv, L.B.2
  • 73
    • 75749091859 scopus 로고    scopus 로고
    • Interleukin-27 inhibits human osteoclastogenesis by abrogating RANKL-mediated induction of nuclear factor of activated T cells c1 and suppressing proximal RANK signaling
    • Kalliolias G.D., Zhao B., Triantafyllopoulou A., Park-Min K.H., Ivashkiv L.B. Interleukin-27 inhibits human osteoclastogenesis by abrogating RANKL-mediated induction of nuclear factor of activated T cells c1 and suppressing proximal RANK signaling. Arthritis Rheum. 2010, 62:402-413.
    • (2010) Arthritis Rheum. , vol.62 , pp. 402-413
    • Kalliolias, G.D.1    Zhao, B.2    Triantafyllopoulou, A.3    Park-Min, K.H.4    Ivashkiv, L.B.5
  • 74
    • 4644225089 scopus 로고    scopus 로고
    • An indispensable role for STAT1 in IL-27-induced T-bet expression but not proliferation of naive CD4+ T cells
    • Kamiya S., Owaki T., Morishima N., Fukai F., Mizuguchi J., Yoshimoto T. An indispensable role for STAT1 in IL-27-induced T-bet expression but not proliferation of naive CD4+ T cells. J. Immunol. 2004, 173:3871-3877.
    • (2004) J. Immunol. , vol.173 , pp. 3871-3877
    • Kamiya, S.1    Owaki, T.2    Morishima, N.3    Fukai, F.4    Mizuguchi, J.5    Yoshimoto, T.6
  • 75
    • 79957851081 scopus 로고    scopus 로고
    • IL-27 renders DC immunosuppressive by induction of B7-H1
    • Karakhanova S., Bedke T., Enk A.H., Mahnke K. IL-27 renders DC immunosuppressive by induction of B7-H1. J. Leukoc. Biol. 2011, 89:837-845.
    • (2011) J. Leukoc. Biol. , vol.89 , pp. 837-845
    • Karakhanova, S.1    Bedke, T.2    Enk, A.H.3    Mahnke, K.4
  • 76
    • 0034044769 scopus 로고    scopus 로고
    • Interferon β in multiple sclerosis: Is IL-12 suppression the key?
    • Karp C. Interferon β in multiple sclerosis: Is IL-12 suppression the key?. Immunol. Today 2000, 21:24-28.
    • (2000) Immunol. Today , vol.21 , pp. 24-28
    • Karp, C.1
  • 77
    • 34247523141 scopus 로고    scopus 로고
    • Discovery and biology of IL-23 and IL-27: Related but functionally distinct regulators of inflammation
    • Kastelein R.A., Hunter C.A., Cua D.J. Discovery and biology of IL-23 and IL-27: Related but functionally distinct regulators of inflammation. Annu. Rev. Immunol. 2007, 25:221-242.
    • (2007) Annu. Rev. Immunol. , vol.25 , pp. 221-242
    • Kastelein, R.A.1    Hunter, C.A.2    Cua, D.J.3
  • 78
    • 79957596746 scopus 로고    scopus 로고
    • T cell-specific overexpression of interleukin-27 receptor α subunit (WSX-1) prevents spontaneous skin inflammation in MRL/lpr mice
    • Kido M., Takeuchi S., Sugiyama N., Esaki H., Nakashima H., Yoshida H., Furue M. T cell-specific overexpression of interleukin-27 receptor α subunit (WSX-1) prevents spontaneous skin inflammation in MRL/lpr mice. Br. J. Dermatol. 2011, 164:1214-1220.
    • (2011) Br. J. Dermatol. , vol.164 , pp. 1214-1220
    • Kido, M.1    Takeuchi, S.2    Sugiyama, N.3    Esaki, H.4    Nakashima, H.5    Yoshida, H.6    Furue, M.7
  • 82
    • 0025012431 scopus 로고
    • Interferons-α and -γ inhibit interleukin-1β-stimulated osteoclast-like cell formation in long-term human marrow cultures
    • Kurihara N., Roodman G.D. Interferons-α and -γ inhibit interleukin-1β-stimulated osteoclast-like cell formation in long-term human marrow cultures. J. Interferon Res. 1990, 10:541-547.
    • (1990) J. Interferon Res. , vol.10 , pp. 541-547
    • Kurihara, N.1    Roodman, G.D.2
  • 83
    • 80054782482 scopus 로고    scopus 로고
    • IL-27 imparts immunoregulatory function to human NK cell subsets
    • Laroni A., Gandhi R., Beynon V., Weiner H.L. IL-27 imparts immunoregulatory function to human NK cell subsets. PLoS One 2011, 6:e26173.
    • (2011) PLoS One , vol.6
    • Laroni, A.1    Gandhi, R.2    Beynon, V.3    Weiner, H.L.4
  • 88
    • 4544281005 scopus 로고    scopus 로고
    • Determination of the critical concentration of neutrophils required to block bacterial growth in tissues
    • Li Y., Karlin A., Loike J.D., Silverstein S.C. Determination of the critical concentration of neutrophils required to block bacterial growth in tissues. J. Exp. Med. 2004, 200:613-622.
