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Volumn 8, Issue 3, 2013, Pages

Interleukin-27 Signaling Promotes Immunity against Endogenously Arising Murine Tumors

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 27;

EID: 84874846166     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0057469     Document Type: Article
Times cited : (19)

References (50)
  • 4
  • 5
    • 34447345406 scopus 로고    scopus 로고
    • The biology and therapeutic potential of interleukin 27
    • Batten M, Ghilardi N, (2007) The biology and therapeutic potential of interleukin 27. J Mol Med 85: 661-672.
    • (2007) J Mol Med , vol.85 , pp. 661-672
    • Batten, M.1    Ghilardi, N.2
  • 6
    • 10744222574 scopus 로고    scopus 로고
    • WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27
    • Pflanz S, Hibbert L, Mattson J, Rosales R, Vaisberg E, et al. (2004) WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27. J Immunol 172: 2225-2231.
    • (2004) J Immunol , vol.172 , pp. 2225-2231
    • Pflanz, S.1    Hibbert, L.2    Mattson, J.3    Rosales, R.4    Vaisberg, E.5
  • 7
    • 18444385868 scopus 로고    scopus 로고
    • IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells
    • Pflanz S, Timans JC, Cheung J, Rosales R, Kanzler H, et al. (2002) IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells. Immunity 16: 779-790.
    • (2002) Immunity , vol.16 , pp. 779-790
    • Pflanz, S.1    Timans, J.C.2    Cheung, J.3    Rosales, R.4    Kanzler, H.5
  • 8
    • 0038326688 scopus 로고    scopus 로고
    • Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment
    • Takeda A, Hamano S, Yamanaka A, Hanada T, Ishibashi T, et al. (2003) Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment. J Immunol 170: 4886-4890.
    • (2003) J Immunol , vol.170 , pp. 4886-4890
    • Takeda, A.1    Hamano, S.2    Yamanaka, A.3    Hanada, T.4    Ishibashi, T.5
  • 9
    • 34247523141 scopus 로고    scopus 로고
    • Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation
    • Kastelein RA, Hunter CA, Cua DJ, (2007) Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation. Annu Rev Immunol 25: 221-242.
    • (2007) Annu Rev Immunol , vol.25 , pp. 221-242
    • Kastelein, R.A.1    Hunter, C.A.2    Cua, D.J.3
  • 10
    • 84856554638 scopus 로고    scopus 로고
    • New directions in the basic and translational biology of interleukin-27
    • Wojno ED, Hunter CA, (2012) New directions in the basic and translational biology of interleukin-27. Trends Immunol 33: 91-97.
    • (2012) Trends Immunol , vol.33 , pp. 91-97
    • Wojno, E.D.1    Hunter, C.A.2
  • 11
    • 78651492594 scopus 로고    scopus 로고
    • IL-27 promotes T cell-dependent colitis through multiple mechanisms
    • Cox JH, Kljavin NM, Ramamoorthi N, Diehl L, Batten M, et al. (2011) IL-27 promotes T cell-dependent colitis through multiple mechanisms. J Exp Med 208: 115-123.
    • (2011) J Exp Med , vol.208 , pp. 115-123
    • Cox, J.H.1    Kljavin, N.M.2    Ramamoorthi, N.3    Diehl, L.4    Batten, M.5
  • 12
    • 34447567140 scopus 로고    scopus 로고
    • IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1
    • Neufert C, Becker C, Wirtz S, Fantini MC, Weigmann B, et al. (2007) IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1. European Journal of Immunology 37: 1809-1816.
    • (2007) European Journal of Immunology , vol.37 , pp. 1809-1816
    • Neufert, C.1    Becker, C.2    Wirtz, S.3    Fantini, M.C.4    Weigmann, B.5
  • 14
    • 64249118418 scopus 로고    scopus 로고
    • Immunologic and therapeutic synergy of IL-27 and IL-2: enhancement of T cell sensitization, tumor-specific CTL reactivity and complete regression of disseminated neuroblastoma metastases in the liver and bone marrow
    • Salcedo R, Hixon JA, Stauffer JK, Jalah R, Brooks AD, et al. (2009) Immunologic and therapeutic synergy of IL-27 and IL-2: enhancement of T cell sensitization, tumor-specific CTL reactivity and complete regression of disseminated neuroblastoma metastases in the liver and bone marrow. J Immunol 182: 4328-4338.
