Synergy of IL-27 and TNF-α in regulating CXCL10 expression in lung fibroblasts: Implications in airway inflammation

American Journal of Respiratory Cell and Molecular Biology

Volumn 48, Issue 4, 2013, Pages 518-530

  Dong, Shanshan ^a,b   Zhang, Xuemei ^b   He, Yujuan ^b   Xu, Fang ^a   Li, Dairong ^a   Xu, Wenchun ^b   Wang, Hong ^b   Yin, Yibing ^b   Cao, Ju ^a  

^a THE FIRST AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY   (China)

^b CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

CXCL10; IL 27; Lung fibroblasts; Signaling pathways; TNF

Indexed keywords

DACTINOMYCIN; FLUTICASONE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; I KAPPA B ALPHA; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 17F; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 27; INTERLEUKIN 6; INTERLEUKIN 8; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RANTES; TUMOR NECROSIS FACTOR ALPHA; CXCL10 PROTEIN, HUMAN; I KAPPA B; IL27 PROTEIN, HUMAN; INTERLEUKIN DERIVATIVE; NF KAPPAB INHIBITOR ALPHA; NF-KAPPAB INHIBITOR ALPHA;

ARTICLE; ASTHMA; CELL ACTIVATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; LUNG FIBROBLAST; LUNG LAVAGE; LUNG TUBERCULOSIS; MAJOR CLINICAL STUDY; PROMOTER REGION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; RESPIRATORY TRACT INFLAMMATION; RNA STABILITY; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TRANSIENT TRANSFECTION; UPREGULATION; WESTERN BLOTTING; BIOSYNTHESIS; CELL CULTURE; CLINICAL TRIAL; FEMALE; FIBROBLAST; GENETICS; LUNG; LUNG DISEASE; MALE; METABOLISM; PATHOLOGY; PHOSPHORYLATION;

BRONCHOALVEOLAR LAVAGE; CELLS, CULTURED; CHEMOKINE CXCL10; FEMALE; FIBROBLASTS; GENE EXPRESSION REGULATION; HUMANS; I-KAPPA B PROTEINS; INTERLEUKINS; LUNG; LUNG DISEASES; MALE; MAP KINASE SIGNALING SYSTEM; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; TUMOR NECROSIS FACTOR-ALPHA;

MLCS; MLOWN;

EID: 84878232252     PISSN: 10441549     EISSN: 15354989     Source Type: Journal    
DOI: 10.1165/rcmb.2012-0340OC     Document Type: Article

References (45)