    • (2004) J. Exp. Med. , vol.200 , pp. 613-622
    • Li, Y.1    Karlin, A.2    Loike, J.D.3    Silverstein, S.C.4
  • 89
    • 79955756479 scopus 로고    scopus 로고
    • Interleukin-27-mediated suppression of human Th17 cells is associated with activation of STAT1 and suppressor of cytokine signaling protein 1
    • Liu H., Rohowsky-Kochan C. Interleukin-27-mediated suppression of human Th17 cells is associated with activation of STAT1 and suppressor of cytokine signaling protein 1. J. Interferon Cytokine Res. 2011, 31:459-469.
    • (2011) J. Interferon Cytokine Res. , vol.31 , pp. 459-469
    • Liu, H.1    Rohowsky-Kochan, C.2
  • 90
    • 33846440515 scopus 로고    scopus 로고
    • Regulation of IL-27 p28 gene expression in macrophages through MyD88- and interferon-gamma-mediated pathways
    • Liu J., Guan X., Ma X. Regulation of IL-27 p28 gene expression in macrophages through MyD88- and interferon-gamma-mediated pathways. J. Exp. Med. 2007, 204:141-152.
    • (2007) J. Exp. Med. , vol.204 , pp. 141-152
    • Liu, J.1    Guan, X.2    Ma, X.3
  • 92
    • 0344304399 scopus 로고    scopus 로고
    • IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms
    • Lucas S., Ghilardi N., Li J., de Sauvage F.J. IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms. Proc. Natl. Acad. Sci. USA 2003, 100:15047-15052.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 15047-15052
    • Lucas, S.1    Ghilardi, N.2    Li, J.3    de Sauvage, F.J.4
  • 93
    • 78651254183 scopus 로고    scopus 로고
    • Structural snapshots of full-length Jak1, a transmembrane gp130/IL-6/IL-6Ralpha cytokine receptor complex, and the receptor-Jak1 holocomplex
    • Lupardus P.J., Skiniotis G., Rice A.J., Thomas C., Fischer S., Walz T., Garcia K.C. Structural snapshots of full-length Jak1, a transmembrane gp130/IL-6/IL-6Ralpha cytokine receptor complex, and the receptor-Jak1 holocomplex. Structure 2011, 19:45-55.
    • (2011) Structure , vol.19 , pp. 45-55
    • Lupardus, P.J.1    Skiniotis, G.2    Rice, A.J.3    Thomas, C.4    Fischer, S.5    Walz, T.6    Garcia, K.C.7
  • 94
    • 0026828552 scopus 로고
    • Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor
    • Lust J.A., Donovan K.A., Kline M.P., Greipp P.R., Kyle R.A., Maihle N.J. Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor. Cytokine 1992, 4:96-100.
    • (1992) Cytokine , vol.4 , pp. 96-100
    • Lust, J.A.1    Donovan, K.A.2    Kline, M.P.3    Greipp, P.R.4    Kyle, R.A.5    Maihle, N.J.6
  • 96
    • 0000824394 scopus 로고
    • Sciencescope
    • Marshall E. Sciencescope. Science 1995, 268:1555.
    • (1995) Science , vol.268 , pp. 1555
    • Marshall, E.1
  • 98
    • 36248965294 scopus 로고    scopus 로고
    • TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology
    • McGeachy M.J., Bak-Jensen K.S., Chen Y., Tato C.M., Blumenschein W., McClanahan T., Cua D.J. TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology. Nat. Immunol. 2007, 8:1390-1397.
    • (2007) Nat. Immunol. , vol.8 , pp. 1390-1397
    • McGeachy, M.J.1    Bak-Jensen, K.S.2    Chen, Y.3    Tato, C.M.4    Blumenschein, W.5    McClanahan, T.6    Cua, D.J.7
  • 100
    • 77949891800 scopus 로고    scopus 로고
    • Critical role of the IFN-stimulated gene factor 3 complex in TLR-mediated IL-27p28 gene expression revealing a two-step activation process
    • Molle C., Goldman M., Goriely S. Critical role of the IFN-stimulated gene factor 3 complex in TLR-mediated IL-27p28 gene expression revealing a two-step activation process. J. Immunol. 2010, 184:1784-1792.
    • (2010) J. Immunol. , vol.184 , pp. 1784-1792
    • Molle, C.1    Goldman, M.2    Goriely, S.3
  • 102
    • 0027364634 scopus 로고
    • Inhibition by lactate dehydrogenase-elevating virus of in vivo interleukin 4 production during immunization with keyhole limpet haemocyanin
    • Monteyne P., Van Broeck J., Van Snick J., Coutelier J. Inhibition by lactate dehydrogenase-elevating virus of in vivo interleukin 4 production during immunization with keyhole limpet haemocyanin. Cytokine 1993, 5:394-397.
    • (1993) Cytokine , vol.5 , pp. 394-397
    • Monteyne, P.1    Van Broeck, J.2    Van Snick, J.3    Coutelier, J.4
  • 104
    • 22544433708 scopus 로고    scopus 로고
    • Augmentation of effector CD8+ T cell generation with enhanced granzyme B expression by IL-27
    • Morishima N., Owaki T., Asakawa M., Kamiya S., Mizuguchi J., Yoshimoto T. Augmentation of effector CD8+ T cell generation with enhanced granzyme B expression by IL-27. J. Immunol. 2005, 175:1686-1693.