    • (2009) J Immunol , vol.182 , pp. 4328-4338
    • Salcedo, R.1    Hixon, J.A.2    Stauffer, J.K.3    Jalah, R.4    Brooks, A.D.5
  • 15
    • 18644381517 scopus 로고    scopus 로고
    • Expression of IL-27 in murine carcinoma cells produces antitumor effects and induces protective immunity in inoculated host animals
    • Chiyo M, Shimozato O, Yu L, Kawamura K, Iizasa T, et al. (2005) Expression of IL-27 in murine carcinoma cells produces antitumor effects and induces protective immunity in inoculated host animals. Int J Cancer 115: 437-442.
    • (2005) Int J Cancer , vol.115 , pp. 437-442
    • Chiyo, M.1    Shimozato, O.2    Yu, L.3    Kawamura, K.4    Iizasa, T.5
  • 17
    • 33745685864 scopus 로고    scopus 로고
    • Interleukin-23 and interleukin-27 exert quite different antitumor and vaccine effects on poorly immunogenic melanoma
    • Oniki S, Nagai H, Horikawa T, Furukawa J, Belladonna ML, et al. (2006) Interleukin-23 and interleukin-27 exert quite different antitumor and vaccine effects on poorly immunogenic melanoma. Cancer Res 66: 6395-6404.
    • (2006) Cancer Res , vol.66 , pp. 6395-6404
    • Oniki, S.1    Nagai, H.2    Horikawa, T.3    Furukawa, J.4    Belladonna, M.L.5
  • 19
    • 77952483010 scopus 로고    scopus 로고
    • IL-27 Directly Restrains Lung Tumorigenicity by Suppressing Cyclooxygenase-2-Mediated Activities
    • Ho MY, Leu SJJ, Sun GH, Tao MH, Tang SJ, et al. (2009) IL-27 Directly Restrains Lung Tumorigenicity by Suppressing Cyclooxygenase-2-Mediated Activities. Journal of Immunology 183: 6217-6226.
    • (2009) Journal of Immunology , vol.183 , pp. 6217-6226
    • Ho, M.Y.1    Leu, S.J.J.2    Sun, G.H.3    Tao, M.H.4    Tang, S.J.5
  • 20
    • 0034687402 scopus 로고    scopus 로고
    • Development of Th1-type immune responses requires the type I cytokine receptor TCCR
    • Chen Q, Ghilardi N, Wang H, Baker T, Xie MH, et al. (2000) Development of Th1-type immune responses requires the type I cytokine receptor TCCR. Nature 407: 916-920.
    • (2000) Nature , vol.407 , pp. 916-920
    • Chen, Q.1    Ghilardi, N.2    Wang, H.3    Baker, T.4    Xie, M.H.5
  • 21
    • 44449084242 scopus 로고    scopus 로고
    • Id1 cooperates with oncogenic Ras to induce metastatic mammary carcinoma by subversion of the cellular senescence response
    • Swarbrick A, Roy E, Allen T, Bishop JM, (2008) Id1 cooperates with oncogenic Ras to induce metastatic mammary carcinoma by subversion of the cellular senescence response. Proc Natl Acad Sci U S A 105: 5402-5407.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 5402-5407
    • Swarbrick, A.1    Roy, E.2    Allen, T.3    Bishop, J.M.4
  • 23
    • 33747588291 scopus 로고    scopus 로고
    • Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells
    • Batten M, Li J, Yi S, Kljavin NM, Danilenko DM, et al. (2006) Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nat Immunol 7: 929-936.
    • (2006) Nat Immunol , vol.7 , pp. 929-936
    • Batten, M.1    Li, J.2    Yi, S.3    Kljavin, N.M.4    Danilenko, D.M.5
  • 24
    • 68149179581 scopus 로고    scopus 로고
    • A critical analysis of the tumour immunosurveillance controversy for 3-MCA-induced sarcomas
    • Schreiber TH, Podack ER, (2009) A critical analysis of the tumour immunosurveillance controversy for 3-MCA-induced sarcomas. Br J Cancer 101: 381-386.
