C5a negatively regulates toll-like receptor 4-induced immune responses

Immunity

Volumn 22, Issue 4, 2005, Pages 415-426

  Hawlisch, Heiko ^a,c   Belkaid, Yasmine ^a   Baelder, Ralf ^a   Hildeman, David ^a   Gerard, Craig ^b   Köhl, Jörg ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C5A; INTERLEUKIN 12; INTERLEUKIN 23; INTERLEUKIN 27; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; TOLL LIKE RECEPTOR 4;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FEMALE; IMMUNE RESPONSE; INNATE IMMUNITY; LEISHMANIA MAJOR; LEISHMANIASIS; MACROPHAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TH1 CELL;

EID: 17444403917     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.immuni.2005.02.006     Document Type: Article

References (46)

1. S. Akira, and K. Takeda Toll-like receptor signalling Nat. Rev. Immunol. 4 2004 499 511
2. J. Aliberti, J.G. Valenzuela, V.B. Carruthers, S. Hieny, J. Andersen, H. Charest, C. Reis e Sousa, A. Fairlamb, J.M. Ribeiro, and A. Sher Molecular mimicry of a CCR5 binding-domain in the microbial activation of dendritic cells Nat. Immunol. 4 2003 485 490
3. S.A. Barber, M.J. Fultz, C.A. Salkowski, and S.N. Vogel Differential expression of interferon regulatory factor 1 (IRF-1), IRF-2, and interferon consensus sequence binding protein genes in lipopolysaccharide (LPS)-responsive and LPS-hyporesponsive macrophages Infect. Immun. 63 1995 601 608
4. Y. Belkaid, C.A. Piccirillo, S. Mendez, E.M. Shevach, and D.L. Sacks CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity Nature 420 2002 502 507
5. Y. Belkaid, E. Von Stebut, S. Mendez, R. Lira, E. Caler, S. Bertholet, M.C. Udey, and D. Sacks CD8+ T cells are required for primary immunity in C57BL/6 mice following low-dose, intradermal challenge with Leishmania major J. Immunol. 168 2002 3992 4000
6. M.C. Braun, E. Lahey, and B.L. Kelsall Selective suppression of IL-12 production by chemoattractants J. Immunol. 164 2000 3009 3017
7. A.M. Buhl, S. Osawa, and G.L. Johnson Mitogen-activated protein kinase activation requires two signal inputs from the human anaphylatoxin C5a receptor J. Biol. Chem. 270 1995 19828 19832
8. S.A. Cain, and P.N. Monk The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74) J. Biol. Chem. 277 2002 7165 7169
9. D.J. Cua, J. Sherlock, Y. Chen, C.A. Murphy, B. Joyce, B. Seymour, L. Lucian, W. To, S. Kwan, and T. Churakova Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain Nature 421 2003 744 748
10. M. Dominguez, I. Moreno, M. Lopez-Trascasa, and A. Torano Complement interaction with trypanosomatid promastigotes in normal human serum J. Exp. Med. 195 2002 451 459
11. T. Fukao, M. Tanabe, Y. Terauchi, T. Ota, S. Matsuda, T. Asano, T. Kadowaki, T. Takeuchi, and S. Koyasu PI3K-mediated negative feedback regulation of IL-12 production in DCs Nat. Immunol. 3 2002 875 881
12. N.P. Gerard, and C. Gerard The chemotactic receptor for human C5a anaphylatoxin Nature 349 1991 614 617
13. F. Gervais, C. Desforges, and E. Skamene The C5-sufficient A/J congenic mouse strain. Inflammatory response and resistance to Listeria monocytogenes J. Immunol. 142 1989 2057 2060
14. H.S. Goodridge, W. Harnett, F.Y. Liew, and M.M. Harnett Differential regulation of interleukin-12 p40 and p35 induction via Erk mitogen-activated protein kinase-dependent and -independent mechanisms and the implications for bioactive IL-12 and IL-23 responses Immunology 109 2003 415 425