    • (2005) J. Immunol. , vol.175 , pp. 1686-1693
    • Morishima, N.1    Owaki, T.2    Asakawa, M.3    Kamiya, S.4    Mizuguchi, J.5    Yoshimoto, T.6
  • 106
    • 33846586062 scopus 로고    scopus 로고
    • Interferon-beta mediates opposing effects on interferon-gamma-dependent Interleukin-12 p70 secretion by human monocyte-derived dendritic cells Scand
    • Nagai T., Devergne O., van Seventer G.A., van Seventer J.M. Interferon-beta mediates opposing effects on interferon-gamma-dependent Interleukin-12 p70 secretion by human monocyte-derived dendritic cells Scand. J. Immunol. 2007, 65:107-117.
    • (2007) J. Immunol. , vol.65 , pp. 107-117
    • Nagai, T.1    Devergne, O.2    van Seventer, G.A.3    van Seventer, J.M.4
  • 107
    • 0344585384 scopus 로고    scopus 로고
    • Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice
    • Nakae S., Nambu A., Sudo K., Iwakura Y. Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice. J. Immunol. 2003, 171:6173-6177.
    • (2003) J. Immunol. , vol.171 , pp. 6173-6177
    • Nakae, S.1    Nambu, A.2    Sudo, K.3    Iwakura, Y.4
  • 109
    • 34447567140 scopus 로고    scopus 로고
    • IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1
    • Neufert C., Becker C., Wirtz S., Fantini M.C., Weigmann B., Galle P.R., Neurath M.F. IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1. Eur. J. Immunol. 2007, 37:1809-1816.
    • (2007) Eur. J. Immunol. , vol.37 , pp. 1809-1816
    • Neufert, C.1    Becker, C.2    Wirtz, S.3    Fantini, M.C.4    Weigmann, B.5    Galle, P.R.6    Neurath, M.F.7
  • 110
    • 1842417179 scopus 로고    scopus 로고
    • Role of interleukin-10 in regulation of T-cell-dependent and T-cell-independent mechanisms of resistance to Toxoplasma gondii
    • Neyer L.E., Grunig G., Fort M., Remington J.S., Rennick D., Hunter C.A. Role of interleukin-10 in regulation of T-cell-dependent and T-cell-independent mechanisms of resistance to Toxoplasma gondii. Infect. Immun. 1997, 65:1675-1682.
    • (1997) Infect. Immun. , vol.65 , pp. 1675-1682
    • Neyer, L.E.1    Grunig, G.2    Fort, M.3    Remington, J.S.4    Rennick, D.5    Hunter, C.A.6
  • 113
    • 36248970671 scopus 로고    scopus 로고
    • IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells
    • Niedbala W., Wei X.Q., Cai B., Hueber A.J., Leung B.P., McInnes I.B., Liew F.Y. IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells. Eur. J. Immunol. 2007, 37:3021-3029.
    • (2007) Eur. J. Immunol. , vol.37 , pp. 3021-3029
    • Niedbala, W.1    Wei, X.Q.2    Cai, B.3    Hueber, A.J.4    Leung, B.P.5    McInnes, I.B.6    Liew, F.Y.7
  • 115
    • 0024458160 scopus 로고
    • Soluble cytokine receptors are present in normal human urine
    • Novick D., Engelmann H., Wallach D., Rubinstein M. Soluble cytokine receptors are present in normal human urine. J. Exp. Med. 1989, 170:1409-1414.
    • (1989) J. Exp. Med. , vol.170 , pp. 1409-1414
    • Novick, D.1    Engelmann, H.2    Wallach, D.3    Rubinstein, M.4
  • 117
    • 79953048089 scopus 로고    scopus 로고
    • Regulation and functions of the IL-10 family of cytokines in inflammation and disease
    • Ouyang W., Rutz S., Crellin N.K., Valdez P.A., Hymowitz S.G. Regulation and functions of the IL-10 family of cytokines in inflammation and disease. Annu. Rev. Immunol. 2011, 29:71-109.
    • (2011) Annu. Rev. Immunol. , vol.29 , pp. 71-109
    • Ouyang, W.1    Rutz, S.2    Crellin, N.K.3    Valdez, P.A.4    Hymowitz, S.G.5
  • 118
    • 33751568890 scopus 로고    scopus 로고
    • IL-27 induces Th1 differentiation via p38 MAPK/T-bet- and intercellular adhesion molecule-1/LFA-1/ERK1/2-dependent pathways
    • Owaki T., Asakawa M., Fukai F., Mizuguchi J., Yoshimoto T. IL-27 induces Th1 differentiation via p38 MAPK/T-bet- and intercellular adhesion molecule-1/LFA-1/ERK1/2-dependent pathways. J. Immunol. 2006, 177:7579-7587.
    • (2006) J. Immunol. , vol.177 , pp. 7579-7587
    • Owaki, T.1    Asakawa, M.2    Fukai, F.3    Mizuguchi, J.4    Yoshimoto, T.5
  • 126
    • 36249017932 scopus 로고    scopus 로고
    • IFN-alpha regulates Toll-like receptor-mediated IL-27 gene expression in human macrophages
    • Pirhonen J., Siren J., Julkunen I., Matikainen S. IFN-alpha regulates Toll-like receptor-mediated IL-27 gene expression in human macrophages. J. Leukoc. Biol. 2007, 82:1185-1192.
