Novel IL27p28/IL12p40 cytokine suppressed experimental autoimmune uveitis by inhibiting autoreactive Th1/Th17 cells and promoting expansion of regulatory T cells

Journal of Biological Chemistry

Volumn 287, Issue 43, 2012, Pages 36012-36021

  Wang, Ren Xi ^a   Yu, Cheng Rong ^a   Mahdi, Rashid M ^a   Egwuagu, Charles E ^a  

^a NATIONAL EYE INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOIMMUNE DISEASE; CYTOKINES; INFLAMMATORY DISEASE; INFLAMMATORY RESPONSE; LYMPH NODE; LYMPHOCYTE PROLIFERATION; MOUSE MODELS; PROOF OF CONCEPT; SINGLE CHAINS; T CELLS; TISSUE INJURY;

CELL PROLIFERATION; CYTOLOGY; DISEASES; GENETIC ENGINEERING; IMMUNOLOGY; MAMMALS; TISSUE;

CELLS;

INTERLEUKIN 10; RECOMBINANT CYTOKINE; RECOMBINANT INTERLEUKIN 12P40; RECOMBINANT INTERLEUKIN 27P28; STAT1 PROTEIN; STAT3 PROTEIN; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; AUTOIMMUNE UVEITIS; CELL EXPANSION; CONTROLLED STUDY; EXPERIMENTAL MODEL; GENETIC ENGINEERING; IMMUNOPATHOGENESIS; IMMUNOREACTIVITY; IMMUNOSUPPRESSIVE TREATMENT; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH17 CELL;

ADOPTIVE TRANSFER; ANIMALS; AUTOIMMUNE DISEASES; CELL PROLIFERATION; CYTOKINE RECEPTOR GP130; DISEASE MODELS, ANIMAL; HUMANS; INTERLEUKIN-12 SUBUNIT P40; INTERLEUKINS; MICE; STAT1 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR; T-LYMPHOCYTES, REGULATORY; TH1 CELLS; TH17 CELLS; UVEITIS;

EID: 84867755894     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.390625     Document Type: Article

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