15. S. Gordon Alternative activation of macrophages Nat. Rev. Immunol. 3 2003 23 35
16. H. Hacker, H. Mischak, G. Hacker, S. Eser, N. Prenzel, A. Ullrich, and H. Wagner Cell type-specific activation of mitogen-activated protein kinases by CpG-DNA controls interleukin-12 release from antigen-presenting cells EMBO J. 18 1999 6973 6982
17. M. Hirschfeld, Y. Ma, J.H. Weis, S.N. Vogel, and J.J. Weis Cutting edge: repurification of lipopolysaccharide eliminates signaling through both human and murine toll-like receptor 2 J. Immunol. 165 2000 618 622
18. H. Ji, K. Ohmura, U. Mahmood, D.M. Lee, F.M. Hofhuis, S.A. Boackle, K. Takahashi, V.M. Holers, M. Walport, and C. Gerard Arthritis critically dependent on innate immune system players Immunity 16 2002 157 168
19. C.L. Karp, M. Wysocka, L.M. Wahl, J.M. Ahearn, P.J. Cuomo, B. Sherry, G. Trinchieri, and D.E. Griffin Mechanism of suppression of cell-mediated immunity by measles virus Science 273 1996 228 231
20. C.L. Karp, A. Grupe, E. Schadt, S.L. Ewart, M. Keane-Moore, P.J. Cuomo, J. Köhl, L. Wahl, D. Kuperman, and S. Germer Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma Nat. Immunol. 1 2000 221 226
21. S. Koyasu The role of PI3K in immune cells Nat. Immunol. 4 2003 313 319
22. P. Kropf, M.A. Freudenberg, M. Modolell, H.P. Price, S. Herath, S. Antoniazi, C. Galanos, D.F. Smith, and I. Muller Toll-like receptor 4 contributes to efficient control of infection with the protozoan parasite Leishmania major Infect. Immun. 72 2004 1920 1928
23. X. Li, J.C. Tupper, D.D. Bannerman, R.K. Winn, C.J. Rhodes, and J.M. Harlan Phosphoinositide 3 kinase mediates Toll-like receptor 4-induced activation of NF-kappa B in endothelial cells Infect. Immun. 71 2003 4414 4420
24. L.A. Lieberman, F. Cardillo, A.M. Owyang, D.M. Rennick, D.J. Cua, R.A. Kastelein, and C.A. Hunter IL-23 provides a limited mechanism of resistance to acute toxoplasmosis in the absence of IL-12 J. Immunol. 173 2004 1887 1893
25. J. Liu, S. Cao, L.M. Herman, and X. Ma Differential regulation of interleukin (IL)-12 p35 and p40 gene expression and interferon (IFN)-gamma-primed IL-12 production by IFN regulatory factor 1 J. Exp. Med. 198 2003 1265 1276
26. H.T. Lu, D.D. Yang, M. Wysk, E. Gatti, I. Mellman, R.J. Davis, and R.A. Flavell Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice EMBO J. 18 1999 1845 1857
27. T. Marth, and B.L. Kelsall Regulation of interleukin-12 by complement receptor 3 signaling J. Exp. Med. 185 1997 1987 1995
28. S. Maruyama, K. Sumita, H. Shen, M. Kanoh, X. Xu, M. Sato, M. Matsumoto, H. Shinomiya, and Y. Asano Identification of IFN regulatory factor-1 binding site in IL-12 p40 gene promoter J. Immunol. 170 2003 997 1001
29. R.K. Mathur, A. Awasthi, P. Wadhone, B. Ramanamurthy, and B. Saha Reciprocal CD40 signals through p38MAPK and ERK-1/2 induce counteracting immune responses Nat. Med. 10 2004 540 544
30. S. Mendez, S.K. Reckling, C.A. Piccirillo, D. Sacks, and Y. Belkaid Role for CD4(+) CD25(+) regulatory T cells in reactivation of persistent leishmaniasis and control of concomitant immunity J. Exp. Med. 200 2004 201 210
