메뉴 건너뛰기




Volumn 208, Issue 1, 2011, Pages 115-123

IL-27 promotes T cell-dependent colitis through multiple mechanisms

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 27; OVALBUMIN; TRANSCRIPTION FACTOR FOXP3;

EID: 78651492594     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20100410     Document Type: Article
Times cited : (114)

References (42)
  • 1
    • 55149112367 scopus 로고    scopus 로고
    • The interleukin-23 axis in intestinal inflammation
    • doi:10.1111/j.1600-065X.2008.00705.x
    • Ahern, P.P., A. Izcue, K.J. Maloy, and F. Powrie. 2008. The interleukin-23 axis in intestinal inflammation. Immunol. Rev. 226:147-159. doi:10.1111/j.1600-065X.2008.00705.x
    • (2008) Immunol. Rev. , vol.226 , pp. 147-159
    • Ahern, P.P.1    Izcue, A.2    Maloy, K.J.3    Powrie, F.4
  • 2
    • 33847163271 scopus 로고    scopus 로고
    • - Th1 cells are the source of IL-10 - Mediated immune suppression in chronic cutaneous leishmaniasis
    • doi:10.1084/jem.20061886
    • - Th1 cells are the source of IL-10 - mediated immune suppression in chronic cutaneous leishmaniasis. J. Exp. Med. 204:285-297. doi:10.1084/jem.20061886
    • (2007) J. Exp. Med. , vol.204 , pp. 285-297
    • Anderson, C.F.1    Oukka, M.2    Kuchroo, V.J.3    Sacks, D.4
  • 5
    • 34447345406 scopus 로고    scopus 로고
    • The biology and therapeutic potential of interleukin 27
    • doi:10.1007/s00109-007-0164-7
    • Batten, M., and N. Ghilardi. 2007. The biology and therapeutic potential of interleukin 27. J. Mol. Med. 85:661-672. doi:10.1007/s00109-007-0164-7
    • (2007) J. Mol. Med. , vol.85 , pp. 661-672
    • Batten, M.1    Ghilardi, N.2
  • 6
    • 33747588291 scopus 로고    scopus 로고
    • Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells
    • doi:10.1038/ni1375
    • Batten, M., J. Li, S. Yi, N.M. Kljavin, D.M. Danilenko, S. Lucas, J. Lee, F.J. de Sauvage, and N. Ghilardi. 2006. Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nat. Immunol. 7:929-936. doi:10.1038/ni1375
    • (2006) Nat. Immunol. , vol.7 , pp. 929-936
    • Batten, M.1    Li, J.2    Yi, S.3    Kljavin, N.M.4    Danilenko, D.M.5    Lucas, S.6    Lee, J.7    De Sauvage, F.J.8    Ghilardi, N.9
  • 7
    • 49149119535 scopus 로고    scopus 로고
    • Cutting edge: IL-27 is a potent inducer of IL-10 but not FoxP3 in murine T cells
    • Batten, M., N.M. Kljavin, J. Li, M.J. Walter, F.J. de Sauvage, and N. Ghilardi. 2008. Cutting edge: IL-27 is a potent inducer of IL-10 but not FoxP3 in murine T cells. J. Immunol. 180:2752-2756.
    • (2008) J. Immunol. , vol.180 , pp. 2752-2756
    • Batten, M.1    Kljavin, N.M.2    Li, J.3    Walter, M.J.4    De Sauvage, F.J.5    Ghilardi, N.6
  • 8
    • 40449100736 scopus 로고    scopus 로고
    • IL-27 induces a Th1 immune response and susceptibility to experimental arthritis
    • Cao, Y., P.D. Doodes, T.T. Glant, and A. Finnegan. 2008. IL-27 induces a Th1 immune response and susceptibility to experimental arthritis. J. Immunol. 180:922-930.