    • (2007) J. Leukoc. Biol. , vol.82 , pp. 1185-1192
    • Pirhonen, J.1    Siren, J.2    Julkunen, I.3    Matikainen, S.4
  • 127
    • 77955926923 scopus 로고    scopus 로고
    • Molecular pathways in the induction of interleukin-27-driven regulatory type 1 cells
    • Pot C., Apetoh L., Awasthi A., Kuchroo V.K. Molecular pathways in the induction of interleukin-27-driven regulatory type 1 cells. J. Interferon Cytokine Res. 2010, 30:381-388.
    • (2010) J. Interferon Cytokine Res. , vol.30 , pp. 381-388
    • Pot, C.1    Apetoh, L.2    Awasthi, A.3    Kuchroo, V.K.4
  • 128
    • 69249083836 scopus 로고    scopus 로고
    • Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells
    • Pot C., Jin H., Awasthi A., Liu S.M., Lai C.Y., Madan R., Sharpe A.H., Karp C.L., Miaw S.C., Ho I.C., Kuchroo V.K. Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells. J. Immunol. 2009, 183:797-801.
    • (2009) J. Immunol. , vol.183 , pp. 797-801
    • Pot, C.1    Jin, H.2    Awasthi, A.3    Liu, S.M.4    Lai, C.Y.5    Madan, R.6    Sharpe, A.H.7    Karp, C.L.8    Miaw, S.C.9    Ho, I.C.10    Kuchroo, V.K.11
  • 129
    • 36749024030 scopus 로고    scopus 로고
    • Transformation of hematopoietic cells and activation of JAK2-V617F by IL-27R, a component of a heterodimeric type I cytokine receptor
    • Pradhan A., Lambert Q.T., Reuther G.W. Transformation of hematopoietic cells and activation of JAK2-V617F by IL-27R, a component of a heterodimeric type I cytokine receptor. Proc. Natl. Acad. Sci. USA 2007, 104:18502-18507.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 18502-18507
    • Pradhan, A.1    Lambert, Q.T.2    Reuther, G.W.3
  • 130
    • 0033556164 scopus 로고    scopus 로고
    • The designer cytokine hyper-interleukin-6 is a potent activator of STAT3-dependent gene transcription in vivo and in vitro
    • Rakemann T. The designer cytokine hyper-interleukin-6 is a potent activator of STAT3-dependent gene transcription in vivo and in vitro. J. Biol. Chem. 1999, 274:1257-1266.
    • (1999) J. Biol. Chem. , vol.274 , pp. 1257-1266
    • Rakemann, T.1
  • 131
    • 37549011741 scopus 로고    scopus 로고
    • IFN-beta modulates the response to TLR stimulation in human DC: Involvement of IFN regulatory factor-1 (IRF-1) in IL-27 gene expression
    • Remoli M.E., Gafa V., Giacomini E., Severa M., Lande R., Coccia E.M. IFN-beta modulates the response to TLR stimulation in human DC: Involvement of IFN regulatory factor-1 (IRF-1) in IL-27 gene expression. Eur. J. Immunol. 2007, 37:3499-3508.
    • (2007) Eur. J. Immunol. , vol.37 , pp. 3499-3508
    • Remoli, M.E.1    Gafa, V.2    Giacomini, E.3    Severa, M.4    Lande, R.5    Coccia, E.M.6
  • 132
    • 48749121088 scopus 로고    scopus 로고
    • Interleukin-12 and interleukin-27 regulate macrophage control of Mycobacterium tuberculosis
    • Robinson C.M., Nau G.J. Interleukin-12 and interleukin-27 regulate macrophage control of Mycobacterium tuberculosis. J. Infect. Dis. 2008, 198:359-366.
    • (2008) J. Infect. Dis. , vol.198 , pp. 359-366
    • Robinson, C.M.1    Nau, G.J.2
  • 133
    • 30344488706 scopus 로고    scopus 로고
    • Interleukin-27R (WSX-1/T-cell cytokine receptor) gene-deficient mice display enhanced resistance to leishmania donovani infection but develop severe liver immunopathology
    • Rosas L.E., Satoskar A.A., Roth K.M., Keiser T.L., Barbi J., Hunter C., de Sauvage F.J., Satoskar A.R. Interleukin-27R (WSX-1/T-cell cytokine receptor) gene-deficient mice display enhanced resistance to leishmania donovani infection but develop severe liver immunopathology. Am. J. Pathol. 2006, 168:158-169.
