-
1
-
-
73349109145
-
Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes
-
Jäger, A., V. Dardalhon, R. A. Sobel, E. Bettelli, and V. K. Kuchroo. 2009. Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes. J. Immunol. 183: 7169-7177.
-
(2009)
J. Immunol.
, vol.183
, pp. 7169-7177
-
-
Jäger, A.1
Dardalhon, V.2
Sobel, R.A.3
Bettelli, E.4
Kuchroo, V.K.5
-
2
-
-
68149179251
-
IL-9 as a mediator of Th17-driven inflammatory disease
-
Nowak, E. C., C. T. Weaver, H. Turner, S. Begum-Haque, B. Becher, B. Schreiner, A. J. Coyle, L. H. Kasper, and R. J. Noelle. 2009. IL-9 as a mediator of Th17-driven inflammatory disease. J. Exp. Med. 206: 1653-1660.
-
(2009)
J. Exp. Med.
, vol.206
, pp. 1653-1660
-
-
Nowak, E.C.1
Weaver, C.T.2
Turner, H.3
Begum-Haque, S.4
Becher, B.5
Schreiner, B.6
Coyle, A.J.7
Kasper, L.H.8
Noelle, R.J.9
-
3
-
-
77957230475
-
Neutralization of IL-9 ameliorates experimental autoimmune encephalomyelitis by decreasing the effector T cell population
-
Li, H., B. Nourbakhsh, B. Ciric, G. X. Zhang, and A. Rostami. 2010. Neutralization of IL-9 ameliorates experimental autoimmune encephalomyelitis by decreasing the effector T cell population. J. Immunol. 185: 4095-4100.
-
(2010)
J. Immunol.
, vol.185
, pp. 4095-4100
-
-
Li, H.1
Nourbakhsh, B.2
Ciric, B.3
Zhang, G.X.4
Rostami, A.5
-
4
-
-
79960703571
-
IL-9 is important for T-cell activation and differentiation in autoimmune inflammation of the central nervous system
-
Li, H., B. Nourbakhsh, M. Cullimore, G. X. Zhang, and A. Rostami. 2011. IL-9 is important for T-cell activation and differentiation in autoimmune inflammation of the central nervous system. Eur. J. Immunol. 41: 2197-2206.
-
(2011)
Eur. J. Immunol.
, vol.41
, pp. 2197-2206
-
-
Li, H.1
Nourbakhsh, B.2
Cullimore, M.3
Zhang, G.X.4
Rostami, A.5
-
5
-
-
56349093347
-
- effector T cells
-
- effector T cells. Nat. Immunol. 9: 1347-1355.
-
(2008)
Nat. Immunol.
, vol.9
, pp. 1347-1355
-
-
Dardalhon, V.1
Awasthi, A.2
Kwon, H.3
Galileos, G.4
Gao, W.5
Sobel, R.A.6
Mitsdoerffer, M.7
Strom, T.B.8
Elyaman, W.9
Ho, I.C.10
-
6
-
-
56349154943
-
Transforming growth factor-β "reprograms" the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset
-
Veldhoen, M., C. Uyttenhove, J. van Snick, H. Helmby, A. Westendorf, J. Buer, B. Martin, C. Wilhelm, and B. Stockinger. 2008. Transforming growth factor-β "reprograms" the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset. Nat. Immunol. 9: 1341-1346.
-
(2008)
Nat. Immunol.
, vol.9
, pp. 1341-1346
-
-
Veldhoen, M.1
Uyttenhove, C.2
Van Snick, J.3
Helmby, H.4
Westendorf, A.5
Buer, J.6
Martin, B.7
Wilhelm, C.8
Stockinger, B.9
-
7
-
-
77952584843
-
The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation
-
Chang, H. C., S. Sehra, R. Goswami, W. Yao, Q. Yu, G. L. Stritesky, R. Jabeen, C. McKinley, A. N. Ahyi, L. Han, et al. 2010. The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation. Nat. Immunol. 11: 527-534.
-
(2010)
Nat. Immunol.