    • (2008) J. Immunol. , vol.180 , pp. 922-930
    • Cao, Y.1    Doodes, P.D.2    Glant, T.T.3    Finnegan, A.4
  • 9
    • 0034687402 scopus 로고    scopus 로고
    • Development of Th1-type immune responses requires the type I cytokine receptor TCCR
    • doi:10.1038/35038103
    • Chen, Q., N. Ghilardi, H. Wang, T. Baker, M.H. Xie, A. Gurney, I.S. Grewal, and F.J. de Sauvage. 2000. Development of Th1-type immune responses requires the type I cytokine receptor TCCR. Nature. 407:916-920. doi:10.1038/35038103
    • (2000) Nature , vol.407 , pp. 916-920
    • Chen, Q.1    Ghilardi, N.2    Wang, H.3    Baker, T.4    Xie, M.H.5    Gurney, A.6    Grewal, I.S.7    De Sauvage, F.J.8
  • 12
    • 76249108969 scopus 로고    scopus 로고
    • The IL-27 p28 subunit binds cytokine-like factor 1 to form a cytokine regulating NK and T cell activities requiring IL-6R for signaling
    • doi:10.4049/jimmunol.0901464
    • Crabé, S., A. Guay-Giroux, A.J. Tormo, D. Duluc, R. Lissilaa, F. Guilhot, U. Mavoungou-Bigouagou, F. Lefouili, I. Cognet, W. Ferlin, et al. 2009. The IL-27 p28 subunit binds cytokine-like factor 1 to form a cytokine regulating NK and T cell activities requiring IL-6R for signaling. J. Immunol. 183:7692-7702. doi:10.4049/jimmunol.0901464
    • (2009) J. Immunol. , vol.183 , pp. 7692-7702
    • Crabé, S.1    Guay-Giroux, A.2    Tormo, A.J.3    Duluc, D.4    Lissilaa, R.5    Guilhot, F.6    Mavoungou-Bigouagou, U.7    Lefouili, F.8    Cognet, I.9    Ferlin, W.10
  • 13
    • 36248970702 scopus 로고    scopus 로고
    • Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells
    • doi:10.1038/ni1540
    • Fitzgerald, D.C., G.X. Zhang, M. El-Behi, Z. Fonseca-Kelly, H. Li, S. Yu, C.J. Saris, B. Gran, B. Ciric, and A. Rostami. 2007. Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells. Nat. Immunol. 8:1372-1379. doi:10.1038/ni1540
    • (2007) Nat. Immunol. , vol.8 , pp. 1372-1379
    • Fitzgerald, D.C.1    Zhang, G.X.2    El-Behi, M.3    Fonseca-Kelly, Z.4    Li, H.5    Yu, S.6    Saris, C.J.7    Gran, B.8    Ciric, B.9    Rostami, A.10
  • 14
    • 27944495565 scopus 로고    scopus 로고
    • T helper 1-inducing property of IL-27/WSX-1 signaling is required for the induction of experimental colitis
    • doi:10.1097/01.MIB.0000191611.05466.1f
    • Honda, K., K. Nakamura, N. Matsui, M. Takahashi, Y. Kitamura, T. Mizutani, N. Harada, H. Nawata, S. Hamano, and H. Yoshida. 2005. T helper 1-inducing property of IL-27/WSX-1 signaling is required for the induction of experimental colitis. Inflamm. Bowel Dis. 11:1044-1052. doi:10.1097/01.MIB. 0000191611.05466.1f
    • (2005) Inflamm. Bowel Dis. , vol.11 , pp. 1044-1052
    • Honda, K.1    Nakamura, K.2    Matsui, N.3    Takahashi, M.4    Kitamura, Y.5    Mizutani, T.6    Harada, N.7    Nawata, H.8    Hamano, S.9    Yoshida, H.10
  • 16
    • 70649113728 scopus 로고    scopus 로고
    • Common variants at five new loci associated with early-onset inflammatory bowel disease
    • Western Regional Alliance for Pediatric IBD; International IBD Genetics Consortium; NIDDK IBD Genetics Consortium; Belgian-French IBD Consortium; Wellcome Trust Case Control Consortium. doi:10.1038/ng.489