    • (2009) Br J Cancer , vol.101 , pp. 381-386
    • Schreiber, T.H.1    Podack, E.R.2
  • 25
    • 0142244181 scopus 로고    scopus 로고
    • Progression to malignancy in the polyoma middle T oncoprotein mouse breast cancer model provides a reliable model for human diseases
    • Lin EY, Jones JG, Li P, Zhu UY, Whitney KD, et al. (2003) Progression to malignancy in the polyoma middle T oncoprotein mouse breast cancer model provides a reliable model for human diseases. American Journal of Pathology 163: 2113-2126.
    • (2003) American Journal of Pathology , vol.163 , pp. 2113-2126
    • Lin, E.Y.1    Jones, J.G.2    Li, P.3    Zhu, U.Y.4    Whitney, K.D.5
  • 26
    • 1842477302 scopus 로고    scopus 로고
    • Cutting edge: early IL-4 production governs the requirement for IL-27-WSX-1 signaling in the development of protective Th1 cytokine responses following Leishmania major infection
    • Artis D, Johnson LM, Joyce K, Saris C, Villarino A, et al. (2004) Cutting edge: early IL-4 production governs the requirement for IL-27-WSX-1 signaling in the development of protective Th1 cytokine responses following Leishmania major infection. J Immunol 172: 4672-4675.
    • (2004) J Immunol , vol.172 , pp. 4672-4675
    • Artis, D.1    Johnson, L.M.2    Joyce, K.3    Saris, C.4    Villarino, A.5
  • 27
    • 27944495565 scopus 로고    scopus 로고
    • T helper 1-inducing property of IL-27/WSX-1 signaling is required for the induction of experimental colitis
    • Honda K, Nakamura K, Matsui N, Takahashi M, Kitamura Y, et al. (2005) T helper 1-inducing property of IL-27/WSX-1 signaling is required for the induction of experimental colitis. Inflamm Bowel Dis 11: 1044-1052.
    • (2005) Inflamm Bowel Dis , vol.11 , pp. 1044-1052
    • Honda, K.1    Nakamura, K.2    Matsui, N.3    Takahashi, M.4    Kitamura, Y.5
  • 28
    • 17444387109 scopus 로고    scopus 로고
    • Impaired Th1 responses in mice deficient in Epstein-Barr virus-induced gene 3 and challenged with physiological doses of Leishmania major
    • Zahn S, Wirtz S, Birkenbach M, Blumberg RS, Neurath MF, et al. (2005) Impaired Th1 responses in mice deficient in Epstein-Barr virus-induced gene 3 and challenged with physiological doses of Leishmania major. Eur J Immunol 35: 1106-1112.
    • (2005) Eur J Immunol , vol.35 , pp. 1106-1112
    • Zahn, S.1    Wirtz, S.2    Birkenbach, M.3    Blumberg, R.S.4    Neurath, M.F.5
  • 29
    • 17944377950 scopus 로고    scopus 로고
    • WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection
    • Yoshida H, Hamano S, Senaldi G, Covey T, Faggioni R, et al. (2001) WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection. Immunity 15: 569-578.
    • (2001) Immunity , vol.15 , pp. 569-578
    • Yoshida, H.1    Hamano, S.2    Senaldi, G.3    Covey, T.4    Faggioni, R.5
  • 30
    • 78049243425 scopus 로고    scopus 로고
    • Conditional Regulatory T-Cell Depletion Releases Adaptive Immunity Preventing Carcinogenesis and Suppressing Established Tumor Growth
    • Teng MWL, Ngiow SF, von Scheidt B, McLaughlin N, Sparwasser T, et al. (2010) Conditional Regulatory T-Cell Depletion Releases Adaptive Immunity Preventing Carcinogenesis and Suppressing Established Tumor Growth. Cancer Research 70: 7800-7809.
    • (2010) Cancer Research , vol.70 , pp. 7800-7809
    • Teng, M.W.L.1    Ngiow, S.F.2    von Scheidt, B.3    McLaughlin, N.4    Sparwasser, T.5
  • 31
    • 77950794689 scopus 로고    scopus 로고
    • Multiple Antitumor Mechanisms Downstream of Prophylactic Regulatory T-Cell Depletion
    • Teng MWL, Swann JB, von Scheidt B, Sharkey J, Zerafa N, et al. (2010) Multiple Antitumor Mechanisms Downstream of Prophylactic Regulatory T-Cell Depletion. Cancer Research 70: 2665-2674.