, vol.11
, pp. 527-534
-
-
Chang, H.C.1
Sehra, S.2
Goswami, R.3
Yao, W.4
Yu, Q.5
Stritesky, G.L.6
Jabeen, R.7
McKinley, C.8
Ahyi, A.N.9
Han, L.10
-
8
-
-
79958219647
-
Biology of the interleukin-9 pathway and its therapeutic potential for the treatment of asthma
-
Oh, C. K., D. Raible, G. P. Geba, and N. A. Molfino. 2011. Biology of the interleukin-9 pathway and its therapeutic potential for the treatment of asthma. Inflamm. Allergy Drug Targets 10: 180-186.
-
(2011)
Inflamm. Allergy Drug Targets
, vol.10
, pp. 180-186
-
-
Oh, C.K.1
Raible, D.2
Geba, G.P.3
Molfino, N.A.4
-
9
-
-
70450177659
-
Association of the X-chromosomal genes TIMP1 and IL9R with rheumatoid arthritis
-
Burkhardt, J., E. Petit-Teixeira, V. H. Teixeira, H. Kirsten, S. Garnier, S. Ruehle, C. Oeser, G. Wolfram, M. Scholz, P. Migliorini, et al. 2009. Association of the X-chromosomal genes TIMP1 and IL9R with rheumatoid arthritis. J. Rheumatol. 36: 2149-2157.
-
(2009)
J. Rheumatol.
, vol.36
, pp. 2149-2157
-
-
Burkhardt, J.1
Petit-Teixeira, E.2
Teixeira, V.H.3
Kirsten, H.4
Garnier, S.5
Ruehle, S.6
Oeser, C.7
Wolfram, G.8
Scholz, M.9
Migliorini, P.10
-
10
-
-
34247523141
-
Discovery and biology of IL-23 and IL-27: Related but functionally distinct regulators of inflammation
-
DOI 10.1146/annurev.immunol.22.012703.104758
-
Kastelein, R. A., C. A. Hunter, and D. J. Cua. 2007. Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation. Annu. Rev. Immunol. 25: 221-242. (Pubitemid 46697908)
-
(2007)
Annual Review of Immunology
, vol.25
, pp. 221-242
-
-
Kastelein, R.A.1
Hunter, C.A.2
Cua, D.J.3
-
11
-
-
18444385868
-
+ T cells
-
DOI 10.1016/S1074-7613(02)00324-2
-
Pflanz, S., J. C. Timans, J. Cheung, R. Rosales, H. Kanzler, J. Gilbert, L. Hibbert, T. Churakova, M. Travis, E. Vaisberg, et al. 2002. IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells. Immunity 16: 779-790. (Pubitemid 34786477)
-
(2002)
Immunity
, vol.16
, Issue.6
, pp. 779-790
-
-
Pflanz, S.1
Timans, J.C.2
Cheung, J.3
Rosales, R.4
Kanzler, H.5
Gilbert, J.6
Hibbert, L.7
Churakova, T.8
Travis, M.9
Vaisberg, E.10
Blumenschein, W.M.11
Mattson, J.D.12
Wagner, J.L.13
To, W.14
Zurawski, S.15
McClanahan, T.K.16
Gorman, D.M.17
Bazan, J.F.18
De Waal, M.R.19
Rennick, D.20
Kastelein, R.A.21
more..
-
12
-
-
0038326688
-
Cutting edge: Role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment
-
Takeda, A., S. Hamano, A. Yamanaka, T. Hanada, T. Ishibashi, T. W. Mak, A. Yoshimura, and H. Yoshida. 2003. Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment. J. Immunol. 170: 4886-4890. (Pubitemid 36554716)
-
(2003)
Journal of Immunology
, vol.170
, Issue.10
, pp. 4886-4890
-
-
Takeda, A.1
Hamano, S.2
Yamanaka, A.3
Hanada, T.4
Ishibashi, T.5
Mak, T.W.6
Yoshimura, A.7
Yoshida, H.8
-
13
-
-
38149045608
-
IL-27 suppresses Th2 cell development and Th2 cytokines production from polarized Th2 cells: A novel therapeutic way for Th2-mediated allergic inflammation
-
Yoshimoto, T., T. Yoshimoto, K. Yasuda, J. Mizuguchi, and K. Nakanishi. 2007. IL-27 suppresses Th2 cell development and Th2 cytokines production from polarized Th2 cells: a novel therapeutic way for Th2-mediated allergic inflammation. J. Immunol. 179: 4415-4423.