    • Imielinski, M., R.N. Baldassano, A. Griffiths, R.K. Russell, V. Annese, M. Dubinsky, S. Kugathasan, J.P. Bradfield, T.D. Walters, P. Sleiman, et al; Western Regional Alliance for Pediatric IBD; International IBD Genetics Consortium; NIDDK IBD Genetics Consortium; Belgian-French IBD Consortium; Wellcome Trust Case Control Consortium. 2009. Common variants at five new loci associated with early-onset inflammatory bowel disease. Nat. Genet. 41:1335-1340. doi:10.1038/ng.489
    • (2009) Nat. Genet. , vol.41 , pp. 1335-1340
    • Imielinski, M.1    Baldassano, R.N.2    Griffiths, A.3    Russell, R.K.4    Annese, V.5    Dubinsky, M.6    Kugathasan, S.7    Bradfield, J.P.8    Walters, T.D.9    Sleiman, P.10
  • 17
    • 41549160626 scopus 로고    scopus 로고
    • Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis
    • doi:10.1016/j.immuni.2008.02.019
    • Izcue, A., S. Hue, S. Buonocore, C.V. Arancibia-Cárcamo, P.P. Ahern, Y. Iwakura, K.J. Maloy, and F. Powrie. 2008. Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis. Immunity. 28:559-570. doi:10.1016/j.immuni.2008.02.019
    • (2008) Immunity. , vol.28 , pp. 559-570
    • Izcue, A.1    Hue, S.2    Buonocore, S.3    Arancibia-Cárcamo, C.V.4    Ahern, P.P.5    Iwakura, Y.6    Maloy, K.J.7    Powrie, F.8
  • 19
    • 34247523141 scopus 로고    scopus 로고
    • Discovery and biology of IL-23 and IL-27: Related but functionally distinct regulators of inflammation
    • doi:10.1146/annurev.immunol.22.012703.104758
    • Kastelein, R.A., C.A. Hunter, and D.J. Cua. 2007. Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation. Annu. Rev. Immunol. 25:221-242. doi:10.1146/annurev.immunol.22. 012703.104758
    • (2007) Annu. Rev. Immunol. , vol.25 , pp. 221-242
    • Kastelein, R.A.1    Hunter, C.A.2    Cua, D.J.3
  • 20
  • 21
    • 34447567140 scopus 로고    scopus 로고
    • IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1
    • doi:10.1002/eji.200636896
    • Neufert, C., C. Becker, S. Wirtz, M.C. Fantini, B. Weigmann, P.R. Galle, and M.F. Neurath. 2007. IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1. Eur. J. Immunol. 37:1809-1816. doi:10.1002/eji.200636896
    • (2007) Eur. J. Immunol. , vol.37 , pp. 1809-1816
    • Neufert, C.1    Becker, C.2    Wirtz, S.3    Fantini, M.C.4    Weigmann, B.5    Galle, P.R.6    Neurath, M.F.7
  • 24
    • 0034891647 scopus 로고    scopus 로고
    • The expression of IL-12 p40 and its homologue, Epstein-Barr virus-induced gene 3, in inflammatory bowel disease
    • doi:10.1097/00054725-200108000-00006
    • Omata, F., M. Birkenbach, S. Matsuzaki, A.D. Christ, and R.S. Blumberg. 2001. The expression of IL-12 p40 and its homologue, Epstein-Barr virus-induced gene 3, in inflammatory bowel disease. Inflamm. Bowel Dis. 7:215-220. doi:10.1097/00054725-200108000-00006
    • (2001) Inflamm. Bowel Dis. , vol.7 , pp. 215-220
    • Omata, F.1    Birkenbach, M.2    Matsuzaki, S.3    Christ, A.D.4    Blumberg, R.S.5
  • 25
    • 18444385868 scopus 로고    scopus 로고
    • IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells
    • doi:10.1016/S1074-7613(02)00324-2
    • Pflanz, S., J.C. Timans, J. Cheung, R. Rosales, H. Kanzler, J. Gilbert, L. Hibbert, T. Churakova, M. Travis, E. Vaisberg, et al. 2002. IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells. Immunity. 16:779-790. doi:10.1016/S1074-7613(02)00324-2
    • (2002) Immunity , vol.16 , pp. 779-790