31. B. Oppmann, R. Lesley, B. Blom, J.C. Timans, Y. Xu, B. Hunte, F. Vega, N. Yu, J. Wang, and K. Singh Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12 Immunity 13 2000 715 725
32. M.C. Perianayagam, V.S. Balakrishnan, A.J. King, B.J. Pereira, and B.L. Jaber C5a delays apoptosis of human neutrophils by a phosphatidylinositol 3-kinase-signaling pathway Kidney Int. 61 2002 456 463
33. S. Pflanz, J.C. Timans, J. Cheung, R. Rosales, H. Kanzler, J. Gilbert, L. Hibbert, T. Churakova, M. Travis, and E. Vaisberg IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells Immunity 16 2002 779 790
34. D. Sacks, and A. Sher Evasion of innate immunity by parasitic protozoa Nat. Immunol. 3 2002 1041 1047
35. H. Sam, and M.M. Stevenson Early IL-12 p70, but not p40, production by splenic macrophages correlates with host resistance to blood-stage Plasmodium chabaudi AS malaria Clin. Exp. Immunol. 117 1999 343 349
36. O. Schulz, A.D. Edwards, M. Schito, J. Aliberti, S. Manickasingham, A. Sher, and C. Reis e Sousa CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal Immunity 13 2000 453 462
37. A. Snijders, C.M. Hilkens, T.C. van der Pouw Kraan, M. Engel, L.A. Aarden, and M.L. Kapsenberg Regulation of bioactive IL-12 production in lipopolysaccharide-stimulated human monocytes is determined by the expression of the p35 subunit J. Immunol. 156 1996 1207 1212
38. G. Trinchieri Interleukin-12 and the regulation of innate resistance and adaptive immunity Nat. Rev. Immunol. 3 2003 133 146
39. R.F. Tsuji, I. Kawikova, R. Ramabhadran, M. Akahira-Azuma, D. Taub, T.E. Hugli, C. Gerard, and P.W. Askenase Early local generation of C5a initiates the elicitation of contact sensitivity by leading to early T cell recruitment J. Immunol. 165 2000 1588 1598
40. A.V. Villarino, E. Huang, and C.A. Hunter Understanding the pro- and anti-inflammatory properties of IL-27 J. Immunol. 173 2004 715 720
41. I.M. Wang, C. Contursi, A. Masumi, X. Ma, G. Trinchieri, and K. Ozato An IFN-gamma-inducible transcription factor, IFN consensus sequence binding protein (ICSBP), stimulates IL-12 p40 expression in macrophages J. Immunol. 165 2000 271 279
42. Y. Wang, Q. Hu, J.A. Madri, S.A. Rollins, A. Chodera, and L.A. Matis Amelioration of lupus-like autoimmune disease in NZB/WF1 mice after treatment with a blocking monoclonal antibody specific for complement component C5 Proc. Natl. Acad. Sci. USA 93 1996 8563 8568
43. M. Wittmann, J. Zwirner, V.A. Larsson, K. Kirchhoff, G. Begemann, A. Kapp, O. Gotze, and T. Werfel C5a suppresses the production of IL-12 by IFN-gamma-primed and lipopolysaccharide-challenged human monocytes J. Immunol. 162 1999 6763 6769
44. D. Yadav, and N. Sarvetnick Cytokines and autoimmunity: redundancy defines their complex nature Curr. Opin. Immunol. 15 2003 697 703
45. A.K. Yi, J.G. Yoon, S.J. Yeo, S.C. Hong, B.K. English, and A.M. Krieg Role of mitogen-activated protein kinases in CpG DNA-mediated IL-10 and IL-12 production: central role of extracellular signal-regulated kinase in the negative feedback loop of the CpG DNA-mediated Th1 response J. Immunol. 168 2002 4711 4720
46. H. Yoshida, S. Hamano, G. Senaldi, T. Covey, R. Faggioni, S. Mu, M. Xia, A.C. Wakeham, H. Nishina, and J. Potter WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection Immunity 15 2001 569 578