-
(2007)
J. Immunol.
, vol.179
, pp. 4415-4423
-
-
Yoshimoto, T.1
Yoshimoto, T.2
Yasuda, K.3
Mizuguchi, J.4
Nakanishi, K.5
-
14
-
-
38449098843
-
Augmentation of antigen-presenting and Th1-promoting functions of dendritic cells by WSX-1 (IL-27R) deficiency
-
Wang, S., Y. Miyazaki, Y. Shinozaki, and H. Yoshida. 2007. Augmentation of antigen-presenting and Th1-promoting functions of dendritic cells by WSX-1 (IL-27R) deficiency. J. Immunol. 179: 6421-6428.
-
(2007)
J. Immunol.
, vol.179
, pp. 6421-6428
-
-
Wang, S.1
Miyazaki, Y.2
Shinozaki, Y.3
Yoshida, H.4
-
15
-
-
36248970701
-
A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells
-
DOI 10.1038/ni1541, PII NI1541
-
Awasthi, A., Y. Carrier, J. P. Peron, E. Bettelli, M. Kamanaka, R. A. Flavell, V. K. Kuchroo, M. Oukka, and H. L. Weiner. 2007. A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells. Nat. Immunol. 8: 1380-1389. (Pubitemid 350131175)
-
(2007)
Nature Immunology
, vol.8
, Issue.12
, pp. 1380-1389
-
-
Awasthi, A.1
Carrier, Y.2
Peron, J.P.S.3
Bettelli, E.4
Kamanaka, M.5
Flavell, R.A.6
Kuchroo, V.K.7
Oukka, M.8
Weiner, H.L.9
-
17
-
-
33747588291
-
Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells
-
DOI 10.1038/ni1375, PII NI1375
-
Batten, M., J. Li, S. Yi, N. M. Kljavin, D. M. Danilenko, S. Lucas, J. Lee, F. J. de Sauvage, and N. Ghilardi. 2006. Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nat. Immunol. 7: 929-936. (Pubitemid 44263906)
-
(2006)
Nature Immunology
, vol.7
, Issue.9
, pp. 929-936
-
-
Batten, M.1
Li, J.2
Yi, S.3
Kljavin, N.M.4
Danilenko, D.M.5
Lucas, S.6
Lee, J.7
De Sauvage, F.J.8
Ghilardi, N.9
-
18
-
-
33747593830
-
Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system
-
DOI 10.1038/ni1376, PII NI1376
-
Stumhofer, J. S., A. Laurence, E. H. Wilson, E. Huang, C. M. Tato, L. M. Johnson, A. V. Villarino, Q. Huang, A. Yoshimura, D. Sehy, et al. 2006. Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nat. Immunol. 7: 937-945. (Pubitemid 44263907)
-
(2006)
Nature Immunology
, vol.7
, Issue.9
, pp. 937-945
-
-
Stumhofer, J.S.1
Laurence, A.2
Wilson, E.H.3
Huang, E.4
Tato, C.M.5
Johnson, L.M.6
Villarino, A.V.7
Huang, Q.8
Yoshimura, A.9
Sehy, D.10
Saris, C.J.M.11
O'Shea, J.J.12
Hennighausen, L.13
Ernst, M.14
Hunter, C.A.15
-
19
-
-
35648988381
-
Suppressive effect of IL-27 on encephalitogenic Th17 cells and the effector phase of experimental autoimmune encephalomyelitis
-
Fitzgerald, D. C., B. Ciric, T. Touil, H. Harle, J. Grammatikopolou, J. Das Sarma, B. Gran, G. X. Zhang, and A. Rostami. 2007. Suppressive effect of IL-27 on encephalitogenic Th17 cells and the effector phase of experimental autoimmune encephalomyelitis. J. Immunol. 179: 3268-3275.
-
(2007)
J. Immunol.
, vol.179
, pp. 3268-3275
-
-
Fitzgerald, D.C.1
Ciric, B.2
Touil, T.3
Harle, H.4
Grammatikopolou, J.5
Das Sarma, J.6
Gran, B.7
Zhang, G.X.8
Rostami, A.9
-
20
-
-
70349736116
-
Cross-regulation of signaling pathways by interferon-γ: Implications for immune responses and autoimmune diseases
-
Hu, X., and L. B. Ivashkiv. 2009. Cross-regulation of signaling pathways by interferon-γ: implications for immune responses and autoimmune diseases. Immunity 31: 539-550.