    • Pflanz, S.1    Timans, J.C.2    Cheung, J.3    Rosales, R.4    Kanzler, H.5    Gilbert, J.6    Hibbert, L.7    Churakova, T.8    Travis, M.9    Vaisberg, E.10
  • 27
    • 0027517545 scopus 로고
    • Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice
    • doi:10.1093/intimm/5.11.1461
    • Powrie, F., M.W. Leach, S. Mauze, L.B. Caddle, and R.L. Coffman. 1993. Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice. Int. Immunol. 5:1461-1471. doi:10.1093/intimm/5.11.1461
    • (1993) Int. Immunol. , vol.5 , pp. 1461-1471
    • Powrie, F.1    Leach, M.W.2    Mauze, S.3    Caddle, L.B.4    Coffman, R.L.5
  • 28
    • 0028519015 scopus 로고
    • Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells
    • doi:10.1016/1074-7613(94)90045-0
    • Powrie, F., M.W. Leach, S. Mauze, S. Menon, L.B. Caddle, and R.L. Coffman. 1994. Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells. Immunity. 1:553-562. doi:10.1016/1074-7613(94)90045-0
    • (1994) Immunity. , vol.1 , pp. 553-562
    • Powrie, F.1    Leach, M.W.2    Mauze, S.3    Menon, S.4    Caddle, L.B.5    Coffman, R.L.6
  • 29
    • 13944281011 scopus 로고    scopus 로고
    • Expression of interleukin-12-related cytokine transcripts in inflammatory bowel disease: Elevated interleukin-23p19 and interleukin-27p28 in Crohn's disease but not in ulcerative colitis
    • doi:10.1097/00054725-200501000-00003
    • Schmidt, C., T. Giese, B. Ludwig, I. Mueller-Molaian, T. Marth, S. Zeuzem, S.C. Meuer, and A. Stallmach. 2005. Expression of interleukin-12-related cytokine transcripts in inflammatory bowel disease: elevated interleukin-23p19 and interleukin-27p28 in Crohn's disease but not in ulcerative colitis. Inflamm. Bowel Dis. 11:16-23. doi:10.1097/00054725-200501000-00003
    • (2005) Inflamm. Bowel Dis. , vol.11 , pp. 16-23
    • Schmidt, C.1    Giese, T.2    Ludwig, B.3    Mueller-Molaian, I.4    Marth, T.5    Zeuzem, S.6    Meuer, S.C.7    Stallmach, A.8
  • 31
    • 33747593830 scopus 로고    scopus 로고
    • Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system
    • doi:10.1038/ni1376
    • Stumhofer, J.S., A. Laurence, E.H. Wilson, E. Huang, C.M. Tato, L.M. Johnson, A.V. Villarino, Q. Huang, A. Yoshimura, D. Sehy, et al. 2006. Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nat. Immunol. 7:937-945. doi:10.1038/ni1376
    • (2006) Nat. Immunol. , vol.7 , pp. 937-945
    • Stumhofer, J.S.1    Laurence, A.2    Wilson, E.H.3    Huang, E.4    Tato, C.M.5    Johnson, L.M.6    Villarino, A.V.7    Huang, Q.8    Yoshimura, A.9    Sehy, D.10
  • 33
    • 34547757390 scopus 로고    scopus 로고
    • Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
    • doi:10.1084/jem.20070602
    • Sun, C.M., J.A. Hall, R.B. Blank, N. Bouladoux, M. Oukka, J.R. Mora, and Y. Belkaid. 2007. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J. Exp. Med. 204:1775-1785. doi:10.1084/jem.20070602
    • (2007) J. Exp. Med. , vol.204 , pp. 1775-1785
    • Sun, C.M.1    Hall, J.A.2    Blank, R.B.3    Bouladoux, N.4    Oukka, M.5    Mora, J.R.6    Belkaid, Y.7
  • 34
    • 33847165817 scopus 로고    scopus 로고
    • Interleukin-10 production by effector T cells: Th1 cells show self control
    • doi:10.1084/jem.20070104