    • (2006) Am. J. Pathol. , vol.168 , pp. 158-169
    • Rosas, L.E.1    Satoskar, A.A.2    Roth, K.M.3    Keiser, T.L.4    Barbi, J.5    Hunter, C.6    de Sauvage, F.J.7    Satoskar, A.R.8
  • 134
    • 78650602324 scopus 로고    scopus 로고
    • IL-27 structural analysis demonstrates similarities with ciliary neurotrophic factor (CNTF) and leads to the identification of antagonistic variants [Immunology]
    • Rousseau F., Basset L., Froger J., Dinguirard N., Chevalier S., Gascan H. IL-27 structural analysis demonstrates similarities with ciliary neurotrophic factor (CNTF) and leads to the identification of antagonistic variants [Immunology]. Proc. Natl. Acad. Sci. USA 2010, 107:19420-19425.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 19420-19425
    • Rousseau, F.1    Basset, L.2    Froger, J.3    Dinguirard, N.4    Chevalier, S.5    Gascan, H.6
  • 135
    • 0026682873 scopus 로고
    • Molecular cloning of a murine IL-6 receptor-associated signal transducer, gp130, and its regulated expression in vivo
    • Saito M., Yoshida K., Hibi M., Taga T., Kishimoto T. Molecular cloning of a murine IL-6 receptor-associated signal transducer, gp130, and its regulated expression in vivo. J. Immunol. 1992, 148:4066-4071.
    • (1992) J. Immunol. , vol.148 , pp. 4066-4071
    • Saito, M.1    Yoshida, K.2    Hibi, M.3    Taga, T.4    Kishimoto, T.5
  • 136
    • 64249118418 scopus 로고    scopus 로고
    • Immunologic and therapeutic synergy of IL-27 and IL-2: Enhancement of T cell sensitization, tumor-specific CTL reactivity and complete regression of disseminated neuroblastoma metastases in the liver and bone marrow
    • Salcedo R., Hixon J.A., Stauffer J.K., Jalah R., Brooks A.D., Khan T., Dai R.M., Scheetz L., Lincoln E., Back T.C., et al. Immunologic and therapeutic synergy of IL-27 and IL-2: Enhancement of T cell sensitization, tumor-specific CTL reactivity and complete regression of disseminated neuroblastoma metastases in the liver and bone marrow. J. Immunol. 2009, 182:4328-4338.
    • (2009) J. Immunol. , vol.182 , pp. 4328-4338
    • Salcedo, R.1    Hixon, J.A.2    Stauffer, J.K.3    Jalah, R.4    Brooks, A.D.5    Khan, T.6    Dai, R.M.7    Scheetz, L.8    Lincoln, E.9    Back, T.C.10
  • 140
    • 78650338317 scopus 로고    scopus 로고
    • IL-27 increases the proliferation and effector functions of human naive CD8+ T lymphocytes and promotes their development into Tc1 cells
    • Schneider R., Yaneva T., Beauseigle D., El-Khoury L., Arbour N. IL-27 increases the proliferation and effector functions of human naive CD8+ T lymphocytes and promotes their development into Tc1 cells. Eur. J. Immunol. 2011, 41:47-59.
    • (2011) Eur. J. Immunol. , vol.41 , pp. 47-59
    • Schneider, R.1    Yaneva, T.2    Beauseigle, D.3    El-Khoury, L.4    Arbour, N.5
  • 141
    • 25444492676 scopus 로고    scopus 로고
    • IL-12 family members: Differential kinetics of their TLR4-mediated induction by Salmonella enteritidis and the impact of IL-10 in bone marrow-derived macrophages
    • Schuetze N., Schoeneberger S., Mueller U., Freudenberg M.A., Alber G., Straubinger R.K. IL-12 family members: Differential kinetics of their TLR4-mediated induction by Salmonella enteritidis and the impact of IL-10 in bone marrow-derived macrophages. Int. Immunol. 2005, 17:649-659.
    • (2005) Int. Immunol. , vol.17 , pp. 649-659
    • Schuetze, N.1    Schoeneberger, S.2    Mueller, U.3    Freudenberg, M.A.4    Alber, G.5    Straubinger, R.K.6
  • 143
    • 63449096318 scopus 로고    scopus 로고
    • Amelioration of experimental allergic rhinitis with suppression of topical immune responses by lack of IL-27/WSX-1 signaling
    • Shimanoe Y., Miyazaki Y., Hara H., Inokuchi A., Yoshida H. Amelioration of experimental allergic rhinitis with suppression of topical immune responses by lack of IL-27/WSX-1 signaling. Ann. Allergy Asthma Immunol. 2009, 102:223-232.
    • (2009) Ann. Allergy Asthma Immunol. , vol.102 , pp. 223-232
    • Shimanoe, Y.1    Miyazaki, Y.2    Hara, H.3    Inokuchi, A.4    Yoshida, H.5
  • 145
    • 80052027515 scopus 로고    scopus 로고
    • Effector T-cell subsets in systemic lupus erythematosus: Update focusing on Th17 cells
    • Shin M.S., Lee N., Kang I. Effector T-cell subsets in systemic lupus erythematosus: Update focusing on Th17 cells. Curr. Opin. Rheumatol. 2011, 23:444-448.
    • (2011) Curr. Opin. Rheumatol. , vol.23 , pp. 444-448
    • Shin, M.S.1    Lee, N.2    Kang, I.3
  • 146
    • 44449146212 scopus 로고    scopus 로고
    • Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: Role of intracellular osteopontin
    • Shinohara M.L., Kim J.H., Garcia V.A., Cantor H. Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: Role of intracellular osteopontin. Immunity 2008, 29:68-78.