-
(2009)
Immunity
, vol.31
, pp. 539-550
-
-
Hu, X.1
Ivashkiv, L.B.2
-
21
-
-
77954939162
-
Identification of an IL-27/osteopontin axis in dendritic cells and its modulation by IFN-g limits IL-17-mediated autoimmune inflammation
-
Murugaiyan, G., A. Mittal, and H. L. Weiner. 2010. Identification of an IL-27/osteopontin axis in dendritic cells and its modulation by IFN-g limits IL-17-mediated autoimmune inflammation. Proc. Natl. Acad. Sci. USA 107: 11495-11500.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 11495-11500
-
-
Murugaiyan, G.1
Mittal, A.2
Weiner, H.L.3
-
22
-
-
76949102494
-
Regulation of IL-9 expression by IL-25 signaling
-
Angkasekwinai, P., S. H. Chang, M. Thapa, H. Watarai, and C. Dong. 2010. Regulation of IL-9 expression by IL-25 signaling. Nat. Immunol. 11: 250-256.
-
(2010)
Nat. Immunol.
, vol.11
, pp. 250-256
-
-
Angkasekwinai, P.1
Chang, S.H.2
Thapa, M.3
Watarai, H.4
Dong, C.5
-
23
-
-
69149107148
-
+ natural regulatory T cells
-
+ natural regulatory T cells. Proc. Natl. Acad. Sci. USA 106: 12885-12890.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 12885-12890
-
-
Elyaman, W.1
Bradshaw, E.M.2
Uyttenhove, C.3
Dardalhon, V.4
Awasthi, A.5
Imitola, J.6
Bettelli, E.7
Oukka, M.8
Van Snick, J.9
Renauld, J.C.10
-
25
-
-
69249083836
-
Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells
-
Pot, C., H. Jin, A. Awasthi, S. M. Liu, C. Y. Lai, R. Madan, A. H. Sharpe, C. L. Karp, S. C. Miaw, I. C. Ho, and V. K. Kuchroo. 2009. Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells. J. Immunol. 183: 797-801.
-
(2009)
J. Immunol.
, vol.183
, pp. 797-801
-
-
Pot, C.1
Jin, H.2
Awasthi, A.3
Liu, S.M.4
Lai, C.Y.5
Madan, R.6
Sharpe, A.H.7
Karp, C.L.8
Miaw, S.C.9
Ho, I.C.10
Kuchroo, V.K.11
-
26
-
-
36248951161
-
Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10
-
DOI 10.1038/ni1537, PII NI1537
-
Stumhofer, J. S., J. S. Silver, A. Laurence, P. M. Porrett, T. H. Harris, L. A. Turka, M. Ernst, C. J. Saris, J. J. O'Shea, and C. A. Hunter. 2007. Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10. Nat. Immunol. 8: 1363-1371. (Pubitemid 350131173)
-
(2007)
Nature Immunology
, vol.8
, Issue.12
, pp. 1363-1371
-
-
Stumhofer, J.S.1
Silver, J.S.2
Laurence, A.3
Porrett, P.M.4
Harris, T.H.5
Turka, L.A.6
Ernst, M.7
Saris, C.J.M.8
O'Shea, J.J.9
Hunter, C.A.10
-
28
-
-
4644225089
-
+ T cells
-
Kamiya, S., T. Owaki, N. Morishima, F. Fukai, J. Mizuguchi, and T. Yoshimoto. 2004. An indispensable role for STAT1 in IL-27-induced T-bet expression but not proliferation of naive CD4+ T cells. J. Immunol. 173: 3871-3877. (Pubitemid 39280750)
-
(2004)
Journal of Immunology
, vol.173
, Issue.6
, pp. 3871-3877
-
-
Kamiya, S.1
Owaki, T.2
Morishima, N.3
Fukai, F.4
Mizuguchi, J.5
Yoshimoto, T.6
-
29
-
-
17644396349
-
Immunology of multiple sclerosis
-
DOI 10.1146/annurev.immunol.23.021704.115707
-
Sospedra, M., and R. Martin. 2005. Immunology of multiple sclerosis. Annu. Rev. Immunol. 23: 683-747. (Pubitemid 40563183)
-
(2005)
Annual Review of Immunology
, vol.23
, pp. 683-747
-
-
Sospedra, M.1
Martin, R.2
-
30
-
-
0029671318
-
Mice with a disrupted IFN-γ gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE)
-
Ferber, I. A., S. Brocke, C. Taylor-Edwards, W. Ridgway, C. Dinisco, L. Steinman, D. Dalton, and C. G. Fathman. 1996. Mice with a disrupted IFN-γ gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE). J. Immunol. 156: 5-7.