1. Murphy DM, O'Byrne PM. Recent advances in the pathophysiology of asthma. Chest 2010;137: 1417-1426.
2. Wang SW, Oh CK, Cho SH, Hu G, Martin R, Demissie-Sanders S, Li K, Moyle M, Yao Z. Amphiregulin expression in human mast cells and its effect on the primary human lung fibroblasts. J Allergy Clin Immunol 2005;115: 287-294.
3. Lewis CC, Chu HW, Westcott JY, Tucker A, Langmack EL, Sutherland ER, Kraft M. Airway fibroblasts exhibit a synthetic phenotype in severe asthma. J Allergy Clin Immunol 2005;115: 534-540.
4. Fukuda K, Fujitsu Y, Seki K, Kumagai N, Nishida T. Differential expression of thymus- and activation-regulated chemokine (CCL17) and macrophage-derived chemokine (CCL22) by human fibroblasts from cornea, skin, and lung. J Allergy Clin Immunol 2003;111: 520-526.
5. Miotto D, Christodoulopoulos P, Olivenstein R, Taha R, Cameron L, Tsicopoulos A, Tonnel AB, Fahy O, Lafitte JJ, Luster AD, et al. Expression of IFN-gamma-inducible protein; monocyte chemotactic proteins 1, 3, and 4; and eotaxin in Th1- and Th2-mediated lung diseases. J Allergy Clin Immunol 2001;107: 664-670.
6. Saetta M, Mariani M, Panina-Bordignon P, Turato G, Buonsanti C, Baraldo S, Bellettato CM, Papi A, Corbetta L, Zuin R, et al. Increased expression of the chemokine receptor CXCR3 and its ligand CXCL10 in peripheral airways of smokers with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2002;165: 1404-1409.
7. Panzner P, Lafitte JJ, Tsicopoulos A, Hamid Q, Tulic MK. Marked up-regulation of T lymphocytes and expression of interleukin-9 in bronchial biopsies from patients with chronic bronchitis with obstruction. Chest 2003;124: 1909-1915.
8. Medoff BD, Sauty A, Tager AM, Maclean JA, Smith RN, Mathew A, Dufour JH, Luster AD. IFN-gamma-inducible protein 10 (CXCL10) contributes to airway hyperreactivity and airway inflammation in a mouse model of asthma. J Immunol 2002;168: 5278-5286.
9. Wark PA, Bucchieri F, Johnston SL, Gibson PG, Hamilton L, Mimica J, Zummo G, Holgate ST, Attia J, Thakkinstian A, et al. IFN-gamma- induced protein 10 is a novel biomarker of rhinovirus-induced asthma exacerbations. J Allergy Clin Immunol 2007;120: 586-593.
10. Quint JK, Donaldson GC, Goldring JJ, Baghai-Ravary R, Hurst JR, Wedzicha JA. Serum IP-10 as a biomarker of human rhinovirus infection at exacerbation of COPD. Chest 2010;137: 812-822.
11. Kelsen SG, Aksoy MO, Georgy M, Hershman R, Ji R, Li X, Hurford M, Solomides C, Chatila W, Kim V. Lymphoid follicle cells in chronic obstructive pulmonary disease overexpress the chemokine receptor CXCR3. Am J Respir Crit Care Med 2009;179: 799-805.
12. Brightling CE, Ammit AJ, Kaur D, Black JL, Wardlaw AJ, Hughes JM, Bradding P. The CXCL10/CXCR3 axis mediates human lung mast cell migration to asthmatic airway smooth muscle. Am J Respir Crit Care Med 2005;171: 1103-1108.
13. Michalec L, Choudhury BK, Postlethwait E, Wild JS, Alam R, Lett- Brown M, Sur S. CCL7 and CXCL10 orchestrate oxidative stress- induced neutrophilic lung inflammation. J Immunol 2002;168: 846-852.
14. Pflanz S, Timans JC, Cheung J, Rosales R, Kanzler H, Gilbert J, Hibbert L, Churakova T, Travis M, Vaisberg E, et al. IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(1) T cells. Immunity 2002;16: 779-790.
15. Villarino AV, Huang E, Hunter CA. Understanding the pro- and antiinflammatory properties of IL-27. J Immunol 2004;173: 715-720.
16. Pflanz S, Hibbert L, Mattson J, Rosales R, Vaisberg E, Bazan JF, Phillips JH, McClanahan TK, de Waal Malefyt R, Kastelein RA. WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27. J Immunol 2004;172: 2225-2231.
17. Guzzo C, Ayer A, Basta S, Banfield BW, Gee K. IL-27 enhances LPSinduced proinflammatory cytokine production via upregulation of TLR4 expression and signaling in human monocytes. J Immunol 2012; 188: 864-873.
18. Hu S, Wong CK, Lam CW. Activation of eosinophils by IL-12 family cytokine IL-27: implications of the pleiotropic roles of IL-27 in allergic responses. Immunobiology 2011;216: 54-65.
19. Cao J, Wong CK, Yin Y, Lam CW. Activation of human bronchial epithelial cells by inflammatory cytokines IL-27 and TNF-alpha: implications for immunopathophysiology of airway inflammation. J Cell Physiol 2010;223: 788-797.
20. Kanda N, Watanabe S. IL-12, IL-23, and IL-27 enhance human betadefensin- 2 production in human keratinocytes. Eur J Immunol 2008; 38: 1287-1296.
21. Cao J, Zhang L, Li D, Xu F, Huang S, Xiang Y, Yin Y, Ren G. IL-27 is elevated in patients with COPD and patients with pulmonary TB and induces human bronchial epithelial cells to produce CXCL10. Chest 2012;141: 121-130.
22. Liu L, Cao Z, Chen J, Li R, Cao Y, Zhu C, Wu K, Wu J, Liu F, Zhu Y. Influenza A virus induces interleukin-27 through cyclooxygenase-2 and protein kinase A signaling. J Biol Chem 2012;287: 11899-11910.