    • Trinchieri, G. 2007. Interleukin-10 production by effector T cells: Th1 cells show self control. J. Exp. Med. 204:239-243. doi:10.1084/jem.20070104
    • (2007) J. Exp. Med. , vol.204 , pp. 239-243
    • Trinchieri, G.1
  • 35
    • 68149163187 scopus 로고    scopus 로고
    • IL-27 regulates homeostasis of the intestinal CD4+ effector T cell pool and limits intestinal inflammation in a murine model of colitis
    • doi:10.4049/jimmunol.0802918
    • Troy, A.E., C. Zaph, Y. Du, B.C. Taylor, K.J. Guild, C.A. Hunter, C.J. Saris, and D. Artis. 2009. IL-27 regulates homeostasis of the intestinal CD4+ effector T cell pool and limits intestinal inflammation in a murine model of colitis. J. Immunol. 183:2037-2044. doi:10.4049/jimmunol.0802918
    • (2009) J. Immunol. , vol.183 , pp. 2037-2044
    • Troy, A.E.1    Zaph, C.2    Du, Y.3    Taylor, B.C.4    Guild, K.J.5    Hunter, C.A.6    Saris, C.J.7    Artis, D.8
  • 38
    • 44849096815 scopus 로고    scopus 로고
    • IL-27R deficiency delays the onset of colitis and protects from helminth-induced pathology in a model of chronic IBD
    • doi:10.1093/intimm/dxn032
    • Villarino, A.V., D. Artis, J.S. Bezbradica, O. Miller, C.J. Saris, S. Joyce, and C.A. Hunter. 2008. IL-27R deficiency delays the onset of colitis and protects from helminth-induced pathology in a model of chronic IBD. Int. Immunol. 20:739-752. doi:10.1093/intimm/dxn032
    • (2008) Int. Immunol. , vol.20 , pp. 739-752
    • Villarino, A.V.1    Artis, D.2    Bezbradica, J.S.3    Miller, O.4    Saris, C.J.5    Joyce, S.6    Hunter, C.A.7
  • 39
    • 33748294322 scopus 로고    scopus 로고
    • Role of IFN-gamma in induction of Foxp3 and conversion of CD4+ CD25- T cells to CD4+ Tregs
    • Wang, Z., J. Hong, W. Sun, G. Xu, N. Li, X. Chen, A. Liu, L. Xu, B. Sun, and J.Z. Zhang. 2006. Role of IFN-gamma in induction of Foxp3 and conversion of CD4+ CD25- T cells to CD4+ Tregs. J. Clin. Invest. 116:2434-2441.
    • (2006) J. Clin. Invest. , vol.116 , pp. 2434-2441
    • Wang, Z.1    Hong, J.2    Sun, W.3    Xu, G.4    Li, N.5    Chen, X.6    Liu, A.7    Xu, L.8    Sun, B.9    Zhang, J.Z.10
  • 40
    • 47049114262 scopus 로고    scopus 로고
    • Epstein-Barr virus-induced gene 3 negatively regulates IL-17, IL-22 and RORgamma t
    • doi:10.1002/eji.200838145
    • Yang, J., M. Yang, T.M. Htut, X. Ouyang, A. Hanidu, X. Li, R. Sellati, H. Jiang, S. Zhang, H. Li, et al. 2008. Epstein-Barr virus-induced gene 3 negatively regulates IL-17, IL-22 and RORgamma t. Eur. J. Immunol. 38:1204-1214. doi:10.1002/eji.200838145
    • (2008) Eur. J. Immunol. , vol.38 , pp. 1204-1214
    • Yang, J.1    Yang, M.2    Htut, T.M.3    Ouyang, X.4    Hanidu, A.5    Li, X.6    Sellati, R.7    Jiang, H.8    Zhang, S.9    Li, H.10
  • 41
    • 57449090428 scopus 로고    scopus 로고
    • Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease
    • doi:10.1016/j.immuni.2008.11.003
    • Zenewicz, L.A., G.D. Yancopoulos, D.M. Valenzuela, A.J. Murphy, S. Stevens, and R.A. Flavell. 2008. Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease. Immunity. 29:947-957. doi:10.1016/j. immuni.2008.11.003
    • (2008) Immunity. , vol.29 , pp. 947-957
    • Zenewicz, L.A.1    Yancopoulos, G.D.2    Valenzuela, D.M.3    Murphy, A.J.4    Stevens, S.5    Flavell, R.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.