    • (2010) Cancer Research , vol.70 , pp. 2665-2674
    • Teng, M.W.L.1    Swann, J.B.2    von Scheidt, B.3    Sharkey, J.4    Zerafa, N.5
  • 35
    • 0033586324 scopus 로고    scopus 로고
    • Adenoviral vectors expressing lymphotactin and interleukin 2 or lymphotactin and interleukin 12 synergize to facilitate tumor regression in murine breast cancer models
    • Emtage PCR, Wan Y, Hitt M, Graham FL, Muller WJ, et al. (1999) Adenoviral vectors expressing lymphotactin and interleukin 2 or lymphotactin and interleukin 12 synergize to facilitate tumor regression in murine breast cancer models. Human Gene Therapy 10: 697-709.
    • (1999) Human Gene Therapy , vol.10 , pp. 697-709
    • Emtage, P.C.R.1    Wan, Y.2    Hitt, M.3    Graham, F.L.4    Muller, W.J.5
  • 36
    • 0032549487 scopus 로고    scopus 로고
    • Combination therapy with interleukin-2 and wild-type p53 expressed by adenoviral vectors potentiates tumor regression in a murine model of breast cancer
    • Putzer BM, Bramson JL, Addison CL, Hitt M, Siegel PM, et al. (1998) Combination therapy with interleukin-2 and wild-type p53 expressed by adenoviral vectors potentiates tumor regression in a murine model of breast cancer. Human Gene Therapy 9: 707-718.
    • (1998) Human Gene Therapy , vol.9 , pp. 707-718
    • Putzer, B.M.1    Bramson, J.L.2    Addison, C.L.3    Hitt, M.4    Siegel, P.M.5
  • 37
    • 60549117359 scopus 로고    scopus 로고
    • Tumor-specific cytotoxic T cell generation and dendritic cell function are differentially regulated by interleukin 27 during development of anti-tumor immunity
    • Shinozaki Y, Wang S, Miyazaki Y, Miyazaki K, Yamada H, et al. (2009) Tumor-specific cytotoxic T cell generation and dendritic cell function are differentially regulated by interleukin 27 during development of anti-tumor immunity. Int J Cancer 124: 1372-1378.
    • (2009) Int J Cancer , vol.124 , pp. 1372-1378
    • Shinozaki, Y.1    Wang, S.2    Miyazaki, Y.3    Miyazaki, K.4    Yamada, H.5
  • 38
    • 10344228778 scopus 로고    scopus 로고
    • IL-27 mediates complete regression of orthotopic primary and metastatic murine neuroblastoma tumors: role for CD8+ T cells
    • Salcedo R, Stauffer JK, Lincoln E, Back TC, Hixon JA, et al. (2004) IL-27 mediates complete regression of orthotopic primary and metastatic murine neuroblastoma tumors: role for CD8+ T cells. J Immunol 173: 7170-7182.
    • (2004) J Immunol , vol.173 , pp. 7170-7182
    • Salcedo, R.1    Stauffer, J.K.2    Lincoln, E.3    Back, T.C.4    Hixon, J.A.5
  • 40
    • 80053469514 scopus 로고    scopus 로고
    • The two faces of interferon-gamma in cancer
    • Zaidi MR, Merlino G, (2011) The two faces of interferon-gamma in cancer. Clin Cancer Res 17: 6118-6124.
    • (2011) Clin Cancer Res , vol.17 , pp. 6118-6124
    • Zaidi, M.R.1    Merlino, G.2
  • 41
    • 0141519112 scopus 로고    scopus 로고
    • IL-27 and IFN-alpha signal via Stat1 and Stat3 and induce T-Bet and IL-12Rbeta2 in naive T cells
    • Hibbert L, Pflanz S, De Waal Malefyt R, Kastelein RA, (2003) IL-27 and IFN-alpha signal via Stat1 and Stat3 and induce T-Bet and IL-12Rbeta2 in naive T cells. J Interferon Cytokine Res 23: 513-522.