23. Kim HS, Go H, Akira S, Chung DH. TLR2-mediated production of IL-27 and chemokines by respiratory epithelial cells promotes bleomycininduced pulmonary fibrosis in mice. J Immunol 2011;187: 4007-4017.
24. Woodman L, Sutcliffe A, Kaur D, Berry M, Bradding P, Pavord ID, Brightling CE. Chemokine concentrations and mast cell chemotactic activity in BAL fluid in patients with eosinophilic bronchitis and asthma, and in normal control subjects. Chest 2006;130: 371-378.
25. Shanmugam N, Ransohoff RM, Natarajan R. Interferon-gamma- inducible protein (IP)-10 mRNA stabilized by RNA-binding proteins in monocytes treated with S100b. J Biol Chem 2006;281: 31212-31221.
26. Kabeer BS, Raja A, Raman B, Thangaraj S, Leportier M, Ippolito G, Girardi E, Lagrange PH, Goletti D. IP-10 response to RD1 antigens might be a useful biomarker for monitoring tuberculosis therapy. BMC Infect Dis 2011;11:135.
27. Tang NL, Chan PK, Wong CK, To KF, Wu AK, Sung YM, Hui DS, Sung JJ, Lam CW. Early enhanced expression of interferon-inducible protein- 10 (CXCL-10) and other chemokines predicts adverse outcome in severe acute respiratory syndrome. Clin Chem 2005;51: 2333-2340.
28. Bafadhel M,McKenna S, Terry S,Mistry V, Reid C, Haldar P,McCormick M, Haldar K, Kebadze T, Duvoix A, et al. Acute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkers. Am J Respir Crit Care Med 2011;184: 662-671.
29. Jiang D, Liang J, Guo R, Xie T, Kelly FL, Martinu T, Yang T, Lovgren AK, Chia J, Liu N, et al. Long-term exposure of chemokine CXCL10 causes bronchiolitis-like inflammation. Am J Respir Cell Mol Biol 2012;46: 592-598.
30. Hammad H, Lambrecht BN. Dendritic cells and epithelial cells: linking innate and adaptive immunity in asthma. Nat Rev Immunol 2008;8: 193-204.
31. Hansel TT, Barnes PJ. New drugs for exacerbations of chronic obstructive pulmonary disease. Lancet 2009;374: 744-755.
32. Vockerodt M, Pinkert D, Smola-Hess S, Michels A, Ransohoff RM, Tesch H, Kube D. The Epstein-Barr virus oncoprotein latent membrane protein 1 induces expression of the chemokine IP-10: importance of mRNA half-life regulation. Int J Cancer 2005;114: 598-605.
33. Dhillon NK, Peng F, Ransohoff RM, Buch S. PDGF synergistically enhances IFN-gamma-induced expression of CXCL10 in blood-derived macrophages: implications for HIV dementia. J Immunol 2007;179: 2722-2730.
34. Sun D, Ding A. MyD88-mediated stabilization of interferon-gamma- induced cytokine and chemokinemRNA. Nat Immunol 2006;7: 375-381.
35. Colgan JD, Hankel IL. Signaling pathways critical for allergic airway inflammation. Curr Opin Allergy Clin Immunol 2010;10: 42-47.
36. Ito K, Caramori G, Adcock IM. Therapeutic potential of phosphatidylinositol 3-kinase inhibitors in inflammatory respiratory disease. J Pharmacol Exp Ther 2007;321: 1-8.
37. Bradding P, Brightling C. Mast cell infiltration of airway smooth muscle in asthma. Respir Med 2007;101:1045.
38. Mercado N, To Y, Ito K, Barnes PJ. Nortriptyline reverses corticosteroid insensitivity by inhibition of phosphoinositide-3-kinase-d. J Pharmacol Exp Ther 2011;337: 465-470.
39. Marwick JA, Caramori G, Casolari P, Mazzoni F, Kirkham PA, Adcock IM, Chung KF, Papi A. A role for phosphoinositol 3-kinase delta in the impairment of glucocorticoid responsiveness in patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol 2010;125: 1146-1153.
40. Raidl M, Sibbing B, Strauch J, Müller K, Nemat A, Schneider PM, Hag H, Erdmann E, Koch A. Impaired TNFalpha-induced VEGF expression in human airway smooth muscle cells from smokers with COPD: role of MAP kinases and histone acetylation: effect of dexamethasone. Cell Biochem Biophys 2007;49: 98-110.
41. Mercado N, To Y, Kobayashi Y, Adcock IM, Barnes PJ, Ito K. p38 mitogen-activated protein kinase-g inhibition by long-acting b2 adrenergic agonists reversed steroid insensitivity in severe asthma. Mol Pharmacol 2011;80: 1128-1135.
42. Casarini M, Ameglio F, Alemanno L, Zangrilli P, Mattia P, Paone G, Bisetti A, Giosuè S. Cytokine levels correlate with a radiologic score in active pulmonary tuberculosis. Am J Respir Crit Care Med 1999; 159: 143-148.
43. Calikoglu M, Sahin G, Unlu A, Ozturk C, Tamer L, Ercan B, Kanik A, Atik U. Leptin and TNF-alpha levels in patients with chronic obstructive pulmonary disease and their relationship to nutritional parameters. Respiration 2004;71: 45-50.
44. Asakura T, Ishii Y, Chibana K, Fukuda T. Leukotriene D4 stimulates collagen production from myofibroblasts transformed by TGF-beta. J Allergy Clin Immunol 2004;114: 310-315.
45. Togo S, Holz O, Liu X, Sugiura H, Kamio K, Wang X, Kawasaki S, Ahn Y, Fredriksson K, Skold CM, et al. Lung fibroblast repair functions in patients with chronic obstructive pulmonary disease are altered by multiple mechanisms. Am J Respir Crit Care Med 2008; 178: 248-260.