    • (2008) Immunity , vol.29 , pp. 68-78
    • Shinohara, M.L.1    Kim, J.H.2    Garcia, V.A.3    Cantor, H.4
  • 147
    • 60549117359 scopus 로고    scopus 로고
    • Tumor-specific cytotoxic T cell generation and dendritic cell function are differentially regulated by interleukin 27 during development of anti-tumor immunity
    • Shinozaki Y., Wang S., Miyazaki Y., Miyazaki K., Yamada H., Yoshikai Y., Hara H., Yoshida H. Tumor-specific cytotoxic T cell generation and dendritic cell function are differentially regulated by interleukin 27 during development of anti-tumor immunity. Int. J. Cancer 2009, 124:1372-1378.
    • (2009) Int. J. Cancer , vol.124 , pp. 1372-1378
    • Shinozaki, Y.1    Wang, S.2    Miyazaki, Y.3    Miyazaki, K.4    Yamada, H.5    Yoshikai, Y.6    Hara, H.7    Yoshida, H.8
  • 149
    • 16244363083 scopus 로고    scopus 로고
    • Production of IL-27 and other IL-12 family cytokines by microglia and their subpopulations
    • Sonobe Y., Yawata I., Kawanokuchi J., Takeuchi H., Mizuno T., Suzumura A. Production of IL-27 and other IL-12 family cytokines by microglia and their subpopulations. Brain Res. 2005, 1040:202-207.
    • (2005) Brain Res. , vol.1040 , pp. 202-207
    • Sonobe, Y.1    Yawata, I.2    Kawanokuchi, J.3    Takeuchi, H.4    Mizuno, T.5    Suzumura, A.6
  • 152
    • 77956428880 scopus 로고    scopus 로고
    • Therapeutic cell engineering with surface-conjugated synthetic nanoparticles
    • Stephan M.T., Moon J.J., Um S.H., Bershteyn A., Irvine D.J. Therapeutic cell engineering with surface-conjugated synthetic nanoparticles. Nat. Med. 2010, 16:1035-1041.
    • (2010) Nat. Med. , vol.16 , pp. 1035-1041
    • Stephan, M.T.1    Moon, J.J.2    Um, S.H.3    Bershteyn, A.4    Irvine, D.J.5
  • 153
    • 33747593830 scopus 로고    scopus 로고
    • Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system
    • Stumhofer J.S., Laurence A., Wilson E.H., Huang E., Tato C.M., Johnson L.M., Villarino A.V., Huang Q., Yoshimura A., Sehy D., et al. Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nat. Immunol. 2006, 7:937-945.
    • (2006) Nat. Immunol. , vol.7 , pp. 937-945
    • Stumhofer, J.S.1    Laurence, A.2    Wilson, E.H.3    Huang, E.4    Tato, C.M.5    Johnson, L.M.6    Villarino, A.V.7    Huang, Q.8    Yoshimura, A.9    Sehy, D.10
  • 157
    • 79952994082 scopus 로고    scopus 로고
    • CD4+ T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs
    • Sun J., Dodd H., Moser E.K., Sharma R., Braciale T.J. CD4+ T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs. Nat. Immunol. 2011, 12:327-334.
    • (2011) Nat. Immunol. , vol.12 , pp. 327-334
    • Sun, J.1    Dodd, H.2    Moser, E.K.3    Sharma, R.4    Braciale, T.J.5
  • 159
    • 0030890718 scopus 로고    scopus 로고
    • Gp130 and the interleukin-6 family of cytokines
    • Taga T., Kishimoto T. Gp130 and the interleukin-6 family of cytokines. Annu. Rev. Immunol. 1997, 15:797-819.
    • (1997) Annu. Rev. Immunol. , vol.15 , pp. 797-819
    • Taga, T.1    Kishimoto, T.2
  • 161
    • 0038326688 scopus 로고    scopus 로고
    • Cutting edge: Role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment
    • Takeda A., Hamano S., Yamanaka A., Hanada T., Ishibashi T., Mak T.W., Yoshimura A., Yoshida H. Cutting edge: Role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment. J. Immunol. 2003, 170:4886-4890.
    • (2003) J. Immunol. , vol.170 , pp. 4886-4890
    • Takeda, A.1    Hamano, S.2    Yamanaka, A.3    Hanada, T.4    Ishibashi, T.5    Mak, T.W.6    Yoshimura, A.7    Yoshida, H.8
  • 163
    • 0037313578 scopus 로고    scopus 로고
    • Interleukin-12 and the regulation of innate resistance and adaptive immunity
    • Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 2003, 3:133-146.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 133-146
    • Trinchieri, G.1
  • 164
    • 68149163187 scopus 로고    scopus 로고
    • IL-27 regulates homeostasis of the intestinal CD4+ effector T cell pool and limits intestinal inflammation in a murine model of colitis
    • Troy A.E., Zaph C., Du Y., Taylor B.C., Guild K.J., Hunter C.A., Saris C.J., Artis D. IL-27 regulates homeostasis of the intestinal CD4+ effector T cell pool and limits intestinal inflammation in a murine model of colitis. J. Immunol. 2009, 183:2037-2044.