    • (2003) J Interferon Cytokine Res , vol.23 , pp. 513-522
    • Hibbert, L.1    Pflanz, S.2    de Waal Malefyt, R.3    Kastelein, R.A.4
  • 42
    • 0344304399 scopus 로고    scopus 로고
    • IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms
    • Lucas S, Ghilardi N, Li J, de Sauvage FJ, (2003) IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and-independent mechanisms. Proc Natl Acad Sci U S A 100: 15047-15052.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 15047-15052
    • Lucas, S.1    Ghilardi, N.2    Li, J.3    de Sauvage, F.J.4
  • 43
    • 40449137091 scopus 로고    scopus 로고
    • Cutting edge: T-bet and IL-27R are critical for in vivo IFN-gamma production by CD8 T cells during infection
    • Mayer KD, Mohrs K, Reiley W, Wittmer S, Kohlmeier JE, et al. (2008) Cutting edge: T-bet and IL-27R are critical for in vivo IFN-gamma production by CD8 T cells during infection. J Immunol 180: 693-697.
    • (2008) J Immunol , vol.180 , pp. 693-697
    • Mayer, K.D.1    Mohrs, K.2    Reiley, W.3    Wittmer, S.4    Kohlmeier, J.E.5
  • 45
    • 36248970701 scopus 로고    scopus 로고
    • A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells
    • Awasthi A, Carrier Y, Peron JP, Bettelli E, Kamanaka M, et al. (2007) A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells. Nat Immunol 8: 1380-1389.
    • (2007) Nat Immunol , vol.8 , pp. 1380-1389
    • Awasthi, A.1    Carrier, Y.2    Peron, J.P.3    Bettelli, E.4    Kamanaka, M.5
  • 46
    • 36248970702 scopus 로고    scopus 로고
    • Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells
    • Fitzgerald DC, Zhang GX, El-Behi M, Fonseca-Kelly Z, Li H, et al. (2007) Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells. Nat Immunol 8: 1372-1379.
    • (2007) Nat Immunol , vol.8 , pp. 1372-1379
    • Fitzgerald, D.C.1    Zhang, G.X.2    El-Behi, M.3    Fonseca-Kelly, Z.4    Li, H.5
  • 47
    • 36248951161 scopus 로고    scopus 로고
    • Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10
    • Stumhofer JS, Silver JS, Laurence A, Porrett PM, Harris TH, et al. (2007) Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10. Nat Immunol 8: 1363-1371.
    • (2007) Nat Immunol , vol.8 , pp. 1363-1371
    • Stumhofer, J.S.1    Silver, J.S.2    Laurence, A.3    Porrett, P.M.4    Harris, T.H.5
  • 48
    • 49149119535 scopus 로고    scopus 로고
    • Cutting edge: IL-27 is a potent inducer of IL-10 but not FoxP3 in murine T cells
    • Batten M, Kljavin NM, Li J, Walter MJ, de Sauvage FJ, et al. (2008) Cutting edge: IL-27 is a potent inducer of IL-10 but not FoxP3 in murine T cells. J Immunol 180: 2752-2756.
    • (2008) J Immunol , vol.180 , pp. 2752-2756
    • Batten, M.1    Kljavin, N.M.2    Li, J.3    Walter, M.J.4    de Sauvage, F.J.5
  • 49
    • 33747593830 scopus 로고    scopus 로고
    • Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system
    • Stumhofer JS, Laurence A, Wilson EH, Huang E, Tato CM, et al. (2006) Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nat Immunol 7: 937-945.
    • (2006) Nat Immunol , vol.7 , pp. 937-945
    • Stumhofer, J.S.1    Laurence, A.2    Wilson, E.H.3    Huang, E.4    Tato, C.M.5
  • 50
    • 84870402902 scopus 로고    scopus 로고
    • Associations between polymorphisms in IL-12A, IL-12B, IL-12Rbeta1, IL-27 gene and serum levels of IL-12p40, IL-27p28 with esophageal cancer
    • Tao YP, Wang WL, Li SY, Zhang J, Shi QZ, et al. (2012) Associations between polymorphisms in IL-12A, IL-12B, IL-12Rbeta1, IL-27 gene and serum levels of IL-12p40, IL-27p28 with esophageal cancer. J Cancer Res Clin Oncol.
    • (2012) J Cancer Res Clin Oncol
    • Tao, Y.P.1    Wang, W.L.2    Li, S.Y.3    Zhang, J.4    Shi, Q.Z.5


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