An lnterleukin-6 receptor-dependent molecular switch mediates signal transduction of the IL-27 cytokine subunit p28 (IL-30) via a gp130 protein receptor homodimer

Journal of Biological Chemistry

Volumn 288, Issue 6, 2013, Pages 4346-4354

  Garbers, Christoph ^a   Spudy, Björn ^b   Aparicio Siegmund, Samadhi ^a   Waetzig, Georg H ^c,e   Sommer, Jan ^a   Hölscher, Christoph ^d,e   Rose John, Stefan ^b,e   Grötzinger, Joachim ^b,e   Lorenzen, Inken ^b   Scheller, Jürgen ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b UNIVERSITY OF KIEL   (Germany)

^c CONARIS Research Institute AG ^*  (Germany)

^d RESEARCH CENTER BORSTEL   (Germany)

^e Cluster of Excellence Inflammation at Interfaces   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHARACTERISTIC PROPERTIES; CYTOKINES; HETERO DIMERS; HOMODIMERS; MEMBRANE-BOUND; MOLECULAR SWITCHES; PROTEIN RECEPTORS; RECEPTOR ANTAGONISTS; REFOLDING;

BIOMOLECULES; SIGNAL TRANSDUCTION; SIGNALING;

IMMUNOLOGY;

BETA ADRENERGIC RECEPTOR; GLYCOPROTEIN GP 130; INTERLEUKIN 27; INTERLEUKIN 6 RECEPTOR; PROTEIN P28; STAT1 PROTEIN; STAT3 PROTEIN; TOCILIZUMAB; CYTOKINE RECEPTOR; IL27 PROTEIN, HUMAN; IL27 PROTEIN, MOUSE; IL27RA PROTEIN, HUMAN; IL27RA PROTEIN, MOUSE; IL6ST PROTEIN, HUMAN; IL6ST PROTEIN, MOUSE; INTERLEUKIN DERIVATIVE; INTERLEUKIN RECEPTOR;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; ESCHERICHIA COLI; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PURIFICATION; PROTEIN REFOLDING; SIGNAL TRANSDUCTION; ANIMAL; CELL STRAIN 3T3; CELL STRAIN COS1; CERCOPITHECUS; GENETICS; METABOLISM; PHYSIOLOGY; PROTEIN MULTIMERIZATION;

ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; CYTOKINE RECEPTOR GP130; HUMANS; INTERLEUKINS; MICE; NIH 3T3 CELLS; PROTEIN MULTIMERIZATION; RECEPTORS, CYTOKINE; RECEPTORS, INTERLEUKIN; SIGNAL TRANSDUCTION;

MLCS; MLOWN;

EID: 84873624088     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.432955     Document Type: Article

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