    • (2009) J. Immunol. , vol.183 , pp. 2037-2044
    • Troy, A.E.1    Zaph, C.2    Du, Y.3    Taylor, B.C.4    Guild, K.J.5    Hunter, C.A.6    Saris, C.J.7    Artis, D.8
  • 166
    • 0036890125 scopus 로고    scopus 로고
    • Interferon-beta differentially regulates expression of the IL-12 family members p35, p40, p19 and EBI3 in activated human dendritic cells
    • van Seventer J.M., Nagai T., van Seventer G.A. Interferon-beta differentially regulates expression of the IL-12 family members p35, p40, p19 and EBI3 in activated human dendritic cells. J. Neuroimmunol. 2002, 133:60-71.
    • (2002) J. Neuroimmunol. , vol.133 , pp. 60-71
    • van Seventer, J.M.1    Nagai, T.2    van Seventer, G.A.3
  • 167
    • 2342614855 scopus 로고    scopus 로고
    • Streptococcus pyogenes and Lactobacillus rhamnosus differentially induce maturation and production of Th1-type cytokines and chemokines in human monocyte-derived dendritic cells
    • Veckman V., Miettinen M., Pirhonen J., Siren J., Matikainen S., Julkunen I. Streptococcus pyogenes and Lactobacillus rhamnosus differentially induce maturation and production of Th1-type cytokines and chemokines in human monocyte-derived dendritic cells. J. Leukoc. Biol. 2004, 75:764-771.
    • (2004) J. Leukoc. Biol. , vol.75 , pp. 764-771
    • Veckman, V.1    Miettinen, M.2    Pirhonen, J.3    Siren, J.4    Matikainen, S.5    Julkunen, I.6
  • 169
    • 78650671831 scopus 로고    scopus 로고
    • STAT1-activating cytokines limit Th17 responses through both T-bet-dependent and -independent mechanisms
    • Villarino A.V., Gallo E., Abbas A.K. STAT1-activating cytokines limit Th17 responses through both T-bet-dependent and -independent mechanisms. J. Immunol. 2010, 185:6461-6471.
    • (2010) J. Immunol. , vol.185 , pp. 6461-6471
    • Villarino, A.V.1    Gallo, E.2    Abbas, A.K.3
  • 173
    • 42249115211 scopus 로고    scopus 로고
    • Interleukin-27 suppresses experimental autoimmune encephalomyelitis during bone marrow stromal cell treatment
    • Wang J., Wang G., Sun B., Li H., Mu L., Wang Q., Li G., Shi L., Jin L., Kostulas N. Interleukin-27 suppresses experimental autoimmune encephalomyelitis during bone marrow stromal cell treatment. J. Autoimmun. 2008, 30:222-229.
    • (2008) J. Autoimmun. , vol.30 , pp. 222-229
    • Wang, J.1    Wang, G.2    Sun, B.3    Li, H.4    Mu, L.5    Wang, Q.6    Li, G.7    Shi, L.8    Jin, L.9    Kostulas, N.10
  • 174
    • 38449098843 scopus 로고    scopus 로고
    • Augmentation of antigen-presenting and Th1-promoting functions of dendritic cells by WSX-1(IL-27R) deficiency
    • Wang S., Miyazaki Y., Shinozaki Y., Yoshida H. Augmentation of antigen-presenting and Th1-promoting functions of dendritic cells by WSX-1(IL-27R) deficiency. J. Immunol. 2007, 179:6421-6428.
    • (2007) J. Immunol. , vol.179 , pp. 6421-6428
    • Wang, S.1    Miyazaki, Y.2    Shinozaki, Y.3    Yoshida, H.4
  • 175
    • 0032079313 scopus 로고    scopus 로고
    • Gp130, the cytokine common signal-transducer of interleukin-6 cytokine family, is downregulated in T cells in vivo by interleukin-6
    • Wang X.J., Taga T., Yoshida K., Saito M., Kishimoto T., Kikutani H. gp130, the cytokine common signal-transducer of interleukin-6 cytokine family, is downregulated in T cells in vivo by interleukin-6. Blood 1998, 91:3308-3314.
    • (1998) Blood , vol.91 , pp. 3308-3314
    • Wang, X.J.1    Taga, T.2    Yoshida, K.3    Saito, M.4    Kishimoto, T.5    Kikutani, H.6
  • 176
    • 0026568919 scopus 로고
    • Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
    • Watanabe-Fukunaga R., Brannan C.I., Copeland N.G., Jenkins N.A., Nagata S. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 1992, 356:314-317.
    • (1992) Nature , vol.356 , pp. 314-317
    • Watanabe-Fukunaga, R.1    Brannan, C.I.2    Copeland, N.G.3    Jenkins, N.A.4    Nagata, S.5
  • 177
    • 22144487678 scopus 로고    scopus 로고
    • A critical role for IL-10 in limiting inflammation during toxoplasmic encephalitis
    • Wilson E.H., Wille-Reece U., Dzierszinski F., Hunter C.A. A critical role for IL-10 in limiting inflammation during toxoplasmic encephalitis. J. Neuroimmunol. 2005, 165:63-74.