-
(1996)
J. Immunol.
, vol.156
, pp. 5-7
-
-
Ferber, I.A.1
Brocke, S.2
Taylor-Edwards, C.3
Ridgway, W.4
Dinisco, C.5
Steinman, L.6
Dalton, D.7
Fathman, C.G.8
-
31
-
-
0037114150
-
IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: Evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination
-
Gran, B., G. X. Zhang, S. Yu, J. Li, X. H. Chen, E. S. Ventura, M. Kamoun, and A. Rostami. 2002. IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination. J. Immunol. 169: 7104-7110. (Pubitemid 36899299)
-
(2002)
Journal of Immunology
, vol.169
, Issue.12
, pp. 7104-7110
-
-
Gran, B.1
Zhang, G.-X.2
Yu, S.3
Li, J.4
Chen, X.-H.5
Ventura, E.S.6
Kamoun, M.7
Rostami, A.8
-
32
-
-
34247247352
-
Interferon-γ regulates susceptibility to collagen-induced arthritis through suppression of interleukin-17
-
DOI 10.1002/art.22453
-
Chu, C. Q., D. Swart, D. Alcorn, J. Tocker, and K. B. Elkon. 2007. Interferon-γ regulates susceptibility to collagen-induced arthritis through suppression of interleukin-17. Arthritis Rheum. 56: 1145-1151. (Pubitemid 46608639)
-
(2007)
Arthritis and Rheumatism
, vol.56
, Issue.4
, pp. 1145-1151
-
-
Chu, C.-Q.1
Swart, D.2
Alcorn, D.3
Tocker, J.4
Elkon, K.B.5
-
33
-
-
19944427136
-
+ T cells in IFN-γ knockout mice is associated with progression of myocarditis to heart failure
-
+ T cells in IFN-γ knockout mice is associated with progression of myocarditis to heart failure. Proc. Natl. Acad. Sci. USA 102: 180-185.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 180-185
-
-
Afanasyeva, M.1
Georgakopoulos, D.2
Belardi, D.F.3
Bedja, D.4
Fairweather, D.5
Wang, Y.6
Kaya, Z.7
Gabrielson, K.L.8
Rodriguez, E.R.9
Caturegli, P.10
-
34
-
-
79955007180
-
IL-9 promotes Th17 cell migration into the central nervous system via CC chemokine ligand-20 produced by astrocytes
-
Zhou, Y., Y. Sonobe, T. Akahori, S. Jin, J. Kawanokuchi, M. Noda, Y. Iwakura, T. Mizuno, and A. Suzumura. 2011. IL-9 promotes Th17 cell migration into the central nervous system via CC chemokine ligand-20 produced by astrocytes. J. Immunol. 186: 4415-4421.
-
(2011)
J. Immunol.
, vol.186
, pp. 4415-4421
-
-
Zhou, Y.1
Sonobe, Y.2
Akahori, T.3
Jin, S.4
Kawanokuchi, J.5
Noda, M.6
Iwakura, Y.7
Mizuno, T.8
Suzumura, A.9
-
35
-
-
34147130293
-
Yin and yang interplay of IFN-γ in inflammation and autoimmune disease
-
DOI 10.1172/JCI31860
-
Zhang, J. 2007. Yin and yang interplay of IFN-γ in inflammation and autoimmune disease. J. Clin. Invest. 117: 871-873. (Pubitemid 46556742)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.4
, pp. 871-873
-
-
Zhang, J.1
|