    • (2005) J. Neuroimmunol. , vol.165 , pp. 63-74
    • Wilson, E.H.1    Wille-Reece, U.2    Dzierszinski, F.3    Hunter, C.A.4
  • 179
  • 180
    • 67649233028 scopus 로고    scopus 로고
    • IL-27 is expressed in chronic human eczematous skin lesions and stimulates human keratinocytes
    • Wittmann M., Zeitvogel J., Wang D., Werfel T. IL-27 is expressed in chronic human eczematous skin lesions and stimulates human keratinocytes. J. Allergy Clin. Immunol. 2009, 124:81-89.
    • (2009) J. Allergy Clin. Immunol. , vol.124 , pp. 81-89
    • Wittmann, M.1    Zeitvogel, J.2    Wang, D.3    Werfel, T.4
  • 188
    • 38149045608 scopus 로고    scopus 로고
    • IL-27 suppresses Th2 cell development and Th2 cytokines production from polarized Th2 cells: A novel therapeutic way for Th2-mediated allergic inflammation
    • Yoshimoto T., Yoshimoto T., Yasuda K., Mizuguchi J., Nakanishi K. IL-27 suppresses Th2 cell development and Th2 cytokines production from polarized Th2 cells: A novel therapeutic way for Th2-mediated allergic inflammation. J. Immunol. 2007, 179:4415-4423.
    • (2007) J. Immunol. , vol.179 , pp. 4415-4423
    • Yoshimoto, T.1    Yoshimoto, T.2    Yasuda, K.3    Mizuguchi, J.4    Nakanishi, K.5
  • 189
    • 33749515631 scopus 로고    scopus 로고
    • Two-sided roles of IL-27: Induction of Th1 differentiation on naive CD4+ T cells versus suppression of proinflammatory cytokine production including IL-23-induced IL-17 on activated CD4+ T cells partially through STAT3-dependent mechanism
    • Yoshimura T., Takeda A., Hamano S., Miyazaki Y., Kinjyo I., Ishibashi T., Yoshimura A., Yoshida H. Two-sided roles of IL-27: Induction of Th1 differentiation on naive CD4+ T cells versus suppression of proinflammatory cytokine production including IL-23-induced IL-17 on activated CD4+ T cells partially through STAT3-dependent mechanism. J. Immunol. 2006, 177:5377-5385.
    • (2006) J. Immunol. , vol.177 , pp. 5377-5385
    • Yoshimura, T.1    Takeda, A.2    Hamano, S.3    Miyazaki, Y.4    Kinjyo, I.5    Ishibashi, T.6    Yoshimura, A.7    Yoshida, H.8
  • 191
    • 17444387109 scopus 로고    scopus 로고
    • Impaired Th1 responses in mice deficient in Epstein-Barr virus-induced gene 3 and challenged with physiological doses of Leishmania major
    • Zahn S., Wirtz S., Birkenbach M., Blumberg R.S., Neurath M.F., von Stebut E. Impaired Th1 responses in mice deficient in Epstein-Barr virus-induced gene 3 and challenged with physiological doses of Leishmania major. Eur. J. Immunol. 2005, 35:1106-1112.
    • (2005) Eur. J. Immunol. , vol.35 , pp. 1106-1112
    • Zahn, S.1    Wirtz, S.2    Birkenbach, M.3    Blumberg, R.S.4    Neurath, M.F.5    von Stebut, E.6
  • 192
    • 79956202545 scopus 로고    scopus 로고
    • Transcriptional suppression of IL-27 production by Mycobacterium tuberculosis-activated p38 MAPK via inhibition of AP-1 binding
    • Zhang J., Qian X., Ning H., Eickhoff C.S., Hoft D.F., Liu J. Transcriptional suppression of IL-27 production by Mycobacterium tuberculosis-activated p38 MAPK via inhibition of AP-1 binding. J. Immunol. 2011, 186:5885-5895.
    • (2011) J. Immunol. , vol.186 , pp. 5885-5895
    • Zhang, J.1    Qian, X.2    Ning, H.3    Eickhoff, C.S.4    Hoft, D.F.5    Liu, J.6
  • 193
    • 77954359269 scopus 로고    scopus 로고
    • Activation of IL-27 p28 gene transcription by interferon regulatory factor 8 in cooperation with interferon regulatory factor 1
    • Zhang J., Qian X., Ning H., Yang J., Xiong H., Liu J. Activation of IL-27 p28 gene transcription by interferon regulatory factor 8 in cooperation with interferon regulatory factor 1. J. Biol. Chem. 2010, 285:21269-21281.
    • (2010) J. Biol. Chem. , vol.285 , pp. 21269-21281
    • Zhang, J.1    Qian, X.2    Ning, H.3    Yang, J.4    Xiong, H.5    Liu, J.6
  • 194
    • 0038299265 scopus 로고    scopus 로고
    • Analysis of cytokine regulators inducing interferon production by mouse uterine natural killer cells
    • Zhang J.H., He H., Borzychowski A.M., Takeda K., Akira S., Croy B.A. Analysis of cytokine regulators inducing interferon production by mouse uterine natural killer cells. Biol. Reprod. 2003, 69:404-411.
    • (2003) Biol. Reprod. , vol.69 , pp. 404-411
    • Zhang, J.H.1    He, H.2    Borzychowski, A.M.3    Takeda, K.4    Akira, S.5    Croy, B.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.